ZBTB16--RARA

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

ZBTB16 RARA

COSMIC

The fusion gene pair ZBTB16--RARA information is not available in COSMIC database.

ChimerKB

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The fusion gene pair ZBTB16--RARA information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
ZBTB16_RARA-/-/ -/-/ - hg18 acute promyelocytic leukemia - - Oncogene; Mitelman
ZBTB16_RARA-/0/ -/0/ Exonic hg18 - - - Oncogene; TICdb
ZBTB16_RARA-/-/ -/-/ - hg18 acute promyelocytic leukemia - 8387545 Oncogene; OMIM

ChimerPUB

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The fusion gene pair ZBTB16--RARA information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
ZBTB16_RARAt(11;17)(q23;q21) / t(11;17)(q23;q12) / t(15;17)(q22;q12) / 23071480pulmonary tuberculosis;tuberculosis - - The variant APL with t(11;17)(q23;q21) cases that are associated with the ZBTB16/RARA fusion gene have been reported as being resistant to all-trans-retinoic acid (ATRA). /// ZBTB16/RARA.
ZBTB16_RARAinv(16) / t(4;11) / t(11;19) / 23091311- PCR - Fifteen fusion transcripts were included: BCR-ABL1, PML-RARA, ZBTB16-RARA, RUNX1-RUNX1T1, CBFB-MYH11, DEK-NUP214, TCF3-PBX1, ETV6-RUNX1, MLL-AFF1, MLL-MLLT4, MLL-MLLT3, MLL-MLLT10, MLL-ELL, MLL-MLLT1, and MLL-MLLT6.
ZBTB16_RARAt(15;17) / 26414475acute promyelocytic leukemia;leukemia - - It is important to identify these cryptic and variant translocations because certain variants, including ZBTB16/RARA and STAT5B/RARA, are resistant to treatment with all-trans retinoic acid, arsenic trioxide, and anthracyclines. /// "With the exception of ZBTB16/RARA, these variants have similar morphologic and immunophenotypic features as classic APL. "

ChimerSEQ

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The fusion gene pair ZBTB16--RARA information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair ZBTB16--RARA information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair ZBTB16--RARA information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
ZBTB16/PLZF-RARA Acute promyelocytic leukemia RT-PCR,FISH t(15;17)(q22;q21),t(11;17)(q23;21) PubMed:8387545

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
ZBTB16/PLZF-RARA ZBTB16/PLZF-RARA-Isoform1 ZBTB16/PLZF _ _ 1 RARA 38504567 1 0 CACAGGCAGACCCATACTgCCATTGAGACCCAGAGCAGC 7849296 _
ZBTB16/PLZF-RARA ZBTB16/PLZF-RARA-Isoform2 ZBTB16/PLZF _ _ 1 RARA 38504566 1 0 CACTTACTGGCTCATTCAgCCATTGAGACCCAGAGCAGC 7849296 _
ZBTB16/PLZF-RARA ZBTB16/PLZF-RARA-Isoform3 ZBTB16/PLZF _ _ 1 RARA _ 1 _ ctggctcattcagCcattgagacc 9389704 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
ZBTB16/PLZF-RARA ZBTB16/PLZF-RARA-Isoform1 - - 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
ZBTB16/PLZF 1) BTB
2) zf-C2H2_6
3) zf-C2H2
4) zf-H2C2_2
1) BTB , BACK , Cullin
2) zf-H2C2_2
3) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2
4) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2 , zf-C2H2_6
RARA 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) BTB
2) zf-C2H2_6
3) zf-C2H2
4) zf-H2C2_2
1) BTB , BACK , Cullin
2) zf-H2C2_2
3) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2
4) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2 , zf-C2H2_6
ZBTB16/PLZF-RARA ZBTB16/PLZF-RARA-Isoform2 - - 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
ZBTB16/PLZF 1) BTB
2) zf-C2H2_6
3) zf-C2H2
4) zf-H2C2_2
1) BTB , BACK , Cullin
2) zf-H2C2_2
3) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2
4) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2 , zf-C2H2_6
RARA 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) BTB
2) zf-C2H2_6
3) zf-C2H2
4) zf-H2C2_2
1) BTB , BACK , Cullin
2) zf-H2C2_2
3) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2
4) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2 , zf-C2H2_6
ZBTB16/PLZF-RARA ZBTB16/PLZF-RARA-Isoform3 - - - -ZBTB16/PLZF 1) BTB
2) zf-C2H2_6
3) zf-C2H2
4) zf-H2C2_2
1) BTB , BACK , Cullin
2) zf-H2C2_2
3) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2
4) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2 , zf-C2H2_6
RARA 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) BTB
2) zf-C2H2_6
3) zf-C2H2
4) zf-H2C2_2
5) zf-C4
6) Hormone_recep
1) BTB , BACK , Cullin
2) zf-H2C2_2
3) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2
4) zf-C2H2 , zf-C2H2_4 , zf-C2H2_2 , zf-C2H2_6
5) zf-C4 , Hormone_recep
6) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
ZBTB16/PLZF-RARA hsa-miR-125a-5phsa-miR-218-5phsa-miR-615-3phsa-miR-138-5p _ Microarray,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
ZBTB16/PLZF-RARA NM_001018011.1 1) TRIM28_HUMAN
2) MITF_HUMAN
3) STAT1_HUMAN
4) ZNF263_HUMAN
5) RUNX1_HUMAN
6) PRDM14_HUMAN
7) ESTROGEN RECEPTOR ALPHA_HUMAN
8) ETS1_HUMAN
9) EGR1_HUMAN
10) FOS_HUMAN
11) GATA2_HUMAN
12) TAL1_HUMAN
13) CTCF_HUMAN
14) BRG1_HUMAN
15) HNF4A_HUMAN
16) FOXA1_HUMAN
17) CEBPA_HUMAN
18) ESR2_HUMAN
19) AR_HUMAN
20) FOXP1_HUMAN
21) ESR1_HUMAN
22) SPI1_HUMAN
1) RXR/RAR_HUMAN
2) NR1H3_HUMAN
3) TFAP2C_HUMAN
4) RB1_HUMAN
5) RBL2_HUMAN
6) GATA3_HUMAN
7) PRDM14_HUMAN
1) TRIM28_HUMAN
2) MITF_HUMAN
3) STAT1_HUMAN
4) ZNF263_HUMAN
5) RUNX1_HUMAN
6) PRDM14_HUMAN
7) ESTROGEN RECEPTOR ALPHA_HUMAN
8) ETS1_HUMAN
9) EGR1_HUMAN
10) FOS_HUMAN
11) GATA2_HUMAN
12) TAL1_HUMAN
13) CTCF_HUMAN
14) BRG1_HUMAN
15) HNF4A_HUMAN
16) FOXA1_HUMAN
17) CEBPA_HUMAN
18) ESR2_HUMAN
19) AR_HUMAN
20) FOXP1_HUMAN
21) ESR1_HUMAN
22) SPI1_HUMAN

TicDB

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The fusion gene pair ZBTB16--RARA information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
ZBTB16 RARA 7849296 CACAGGCAGACCCATACTgCCATTGAGACCCAGAGCAGC
ZBTB16 RARA 7849296 CACTTACTGGCTCATTCAgCCATTGAGACCCAGAGCAGC
ZBTB16 RARA 9389704 ctggctcattcagCcattgagacc

TUMOR FUSION Gene Data Portal

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The fusion gene pair ZBTB16--RARA information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair ZBTB16--RARA information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair ZBTB16--RARA information is not available in ConjoinG Database.

1000Genome

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Fusion gene ZBTB16--RARA has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene ZBTB16--RARA is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene ZBTB16--RARA is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene ZBTB16--RARA is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene ZBTB16--RARA was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair ZBTB16--RARA information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene ZBTB16--RARA is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene ZBTB16--RARA has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene ZBTB16 is a known oncogene according to ONGENE database.


The tail gene RARA is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene ZBTB16 is cancer associated according to Bushman Cancer Gene database.


The tail gene RARA is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene ZBTB16 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene RARA is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene ZBTB16--RARA is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene ZBTB16--RARA is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair ZBTB16--RARA information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene ZBTB16--RARA is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene ZBTB16--RARA has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair ZBTB16--RARA information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair ZBTB16--RARA information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair ZBTB16--RARA information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene ZBTB16--RARA is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair ZBTB16--RARA information is not available in ChromothripsisDB database.