TRIM33--RET

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TRIM33 RET

COSMIC

The fusion gene pair TRIM33--RET information is not available in COSMIC database.

ChimerKB

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The fusion gene pair TRIM33--RET information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
TRIM33_RET-/2976/ -/2369/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
TRIM33_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10439047 Oncogene; Cosmic_nonrecurrent
TRIM33_RET-/0/ -/0/ Exonic hg18 - - - Oncogene; TICdb

ChimerPUB

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The fusion gene pair TRIM33--RET information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TRIM33_RET- 23533264lung cancer;non small cell lung cancer - - Confirmed partial responses were observed in 2 patients, including one harboring a novel TRIM33-RET fusion. /// "Confirmed partial responses were observed in 2 patients, including one harboring a novel TRIM33-RET fusion. "

ChimerSEQ

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The fusion gene pair TRIM33--RET information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
TRIM33_RETchr1/114964057/- chr10/43612031/+ 1p13.2 10q11.21 Exonic hg19 In-Frame Inter-chr LUAD TCGA-55-6543-01A Oncogene; FusionScan
TRIM33_RETchr1/114964058/- chr10/43612032/+ 1p13.2 10q11.21 Exonic hg19 In-frame Inter-chr LUAD TCGA-55-6543-01A Oncogene; PRADA

ChiTaRS 2.1

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The fusion gene pair TRIM33--RET information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair TRIM33--RET information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
TRIM33-RET Papillary thyroid carcinomas RT-PCR _ PubMed:10439047

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
TRIM33-RET TRIM33-RET TRIM33 114944086 0 0 RET 43610149 1 1 GAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTgAAATGTGAACGTCTTCTGCAAA 10439047 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
TRIM33-RET TRIM33-RET 1) Bromodomain
1) PHD , Bromodomain , ASF1_hist_chap , DUP902
1) Pkinase_Tyr
1) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
TRIM33 1) zf-RING_2
2) zf-B_box
3) PHD
4) Bromodomain
1) UQ_con , ubiquitin
2) zf-B_box
3) PHD , Bromodomain , JmjC , RRM_1
4) PHD , Bromodomain , ASF1_hist_chap , DUP902
RET 1) Cadherin
2) Pkinase_Tyr
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Cadherin
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
TRIM33-RET hsa-miR-31-5phsa-miR-29a-3phsa-miR-215-5phsa-miR-192-5p hsa-miR-21-5phsa-miR-19b-3phsa-miR-744-5phsa-let-7a-3p Report assay,qPCR,Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
TRIM33-RET NM_015906.3 1) MITF_HUMAN
2) RB1_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) ZNF263_HUMAN
6) E2F4_HUMAN
7) P53_HUMAN
8) RUNX1_HUMAN
9) PRDM14_HUMAN
10) ESTROGEN RECEPTOR ALPHA_HUMAN
11) ETS1_HUMAN
12) EGR1_HUMAN
13) FOS_HUMAN
14) GATA2_HUMAN
15) GATA3_HUMAN
16) CTCF_HUMAN
17) BRG1_HUMAN
18) EPAS1_HUMAN
19) HNF4A_HUMAN
20) TFAP2C_HUMAN
21) FOXA1_HUMAN
22) CEBPA_HUMAN
23) ESR1_HUMAN
24) ESR2_HUMAN
25) FOXP1_HUMAN A
26) NR1H3_HUMAN A
27) SPI1_HUMAN A
28) TRIM24_HUMAN
1) SOX10_HUMAN
2) TRIM28_HUMAN
1) 21258399
2) 20385362
3) 19122651
4) 20385362
5) 19887448
6) 21247883
7) 21394211
8) 20019798
9) 20953172
10) 20547749
11) 20019798
12) 20690147
13) 20139302
14) 21808000
15) 21878914
16) 21795385
17) 19505939
18) 21447827
19) 21646355
20) 21572391
21) 21572391
22) 20219941
23) 20348243
24) 21235772
25) 21924763 A
26) 22292898 A
27) 21241896 A
28) 21164480

TicDB

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The fusion gene pair TRIM33--RET information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
TRIM33 RET 10439047 GAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTgAAATGTGAACGTCTTCTGCAAA

TUMOR FUSION Gene Data Portal

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The fusion gene pair TRIM33--RET information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
LUAD 55-6543-01A TRIM33__RET 1.7 1:114964058/-1 10:43612032/1 tier1 In-frame 18635 NA

FusionCancer

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The fusion gene pair TRIM33--RET information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TRIM33--RET information is not available in ConjoinG Database.

1000Genome

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Fusion gene TRIM33--RET has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TRIM33--RET is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TRIM33--RET is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TRIM33--RET is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TRIM33--RET was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TRIM33--RET information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TRIM33--RET is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TRIM33--RET has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TRIM33 is not a known oncogene according to ONGENE database.


The tail gene RET is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TRIM33 is cancer associated according to Bushman Cancer Gene database.


The tail gene RET is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TRIM33 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene RET is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TRIM33--RET is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TRIM33--RET is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TRIM33--RET information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TRIM33--RET is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TRIM33--RET has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TRIM33--RET information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair TRIM33--RET information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TRIM33--RET information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene TRIM33--RET is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TRIM33--RET information is not available in ChromothripsisDB database.