| TRAF1_ALK | - |
25501114 | acute myeloid leukemia;anaplastic large cell lymphoma;myeloid leukemia;leukemia;lymphoma |
FISH;PCR |
- |
ATIC is the second most common partner of variant ALK rearrangements, while the TRAF1-ALK fusion gene was first reported in 2013, and this is the second reported case of ALK(+) ALCL carrying TRAF1-ALK. /// We subsequently confirmed ATIC-ALK and TRAF1-ALK fusions by reverse transcriptase PCR and nucleotide sequencing.
|
| TRAF1_ALK | - |
23999969 | anaplastic large cell lymphoma;lymphoma;hematologic malignancy |
- |
- |
The TRAF1-ALK fusion transcript was confirmed at the mRNA level by Sanger sequencing and the fusion protein was visualized by Western blot. /// The discovery of this TRAF1-ALK fusion expands the diversity of known ALK fusion partners and highlights the power of deep sequencing for fusion transcript discovery. /// Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma..
|
| TRAF1_ALK | t(2;5)(p23;q35) / |
26187744 | anaplastic large cell lymphoma;lymphoma |
PCR |
- |
Non-allele-specific ALK RT-qPCR revealed ALK overexpression and 5' RACE PCR revealed that the patient's lymphoma expressed a TRAF1-ALK fusion. /// Detection of a TRAF1-ALK fusion in an anaplastic large cell lymphoma patient with chemotherapy and ALK inhibitor-resistant disease.. /// We report the case of an ALCL patient whose tumor harbored the newly recognized TRAF1-ALK fusion and describe the clinical outcome after treatment with an ALK inhibitor.
|
| TRAF1_ALK | - |
25533804 | anaplastic large cell lymphoma;lymphoma |
- |
- |
A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation.. /// These data indicate that the activation of NFkB signaling contributes to the neoplastic phenotype of TRAF1-ALK ALCL. /// The treatment with proteasome inhibitors of TRAF1-ALK cells led to the downregulation of p50/p52 and lymphoma growth inhibition.
|