TPR--NTRK1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TPR NTRK1

COSMIC

The fusion gene pair TPR--NTRK1 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair TPR--NTRK1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
TPR_NTRK1chr1/184610797/ chr1/155112034/ Exonic hg18 - - - Kinase; ChimerDB2
TPR_NTRK1-/72/ -/299/ Exonic hg18 - - - Kinase; TICdb
TPR_NTRK1-/917/ -/118/ Exonic hg18 - - - Kinase; TICdb

ChimerPUB

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The fusion gene pair TPR--NTRK1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TPR_NTRK1- 26001971colorectal cancer;colorectal carcinoma;lung cancer;colon cancer PCR - One of these rearrangements is a TPM3-NTRK1 fusion already observed in colon cancer, while the second one is a TPR-NTRK1 fusion never described in this type of cancer.
TPR_NTRK1- 9172002- - - In a previous study, we showed that two tumors carrying the TPR/NTRK1 rearrangement contained structurally different oncogenes named TRK-T1 and TRK-T2. /// "In this paper, we report (1) the cDNA structure of TRK-T2, (2) evidence that TRK-T2 is generated by different rearrangements in two thyroid tumors, and (3) a detailed analysis of the three different TPR/NTRK1 rearrangements. "
TPR_NTRK1- 26367451thyroid nodule;thyroid carcinoma - - These gene fusions included ETV6/NTRK3 (n=3) and TPR/NTRK1 (n=1).

ChimerSEQ

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The fusion gene pair TPR--NTRK1 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair TPR--NTRK1 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair TPR--NTRK1 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
TPR-NTRK1 Papillary thyroid carcinoma PCR,DNA sequencing,Southern blot _ PubMed:9172002

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
TPR-NTRK1 TPR-NTRK1-Isoform1 TPR 186319400 1 0 NTRK1 156844361 1 0 ATGGAAGTCCAAGTTGCTTCTCAGTCTTCACAGAGAACTGGTAAAgACACTAACAGCACATCTGGAGACCCGGTGGAGAAGAAGGA 7565764 _
TPR-NTRK1 TPR-NTRK1-Isoform2 TPR 186319329 0 0 NTRK1 156844050 1 0 AATTGTAAATAAACAAGTACTTCTTGGGATTATAATATATCCTGTCaATCCATCCCCCCTCGTCCCATGAAGGAATGAGTCCCAGAGTAGGCAGGGGACTCAC 9172002 _
TPR-NTRK1 TPR-NTRK1-Isoform3 TPR 186318497 1 0 NTRK1 156843869 1 0 ATTTCTTAACACAAGGGAAATAAATAACTAATAATTGTATGCAGACTTTCTGATTTACAcTTCTGGAGTCCTGGTGTCCCGCTGTTCTGGCCTCCTTACCCTCT 9172002 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
TPR-NTRK1 TPR-NTRK1-Isoform1 1) TPR_MLP1_2
- 1) Pkinase_Tyr
1) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
TPR 1) TPR_MLP1_2
-NTRK1 1) LRR_8
2) TPKR_C2
3) Pkinase_Tyr
1) Cys_knot , Flagellin_N , Internalin_N , LRR_5 , Laminin_N , VWA , DUF3439 , Hormone_6 , LRRNT , LRR_6 , Lys , E1_DerP2_DerF2 , I-set , LRR_1 , LRR_7 , Trypsin , Flagellin_C , Ig_2 , V-set , LRR_8 , LRR_4
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) LRR_8
2) TPKR_C2
1) Cys_knot , Flagellin_N , Internalin_N , LRR_5 , Laminin_N , VWA , DUF3439 , Hormone_6 , LRRNT , LRR_6 , Lys , E1_DerP2_DerF2 , I-set , LRR_1 , LRR_7 , Trypsin , Flagellin_C , Ig_2 , V-set , LRR_8 , LRR_4
TPR-NTRK1 TPR-NTRK1-Isoform2 1) TPR_MLP1_2
- 1) Pkinase_Tyr
1) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
TPR 1) TPR_MLP1_2
-NTRK1 1) LRR_8
2) TPKR_C2
3) Pkinase_Tyr
1) Cys_knot , Flagellin_N , Internalin_N , LRR_5 , Laminin_N , VWA , DUF3439 , Hormone_6 , LRRNT , LRR_6 , Lys , E1_DerP2_DerF2 , I-set , LRR_1 , LRR_7 , Trypsin , Flagellin_C , Ig_2 , V-set , LRR_8 , LRR_4
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) LRR_8
2) TPKR_C2
1) Cys_knot , Flagellin_N , Internalin_N , LRR_5 , Laminin_N , VWA , DUF3439 , Hormone_6 , LRRNT , LRR_6 , Lys , E1_DerP2_DerF2 , I-set , LRR_1 , LRR_7 , Trypsin , Flagellin_C , Ig_2 , V-set , LRR_8 , LRR_4
TPR-NTRK1 TPR-NTRK1-Isoform3 1) TPR_MLP1_2
- 1) Pkinase_Tyr
1) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
TPR 1) TPR_MLP1_2
-NTRK1 1) LRR_8
2) TPKR_C2
3) Pkinase_Tyr
1) Cys_knot , Flagellin_N , Internalin_N , LRR_5 , Laminin_N , VWA , DUF3439 , Hormone_6 , LRRNT , LRR_6 , Lys , E1_DerP2_DerF2 , I-set , LRR_1 , LRR_7 , Trypsin , Flagellin_C , Ig_2 , V-set , LRR_8 , LRR_4
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) LRR_8
2) TPKR_C2
1) Cys_knot , Flagellin_N , Internalin_N , LRR_5 , Laminin_N , VWA , DUF3439 , Hormone_6 , LRRNT , LRR_6 , Lys , E1_DerP2_DerF2 , I-set , LRR_1 , LRR_7 , Trypsin , Flagellin_C , Ig_2 , V-set , LRR_8 , LRR_4

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
TPR-NTRK1 _ hsa-miR-375hsa-miR-1180-3phsa-miR-615-3phsa-miR-378a-5p _

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
TPR-NTRK1 NM_003292.2 1) HIF1A_HUMAN
2) RB1_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) E2F4_HUMAN
6) ETS1_HUMAN
7) FOS_HUMAN
8) GATA3_HUMAN
9) BRG1_HUMAN
10) TFAP2C_HUMAN
11) FOXA1_HUMAN
12) CTCF_HUMAN
1) ZNF263_HUMAN
2) PRDM14_HUMAN
3) ESTROGEN RECEPTOR ALPHA_HUMAN
4) EGR1_HUMAN
5) HNF4A_HUMAN
6) ESR1_HUMAN
7) NR1H3_HUMAN
1) 19828020
2) 20385362
3) 19122651
4) 20385362
5) 21247883
6) 20019798
7) 20139302
8) 21878914
9) 19505939
10) 21572391
11) 21572391
12) 20219941

TicDB

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The fusion gene pair TPR--NTRK1 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
TPR NTRK1 7565764 ATGGAAGTCCAAGTTGCTTCTCAGTCTTCACAGAGAACTGGTAAAgACACTAACAGCACATCTGGAGACCCGGTGGAGAAGAAGGA
TPR NTRK1 9172002 AATTGTAAATAAACAAGTACTTCTTGGGATTATAATATATCCTGTCaATCCATCCCCCCTCGTCCCATGAAGGAATGAGTCCCAGAGTAGGCAGGGGACTCAC
TPR NTRK1 9172002 ATTTCTTAACACAAGGGAAATAAATAACTAATAATTGTATGCAGACTTTCTGATTTACAcTTCTGGAGTCCTGGTGTCCCGCTGTTCTGGCCTCCTTACCCTCT

TUMOR FUSION Gene Data Portal

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The fusion gene pair TPR--NTRK1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair TPR--NTRK1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TPR--NTRK1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene TPR--NTRK1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TPR--NTRK1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TPR--NTRK1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TPR--NTRK1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TPR--NTRK1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TPR--NTRK1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TPR--NTRK1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TPR--NTRK1 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TPR is a known oncogene according to ONGENE database.


The tail gene NTRK1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TPR is cancer associated according to Bushman Cancer Gene database.


The tail gene NTRK1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TPR is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene NTRK1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TPR--NTRK1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TPR--NTRK1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TPR--NTRK1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TPR--NTRK1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TPR--NTRK1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TPR--NTRK1 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair TPR--NTRK1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TPR--NTRK1 is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
TPR--NTRK1Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infantshttps://www.nature.com/articles/s41467-018-04650-6

Cortex_Dataset

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Fusion gene TPR--NTRK1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TPR--NTRK1 information is not available in ChromothripsisDB database.