TPM3--NTRK1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TPM3 NTRK1

COSMIC

The fusion gene pair TPM3--NTRK1 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair TPM3--NTRK1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
TPM3_NTRK1-/717/ -/1262/ Exonic hg19 - - - - Cosmic_recurrent
TPM3_NTRK1-/717+9360/ -/1262-154/ Exonic hg19 - - - - Cosmic_recurrent
TPM3_NTRK1-/717+6032/ -/1262-84/ Exonic hg19 - - - - Cosmic_recurrent
TPM3_NTRK1-/717+9871/ -/1262-217/ Exonic hg19 - - - - Cosmic_recurrent
TPM3_NTRK1-/-/ -/-/ - hg19 colon cancer - 22895193 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 papillary thyroid carcinoma - 11114633 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10074915 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 papillary thyroid carcinoma - 16483615 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 papillary thyroid carcinoma - 1384673 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10646882 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 papillary thyroid carcinoma - 15273715 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 other carcinoma - 2869410 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 papillary thyroid carcinoma - 7590742 - Cosmic_nonrecurrent
TPM3_NTRK1-/-/ -/-/ - hg19 papillary thyroid carcinoma - 8626874 - Cosmic_nonrecurrent
TPM3_NTRK1chr1/152422287/ chr1/155110984/ Exonic hg18 - - - - ChimerDB2

ChimerPUB

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The fusion gene pair TPM3--NTRK1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TPM3_NTRK1- 26472021colorectal cancer;gastric cancer FISH - NGS was performed on the 3 IHC positive cases and confirmed TPM3-NTRK1 rearrangements in the two CRC cases. /// NGS was performed on the 3 IHC positive cases and confirmed TPM3-NTRK1 rearrangements in the two CRC cases.
TPM3_NTRK1- 26892443melanoma FISH - RNA sequencing identified a kinase fusion in five of the six sequenced tumors: TPM3-NTRK1 (2 tumors), complex rearrangements involving TPM3, ALK, and IL6R (1 tumor), BAIAP2L1-BRAF (1 tumor), and EML4-BRAF (1 disseminating tumor).
TPM3_NTRK1- 26716414colon cancer FISH - NTRK1 fusions were mutually exclusive oncogenic drivers of colon cancer that were accompanied with in vitro potential of colony formation and in vivo tumorigenicity comparable to KM12, a human colon cancer cell line harboring TPM3-NTRK1 fusion. /// "Here we identified recurrent LMNA-NTRK1 and TPM3-NTRK1 fusions in Korean patients with colon cancer (3 out of 147, 2%) through next-generation RNA sequencing (RNA-seq). "
TPM3_NTRK1- 25527197- - - These recent developments have led us to revisit an old oncogene, Trk (originally identified as OncD), which encodes the TPM3-NTRK1 gene fusion and was one of the first transforming chromosomal rearrangements identified 32 years ago.
TPM3_NTRK1- 7590742- - - Therefore, due to the splicing mechanism, all of the TPM3/NTRK1 gene fusions encoded an invariable transcript and the same chimeric protein of 70 kDa, which was constitutively phosphorylated on tyrosine. /// "In two of the three tumors the simultaneous presence of the reciprocal products of the TPM3/NTRK1 recombination, 5'TPM3-3'NTRK1 and 5'NTRK1-3'TPM3 sequences, respectively, and the previously demonstrated localization of both genes on the long arm of chromosome 1 lead us to suggest that an intrachromosomal inversion could be responsible for their recombination. "
TPM3_NTRK1- 26200269mucinous carcinoma - - Within the KRAS-negative cases, we found numerous potentially targetable gene fusions and mutations, including CD74-NRG1, VAMP2-NRG1, TRIM4-BRAF, TPM3-NTRK1, and EML4-ALK gene fusions and ERBB2, BRAF, and PIK3CA mutations.
TPM3_NTRK1- 25384085thyroid carcinoma;cholangiocarcinoma;lung cancer PCR - On the basis of our experience with performing AMP on 986 clinical FFPE samples, we show its potential as both a robust clinical assay and a powerful discovery tool, which we used to identify new therapeutically important gene fusions: ARHGEF2-NTRK1 and CHTOP-NTRK1 in glioblastoma, MSN-ROS1, TRIM4-BRAF, VAMP2-NRG1, TPM3-NTRK1 and RUFY2-RET in lung cancer, FGFR2-CREB5 in cholangiocarcinoma and PPL-NTRK1 in thyroid carcinoma.
TPM3_NTRK1- 24962792colorectal carcinoma PCR - Finally, using quantitative reverse transcriptase PCR and immunohistochemistry (IHC) we identified the TPM3-NTRK1 rearrangement in a CRC clinical sample, therefore suggesting that this chromosomal translocation is indeed a low frequency recurring event in CRC and that such patients might benefit from therapy with TRKA kinase inhibitors. /// The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition. /// The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.. /// "We report the detailed characterization of the TPM3-NTRK1 genomic rearrangement in KM12?cells and through a cellular screening approach, the identification of NMS-P626, a novel highly potent and selective TRKA inhibitor. " /// NMS-P626 suppressed TPM3-TRKA phosphorylation and downstream signaling in KM12 cells and showed remarkable antitumor activity in mice bearing KM12 tumors. /// "NTRK1 was originally isolated from a colorectal carcinoma (CRC) sample as component of a somatic rearrangement (TPM3-NTRK1) resulting in expression of the oncogenic chimeric protein TPM3-TRKA, but there has been no subsequent report regarding the relevance of this oncogene in CRC. " /// The KM12 human CRC cell line expresses the chimeric TPM3-TRKA protein and is hypersensitive to TRKA kinase inhibition.
TPM3_NTRK1- 26001971colorectal cancer;colorectal carcinoma;lung cancer;colon cancer PCR - One of these rearrangements is a TPM3-NTRK1 fusion already observed in colon cancer, while the second one is a TPR-NTRK1 fusion never described in this type of cancer.
TPM3_NTRK1- 26563355colorectal cancer - - The TPM3-NTRK1 rearrangement is a recurring event in CRC that renders tumors sensitive to TRKA kinase inhibitors in preclinical models. /// The TPM3-NTRK1 rearrangement is a recurring event in CRC that renders tumors sensitive to TRKA kinase inhibitors in preclinical models.
TPM3_NTRK1- 10074915thyroid carcinoma - - Reciprocal NTRK1/TPM3 transcripts were found in 4 of 5 tumors with TPM3/NTRK1 re-arrangement, indicating an intra-chromosomal balanced reciprocal inversion. /// "Reciprocal NTRK1/TPM3 transcripts were found in 4 of 5 tumors with TPM3/NTRK1 re-arrangement, indicating an intra-chromosomal balanced reciprocal inversion." /// "Oncogenic fusion of the NTRK1 tyrosine kinase domain with the amino-terminal part of the tropomyosin gene (TPM3/NTRK1, trk) was observed in 5 tumors. "

ChimerSEQ

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The fusion gene pair TPM3--NTRK1 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
TPM3_NTRK1chr1/154142875/- chr1/156845311/+ 1q21.3 1q23.1 Exonic hg19 In-Frame Intra-chr SARC TCGA-DX-A3UA-01A - FusionScan
TPM3_NTRK1chr1/154142875/- chr1/156845871/+ 1q21.3 1q23.1 Exonic hg19 In-Frame Intra-chr SARC TCGA-DX-A3UA-01A - FusionScan
TPM3_NTRK1chr1/154155663/ chr1/156845339/ 1q21.3 1q23.1 Exonic hg19 - Intra-chr NA M55337 - ChiTaRs
TPM3_NTRK1chr1/154155663/ chr1/156844361/ 1q21.3 1q23.1 Exonic hg19 - Intra-chr NA X03541 - ChiTaRs
TPM3_NTRK1chr1/154142876/- chr1/156844363/+ 1q21.3 1q23.1 Exonic hg19 In-frame Intra-chr THCA TCGA-EL-A3D4-01A - PRADA

ChiTaRS 2.1

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The fusion gene pair TPM3--NTRK1 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human M55337TPM3--NTRK1 TPM31 154155584 154155663 - 86 165 100 NTRK11 156845339 156845945 + 156 354 99.5
Human M55336TPM3--NTRK1 TPM31 154155584 154155663 - 59 138 100 NTRK11 156845339 156845972 + 129 354 99.6
Human X03541TPM3--NTRK1 TPM31 154142876 154155663 - 165 896 99.8 NTRK11 156844361 156851636 + 895 2293 99.5

FARE-CAFE

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The fusion gene pair TPM3--NTRK1 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair TPM3--NTRK1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair TPM3--NTRK1 information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
SARC DX-A3UA-01A TPM3__NTRK1 3.7 1:154142876/-1 1:156845312/1 tier1 In-frame 18491 NA
THCA EL-A3D4-01A TPM3__NTRK1 3.7 1:154142876/-1 1:156844363/1 tier1 In-frame 18492 NA

FusionCancer

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The fusion gene pair TPM3--NTRK1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TPM3--NTRK1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene TPM3--NTRK1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TPM3--NTRK1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TPM3--NTRK1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TPM3--NTRK1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TPM3--NTRK1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TPM3--NTRK1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TPM3--NTRK1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TPM3--NTRK1 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TPM3 is not a known oncogene according to ONGENE database.


The tail gene NTRK1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TPM3 is cancer associated according to Bushman Cancer Gene database.


The tail gene NTRK1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TPM3 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene NTRK1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TPM3--NTRK1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TPM3--NTRK1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TPM3--NTRK1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TPM3--NTRK1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TPM3--NTRK1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TPM3--NTRK1 information is available in Klijn Dataset.

Cell lineGene 5'Gene 3'Read evidenceKinaseChromosome 5'Position 5'Chromosome 3'Position 3'Fusion type DNAFusion type RNAFusion protein lengthTissueKnown Fusion
KM-12TPM3NTRK169Y11541428761156844363InversioninFrame655Colo-RectalFull fusion known

Fimereli_Dataset

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The fusion gene pair TPM3--NTRK1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TPM3--NTRK1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene TPM3--NTRK1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TPM3--NTRK1 information is not available in ChromothripsisDB database.