TPM3--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TPM3 ALK

COSMIC

The fusion gene pair TPM3--ALK information is available in COSMIC database.

Link
TPM3--ALK

ChimerKB

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The fusion gene pair TPM3--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
TPM3_ALK-/717/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
TPM3_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 17464320 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 10216106 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 10934142 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 12707379 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 16360423 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 10610119 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 16984614 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 16651537 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 17063337 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 19135051 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 19545284 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 - - 24445538 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 benign melanocytic nevus - 24445538 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 benign melanocytic nevus - 24698967 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/-/ -/-/ - hg19 - - 24698967 Oncogene; Cosmic_nonrecurrent
TPM3_ALK-/7298/ -/825/ Exonic hg18 - - - Oncogene; TICdb

ChimerPUB

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The fusion gene pair TPM3--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TPM3_ALKinv(2)(p23q35) / t(2;5)(p23;q35) / t(1;2)(q25;p23) / t(2;5) / 10702393non Hodgkin Lymphoma FISH - Recently, various cytogenetic, molecular, and protein studies have provided evidence for the existence of several types of variant ALK fusions in up to 20% of ALK+ ALCL, of which only one, a TPM3-ALK fusion resulting from a t(1;2)(q25;p23), has so far been cloned. /// "Recently, various cytogenetic, molecular, and protein studies have provided evidence for the existence of several types of variant ALK fusions in up to 20% of ALK+ ALCL, of which only one, a TPM3-ALK fusion resulting from a t(1;2)(q25;p23), has so far been cloned."
TPM3_ALK- 14631806anaplastic large cell lymphoma;anaplastic large cell lymphoma;lymphoma FISH;PCR - The morphological investigations are supplemented by karyotyping and/or by a demonstration of breakpoint at 2p23 harboring ALK gene (FISH), and by molecular detection of chimeric genes characteristic of ALK+ lymphomas (NPM-ALK, ATIC-ALK, TPM3-ALK, TFG-ALK, and some even rarer rearrangements).
TPM3_ALK- 25416234anaplastic large cell lymphoma;lymphoma FISH - Here we report on an ALK-positive ALCL patient, who had complex translocations with TPM3-ALK revealed by RNA sequencing, with a very aggressive clinical course.
TPM3_ALK- 22252991anaplastic large cell lymphoma;renal cell carcinoma;lung cancer;lymphoma FISH - Using 5'- rapid amplification of complementary DNA ends, we detected TPM3-ALK and EML4-ALK in these tumors. /// "Using 5'- rapid amplification of complementary DNA ends, we detected TPM3-ALK and EML4-ALK in these tumors. "
TPM3_ALK- 16360423- FISH - Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: an unusual presentation of an unusual neoplasm.. /// "We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.. " /// "We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.."
TPM3_ALKp23;q35 / t(1;2)(q25;p23) / t(2;3)(p23;q21) / 10807789lymphoma - - However, the ALK gene at 2p23 may also be involved in 2 variant translocations, namely t(1;2)(q25;p23) and t(2;3)(p23;q21), which create the TPM3-ALK and TFG-ALK fusion genes, respectively.
TPM3_ALKt(2;5)(p23;q35) / t(1;2)(q25;p23) / t(2;3)(p23;q21) / t(2;17)(p23;q23) / inv(2)(p23q35) / 15208656anaplastic large cell lymphoma;lymphoma - - Recent studies demonstrated that ALK may also be involved in variant translocations, namely, t(1;2)(q25;p23), t(2;3)(p23;q21), t(2;17)(p23;q23) and inv(2)(p23q35), which create the TPM3-ALK, TFG-ALK5, CLTC-ALK, and ATIC-ALK fusion genes, respectively. /// "We stably transfected the cDNAs coding for NPM-ALK, TPM3-ALK, TFG-ALK, CLTC-ALK or ATIC-ALK into nonmalignant NIH3T3 cells. " /// "Moreover, our results show that the in vitro transforming capacity of NIH3T3-transfected cells are in relation to the level of X-ALK fusion proteins excepted for TPM3-ALK for which there is an inverse correlation." /// "Moreover, our results show that the in vitro transforming capacity of NIH3T3-transfected cells are in relation to the level of X-ALK fusion proteins excepted for TPM3-ALK for which there is an inverse correlation. "
TPM3_ALK- 17063337pneumonia - - A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusion.. /// The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor.
TPM3_ALKt(2;5)(p23;q35) / t(2;5) / t(1;2) / t(1;2)(q25;p23) / 10216106anaplastic large cell lymphoma;lymphoma PCR - A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation.. /// "Activation of the ALK catalytic domain probably results from homodimerization of the hybrid protein TPM3-ALK, through the TPM3 protein-protein interaction domain. "
TPM3_ALKt(1;2) / 10610119anaplastic large cell lymphoma;lymphoma - - Complex variant translocation t(1;2) with TPM3-ALK fusion due to cryptic ALK gene rearrangement in anaplastic large-cell lymphoma..
TPM3_ALK- 10934142- - - We have cloned two ALK fusion genes, TPM4-ALK and TPM3-ALK, which encode approximately 95-kd fusion oncoproteins characterized by constitutive kinase activity and tyrosylphosphorylation. /// "We have cloned two ALK fusion genes, TPM4-ALK and TPM3-ALK, which encode approximately 95-kd fusion oncoproteins characterized by constitutive kinase activity and tyrosylphosphorylation." /// "Notably, a TPM3-ALK oncogene was reported recently in anaplastic lymphoma, and TPM3-ALK is thereby the first known fusion oncogene that transforms, in vivo, both mesenchymal and lymphoid human cell lineages.. " /// TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors..
TPM3_ALKt(2;5)(p23;q35) / t(1;2)(q21;p23) / 16651537anaplastic large cell lymphoma;lymphoma - - This approach accurately identified the nucleophosmin (NPM)-ALK fusion protein in an anaplastic large cell lymphoma (ALCL)-derived cell line carrying the t(2;5)(p23;q35), and the TPM3-ALK in a clinical biopsy of inflammatory myofibroblastic tumor (IMT) carrying the t(1;2)(q21;p23).
TPM3_ALKt(2;5)(p23;q35) / t(1;2)(q25;p23) / 17720243anaplastic large cell lymphoma;non Hodgkin lymphoma;lymphoma PCR;RT-PCR - One of these is the t(1;2)(q25;p23) which results in the formation of the chimeric protein TPM3-ALK. /// Our results demonstrate the overlapping and unique transcriptional patterns associated with the NPM-ALK and TPM3-ALK fusions in ALCL.. /// "While several of the signaling pathways induced by NPM-ALK have been elucidated, those involved in ALCLs harboring TPM3-ALK are largely unknown." /// "While several of the signaling pathways induced by NPM-ALK have been elucidated, those involved in ALCLs harboring TPM3-ALK are largely unknown. " /// Analysis of gene expression profile of TPM3-ALK positive anaplastic large cell lymphoma reveals overlapping and unique patterns with that of NPM-ALK positive anaplastic large cell lymphoma.. /// "In order to investigate the expression profiles of ALCLs carrying the NPM-ALK and TPM3-ALK fusions, we carried out cDNA microarray analysis of two ALCL tissue samples, one expressing the NPM-ALK fusion protein and the other the TPM3-ALK fusion protein." /// "In order to investigate the expression profiles of ALCLs carrying the NPM-ALK and TPM3-ALK fusions, we carried out cDNA microarray analysis of two ALCL tissue samples, one expressing the NPM-ALK fusion protein and the other the TPM3-ALK fusion protein. "
TPM3_ALK- 25596129- - - Lentivirus vectors containing a TPM3-ALK fusion gene lacking various lengths of TPM3 were constructed and expressed in HEK293T and NIH3T3 cell lines. /// The purpose of this study was to clarify the role of the TPM3 region in the transformation of IMT via TPM3-ALK. /// "Western blot showed phosphorylation of ALK, ERK1/2, and STAT3 in HEK293T cells transfected with TPM3-ALK. " /// Blue-native polyacrylamide gel electrophoresis (BN-PAGE) revealed that TPM3-ALK dimerization increased in proportion to the length of TPM3. /// Oncogenic TPM3-ALK activation requires dimerization through the coiled-coil structure of TPM3.. /// "Focus formation assay revealed loss of contact inhibition in NIH3T3 cells transfected with full-length TPM3-ALK, but not with ALK alone. " /// "Thus, the coiled-coil structure of TPM3 contributes to the transforming ability of the TPM3-ALK fusion protein, and longer TPM3 region leads to higher dimer formation." /// "Thus, the coiled-coil structure of TPM3 contributes to the transforming ability of the TPM3-ALK fusion protein, and longer TPM3 region leads to higher dimer formation. "
TPM3_ALKp23;q35 / t(2;5) / 10994999anaplastic large cell lymphoma;non Hodgkin lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - in some instances, the breakpoints have been cloned and the genes forming a new fusion gene with ALK have been identified: ATIC-ALK, TFG-ALK and TPM3-ALK.
TPM3_ALK- 26773439renal cell carcinoma - - Further investigation revealed ALK rearrangements in all cases, manifested molecularly by fusion transcripts of either VCL-ALK (3 patients all with sickle cell trait which had been previously reported) or TPM3-ALK (3 patients, none with sickle cell trait).
TPM3_ALK- 22591683anaplastic large cell lymphoma;lymphoma - - ALK-positive anaplastic large cell lymphoma with TPM3-ALK translocation..
TPM3_ALK- 18660380juvenile xanthogranuloma - - One case successfully analyzed by molecular techniques revealed TPM3-ALK fusion. /// One case successfully analyzed by molecular techniques revealed TPM3-ALK fusion.
TPM3_ALK- 20870660- - - Malignant high-grade histological transformation of inflammatory myofibroblastic tumour associated with amplification of TPM3-ALK. /// Malignant high-grade histological transformation of inflammatory myofibroblastic tumour associated with amplification of TPM3-ALK..
TPM3_ALK- 19545284anaplastic large cell lymphoma;lymphoma - - The remaining seven ALCL stained for ALK in the cytoplasm only: two expressed TPM3-ALK, one ATIC-ALK, one MYH9-ALK.
TPM3_ALK- 17660712anaplastic large cell lymphoma;lymphoma - - Overexpression and activation of TPM3-ALK tyrosine kinase fusion protein is a causal oncogenic event in the development of Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic ALK-positive tumors.

ChimerSEQ

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The fusion gene pair TPM3--ALK information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
TPM3_ALKchr1/154144580/ chr2/29446307/ 1q21.3 2p23.2 Exonic hg19 - Inter-chr NA AF362886 Oncogene; ChiTaRs
TPM3_ALKchr1/154137866/ chr2/29446396/ 1q21.3 2p23.2 Exonic hg19 - Inter-chr anaplastic large cell lymphoma;myofibroblastic sarcoma AF112866 Oncogene; ChiTaRs

ChiTaRS 2.1

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The fusion gene pair TPM3--ALK information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human AF362886TPM3--ALK TPM31 154142876 154144580 - 12 220 97.2 ALK2 29446307 29446402 - 212 308 96.9
Human AF112866TPM3--ALK TPM31 154135578 154137866 - 1 2289 99.6 ALK2 29446396 29447503 - 2289 3394 99.1

FARE-CAFE

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The fusion gene pair TPM3--ALK information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
TPM3-ALK A)Inflammatory myofibroblastic tumor,B)Anaplastic large cell lymphoma A)FISH,G-Banding,RT-PCR,B)PCR,Western blot,FISH,DNA sequencing,RT-PCR,RACE t(1;2)(q25;p23) PubMed:10216106

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
TPM3-ALK TPM3-ALK TPM3 154135766 0 0 ALK 29447412 0 0 ACTCAAAACATGGCTAGTGTGGCTGAGGGGCTAAAATTTAATTGTATTTCATTGTAGTTCATTTAAATTTGGCTACCTGTGGCTAGTGGCTATTATATTGGACAATGCATTTCTAAATATTCAGATCCTGGGCAGAAGTTGGCTTTGACATGAAGAAAGACTTCTTAGAAAGGAAGGAAGTAGACCGgGGGAACTGAGCACATAGCGGGTGACTCATTTGCCCTGGCCCATGTGTTGGGGGGCTGGGCTTTACACACAGAATCTACCCACTGAATCACAA _ AF112866

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
TPM3-ALK TPM3-ALK 1) GVQW
- 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
TPM3 1) Tropomyosin
2) Laminin_II
1) Actin , Myosin_head , Tropomyosin , Troponin
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Tropomyosin
2) Laminin_II
1) Actin , Myosin_head , Tropomyosin , Troponin

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
TPM3-ALK hsa-miR-132-3p hsa-miR-1hsa-miR-16-5phsa-miR-145-5phsa-miR-26b-5phsa-miR-615-3phsa-miR-92a-3p Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
TPM3-ALK NM_001043351.1 - 1) TRIM28_HUMAN
2) MITF_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) P53_HUMAN
6) RUNX1_HUMAN
7) PRDM14_HUMAN
8) ESTROGEN RECEPTOR ALPHA_HUMAN
9) EGR1_HUMAN
10) FOS_HUMAN
11) GATA3_HUMAN
12) E2F1_HUMAN
13) SOX2_HUMAN
14) CTCF_HUMAN
15) BRG1_HUMAN
16) HNF4A_HUMAN
17) TFAP2C_HUMAN
18) FOXA1_HUMAN
19) ESR1_HUMAN
20) NR1H3_HUMAN
21) SETDB1_HUMAN
-

TicDB

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The fusion gene pair TPM3--ALK information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
TPM3 ALK AF112866 ACTCAAAACATGGCTAGTGTGGCTGAGGGGCTAAAATTTAATTGTATTTCATTGTAGTTCATTTAAATTTGGCTACCTGTGGCTAGTGGCTATTATATTGGACAATGCATTTCTAAATATTCAGATCCTGGGCAGAAGTTGGCTTTGACATGAAGAAAGACTTCTTAGAAAGGAAGGAAGTAGACCGgGGGAACTGAGCACATAGCGGGTGACTCATTTGCCCTGGCCCATGTGTTGGGGGGCTGGGCTTTACACACAGAATCTACCCACTGAATCACAA

TUMOR FUSION Gene Data Portal

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The fusion gene pair TPM3--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair TPM3--ALK information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TPM3--ALK information is not available in ConjoinG Database.

1000Genome

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Fusion gene TPM3--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TPM3--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TPM3--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TPM3--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TPM3--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TPM3--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TPM3--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TPM3--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TPM3 is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TPM3 is cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TPM3 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TPM3--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TPM3--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TPM3--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TPM3--ALK is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TPM3--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TPM3--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair TPM3--ALK information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TPM3--ALK is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
TPM3--ALKThe pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7

Cortex_Dataset

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Fusion gene TPM3--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TPM3--ALK information is not available in ChromothripsisDB database.