TFE3--PSF

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TFE3 PSF

COSMIC

The fusion gene pair TFE3--PSF information is not available in COSMIC database.

ChimerKB

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The fusion gene pair TFE3--PSF information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair TFE3--PSF information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TFE3_PSF- 23224603perivascular epithelioid cell tumors FISH;PCR;RT-PCR - Reverse transcriptase-polymerase chain reactions (RT-PCR) for ASPL/TFE3, PRCC/TFE3, CLTC/TFE3, PSF/TFE3, and NonO/TFE3 gene fusions all revealed negative results.
TFE3_PSF- 19606011neuroblastoma FISH - Molecular cloning using 5' rapid amplification of complementary DNA ends and subsequent reverse transcription-polymerase chain reaction revealed an SFPQ/PSF-TFE3 gene fusion. /// We report a case of perivascular epithelioid cell tumor (PEComa) with an SFPQ/PSF-TFE3 gene fusion in a 14-year-old girl treated for adrenal neuroblastoma for 4 years. /// "To the best of our knowledge, this is the second reported case of metachronous PEComa subsequent to a primary tumor, and the first report confirming an SFPQ/PSF-TFE3 gene fusion in PEComa.. " /// Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma.. /// "To the best of our knowledge, this is the second reported case of metachronous PEComa subsequent to a primary tumor, and the first report confirming an SFPQ/PSF-TFE3 gene fusion in PEComa.."
TFE3_PSF- 26274027perivascular epithelioid cell tumors;renal cancer FISH - PSF-TFE3 fusion genes were confirmed by reverse transcription polymerase chain reaction in cases (7/7) in which a novel PSF-TFE3 fusion point was identified. /// "Furthermore, we developed a PSF-TFE3 fusion fluorescence in situ hybridization assay for the detection of the PSF-TFE3 fusion gene and detected it in all 12 cases. "
TFE3_PSF- 25651471perivascular epithelioid cell neoplasm FISH - Combined RNA sequencing and fluorescence in situ hybridization analysis identified 9 (23%) TFE3 gene-rearranged tumors, with 3 cases showing an SFPQ/PSF-TFE3 fusion and 1 case showing a novel DVL2-TFE3 gene fusion.
TFE3_PSFt(6;11)(p21;q12) / p11;q21 / p11;q25 / p11;q23 / 19396149renal cell carcinoma - - three cases t(X;1)(p11;p34) resulting in a PSF-TFE3 gene fusion, one t(X;17)(p11;q25) resulting in an ASPL-TFE3 gene fusion, and one t(X;3)(p11;q23) with an unknown TFE3 gene fusion.
TFE3_PSFp11.2;q23 / 12917640anaplastic large cell lymphoma;adenocarcinoma;lymphoma - - 2 translocations and resulting TFE3 gene fusions (PRCC-TFE3, PSF-TFE3, NONO-TFE3, ASPL-TFE3), encoding related aberrant transcription factors.
TFE3_PSF- 23628822renal cell carcinoma - - Reverse transcription polymerase chain reaction and Sanger sequencing confirmed the previously reported PSF-TFE3 gene fusion between exon 9 of PSF and exon 6 of TFE3 in the UOK 145 cell line and in one of 2 clinical cases of Xp11.2 RCC. /// A novel PSF-TFE3 gene fusion between exon 9 of PSF and exon 5 of TFE3 was detected in the second clinical case of Xp11.2 RCC.. /// UOK 145 cells and fresh frozen tissue from 2 clinical cases of Xp11.2 RCC found to harbor the PSF-TFE3 gene rearrangement (by cytogenetic testing) were collected. /// Xp11.2 translocation renal cell carcinoma with PSF-TFE3 rearrangement.. /// "However, exclusive cytoplasmic localization of a TFE3 fusion protein was reported in UOK 145 cells, a cell line derived from an Xp11.2 RCC harboring the PSF-TFE3 translocation. "
TFE3_PSF- 25582502kidney cancer - - Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) with PSF-TFE3 gene fusion is a rare neoplasm. /// A case of PSF-TFE3 gene fusion in Xp11.2 renal cell carcinoma with melanotic features.. /// We describe an additional case of Xp11.2 RCC with PSF-TFE3 showing melanotic features. /// Xp11.2 RCC with PSF-TFE3 inevitably requires differentiation from other kidney neoplasms. /// Only 22 cases of Xp11.2 RCCs with PSF-TFE3 have been reported to date. /// "Genetically, we demonstrated PSF-TFE3 fusion between exon 9 of PSF and exon 5 of TFE3. "
TFE3_PSF- 19228722renal cell carcinoma - - The remaining two patients had PRCC-TFE3 and PSF-TFE3 gene fusions, respectively.
TFE3_PSF- 25621681perivascular epithelioid cell tumors - - Molecular pathological assays confirmed a PSF-TFE3 gene fusion in one of our cases.
TFE3_PSF- 19809274renal cell carcinoma;melanoma - - Melanotic Xp11 translocation renal cancer: a case with PSF-TFE3 gene fusion and up-regulation of melanogenetic transcripts.. /// The morphologic and immunohistochemical discrepancies between this intriguing melanotic tumor and other documented renal cell carcinomas bearing identical PSF-TFE3 gene fusion may suggest melanotic Xp11 translocation renal cancer is a distinct entity among the MiT/TFE family neoplasms.. /// "Reverse transcription-polymerase chain reaction and validating sequencing demonstrated PSF-TFE3 gene fusion, a novel exon composition juxtaposing PSF exon 9 to TFE3 exon 5. "

ChimerSEQ

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The fusion gene pair TFE3--PSF information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair TFE3--PSF information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair TFE3--PSF information is not available in FARE-CAFE.

TicDB

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The fusion gene pair TFE3--PSF information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair TFE3--PSF information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair TFE3--PSF information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TFE3--PSF information is not available in ConjoinG Database.

1000Genome

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Fusion gene TFE3--PSF has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TFE3--PSF is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TFE3--PSF is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TFE3--PSF is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TFE3--PSF was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TFE3--PSF information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TFE3--PSF is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TFE3--PSF has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TFE3 is a known oncogene according to ONGENE database.


The tail gene PSF is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TFE3 is cancer associated according to Bushman Cancer Gene database.


The tail gene PSF is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TFE3 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene PSF is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TFE3--PSF is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TFE3--PSF is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TFE3--PSF information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TFE3--PSF is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TFE3--PSF has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TFE3--PSF information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair TFE3--PSF information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TFE3--PSF information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene TFE3--PSF is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TFE3--PSF information is not available in ChromothripsisDB database.