TFE3--PRCC

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TFE3 PRCC

COSMIC

The fusion gene pair TFE3--PRCC information is not available in COSMIC database.

ChimerKB

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The fusion gene pair TFE3--PRCC information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
TFE3_PRCC-/-/ -/-/ - hg19 papillary renal cell carcinoma - 8986805 - Cosmic_nonrecurrent
TFE3_PRCC-/-/ -/-/ - hg18 papillary renal cell carcinoma - 8872474 - OMIM

ChimerPUB

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The fusion gene pair TFE3--PRCC information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TFE3_PRCC- 23224603perivascular epithelioid cell tumors FISH;PCR;RT-PCR - Reverse transcriptase-polymerase chain reactions (RT-PCR) for ASPL/TFE3, PRCC/TFE3, CLTC/TFE3, PSF/TFE3, and NonO/TFE3 gene fusions all revealed negative results.
TFE3_PRCC- 26975036renal cell carcinoma;alveolar soft part sarcoma;sarcoma FISH - We corroborate prior data showing that the PRCC-TFE3 RCCs are the only known Xp11 translocation RCC molecular subtype that are consistently cathepsin K positive.
TFE3_PRCCp11.2;q21 / 16807766renal cell carcinoma - - Chromosomal analysis disclosed a t(X;1)(p11.2;q21) translocation, which is known to result in a PRCC-TFE3 gene fusion. /// "Recently, a unique translocation between the X chromosome and chromosome 1 or t(X;1) has been described in several reports of renal cell carcinomas (RCCs) diagnosed in children and adolescents that results in PRCC-TFE3 gene fusion. " /// PRCC-TFE3 renal cell carcinoma in a boy with a history of contralateral mesoblastic nephroma..
TFE3_PRCCt(6;11)(p21;q12) / p11;q21 / p11;q25 / p11;q23 / 19396149renal cell carcinoma - - five cases t(X;1)(p11;q21) resulting in a PRCC-TFE3 gene fusion.
TFE3_PRCCt(6;11) / p11;q21 / p11;q25 / 21602817renal cell carcinoma;alveolar soft part sarcoma;sarcoma - - We performed immunohistochemistry for cathepsin K on 14 genetically confirmed t(X;1)(p11;q21) carcinomas, harboring the PRCC-TFE3 gene fusion. /// "However, 12 of 14 PRCC-TFE3 carcinomas expressed cathepsin K." /// "However, 12 of 14 PRCC-TFE3 carcinomas expressed cathepsin K. " /// "The difference in expression of cathepsin K between the PRCC-TFE3 and ASPSCR1-TFE3 carcinomas, together with the observed clinical differences between these subtypes of Xp11 translocation carcinomas, suggests the possibility of functional differences between these two related fusion proteins.. "
TFE3_PRCCp11.2;q21 / p11.2;q25 / 12459622renal cell carcinoma - - We report the morphologic, immunophenotypic, ultrastructural, and molecular features of 11 renal carcinomas bearing a t(X;1)(p11.2;q21) and/or the resulting PRCC-TFE3 gene fusion. /// "PRCC-TFE3 renal carcinomas: morphologic, immunohistochemical, ultrastructural, and molecular analysis of an entity associated with the t(X;1)(p11.2;q21).. " /// Both tumors tested contained PRCC-TFE3 fusion transcripts.
TFE3_PRCCp11.2;q23 / 12917640anaplastic large cell lymphoma;adenocarcinoma;lymphoma - - 2 translocations and resulting TFE3 gene fusions (PRCC-TFE3, PSF-TFE3, NONO-TFE3, ASPL-TFE3), encoding related aberrant transcription factors. /// "The present renal tumor demonstrated morphologic and immunohistochemical features of both PRCC-TFE3 and ASPL-TFE3 carcinomas, including strong nuclear immunoreactivity for the TFE3 C-terminal and only minimal expression of epithelial proteins. "
TFE3_PRCC- 19228722renal cell carcinoma - - The remaining two patients had PRCC-TFE3 and PSF-TFE3 gene fusions, respectively.
TFE3_PRCC- 15316311renal cell carcinoma - - This classification includes the recently described renal cell carcinomas with the ASPL-TFE3 gene fusion and carcinomas with a PRCC-TFE3 gene fusion.
TFE3_PRCC- 25048860kidney cancer - - A total of five TFE3 gene fusions (PRCC-TFE3, ASPSCR1-TFE3, SFPQ-TFE3, NONO-TFE3, and CLTC-TFE3) and one TFEB gene fusion (MALAT1-TFEB) have been identified in RCC tumours and characterized at the mRNA transcript level.
TFE3_PRCCp11;q25 / p11;q21 / 24309327renal cell carcinoma - - The most common subtypes are the ASPSCR1-TFE3 renal cell carcinomas resulting from t(X;17)(p11;q25) translocation, and the PRCC-TFE3 renal cell carcinomas, resulting from t(X;1)(p11;q21) translocation. /// "In conclusion, ASPSCR1-TFE3 renal cell carcinomas are more likely to present at advanced stage (particularly node-positive disease) than are PRCC-TFE3 renal cell carcinomas. " /// "Two PRCC-TFE3 renal cell carcinomas recurred late (at 20 and 30 years, respectively). " /// The tendency for PRCC-TFE3 renal cell carcinomas to recur late warrants long-term follow-up. /// We also reviewed the literature for all published cases of ASPSCR1-TFE3 and PRCC-TFE3 renal cell carcinomas and contacted all corresponding authors to obtain or update the published follow-up information. /// "Regional lymph nodes were involved by metastasis in 24 of the 32 ASPSCR1-TFE3 cases in which nodes were resected, compared with 5 of 14 PRCC-TFE3 cases (P=0.02).. "
TFE3_PRCC- 16010549lactic acidosis;MELAS;renal cancer;renal cell carcinoma - - We reported a case of a 2-year-old boy with RCC associated with TFE3 translocation resulting in a PRCC-TFE3 fusion gene.
TFE3_PRCC- 12351585renal cell carcinoma - - A PRCC-TFE3 fusion gene is typically encountered in t(X;1)-positive non-familial papillary RCCs and results in abrogation of the cell cycle mitotic spindle checkpoint in a dominant-negative fashion, thus leading to RCC.
TFE3_PRCCt(9;11) / 16575003Hurler's syndrome - - At the molecular level, three tumors contained the ASPL-TFE3 fusion, two contained Alpha-TFEB, and one contained PRCC-TFE3.
TFE3_PRCCp11.2;q21.2 / 8872474renal cell carcinoma;sarcoma - - Notably the generation of the chimaeric PRCC-TFE3 gene appears to be accompanied by complete loss of normal TFE3 transcripts.

ChimerSEQ

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The fusion gene pair TFE3--PRCC information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair TFE3--PRCC information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair TFE3--PRCC information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
TFE3-PRCC Renal cell carcinoma PCR,RACE,Q-banding,FISH,RT-PCR t(X;1)(p11;q21) PubMed: 8431910

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
TFE3-PRCC TFE3-PRCC TFE3 _ _ 0 PRCC _ 1 _ _ _ _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
TFE3-PRCC TFE3-PRCC - - - -TFE3 1) MITF_TFEB_C_3_N
2) HLH
3) DUF3371
1) HLH , Myc-LZ , PAS , LIM
PRCC 1) PRCC
- 1) MITF_TFEB_C_3_N
2) HLH
3) DUF3371
4) PRCC
1) HLH , Myc-LZ , PAS , LIM

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
TFE3-PRCC hsa-miR-877-5phsa-miR-421hsa-miR-18a-3p hsa-miR-335-5phsa-miR-455-3p NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
TFE3-PRCC _ - - -

TicDB

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The fusion gene pair TFE3--PRCC information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair TFE3--PRCC information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
KIRP BQ-5882-01A TFE3__PRCC 0.26 X:48896632/-1 1:156752074/1 tier1 In-frame 17710 NA
KIRP BQ-5887-01A TFE3__PRCC 0.26 X:48896632/-1 1:156756400/1 tier1 In-frame 17711 NA

FusionCancer

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The fusion gene pair TFE3--PRCC information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TFE3--PRCC information is not available in ConjoinG Database.

1000Genome

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Fusion gene TFE3--PRCC has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TFE3--PRCC is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TFE3--PRCC is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TFE3--PRCC is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TFE3--PRCC was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TFE3--PRCC information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TFE3--PRCC is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TFE3--PRCC has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TFE3 is a known oncogene according to ONGENE database.
The tail gene PRCC is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TFE3 is cancer associated according to Bushman Cancer Gene database.


The tail gene PRCC is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TFE3 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene PRCC is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TFE3--PRCC is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TFE3--PRCC is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TFE3--PRCC information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TFE3--PRCC is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TFE3--PRCC has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TFE3--PRCC information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair TFE3--PRCC information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TFE3--PRCC information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene TFE3--PRCC is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TFE3--PRCC information is not available in ChromothripsisDB database.