TFE3--ASPSCR1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TFE3 ASPSCR1

COSMIC

The fusion gene pair TFE3--ASPSCR1 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair TFE3--ASPSCR1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
TFE3_ASPSCR1-/1145/ -/1031/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
TFE3_ASPSCR1-/1040/ -/1031/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
TFE3_ASPSCR1-/-/ -/-/ - hg19 alveolar soft part sarcoma - 11244503 Oncogene; Cosmic_nonrecurrent
TFE3_ASPSCR1-/-/ -/-/ - hg19 renal cell carcinoma - 15138551 Oncogene; Cosmic_nonrecurrent
TFE3_ASPSCR1-/-/ -/-/ - hg19 renal cell carcinoma - 11438465 Oncogene; Cosmic_nonrecurrent
TFE3_ASPSCR1-/-/ -/-/ - hg19 alveolar soft part sarcoma - 18094412 Oncogene; Cosmic_nonrecurrent
TFE3_ASPSCR1-/-/ -/-/ - hg19 renal cell carcinoma - 17149613 Oncogene; Cosmic_nonrecurrent
TFE3_ASPSCR1-/-/ -/-/ - hg19 papillary renal cell carcinoma - 11358836 Oncogene; Cosmic_nonrecurrent
TFE3_ASPSCR1-/-/ -/-/ - hg18 alveolar soft part sarcoma - 11244503 Oncogene; OMIM

ChimerPUB

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The fusion gene pair TFE3--ASPSCR1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TFE3_ASPSCR1p11.2;q25 / 17543078AIDS;alveolar soft part sarcoma FISH - Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas.. /// Molecular confirmation of ASPSCR1-TFE3 gene fusion is applicable to routinely processed archival and diagnostic tumour samples and aids in the differential diagnosis of ASPS.. /// The presence of the resulting ASPSCR1-TFE3 fusion transcripts was assessed by reverse transcriptase-polymerase chain reaction. /// "In addition to wild-type TFE3, ASPSCR1-TFE3 fusion transcripts (three type 1 and two type 2 transcripts) were detected in all cases. "
TFE3_ASPSCR1- 23828314chordoma;papillary renal cell carcinoma;perivascular epithelioid cell tumors;renal cell carcinoma FISH - We further demonstrate the unbalanced separation is atypical, with TFE3/ASPSCR1 fusion and loss of the derivative X chromosome but also an unanticipated normal X chromosome gain in both males and females.
TFE3_ASPSCR1t(6;11) / p11;q21 / p11;q25 / 21602817renal cell carcinoma;alveolar soft part sarcoma;sarcoma - - eight genetically confirmed t(X;17)(p11;q25) carcinomas, harboring the ASPSCR1-TFE3 gene fusion. /// "However, the expression of cathepsin K in specific genetic subtypes of Xp11 translocation carcinomas, as well as alveolar soft part sarcoma, which harbors the same ASPSCR1-TFE3 gene fusion as some Xp11 translocation carcinomas, has not been addressed. " /// "and 18 alveolar soft part sarcomas (12 genetically confirmed), harboring the identical ASPSCR1-TFE3 gene fusion. " /// "Expression of cathepsin K distinguishes alveolar soft part sarcoma from the ASPSCR1-TFE3 carcinoma, harboring the same gene fusion." /// "Expression of cathepsin K distinguishes alveolar soft part sarcoma from the ASPSCR1-TFE3 carcinoma, harboring the same gene fusion. " /// "The latter can be useful diagnostically, especially when alveolar soft part sarcoma presents in an unusual site (such as bone) or with clear cell morphology, which raises the differential diagnosis of metastatic ASPSCR1-TFE3 renal cell carcinoma. " /// "In contrast, all eight ASPSCR1-TFE3 carcinomas were completely negative for cathepsin K. " /// "The difference in expression of cathepsin K between the PRCC-TFE3 and ASPSCR1-TFE3 carcinomas, together with the observed clinical differences between these subtypes of Xp11 translocation carcinomas, suggests the possibility of functional differences between these two related fusion proteins.. "
TFE3_ASPSCR1p11;q25 / p11;q21 / 24309327renal cell carcinoma - - The most common subtypes are the ASPSCR1-TFE3 renal cell carcinomas resulting from t(X;17)(p11;q25) translocation, and the PRCC-TFE3 renal cell carcinomas, resulting from t(X;1)(p11;q21) translocation. /// "however, 11 of 13 evaluable patients with ASPSCR1-TFE3 renal cell carcinomas who presented with N1M0 disease remained disease free. " /// "Regional lymph nodes were involved by metastasis in 24 of the 32 ASPSCR1-TFE3 cases in which nodes were resected, compared with 5 of 14 PRCC-TFE3 cases (P=0.02).. " /// We also reviewed the literature for all published cases of ASPSCR1-TFE3 and PRCC-TFE3 renal cell carcinomas and contacted all corresponding authors to obtain or update the published follow-up information. /// "Study of two new, unpublished cases, and review of the literature revealed that 8/8 patients who presented with distant metastasis had ASPSCR1-TFE3 renal cell carcinomas, and all but one of these patients either died of disease or had progressive disease. " /// "In conclusion, ASPSCR1-TFE3 renal cell carcinomas are more likely to present at advanced stage (particularly node-positive disease) than are PRCC-TFE3 renal cell carcinomas. "
TFE3_ASPSCR1- 21074195renal cell carcinoma - - ASPSCR1-TFE3 might be the most aggressive among the transcription factor E3 fusion genes.. /// Distant metastasis developed in the 2 patients with ASPSCR1-TFE3 fusion vs 1 of 11 with other fusion genes.
TFE3_ASPSCR1- 18094412alveolar soft part sarcoma;sarcoma PCR - RNA extracted from available fresh-frozen and formalin-fixed paraffin-embedded human ASPS tumors were analyzed for ASPSCR1-TFE3 fusion transcript expression using reverse transcription-PCR and by angiogenesis oligomicroarrays with immunohistochemical confirmation. /// ASPSCR1-TFE3 fusion transcripts were identified in 16 of 18 ASPS samples.
TFE3_ASPSCR1- 25268941renal cell carcinoma;alveolar soft part sarcoma;sarcoma - - Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma.
TFE3_ASPSCR1- 26516944alveolar soft part sarcoma - - Real-time polymerase chain reaction to detect the ASPSCR1-TFE3 fusion transcript on paraffin-embedded tissue blocks has been shown to be more sensitive and specific than detection of TFE3 by immunohistochemical stain. /// The recent discovery of the role of the ASPSCR1-TFE3 fusion protein in the MET proto-oncogene signaling pathway promoting angiogenesis and cell proliferation offers a promising targeted molecular therapy.

ChimerSEQ

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The fusion gene pair TFE3--ASPSCR1 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair TFE3--ASPSCR1 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair TFE3--ASPSCR1 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair TFE3--ASPSCR1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair TFE3--ASPSCR1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair TFE3--ASPSCR1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TFE3--ASPSCR1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene TFE3--ASPSCR1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TFE3--ASPSCR1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TFE3--ASPSCR1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TFE3--ASPSCR1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TFE3--ASPSCR1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TFE3--ASPSCR1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TFE3--ASPSCR1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TFE3--ASPSCR1 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TFE3 is a known oncogene according to ONGENE database.


The tail gene ASPSCR1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TFE3 is cancer associated according to Bushman Cancer Gene database.


The tail gene ASPSCR1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TFE3 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ASPSCR1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TFE3--ASPSCR1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TFE3--ASPSCR1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TFE3--ASPSCR1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TFE3--ASPSCR1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TFE3--ASPSCR1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TFE3--ASPSCR1 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair TFE3--ASPSCR1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TFE3--ASPSCR1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene TFE3--ASPSCR1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TFE3--ASPSCR1 information is not available in ChromothripsisDB database.