| TEL_RUNX1 | t(12;21)(p13;q22) / t(12;21) / |
27065576 | acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia |
FISH |
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We analyzed the t(12;21) translocation and other related abnormalities using the fluorescent in situ hybridization (FISH) technique with the ETV6(TEL)/RUNX1(AML1) ES dual color translocation probe. /// "The frequency of FISH abnormalities in pediatric ALL cases were as follows: 8.5?% for t(12;21)(p13;q22) ETV6/RUNX1 fusion, 6.0?% for RUNX1 amplification, 3.0?% for tetrasomy/trisomy 21, 1.8?% for ETV6 deletion, 1.21?% for ETV6 deletion with RUNX1 amplification, 1.21?% for ETV6 amplification with RUNX1 amplification, 0.6?% for polyploidy, 0.6?% for RUNX1 deletion, and 0.6?% for diminished ETV6 signal. " /// Evaluation of ETV6/RUNX1 Fusion and Additional Abnormalities Involving ETV6 and/or RUNX1 Genes Using FISH Technique in Patients with Childhood Acute Lymphoblastic Leukemia..
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| TEL_RUNX1 | t(12;21)(p12;q22) / |
15179033 | - |
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Human chromosomal translocation t(12;21)(p12;q22) is one of the most frequent rearrangement in human leukemia, and produces the TEL/RUNX1 fusion protein. /// It appears that loss of TEL function activates a pathway that cooperates with TEL/RUNX1 and sequesters coactivator(s) into nonfunctional complex in the cytoplasm thus inhibiting transcription of target genes.. /// Immunoprecipitation and immunofluorescence analysis showed that p300 interacts with TEL/RUNX1 and is sequestered in the cytoplasm by it. /// These results suggest that the p300-TEL/RUNX1 complex and heterodimerization of TEL/RUNX1 with TEL may be responsible for the ability of TEL/RUNX1 to inhibit RUNX1-mediated transactivation. /// "Here, we demonstrate that the repressor activity of TEL/ RUNX1 differs from that of TEL, even though both TEL and TEL/RUNX1 interact with the nuclear hormone co-repressor (N-CoR) and histone deacetylase (mSin3A) in vivo. " /// "Co-immunoprecipitation experiments demonstrated that TEL/RUNX1 forms homodimers in vivo, and heterodimerizes with the TEL when the two proteins are expressed together. " /// The TEL/RUNX1 fusion protein creates a transcriptional repressor that interferes in dominant fashion with RUNX1-dependent transactivation. /// Mechanism of transcriptional repression by TEL/RUNX1 fusion protein..
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| TEL_RUNX1 | t(8;21) / t(16;21) / t(3;21) / t(12;21) / |
16105753 | acute myeloid leukemia;myeloid leukemia;leukemia |
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Runx1 has been identified in leukemia-associated chromosomal translocations, including t(8;21) (Runx1-ETO/MTG8), t(16;21) (Runx1-MTG16), t(3;21) (Runx1-Evi1), t(12;21) (TEL-Runx1), and t(X;21) (Runx1-Fog2).
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| TEL_RUNX1 | - |
19403666 | B lymphocytic leukemia |
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The TEL-RUNX1 fusion gene from acute B-lymphocytic leukemia retains almost all of the RUNX1 sequence but does not prevent B-cell proliferation in the same assay.
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