TEL--MN1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TEL MN1

COSMIC

The fusion gene pair TEL--MN1 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair TEL--MN1 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair TEL--MN1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TEL_MN1del(22)(q12.2) / del(22) / 22436304craniofacial abnormalities;neuroectodermal tumor;neurofibroma;vestibular schwannomas FISH - MN1, initially cloned from a patient with meningioma, is an oncogene in murine hematopoiesis and participates as a fusion gene (TEL/MN1) in human myeloid leukemias.
TEL_MN1t(12;22)(p13;q11) / t(12;22) / 17369854acute myeloid leukemia;myeloid leukemia;leukemia - - The translocation t(12;22)(p13;q11) creates an MN1-TEL fusion gene leading to acute myeloid leukemia. /// "Compared to MN1, the same transactivation domains in MN1-TEL are poorly stimulated by p160, p300 or histone deacetylase inhibitors, indicating that the block of RAR-mediated transcription by MN1-TEL is caused by dysfunctional transactivation domains rather than by recruitment of corepressors. " /// "We show that MN1-TEL inhibits retinoic acid receptor (RAR)-mediated transcription, counteracts coactivators such as p160 and p300, and acts as a dominant-negative mutant of MN1. " /// "In MN1-TEL, the transactivating domains of MN1 are combined with the DNA-binding domain of TEL. " /// The MN1-TEL myeloid leukemia-associated fusion protein has a dominant-negative effect on RAR-RXR-mediated transcription..
TEL_MN1t(12;22) / 12569362acute myeloid leukemia;myeloid leukemia;leukemia;sarcoma - - The t(12;22) creates an MN1-TEL fusion gene leading to acute myeloid leukemia.
TEL_MN1t(12;21)(p13;q22) / t(12;21) / t(12;22)(p13;q11) / t(12;22) / 9671410- PCR;RT-PCR - No MN1-TEL fusion could be detected upon RT-PCR analysis, in contrast to the previously investigated t(12;22).
TEL_MN1t(12;22)(p13;q11) / 16081688leukemia - - The MN1-TEL (meningioma 1-translocation-ETS-leukemia) fusion oncoprotein is the product of the t(12;22)(p13;q11) in human myeloid leukemia consisting of N-terminal MN1 sequences, a transcriptional coactivator, fused to C-terminal TEL sequences, an E26-transformation-specific (ETS) transcription factor. /// MN1-TEL also promoted the proliferation of thymocytes while it blocked their differentiation from CD4-/CD8- to CD4+/CD8+ in vivo. /// "We conclude that MN1-TEL exerts its nonlineage-specific leukemogenic effects by promoting the growth of primitive progenitors and blocking their differentiation, but cooperative mutations are necessary to fully induce leukemic transformation.. " /// "After induction, MN1-TEL expression was detected in both myeloid and lymphoid cells. " /// "To analyze the role of MN1-TEL in leukemogenesis, we created a site-directed transgenic (knock-in) mouse model carrying a conditional MN1-TEL transgene under the control of the Aml1 regulatory sequences. " /// Activation of MN1-TEL expression enhanced the repopulation ability of myeloid progenitors in vitro as well as partially inhibited their differentiation in vivo. /// MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice..
TEL_MN1p13;q11 / 16105979acute myeloid leukemia;myeloid leukemia;leukemia - - 22)(p13;q11) in human myeloid leukemia generates an MN1-TEL (meningioma 1-translocation-ETS-leukemia) fusion oncoprotein. /// "Coexpression of MN1-TEL and IL-3, but not SCF, rapidly caused a fatal myeloproliferative disease rather than acute myeloid leukemia (AML). " /// Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9.. /// Enforced expression of MN1-TEL in multipotent hematopoietic progenitors in knock-in mice perturbed growth and differentiation of myeloid as well as lymphoid cells. /// "Because MN1-TEL+ AML patient cells overexpress HOXA9 (homeobox A9), we tested the effect of coexpression of MN1-TEL and HOXA9 in mice and found that 90% of MN1-TEL+/HOXA9+ mice developed AML much more rapidly than control HOXA9+ mice. " /// Here we addressed the role of MN1-TEL in myeloid leukemogenesis using the same mouse model. /// "Thus, the leukemogenic effect of MN1-TEL in our knock-in mice is pleiotropic, and the type of secondary mutation determines disease outcome.. "
TEL_MN1inv (16) / 19379599acute myeloid leukemia;myeloid leukemia;leukemia - - This article reviews the role of MN1 in acute myeloid leukemia including MN1 gene structure and action mechanism, MN1-TEL and AML with normal karyotype, MN1 and inv (16) AML, MN1 and retinoic ocid-resistance, and so on..
TEL_MN1t(12;22)(p13;q11) / t(12;22) / p13;q11.2 / t(12;22)(p13;q11-12) / 21965128acute myeloid leukemia;myeloid leukemia;leukemia RT-PCR - Thus, the AMU-AML1 cell line is useful for studying the biological consequences of t(12;22)(p13;q11.2) lacking chimeric MN1-TEL.. /// "Establishment of a novel human myeloid leukemia cell line, AMU-AML1, carrying t(12;22)(p13;q11) without chimeric MN1-TEL and with high expression of MN1.. " /// The chimeric transcript and protein of MN1-TEL could not be detected by reverse-transcriptase polymerase chain reaction or Western blot analysis.
TEL_MN1p13;q11 / t(5;12)(q33;p13) / 11094079myeloid leukemia;leukemia;sarcoma - - The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity.. /// "By contrast to other chimeric proteins that contain TEL's PNT domain, such as TEL-platelet-derived growth factor beta receptor in t(5;12)(q33;p13), MN1-TEL contains the DBD of TEL. " /// "The N-terminal MN1 moiety is rich in proline residues and contains two polyglutamine stretches, suggesting that MN1-TEL may act as a deregulated transcription factor. " /// The transactivating capacity of MN1-TEL depended on both the DBD of TEL and sequences in MN1. /// "We now show that MN1-TEL type I, unlike TEL and MN1, transforms NIH 3T3 cells. " /// MN1-TEL contributes to leukemogenesis by a mechanism distinct from that of other chimeric proteins containing TEL.. /// "Furthermore, we demonstrate that MN1 has transcription activity and that MN1-TEL acts as a chimeric transcription factor on the Moloney sarcoma virus long terminal repeat and a synthetic promoter containing TEL binding sites. "
TEL_MN1t(12;22) / t(12;22)(p12;q11) / 16810199acute myeloid leukemia;myeloid leukemia;leukemia - - MN1-TEL is the product of the recurrent t(12;22)(p12;q11) associated with human myeloid malignancies. /// "MN1-TEL, the product of the t(12;22) in human myeloid leukemia, immortalizes murine myeloid cells and causes myeloid malignancy in mice.. " /// "MN1-TEL functions as an activated transcription factor, exhibiting weak transforming activity in NIH3T3 fibroblasts that depends on the presence of a functional TEL DNA-binding domain, the N-terminal transactivating sequences of MN1 and C-terminal sequences of MN1. " /// "We infer that MN1-TEL is a hematopoietic oncogene that stimulates the growth of hematopoietic cells, but depends on secondary mutations to cause leukemia in mice.. " /// We determined the transforming activity of MN1-TEL in mouse bone marrow (BM) by using retroviral transfer.
TEL_MN1t(12;22)(p13;q11) / 17476096acute myeloid leukemia;myeloid leukemia;leukemia - - Reverse transcriptase polymerase chain reaction revealed the TEL-MN1 fusion transcript.
TEL_MN1p13;q11 / t(12;22) (p13;q11) / t(5;12) / 7731705lymphoid leukemia - - The translocation results in transcription of the reciprocal fusion mRNAs, MN1-TEL and TEL-MN1, of which MN1-TEL is likely to encode an aberrant transcription factor containing the ETS DNA-binding domain of TEL.
TEL_MN1t(12;22) / 16912223acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - Recently, it has been shown in a mouse model that the fusion protein MN1-TEL can promote growth of primitive hematopoietic progenitor cells (HPCs) and, in cooperation with HOXA9, induce AML.

ChimerSEQ

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The fusion gene pair TEL--MN1 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair TEL--MN1 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair TEL--MN1 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair TEL--MN1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair TEL--MN1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair TEL--MN1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TEL--MN1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene TEL--MN1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TEL--MN1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TEL--MN1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TEL--MN1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TEL--MN1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TEL--MN1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TEL--MN1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TEL--MN1 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TEL is a known oncogene according to ONGENE database.


The tail gene MN1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TEL is cancer associated according to Bushman Cancer Gene database.


The tail gene MN1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TEL is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene MN1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TEL--MN1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TEL--MN1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TEL--MN1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TEL--MN1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TEL--MN1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TEL--MN1 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair TEL--MN1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TEL--MN1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene TEL--MN1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TEL--MN1 information is not available in ChromothripsisDB database.