TAL1--SIL

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TAL1 SIL

COSMIC

The fusion gene pair TAL1--SIL information is not available in COSMIC database.

ChimerKB

Top
The fusion gene pair TAL1--SIL information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

Top
The fusion gene pair TAL1--SIL information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TAL1_SILp32;q11 / 11960364T ALL;leukemia FISH - A single split-signal FISH probe set allows detection of TAL1 translocations as well as SIL-TAL1 fusion genes in a single test.. /// "We show that this split-signal FISH probe set allows reliable detection of the unaffected SIL-TAL1 gene region with a fusion signal, SIL-TAL1 fusion genes with loss of the SIL-U signal, and TAL1 gene translocations with a split-signal, independent of the involved partner gene.. "
TAL1_SILdel(17)(q12) / del(5)(q35) / del(7)(q34) / del(9)(q34) / del(12)(p13) / del(14)(q11) / 20065082leukemia FISH - CDKN2A-B/9p21 and GRIK2/6q16 deletions, TCR and TLX3 rearrangements, SIL-TAL1, CALM-AF10, MLL-translocations, del(17)(q12)/NF1 and other cryptic genomic imbalances, i.e.
TAL1_SILt(5;14) / t(5;14)(q35;q32) / 15194534T ALL FISH;PCR;RT-PCR - In addition, HOX11L2 and SIL-TAL1 expression was studied using reverse transcription polymerase chain reaction (RT-PCR).
TAL1_SIL- 15042105acute lymphoblastic leukemia;T ALL;lymphoblastic leukemia;leukemia FISH - Probe sets were developed for the genes TCF3 (E2A) at 19p13, MLL at 11q23, ETV6 at 12p13, BCR at 22q11, SIL-TAL1 at 1q32 and TLX3 (HOX11L2) at 5q35.
TAL1_SIL- 23210573acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia FISH;PCR - BCR-ABL1, FUS-ERG, MLL-AF4, ETV6-RUNX1, E2A-PBX1, dupMLL, MLL-AF10, MLL-ENL, SET-NUP214 and SIL-TAL1 were detected in 36 (14.06%), 14 (5.47%), 14 (5.47%), four (1.56%), four (1.56%), five (1.95%), four (1.56%), two (0.78%), two (0.78%) and five patients (1.95%), respectively.
TAL1_SILdel(11)(p12;p13) / 21357790T ALL;leukemia - - In 22 patients with T-ALL who had late relapses (at least 2.5 years from diagnosis), we studied TCR gene rearrangement status at first and second presentation, NOTCH1 gene mutations, and the presence of the SIL-TAL1 gene fusion.
TAL1_SILdel(1p) / del(1p) / 12681356T ALL;leukemia PCR;RT-PCR - Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR.. /// A reverse transcriptase real-time PCR assay to quantify SIL-TAL1 fusion genes is described. /// A SIL-TAL1 fusion gene RNA transcript was built that permitted absolute standard curves to be generated. /// "No RAG2 expression was detected in these expanded samples, suggesting that the clones bearing the SIL-TAL1 fusion gene may have existed at low levels prior to the ex vivo expansion.. " /// "However, when lymphocytes from three adults were cultured in vitro the SIL-TAL1 transcript was detectable in the RNA isolates. " /// None of the samples showed any SIL-TAL1 expression.
TAL1_SIL- 8640718acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia PCR - Two types of markers, namely the clone-specific markers including T-cell receptor (TCR) gamma, TCR delta, and Ig heavy-chain (IgH) gene rearrangements, and malignancy-specific fusion gene mRNA such as SIL-TAL-1, BCR-ABL, and HRX-partner genes, were investigated by molecular biology techniques in 65 Chinese patients with acute lymphoblastic leukemia (ALL).
TAL1_SIL- 9275514acute lymphoblastic leukemia;T ALL;lymphoblastic leukemia;leukemia PCR - In addition, we performed comparative study of MRD detection by using both T cell receptor (TCR) gamma gene as gene specific marker and SIL-TAL-1 fusion gene as tumor-specific marker in one T-ALL patient.
TAL1_SILt(1;19) / t(4;11) / t(8;21) / t(9;22) / t(12;21) / t(15;17) / inv (16) / 10602411- PCR;RT-PCR - A total of nine well-defined chromosome aberrations with fusion gene transcripts were selected: t(1;19) with E2A-PBX1, t(4;11) with MLL-AF4, t(8;21) with AML1-ETO, t(9;22) with BCR-ABL p190 and BCR-ABL p210, t(12;21) with TEL-AML1, t(15;17) with PML-RARA, inv (16) with CBFB-MYH11, and microdeletion 1p32 with SIL-TAL1.
TAL1_SIL- 25543465T ALL PCR;RT-PCR - [Correlation between expression of SIL-TAL1 fusion gene and deletion of 6q in T-cell acute lymphoblastic leukemia].. /// "Array-CGH results of 2 T-ALL cases with SIL-TAL1 rearrangement revealed that this fusion gene was resulted from a cryptic deletion of 1p32, and the overlap region of 6q deletion was 6q14.1-16.3. " /// "The results showed that SIL-TAL1 rearrangements were identified in 10/26 (38.5%) pediatric and 2/42 (4.8%) adult T-ALL cases, which indicate a pediatric preference for SIL-TAL1 rearrangements in T-ALL. " /// The incidence of SIL-TAL1 rearrangements was analyzed by nest real-time quantitative polymerase chain reaction (RT-PCR) in 68 patients with T-ALL. /// The present study was designed to investigate the prevalence and clinical significance of SIL-TAL1 rearrangements in T-cell acute lymphoblastic leukemia (T-ALL). /// "In contrast to the cases without SIL-TAL1 fusion, there are many adverse prognostic factors in the cases with SIL-TAL1 fusion, such as higher WBC count and higher LDH levels. " /// These cases with SIL-TAL1 fusion had a higher white blood cell (WBC) count and higher serum levels of lactate dehydrogenase (LDH) than cases without SIL-TAL1 fusion.
TAL1_SIL- 9080116T ALL - - Therefore, we tried to interfere with the transcription of the SIL/tal-1 fusion gene, the most common form of aberrant tal-1, by treatment with antisense oligodeoxynucleotides (ODNs). /// With both approaches a single-dose application of 3 mumol of ODN led to a significant antiproliferative effect of a about 25-60% in two T-ALL cell lines characterized by the SIL/tal-1 fusion gene. /// "The potential of two different strategies was investigated, one targeting the cell line specific SIL/tal-1 fusion region, the other using an ODN complementary to tal-1 sequence downstream of the region not affected by any of the known types of tal-1 rearrangement. "
TAL1_SIL- 12859878leukemia PCR;RT-PCR - Of the 191 leukemic samples, 86 (45.0%) carried 14 types of fusion genes including SIL/TAL1, MLL/AF1q, E2A/PBX1, MLL/AF6, AML1/ETO, MLL/AF9, TEL/ABL, BCR/ABL, MLL/AF10, dupMLL, MLL/ENL, TEL/AML1, PML/RARalpha and CBFbeta/MYH11.
TAL1_SIL- 19562638T ALL PCR;RT-PCR - SIL-TAL1 fusion gene negative impact in T-cell acute lymphoblastic leukemia outcome.. /// SIL-TAL1 fusion gene and the ectopic expression of HOX11L2 are common molecular abnormalities in T-cell acute lymphoblastic leukemia (T-ALL). /// "Considering patients younger than nine years-old, those with SIL-TAL1(+) presented a poorer outcome (p = 0.02). " /// "SIL-TAL1(+) and HOX11L2(+) accounted for 26.7% and 10.3% of the cases, respectively. " /// The results of this study suggest that in the Brazilian population only the presence of SIL-TAL1 can predict outcome in a restricted group of patients..
TAL1_SIL- 24103876acute myeloid leukemia;acute lymphoblastic leukemia;myeloid leukemia; - - The expression of miR-203 was significantly related with the gender, immunophenotype, chromosome, fusion gene, BCR-ABL, SIL-TAL1 and prednisone experiment in pediatric ALL and the gender, chromosome, fusion gene, SIL-TAL1 in pediatric acute leukemia (P<0.05).
TAL1_SILt(8;14) (q24;q11) / 12130513acute lymphoblastic leukemia;T ALL;lymphoblastic leukemia;leukemia;hematologic malignancy - - SIL-TAL1 fusion was detected in association with HOX11 expression in one patient and with a t(8;14) (q24;q11) in another. /// SIL-TAL1/SCL fusion was detected in 6 patients.
TAL1_SIL- 20704789acute lymphoblastic leukemia;T ALL;lymphoblastic leukemia;leukemia - - The fusion gene detection in 5 cases showed MLL rearrangements in two cases and positive SIL/TAL1 fusion gene in one case.
TAL1_SIL- 14961040T ALL PCR - Current MRD studies in T-cell acute lymphoblastic leukemia (T-ALL) mainly use T-cell receptor gamma, delta and SIL-TAL1 gene rearrangements as MRD-PCR targets.
TAL1_SIL- 21880637acute myeloid leukemia;myeloid leukemia;leukemia - - Patients were also investigated for NOTCH1, FBXW7, WT1, and JAK1 mutations together with CALM-AF10, SET-NUP214, and SIL-TAL1 gene rearrangements. /// "NOTCH1 mutations, FBXW7 mutations, WT1 mutations, JAK1 mutations, SIL-TAL1 fusions, SET-NUP214 fusions and CALM-AF10 fusions were present in 44/96 (45.8%), 9/96 (9.4%), 4/96 (4.1%), 3/49 (6.1%), 9/48 (18.8%), 3/48 (6.3%) and 0/48 (0%) of patients, respectively. "
TAL1_SIL- 22994759acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia FISH;PCR;RT-PCR - Five major risk stratifying fusion genes in ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1 and SIL-TAL1. /// 11) and SIL-TAL1 (Del 1p32) were found in 82/104 (79%) patients.
TAL1_SILinv(7)(p15q34) / t(7;7)(p15;q34) / 17039236T ALL PCR - Other molecular and/or cytogenetic aberrations frequently found in subtypes of T-ALL (SIL-TAL1, CALM-AF10, HOX11, HOX11L2) were not detected in the TCRbeta-HOXA rearranged cases except for deletion 9p21 and NOTCH1 activating mutations, which were present in 64 and 67%, respectively.
TAL1_SIL- 9432040T ALL PCR;RT-PCR - Since tal(d) lead to expression of a SIL-TAL1 fusion transcript, irrespective of the genomic breakpoint, we have used a single monoplex RT-PCR reaction to screen 55 T-ALL patients at diagnosis. /// "SIL-TAL1 RT-PCR screening should therefore increase the detection rate of tal(d) by approximately 15-20%, with an at least comparable sensitivity to tal(d) genomic PCR, and represents a more practical and economic alternative to multiple DNA PCRs or Southern blotting when incorporated into molecular screening for multiple transcripts at diagnosis.. " /// "SIL-TAL1 transcripts were demonstrated in 12 (22%) cases, including 7/27 (26%) children <15 years of age, 2/8 (25%) adolescents and 2/17 (12%) adults aged >20 years. " /// Simultaneous SIL-TAL1 RT-PCR detection of all tal(d) deletions and identification of novel tal(d) variants.. /// "SIL-TAL1 RT-PCR was preferrable to tal(d) DNA PCR since it allowed the simultaneous detection of tal(d), tal(d2) and two previously undescribed tal(d) variants. "
TAL1_SIL- 8630377T ALL - - No constant genetic alteration has yet been unravelled in T-cell acute lymphoblastic leukemia (T-ALL), and, to date, the most frequent alteration, the SIL-TAL1 deletion, is found in approximately 20% of cases.
TAL1_SILt(1;14)(p32;q11) / t(1;14) / t(1;14) / 1402666T ALL;leukemia - - In these cells, tal-1 is expressed via SIL-tal-1 fused transcripts.
TAL1_SIL- 18021563acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia PCR - SIL-TAL1 had been found in 4 of 7 of T-lineage leukemias.
TAL1_SIL- 24040098disseminated intravascular coagulation;tumor lysis syndrome - - SIL-TAL1 rearrangement is common in T-cell acute lymphoblastic leukemia (T-ALL), however its prognostic implication remains controversial. /// These data demonstrate that SIL-TAL1 rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.. /// "To investigate the clinical characteristics and outcome of this subtype in Chinese population, we systemically reviewed 62 patients with newly diagnosed T-ALL, including 15 patients with SIL-TAL1 rearrangement. " /// SIL-TAL1 rearrangement is related with poor outcome: a study from a Chinese institution.. /// "Moreover, the SIL-TAL1(+) mice models exerted a tendency of TLS/DIC and seemed vulnerable towards chemotherapy, which further simulated our clinical settings. " /// "We found that SIL-TAL1(+) T-ALL was characterized by higher white blood cell count (P = 0.029) at diagnosis, predominant cortical T-ALL immunophenotype (P = 0.028) of the leukemic blasts, and a higher prevalence of tumor lysis syndrome (TLS, P<0.001) and disseminated intravascular coagulation (DIC, P<0.001), which led to a higher early mortality (P = 0.011). " /// "Compared with SIL-TAL1(-) patients, SIL-TAL1(+) patients had shorter relapse free survival (P = 0.007) and overall survival (P = 0.002). " /// "Our NOD/SCID xenotransplantation model also demonstrated that SIL-TAL1(+) mice models had earlier disease onset, higher leukemia cell load in peripheral blood and shorter overall survival (P<0.001). "
TAL1_SIL- 12199779T ALL PCR - By searching GenBank, we identified PAC RP1-18D14 which contains SIL, TAL-1 and 633-DNA, confirming this novel rearrangement as a new deletion of the SIL/TAL-1 locus.. /// Deletions involving the SIL-TAL-1 locus are seen in 15% of T-acute lymphoblastic leukaemias (T-ALL). /// Molecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell acute lymphoblastic leukaemia..
TAL1_SIL- 7773964T ALL;leukemia PCR;RT-PCR - Moreover, analysis of the Tald rearrangement by DNA-based PCR in four patients with SIL-TAL-1 fusion revealed the type A (Tald1) rearrangement in all cases. /// "In this study, we established a ""nested"" retrotranscriptase/polymerase chain reaction (RT/PCR) technique which allows detection of the SIL-TAL-1 transcriptional expression. " /// "Sequence analysis demonstrated the presence of N region and non-random ""P"" nucleotide, as well as base deletions at the genomic SIL-TAL-1 joining site. " /// RT/PCR detection of SIL-TAL-1 fusion mRNA in Chinese T-cell acute lymphoblastic leukemia (T-ALL).. /// "In about 20% of T-cell acute lymphoblastic leukemias (T-ALL), this gene is disrupted in its 5' portion by a site-specific 100-kg deletion and is fused with the 5' part of the SIL gene, to form SIL-TAL-1 chimeric gene. "
TAL1_SIL- 15054041acute lymphoblastic leukemia;T ALL;lymphoblastic leukemia;leukemia - - TAL1/LMO1 deregulation is more frequent in alphabeta-lineage T-ALL, when it is predominantly due to SIL-TAL1 rearrangements in children but to currently unknown mechanisms in adolescents and adults. /// "In keeping with preferential alphabeta-lineage involution, the incidence of SIL-TAL1 and HOX11L2 deregulation decreased with age. " /// "Half demonstrate HOX11, HOX11L2, SIL-TAL1, or CALM-AF10 deregulation, with each being associated with a specific, age-independent stage of maturation arrest. "
TAL1_SIL- 8350619T cell lymphoma;T ALL;leukemia;lymphoma PCR - SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia.. /// "Here we used a polymerase chain reaction (PCR) assay to identify the 90 kb SIL-TAL1 deletion in a group of 19 cutaneous T-cell lymphomas and a series of 142 T-ALL patients (76 children, 66 adults). " /// "While none of the T-cell lymphoma exhibited a SIL-TAL1 recombination, seven T-ALL cases showed a type d1 and two patients a type d2 deletion. " /// Sequence analysis of SIL-TAL1 breakpoints revealed marked heterogeneity at the junctional region among the nine patients due to random deletion and insertion of N-region nucleotides or templated P-nucleotide addition mediated via illegitimate V(D)J recombinase action.
TAL1_SIL- 23904235acute lymphoblastic leukemia;T ALL;lymphoblastic leukemia;leukemia - - Other, non-T-cell receptor chromosomal aberrations, such as SIL-TAL1 deletions, have likewise been recognized as V(D)J recombination associated aberrations.
TAL1_SIL- 19631984T ALL;lymphoblastic leukemia;leukemia - - Other alterations included MLL(+) (n=4), SIL-TAL1(+) (n=3), FLT3 mutation (n=1) and HOX11L2(+) (n=1).
TAL1_SIL- 23317202acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia FISH;PCR;RT-PCR - RFS with BCR-ABL, MLL-AF4, TCF3-PBX1 and SIL-TAL1 was less than 10 months (8.0, 3.6, 5.5 and 8.1 months, respectively). /// 11) and SIL-TAL1 (del 1p32) were found in 89/101 (88.1%) patients.
TAL1_SIL- 19194200acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia ISH - None of the T-cell ALL cases were positive for either SIL-TAL1 or HOX11L2.

ChimerSEQ

Top
The fusion gene pair TAL1--SIL information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

Top
The fusion gene pair TAL1--SIL information is not available in CHITARS database.

FARE-CAFE

Top
The fusion gene pair TAL1--SIL information is not available in FARE-CAFE.

TicDB

Top
The fusion gene pair TAL1--SIL information is not available in TicDB.

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair TAL1--SIL information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

Top
The fusion gene pair TAL1--SIL information is not available in FusionCancer Database.

ConjoinG

Top
The fusion gene pair TAL1--SIL information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene TAL1--SIL has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene TAL1--SIL is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

Top
Fusion gene TAL1--SIL is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene TAL1--SIL is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene TAL1--SIL was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair TAL1--SIL information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene TAL1--SIL is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene TAL1--SIL has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene TAL1 is a known oncogene according to ONGENE database.


The tail gene SIL is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene TAL1 is cancer associated according to Bushman Cancer Gene database.
The tail gene SIL is not cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene TAL1 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene SIL is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene TAL1--SIL is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene TAL1--SIL is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair TAL1--SIL information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene TAL1--SIL is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene TAL1--SIL has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair TAL1--SIL information is not available in Klijn Dataset.

Fimereli_Dataset

Top
The fusion gene pair TAL1--SIL information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair TAL1--SIL information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

Top
Fusion gene TAL1--SIL is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair TAL1--SIL information is not available in ChromothripsisDB database.