TACC3--FGFR3

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

TACC3 FGFR3

COSMIC

The fusion gene pair TACC3--FGFR3 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair TACC3--FGFR3 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair TACC3--FGFR3 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
TACC3_FGFR34p16.3 / 23298836- - - These results demonstrated that the FGFR3-TACC3 gene fusion is expressed in human cancer and generates an oncogenic protein that promotes tumorigenesis in glioblastoma.. /// The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma.. /// "We performed whole transcriptome sequencing to identify fusion genes in glioma and discovered FGFR3-TACC3 fusions in 4 of 48 glioblastoma samples from patients both of mixed European and of Asian descent, but not in any of 43 low-grade glioma samples tested. " /// "We performed whole transcriptome sequencing to identify fusion genes in glioma and discovered FGFR3-TACC3 fusions in 4 of 48 glioblastoma samples from patients both of mixed European and of Asian descent, but not in any of 43 low-grade glioma samples tested."
TACC3_FGFR3- 26869289cervical cancer;gallbladder cancer;oral cancer - - Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation.. /// "These results demonstrate that FGFR3 kinase activity is essential for the oncogenic effects of the FGFR3-TACC3 fusion protein and could serve as a therapeutic target, but that phosphorylated tyrosine residues within the TACC3-derived portion are not critical for activity. "
TACC3_FGFR3- 26425723cervical cancer - - FGFR3-TACC3: A novel gene fusion in cervical cancer.. /// "We report the first three cases of cervical carcinoma harboring an FGFR3-TACC3 fusion, which serves as a novel therapeutic target. " /// One of the patients whose tumor contained the FGFR3-TACC3 fusion was treated with an investigational FGFR tyrosine kinase inhibitor.
TACC3_FGFR3- 25535896lung cancer - - In addition, we showed that the FGFR3-TACC3 fusion gene promotes cell proliferation, colony formation, and transforming ability in vitro, whereas the?FGFR3-TACC3 K508M mutant or treatment with the FGFR inhibitor PD173074 abrogates these effects, suggesting that FGFR3-TACC3 most likely exerts its effects through activation of FGFR kinase activity. /// Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma.. /// "Furthermore, we found certain new isoforms of the FGFR3-TACC3 fusion transcripts, such as a gene fusion between exon 18 of FGFR3 and exon 6 or exon 14 of TACC3 and agene fusion between exon 19 of FGFR3 and exon 11 of TACC3." /// "Furthermore, we found certain new isoforms of the FGFR3-TACC3 fusion transcripts, such as a gene fusion between exon 18 of FGFR3 and exon 6 or exon 14 of TACC3 and agene fusion between exon 19 of FGFR3 and exon 11 of TACC3. " /// "In this study, for the first time, we found that fibroblast growth factor receptor 3-transforming acidic coiled-coil-containing protein 3 (FGFR3-TACC3) fusion transcripts are recurrently detected in NPC." /// "In this study, for the first time, we found that fibroblast growth factor receptor 3-transforming acidic coiled-coil-containing protein 3 (FGFR3-TACC3) fusion transcripts are recurrently detected in NPC. " /// "Taken together, our data demonstrated the oncogenic role of FGFR3-TACC3 in vitro, indicating that FGFR3-TACC3 may be useful as a diagnostic marker and therapeutic target in cancers. " /// "Additionally, FGFR3-TACC3 could trigger activation of the ERK and Akt signaling pathways, whereas FGFR3-TACC3 K508M mutant could not, suggesting that these 2 signaling pathways might be involved in the function of FGFR3-TACC3. "
TACC3_FGFR3- 25135958astrocytoma - - Sixty-seven in-frame fusion transcripts were identified, including three recurrent fusion transcripts: FGFR3-TACC3, RNF213-SLC26A11, and PTPRZ1-MET (ZM).
TACC3_FGFR3- 25609060- PCR;RT-PCR - The two patients with FGFR3-TACC3 rearrangements who received JNJ-42756493 manifested clinical improvement with stable disease and minor response, respectively. /// Three of 85 IDH1/2 wild-type (3.5%) but none of 126 IDH1/2-mutant grade II and III gliomas harbored FGFR3-TACC3 fusions. /// JNJ-42756493 inhibited growth of glioma cells harboring FGFR3-TACC3 in vitro and in vivo. /// FGFR3-TACC3 fusions were associated with strong and homogeneous FGFR3 immunostaining. /// FGFR3-TACC3 fusions are associated with uniform intratumor expression of the fusion protein. /// FGFR3-TACC3 fusions are associated with uniform intratumor expression of the fusion protein.
TACC3_FGFR3- 25294908non small cell lung cancer;lung cancer;adenocarcinoma - - FGFR3-TACC3 rearrangements occur in a subset of patients with lung adenocarcinoma. /// Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma. /// "Two additional patients harboring FGFR3-TACC3 were identified by screening our entire cohort (overall prevalence, 0.5%). " /// Expression of FGFR3-TACC3 led to IL3 independent growth in Ba/F3 cells. /// We identified a FGFR3-TACC3 fusion event in one of 24 patients from this subset using targeted NGS. /// Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma..

ChimerSEQ

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The fusion gene pair TACC3--FGFR3 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair TACC3--FGFR3 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair TACC3--FGFR3 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair TACC3--FGFR3 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair TACC3--FGFR3 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair TACC3--FGFR3 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair TACC3--FGFR3 information is not available in ConjoinG Database.

1000Genome

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Fusion gene TACC3--FGFR3 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene TACC3--FGFR3 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene TACC3--FGFR3 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene TACC3--FGFR3 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene TACC3--FGFR3 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair TACC3--FGFR3 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene TACC3--FGFR3 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene TACC3--FGFR3 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene TACC3 is not a known oncogene according to ONGENE database.


The tail gene FGFR3 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene TACC3 is cancer associated according to Bushman Cancer Gene database.


The tail gene FGFR3 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene TACC3 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene FGFR3 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene TACC3--FGFR3 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene TACC3--FGFR3 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair TACC3--FGFR3 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene TACC3--FGFR3 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene TACC3--FGFR3 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair TACC3--FGFR3 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair TACC3--FGFR3 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair TACC3--FGFR3 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene TACC3--FGFR3 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair TACC3--FGFR3 information is not available in ChromothripsisDB database.