SYT--SSX2

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SYT SSX2

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The fusion gene pair SYT--SSX2 information is not available in COSMIC database.

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The fusion gene pair SYT--SSX2 information is not available in CHIMERKB (CHIMERDB 3.0) database.

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The fusion gene pair SYT--SSX2 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
SYT_SSX2p11.2;q11.2 / 10398111synovial sarcoma;sarcoma FISH - Identification of the t(X;18)(p11.2;q11.2) and the fusion gene products, SYT-SSX1 and SYT-SSX2, associated with a high proportion of synovial sarcomas, has been shown to be a useful diagnostic aid.
SYT_SSX2p11.2;q11.2 / 18992642synovial sarcoma;sarcoma FISH - We uncovered a complex cryptic rearrangement that gives rise to the characteristic SYT-SSX2 fusion gene in a monophasic synovial sarcoma.. /// Cryptic chromosome rearrangement resulting in SYT-SSX2 fusion gene in a monophasic synovial sarcoma.. /// "Comparative genomic hybridization detected losses of Xq21qter, 18p, and 18q12qter, indicating that the marker also contained DNA sequences from Xp22q21, and reverse-transcription polymerase chain reaction demonstrated a SYT-SSX2 fusion transcript. "
SYT_SSX2p11;q11 / 22393780synovial sarcoma;sarcoma FISH;PCR;RT-PCR - [Analysis of SYT/SSX1 and SYT/SSX2 fusion genes from synovial sarcoma].. /// "The expression analysis of SYT/SSX1 and SYT/SSX2 chimeric transcripts was performed in formalin-fixed soft tissue tumour specimens and the diagnostic validity of immunohistochemistry, FISH and RT-PCR methods was compared. " /// The chimeric transcripts were detected in 12 from 16 synovial sarcomas: 7 SYT/SSX1 and 5 SYT/SSX2 fusion variants.
SYT_SSX2p11.2;q11.2 / 8579118synovial sarcoma;sarcoma FISH - This was consistent with cytogenetic data in four cases and reverse transcription polymerase chain reaction analysis using primers known to amplify both SYT-SSX1 and SYT-SSX2 transcripts.
SYT_SSX2p11.2;q11.2 / 12037676testis cancer FISH - By interphase FISH analyses of 10 cases SYT-SSX2 translocations were found to be the most abundant in all but one of the cases, in which SYT-SSX1 was predominating. /// "Through this translation the SYT gene on chromosome 18 is fused with a testis/cancer antigen gene on the X chromosome, generating either a SYT-SSX1, SYT-SSX2, or less often a SYT-SSX4 fusion gene. " /// In all 12 cases the SYT-SSX1 and SYT-SSX2 fusions resulted in identical SYT-SSX fusion transcripts. /// "From 121 SYT-SSX positive primary tumors, co-expression of SYT-SSX1 and SYT-SSX2 was seen in 12 cases (10%), which were characterized in further detail both at the RNA, DNA and chromosomal level. " /// "It has been anticipated that the individual synovial sarcoma carries only one of these variants, however, in this study we demonstrated that SYT-SSX1 and SYT-SSX2 co-exist in a significant proportion of the cases. " /// Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas..
SYT_SSX2p11;q11 / 11782370synovial sarcoma;sarcoma - - They consistently show a specific t(X;18;p11;q11), which usually represents either of two gene fusions, SYT-SSX1 or SYT-SSX2, encoding putative transcriptional proteins differing at 13 amino acid positions. /// "Among other comparisons, there was a strong association of fusion type and morphology (P < 0.001), with almost all of the SYT-SSX2 tumors showing absence of glandular differentiation (monophasic histology) and almost all of the biphasic tumors containing SYT-SSX1. " /// "Within the subset of patients with localized disease at diagnosis (n = 202), the median and 5-year survival for the SYT-SSX1 and the SYT-SSX2 groups were 9.2 years and 61% versus 13.7 years and 77%, respectively. " /// "Median and 5-year overall survivals for the SYT-SSX1 and SYT-SSX2 groups were 6.1 years and 53%, and 13.7 years and 73%, respectively. " /// "Overall survival was significantly better among SYT-SSX2 cases (P = 0.03), among cases localized at diagnosis (P < 0.0001), and among patients with primary tumors < 5 cm in greatest dimension (P = 0.01). " /// "specifically, the male:female ratio of SYT-SSX1 cases was 1:1, whereas for SYT-SSX2 cases, it was close to 1:2. " /// "Previous studies have suggested that patients with SYT-SSX2 tumors do better than those with SYT-SSX1 tumors, but the study groups were too limited to be conclusive. " /// "SYT-SSX1 and SYT-SSX2 fusions were detected in 147 tumors (61%) and 91 tumors (37%), respectively. " /// "Patients whose tumors contained the SYT-SSX2 fusion (P = 0.08) or were smaller (P = 0.12) showed a trend toward better survival by log-rank test, whereas tumor histology had no impact (P = 0.8). "
SYT_SSX2p11.2;q11.2 / 7655467synovial sarcoma;sarcoma - - Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas..
SYT_SSX2p11.2;q11.2 / 26774699synovial sarcoma;sarcoma - - Cytogenetically, more than 90% of SS is characterized by the t(X;18)(p11.2;q11.2), translocation resulting in two chimeric fusion genes SYT-SSX1?and SYT-SSX2, confirming histological diagnosis.
SYT_SSX2p11;q11 / 12469233synovial sarcoma;sarcoma PCR;RT-PCR - Real-time PCR is useful in detecting and distinguishing SYT-SSX1 from SYT-SSX2 gene fusions in synovial sarcoma. /// This study was designed to evaluate the utility of a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay to detect and distinguish SYT-SSX1 and SYT-SSX2 fusions in fresh and archival specimens of synovial sarcoma in pediatric patients seen at St. /// SYT-SSX1 transcripts were found in 18/24 (75%) of the tumors while SYT-SSX2 transcripts were identified in 3/24 (12.5%). /// Real-time polymerase chain reaction as an aid for the detection of SYT-SSX1 and SYT-SSX2 transcripts in fresh and archival pediatric synovial sarcoma specimens: report of 25 cases from St. /// Positive results for either SYT-SSX1 or SYT-SSX2 were obtained in 21/25 (84%) cases. /// "In addition, distinguishing SYT-SSX1 from SYT-SSX2 fusions with these methods allow for prospective collection of information that may clarify issues of prognostic relevance.. " /// SYT-SSX2 fusions were compared.
SYT_SSX2p11.2;q11.2 / 9688183synovial sarcoma;sarcoma PCR - Identification of the t(X;18)(p11.2;q11.2) translocation and detection of the resulting SYT-SSX1 or SYT-SSX2 fusion transcripts are useful diagnostic markers for synovial sarcoma. /// "In seven cases, the SYT-SSX1 or SYT-SSX2 fusion transcripts were demonstrated in frozen tissue using a different PCR assay. " /// The type of the fusion was identified by the specific restriction enzyme digestion pattern as SYT-SSX1 in 13 cases and SYT-SSX2 in 7 cases.
SYT_SSX2p11.2;q11.2 / 15350633synovial sarcoma;sarcoma - - Synovial sarcoma (SS) is characterized by the t(X;18)(p11.2;q11.2) chromosomal translocation, which results in generating either SYT-SSX1, SYT-SSX2 or, infrequently, SYT-SSX4 fusion gene. /// The ratio of SYT-SSX1:SYT-SSX2 fusion was 7:18 for monophasic and 2:7 for biphasic tumors in the Slovenian group. /// "Whereas the frequency of different SYT-SSX fusions in the Dutch group was similar to that reported in the literature, we found an unexpectedly high number of tumors with SYT-SSX2 fusion in the Slovenian group. " /// "The ratio of SYT-SSX1:SYT-SSX2 fusions is close to 2:1 in the majority of studies, and SYT-SSX2 fusion has been only rarely observed in biphasic SS. " /// Are there geographical differences in the frequency of SYT-SSX1 and SYT-SSX2 chimeric transcripts in synovial sarcoma?.
SYT_SSX2- 18384223synovial sarcoma;sarcoma - - A subsequent molecular analysis revealed SYT-SSX2 gene fusion, which confirmed the diagnosis of synovial sarcoma.
SYT_SSX2- 22862905synovial sarcoma;sarcoma - - The presence of an SYT-SSX1 and/or SYT-SSX2 gene fusion resulting from t(X;18) was demonstrated from paraffin blocks by reverse transcriptase polymerase chain reaction in five cases.
SYT_SSX2- 22393682synovial sarcoma;renal cell carcinoma;sarcoma - - The diagnosis was supported by reverse transcription-polymerase chain reaction which demonstrated SYT-SSX2 gene fusion.
SYT_SSX2p11.2;q11.2 / 12201571synovial sarcoma;sarcoma - - A rare synovial sarcoma of the kidney exhibiting translocation (X;18) and SYT-SSX2 fusion gene..
SYT_SSX2- 12485482synovial sarcoma;sarcoma PCR - 18) was detected in both cases, which generated SYT-SSX1 and SYT-SSX2 fusion gene respectively.
SYT_SSX2p11.2;q11.2 / 10565298synovial sarcoma;sarcoma - - Even if recent data has implicated that the type of fusion gene (SYT/SSX1 or SYT/SSX2) can be of prognostic importance, the cellular and molecular mechanisms underlying the clinical behavior of synovial sarcoma are still poorly understood.
SYT_SSX2- 12687023synovial sarcoma;sarcoma - - The SYT-SSXI and SYT-SSX2 fusion genes, derived by reciprocal translocations t(X;18), are acquired genetic events strongly associated with the tumorigenesis of synovial sarcoma. /// "In approaching the mechanisms underlying the formation of these fusion oncogenes, we have analysed the genomic sequences surrounding the SYT-SSX breakpoints in 10 tumors, two expressing SYT-SSXI and eight expressing SYT-SSX2 fusion transcripts. "
SYT_SSX2- 24638484Hodgkin lymphoma;nephroblastoma PCR - Reverse transcription followed by PCR of the junctional regions of the SYT-SSX1 and SYT-SSX2 fusion gene transcripts resulted in a positive band at the expected size, corresponding to positivity for the SYT-SSX transcript and confirming the diagnostic translocation.The patient had an uneventful post-operative period and follow-up after 1 year revealed no evidence of recurrence.
SYT_SSX2- 14704716synovial sarcoma;sarcoma - - For five cases, the presence of either an SYT-SSX1 (three cases) or SYT-SSX2 (two cases) gene fusion was known.
SYT_SSX2- 12683902carcinosarcoma - - Pulmonary synovial sarcoma is a rare neoplasm recently recognized as a distinct entity and characterized by t(X;18) translocation and production of at least 2 fusion genes, SYT-SSX1 and SYT-SSX2. /// SYT-SSX2 variant of primary pulmonary synovial sarcoma with focal expression of CD117 (c-Kit) protein and a poor clinical outcome.. /// We report a case of primary pulmonary synovial sarcoma with the SYT-SSX2 phenotype and a rapidly progressive downhill course. /// Previous reports have suggested that the soft tissue synovial sarcomas with SYT-SSX2 phenotype have a favorable clinical outcome.
SYT_SSX2- 16682293synovial sarcoma;sarcoma - - A variant of the SYT-SSX2 fusion gene in a case of synovial sarcoma.. /// "Here we report a case of synovial sarcoma with a novel form of the SYT-SSX2 fusion transcript, in which 75 bases were inserted at the common fusion junction. " /// "The structure of SYT-SSX2 suggests that the fusion transcript in this case was created using a cryptic splicing acceptor site 15 bases upstream of the genomic fusion point, incorporating intronic sequences in mature mRNA. " /// "Reexamination of two variant SYT-SSX2 genes reported previously revealed that unknown sequences inserted at the common junction points were derived from intron sequences, as in the present case.. "
SYT_SSX2p11.2;q11.2 / 16462762synovial sarcoma;sarcoma - - SYT-SSX2 is the fusion product of the chromosomal translocation, t(X;18)(p11.2;q11.2), which occurs in synovial sarcoma, a soft tissue tumor. /// The synovial sarcoma translocation protein SYT-SSX2 recruits beta-catenin to the nucleus and associates with it in an active complex.. /// beta-Catenin accumulation in the nucleus led to the formation of a transcriptionally active nuclear complex that contained SYT-SSX2 and beta-catenin. /// SYT-SSX2 is known to associate with chromatin remodeling complexes and is proposed to be involved in controlling gene expression. /// "Interestingly, known target genes of canonical Wnt were not activated as a result of SYT-SSX2 expression, nor was the nuclear localization of beta-catenin due to one of the signaling pathways normally implicated in this event. " /// "These results unravel a novel pathway in the control of beta-catenin cellular transport and strongly suggest that SYT-SSX2 contributes to tumor development, in part through beta-catenin signaling.. " /// "More importantly, depletion of SYT-SSX2 in primary synovial sarcoma cells resulted in loss of nuclear beta-catenin signal and a significant decrease in its signaling activity. " /// We report that SYT-SSX2 plays a direct role in beta-catenin regulation.
SYT_SSX2- 20930682synovial sarcoma;sarcoma PCR;RT-PCR - A SYT-SSX2 fusion gene transcript was detected as a result of RT-PCR analysis.
SYT_SSX2- 15330802synovial sarcoma;sarcoma - - One biphasic tumour had a SYT-SSX2 fusion gene.
SYT_SSX2- 11866984synovial sarcoma;adenocarcinoma;sarcoma PCR;RT-PCR - All 10 biphasic synovial sarcoma cases had the SYT-SSX1 fusion, whereas 12 of 18 monophasic synovial sarcoma had the SYT-SSX1 and 6 had the SYT-SSX2 fusion gene (P < 0.05). /// "In 33 SYT-SSX positive synovial sarcomas, 22 had SYT-SSX1 and 6 had SYT-SSX2 fusion transcripts. " /// (2) There was an association between SYT-SSX fusion type and histologic subtype.SYT-SSX2 fusion transcript could only be found in monophasic synovial sarcomas..
SYT_SSX2- 17418406synovial sarcoma;sarcoma - - They show that expression of the SYT-SSX2 fusion gene yields a highly penetrant and representative model of human synovial sarcoma, but only if expression occurs in a particular biologic context.
SYT_SSX2- 10889911synovial sarcoma;sarcoma PCR;RT-PCR - Subsequent sequence analysis confirmed that the detected messages were derived from the SYT-SSX1 fusion gene in two cases and from SYT-SSX2 in one.
SYT_SSX2- 20830232synovial sarcoma;sarcoma - - Primary pulmonary biphasic synovial sarcoma confirmed by molecular detection of a SYT-SSX2 fusion gene: report of 1 case.. /// "Reverse transcriptase polymerase chain reaction, performed using RNA extracted from frozen tumor samples for the detection of SYT-SSX fusion gene, amplified a single 331-bp fragment that was characteristic of the SYT-SSX2 fusion transcripts. " /// "We report a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by SYT-SSX2 fusion transcripts, and present a brief review of the literature on Korean cases.. " /// " We experienced a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by immunohistochemistry and molecular testing of SYT-SSX2 fusion transcripts. "
SYT_SSX2- 22007079synovial sarcoma;sarcoma - - Synovial sarcoma of the tongue confirmed by molecular detection of the SYT-SSX2 fusion gene transcript..
SYT_SSX2p11.2;q11.2 / 9311017synovial sarcoma;sarcoma;mesothelioma PCR;RT-PCR - Applying reverse transcriptase polymerase chain reaction (RT-PCR) analysis, the SYT-SSX2 chimeric gene transcripts that result from the translocation, t(X;18)(p11.2;q11.2), found in most synovial sarcomas could be demonstrated.
SYT_SSX2p11.2;q11.2 / 10397263synovial sarcoma;sarcoma PCR - Cytogenetically, synovial sarcoma (SS) is characterized by the translocation t(X;18)(p11.2;q11.2), resulting in a fusion between the SYT gene on chromosome 18 and SSX1 or SSX2 on the X chromosome and the formation of new chimeric genes, SYT-SSX1 or SYT-SSX2. /// "The hazard ratio (with respect to metastasis-free survival for patients with SYT-SSX1 versus patients with SYT-SSX2 fusion transcripts was 7.4 (95% confidence interval, 1.5-36. " /// We examined the potential clinical relevance of SYT-SSX1 and SYT-SSX2 fusion transcripts together with tumor proliferation. /// "One case carrying an atypical transcript with a 57-bp insert was excluded, leaving 13 SYT-SSX1 and 19 SYT-SSX2 cases for analysis. " /// "There was also an association with reduced overall survival for patients with SYT-SSX1 compared to patients with SYT-SSX2 (hazard ratio, 8.5. " /// The 5-year metastasis-free survival for patients with SYT-SSX1 was 42% versus 89% for patients with SYT-SSX2.
SYT_SSX2p11;q11 / 11433527synovial sarcoma;sarcoma PCR;RT-PCR - It has been shown that patients with SYT/SSX1 fusion genes have a shorter metastasis-free survival than do patients with SYT/SSX2. /// "Combining cytogenetic complexity and transcript data, we found that the subgroup of patients with tumors showing simple karyotypes and SYT/SSX2 fusion had the best clinical outcome (2/8 patients developed metastases), and those with tumors showing complex karyotypes together with SYT/SSX1 fusion the worst (6/7 patients developed metastases). " /// "Two patients had variant SYT/SSX2 transcripts, with 57 bp and 141 bp inserts, respectively, between the known SYT and SSX2 sequences. " /// "The reciprocal transcripts SSX1/SYT and SSX2/SYT were detected using nested PCR in 11 of the 40 samples with SYT/SSX1 and 5 of the 23 samples with SYT/SSX2, respectively. " /// Tumors with SYT/SSX2 less often (4/12 vs. /// "SYT/SSX1 was found in 40 tumors from 33 patients, SYT/SSX2 in 23 tumors from 20 patients, and SYT/SSX4 in one case. " /// "Among 20 blood samples, SYT/SSX1 and SYT/SSX2 were detected in one sample each. " /// Patients with tumors with SYT/SSX1 fusions had a higher risk of developing metastases compared to those with SYT/SSX2 fusions (P = 0.01). /// "This translocation results in rearrangements of the SYT gene in 18q11 and one of the SSX1, SSX2, or SSX4 genes in Xp11, creating a SYT/SSX1, SYT/SSX2, or SYT/SSX4 chimeric gene. "
SYT_SSX2p11.2;q11.2 / 10879732synovial sarcoma;sarcoma PCR;RT-PCR - In the present work, we analyze a series of 36 SS surgical samples (from 34 patients) by RT-PCR for the presence of the SYT-SSX1 or the SYT-SSX2 fusion transcript. /// Our results showed a significant correlation between the SYT-SSX2 fusion and the monophasic SS histologic subtype.
SYT_SSX2p11;q11 / 7495284synovial sarcoma;sarcoma PCR;RT-PCR - Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript.. /// 19 cases were positive for SYT-SSX1 and 10 for SYT-SSX2. /// "In a single histologically unremarkable monophasic SS, a slightly larger SYT-SSX2 RT-PCR product was observed. "
SYT_SSX2p11;q11 / 9428816synovial sarcoma;sarcoma RT-PCR - The SYT-SSX1 and SYT-SSX2 fusion transcripts were detected in 29 (64 percent) and 16 (36 percent) of the tumors, respectively. /// "biphasic) and SSX1 or SSX2 involvement in the fusion transcript: all 12 biphasic synovial sarcomas had a SYT-SSX1 fusion transcript, and all 16 tumors that were positive for SYT-SSX2 were monophasic. " /// SYT-SSX1 and SYT-SSX2 are thought to tunction as aberrant transcriptional regulators. /// Kaplan-Meier analysis of 39 patients with localized tumors showed that the 15 patients with SYT-SSX2 had significantly better metastasis-free survival than the 24 patients with SYT-SSX1 (P=0.03 by multivariate analysis.
SYT_SSX2p11.2;q11.2 / 7539744synovial sarcoma;sarcoma PCR - PCR analysis demonstrates the presence of SYT-SSX1 or SYT-SSX2 fusion transcripts in 29 of 32 of the synovial sarcomas examined, indicating that the detection of these hybrid transcripts by PCR may represent a very useful diagnostic method. /// Sequence analysis has demonstrated heterogeneity in the fusion transcripts with the formation of two distinct SYT-SSX1 fusion junctions and two distinct SYT-SSX2 fusion junctions..
SYT_SSX2p11.2;q11.2 / 10095437gastrointestinal cancer PCR;RT-PCR - One case of recurrent spindle cell sarcoma originally classified as a fibrosarcoma revealed a SYT-SSX2 fusion transcript. /// DNA sequencing of PCR products enabled the assignment of fusion transcripts to either the SYT-SSX1 or the SYT-SSX2 variant.
SYT_SSX2p11.2;q11.2 / 11826189synovial sarcoma;sarcoma PCR;RT-PCR - All 13 non-synovial sarcomas tested were negative for SYT-SSX1 and SYT-SSX2 fusion transcripts. /// Twenty-nine of 30 (96.7%) histologically diagnosed FFPE synovial sarcomas were positive for the presence of either the SYT-SSX1 or SYT-SSX2 fusion transcripts. /// "We have developed a real-time, reverse transcriptase-polymerase chain reaction (RT-PCR) multiplex assay for the identification of the primary fusion transcript types (SYT-SSX1 and SYT-SSX2) from formalin-fixed, paraffin-embedded (FFPE) tissues. " /// "Twelve of 14 (85.7%) and 2 of 14 (14.3%) biphasic synovial sarcomas were positive for SYT-SSX1 and SYT-SSX2, respectively. " /// "Ten of 16 (62.5%) and five of 16 (31.25%) monophasic fibrous synovial sarcomas were positive for SYT-SSX1 and SYT-SSX2, respectively. "
SYT_SSX2p11.2;q11.2 / 27126659synovial sarcoma;sarcoma PCR - RNA was purified from the tissue block sections and then subjected to One-step reverse transcriptase real-time PCR using sequence specific hydrolysis probes for simultaneous detection of either SYT-SSX1 or SYT-SSX2 fusion transcript.
SYT_SSX2- 15257548synovial sarcoma;sarcoma - - SYT-SSX1 and SYT-SSX2 fusion gene transcripts were detected in 9 and 2 cases, respectively.
SYT_SSX2- 9950196desmoplastic small round cell tumor;soft tissue neoplasm;spindle cell sarcoma - - Reverse transcriptase-polymerase chain reaction revealed the SYT/SSX2 fusion transcript of the synovial sarcoma t(X;18) chromosomal rearrangement.
SYT_SSX2- 24560202synovial sarcoma;sarcoma PCR;RT-PCR - The diagnosis was confirmed in molecular biology by reverse transcription polymerase chain reaction (RT-PCR) which demonstrated a unique chromosomal translocation t(X;18) with SYT-SSX2 fusion transcripts.
SYT_SSX2- 10446966synovial sarcoma;sarcoma PCR - On the other hand, no association was found between the IGF-1R and type of fusion gene transcript (SYT-SSX1 or SYT-SSX2).
SYT_SSX2- 15879502synovial sarcoma;sarcoma PCR;RT-PCR - In our review of primary pulmonary synovial sarcomas confirmed by molecular detection of SYT-SSX fusion gene transcripts, the SYT-SSX2 fusion protein expression correlates with poorer prognosis.
SYT_SSX2- 15735574synovial sarcoma;sarcoma PCR;RT-PCR - Biphasic synovial sarcoma expressed the SYT-SSX1 fusion transcript, whereas the monophasic subtype expressed the SYT-SSX2 fusion transcript.
SYT_SSX2- 12004001synovial sarcoma;sarcoma PCR;RT-PCR - Only two of the cases studied harbored SYT-SSX1 and SYT-SSX2 fusion transcripts, respectively. /// RNA extracted from formalin-fixed paraffin-embedded tissue blocks was evaluated for the presence of SYT-SSX1 and SYT-SSX2 fusion transcripts by RT-PCR.
SYT_SSX2- 15140553synovial sarcoma;sarcoma PCR;RT-PCR - Case 2 exhibited a biphasic synovial sarcoma of the mediastinum containing an SYT-SSX2 fusion transcript, which is a rare fusion type in biphasic synovial sarcomas of the limbs. /// We reviewed previous reports of thoracic synovial sarcomas containing an analysis of the SYT-SSX fusion transcript and found that case 2 in the present study was the first description of a biphasic synovial sarcoma of the thorax with an SYT-SSX2 fusion transcript. /// "However, the number of reported cases was not sufficient to conclude that SYT-SSX2 fusion in biphasic synovial sarcoma of the thorax is, indeed, rare. " /// " Synovial sarcoma (SS) is characterized by a chromosomal translocation resulting in the expression of an SYT-SSX chimeric transcript, usually SYT-SSX1 or SYT-SSX2. " /// The presence of SYT-SSX2 chimeric transcripts was confirmed by reverse transcript polymerase chain reaction (RT-PCR) and a direct sequencing analysis in both cases.
SYT_SSX2- 11487273synovial sarcoma;sarcoma PCR;RT-PCR - Twelve, 10 and 1 case carried the SYT-SSX1, SYT-SSX2 and SYT-SSX4 fusion transcript, respectively.
SYT_SSX2- 10685632synovial sarcoma;sarcoma PCR;RT-PCR - Three tumors had SYT-SSX2 fusion transcripts, whereas 19 had SYT-SSX1 phenotype.
SYT_SSX2p11.2;q11.2 / 15338724synovial sarcoma;sarcoma - - Moreover, clinical correlations have demonstrated that SYT-SSX1 leads to a poor clinical outcome while the fusion SYT-SSX2 provides survival advantages to the patients..
SYT_SSX2- 12150740synovial sarcoma;sarcoma PCR;RT-PCR - Among 33 SYT-SSX-positive synovial sarcomas, 22 tumors had an SYT-SSX 1 fusion transcript, whereas 6 tumors had an SYT-SSX2 fusion transcript. /// SYT-SSX2 fusion transcripts can only be found in monophasic synovial sarcoma.. /// "All 10 biphasic synovial sarcomas had the SYT-SSX1 fusion, whereas all tumors with SYT-SSX2 were of monophasic morphology (P < 0.05). "
SYT_SSX2- 15725802synovial sarcoma;sarcoma - - SYT-SSX1 fusion transcripts were detected in 22 cases (56.4%) and SYT-SSX2 fusion transcripts in 17 cases.
SYT_SSX2p11.2;q11.2 / 11107170synovial sarcoma;sarcoma - - This molecular genetics methodology has now been applied to numerous tumor samples and has led to the finding that, in contrast to tumors carrying SYT-SSX2 fusions, SYT-SSX1-positive tumors more often exhibit a biphasic histology, show a higher proliferation rate, and are associated with a poorer clinical outcome.
SYT_SSX2- 20377831synovial sarcoma;sarcoma - - Upon tumor recurrence, molecular detection of SYT-SSX2 fusion transcripts lead to the diagnosis of synovial sarcoma of the kidney.
SYT_SSX2p11.2;q11.2 / 12065783synovial sarcoma;sarcoma PCR;RT-PCR - In the present investigation, we describe a new SS case that was previously shown to be negative for SYT/SSX1 and SYT/SSX2 expression by conventional reverse transcription polymerase chain reaction (RT-PCR) methods.
SYT_SSX2- 15747098synovial sarcoma PCR;RT-PCR - In this study, we developed a simple and rapid method for the simultaneous detection of SYT-SSX1 and SYT-SSX2 rearrangements by using a LightCycler real-time one-step reverse transcriptase polymerase chain reaction (RT-PCR) technology (Roche). /// "In most cases, it results in fusion of the SYT gene with the SSX1 or SSX2 gene, thus creating SYT-SSX1 or SYT-SSX2 rearrangement. " /// "With this method, 27 tumors (9 synovial sarcomas and 18 nonsynovial sarcomas) were studied and showed SYT-SSX1 rearrangement in 6 cases and SYT-SSX2 in 3 cases. "
SYT_SSX2p11;q11 / 9285793synovial sarcoma;sarcoma - - Indirect immunofluorescence analysis of COS-1 cells expressing tagged or untagged SYT, SSX2, SYT-SSX1 or SYT-SSX2 indicated that all these proteins are localized in the nucleus, excluding the nucleoli.
SYT_SSX2- 16557383synovial sarcoma;sarcoma - - Fourteen patients with SYT-SSX1 rearrangements and nine patients with biphasic tumor subtypes had better prognosis than the eight patients with SYT-SSX2 rearrangements and 13 patients with monophasic subtypes, respectively.
SYT_SSX2p11.2;q11.2 / 24228088synovial sarcoma;sarcoma - - This is caused by de-repression of the transcription of E-cadherin by SYT-SSX1 and SYT-SSX2, which dissociate Snail or Slug, respectively, from the E-cadherin promoter.
SYT_SSX2p11.2;q11.2 / 10824918synovial sarcoma;sarcoma - - These tumors were classified by reverse transcription-polymerase chain reaction to SYT-SSX1 and SYT-SSX2 types. /// It has been suggested that patients who have SS bearing SYT-SSX1 fusion have worse prognosis than those bearing SYT-SSX2 fusion.
SYT_SSX2- 16226798synovial sarcoma;sarcoma - - The finding of the SYT-SSX2 translocation is generally associated with a better prognosis, besides tumor negative margins after excision offer the possibility of a better outlook for this patient..
SYT_SSX2- 10396284synovial sarcoma;fibrous histiocytoma;sarcoma;histiocytoma - - The chromosomal translocation t(X;18), which generates SYT-SSX1 and SYT-SSX2 fusion products, is a sensitive marker for synovial sarcoma.
SYT_SSX2- 17509396synovial sarcoma;gastrointestinal stromal tumor;sarcoma - - Primary monophasic synovial sarcoma of the duodenum with SYT/SSX2 type of translocation.. /// We report a case of a primary synovial sarcoma of the distal duodenum with SYT/SSX2 type of the t(X;18) translocation.
SYT_SSX2- 21454665synovial sarcoma;sarcoma - - Synovial sarcoma is an aggressive soft tissue tumor characterized by a chromosomal translocation between chromosome 18 and X, generating oncoproteins such as SYT-SSX1 and SYT-SSX2.
SYT_SSX2- 17130329synovial sarcoma;sarcoma - - Diagnosis was confirmed with SYT-SSX2 translocation detection..
SYT_SSX2- 17334332synovial sarcoma;rhabdomyosarcoma;ewing sarcoma;sarcoma PCR;RT-PCR - Real-time RT-PCR assays specific for Ewing's sarcoma (EWS-FLI1, EWS-ERG, EWS-ETV1, EWS-ETV4, and EWS-FEV), synovial sarcoma (SYT-SSX1 and SYT-SSX2), and rhabdomyosarcoma (PAX3-FKHR and PAX7-FKHR) were tested across the samples.
SYT_SSX2- 11866985synovial sarcoma;sarcoma PCR;RT-PCR - A specific SYT-SSX RT-PCR product was found in 19 of 20 (95%) synovial sarcomas tested and of the 13 tumors containing SYT-SSX2, 10 were monophasic.
SYT_SSX2- 18563504synovial sarcoma;sarcoma - - These mice develop synovial sarcoma when SYT-SSX2 is expressed within myoblasts, thereby identifying a source of this enigmatic tumor and establishing a mouse model of this disease that recapitulates the clinical, histologic, immunohistochemical, and transcriptional profile of human synovial sarcomas.
SYT_SSX2- 12173050synovial sarcoma;sarcoma - - and (2) that the SYT-SSX1 fusion type has a stronger influence on these mechanisms than SYT-SSX2. /// "In this study we made use of the SYT-SSX1 vs SYT-SSX2 concept to investigate whether major, tumour relevant, and growth regulatory proteins (e.g. " /// " A recent large multi-centre study convincingly confirmed previous observations that the SYT-SSX1 fusion type, compared to SYT-SSX2, of synovial sarcoma is associated with a worse clinical outcome. "
SYT_SSX2- 15364967synovial sarcoma;sarcoma - - Median and 5-year metastasis-free survivals (MFS) were 84 months and 54.2% for SYT-SSX1 versus 50 months and 47.6% for SYT-SSX2 (P = .76). /// "Among those patients with localized disease at diagnosis, median and 5-year disease-specific survivals (DSS) for the SYT-SSX1 and SYT-SSX2 subgroups were 126 months and 67.4% versus 82 months and 63.2%, respectively (P = .12). " /// "The following parameters were examined for their potential prognostic value: age at diagnosis, sex, tumor site (extremities v proximal/truncal), size, histology, mitotic count, necrosis, histologic grade (Federation Nationale des Centres de Lutte Contre le Cancer system), stage (1997 tumor-node-metastasis system classification), surgical margin status (assessed histologically), and fusion type (SYT-SSX1 v SYT-SSX2). "
SYT_SSX2- 11720441synovial sarcoma;sarcoma - - However, we could not confirm the prediction value of the biphasic subtype for the presence of the SYT-SSX1 transcript since in our hands 6 out 33 (18%) biphasic tumours carried the SYT-SSX2 transcript..
SYT_SSX2- 16849535synovial sarcoma;sarcoma - - We report here that SYT-SSX1 and SYT-SSX2 interact preferentially with Snail or Slug, respectively, and prevent these transcriptional repressors from binding to the proximal E-cadherin promoter as shown by coimmunoprecipitation and chromatin immunoprecipitation. /// Luciferase reporter assays reveal that SYT-SSX1 and SYT-SSX2 can respectively overcome the Snail- or Slug-mediated repression of E-cadherin transcription. /// "The striking spontaneous mesenchymal to epithelial differentiation in this cancer is reminiscent of a developmental switch, but the only clue to its mechanistic basis has been the observation that most cases of synovial sarcoma with glandular epithelial differentiation (GED) contain SYT-SSX1 instead of SYT-SSX2. " /// SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma..
SYT_SSX2- 11368913synovial sarcoma;sarcoma - - In the present investigation we cloned and sequenced the full-length cDNA of SYT/SSX1, SYT/SSX2 and SYT/SSX4 from synovial sarcoma tissues. /// The SYT/SSX4 and SYT/SSX2 open reading frame also differed from previously reported SYT/SSX sequences by an in-frame addition of 93bp exon located in the junction between exon 7 and 8 of the SYT.
SYT_SSX2- 16247461synovial sarcoma;sarcoma - - SYT-SSX2, a fusion also frequently found in synovial sarcoma, is necessary for maintaining Igf2 expression in the synovial sarcoma cell line, and the increased IGF2 synthesis protects cells from anoikis and is required for tumor formation in vivo.
SYT_SSX2p13;q25 / 11422798synovial sarcoma;sarcoma PCR;RT-PCR - Primary synovial sarcoma of the kidney: Report of a case confirmed by molecular detection of the SYT-SSX2 fusion transcripts.. /// "The SYT-SSX2 fusion transcripts were detected by a reverse transcription-polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissue. "
SYT_SSX2- 15500711leiomyosarcoma PCR;RT-PCR - Of the 34 cases of SS 28 (93.3%) expressed SSX-SYT chimeric transcripts (14 were positive for SYT-SSX1, 9 for SYT-SSX2).
SYT_SSX2- 15641030synovial sarcoma;sarcoma PCR - SYT/SSX1 translocations are seen in nearly three times as many synovial sarcomas as SYT/SSX2 translocations. /// "Although the SYT/SSX2 fusion is usually associated with the monophasic disease pattern, the SYT/SSX1 fusion is present in tumors with biphasic or monophasic patterns. "
SYT_SSX2- 11395555synovial sarcoma;sarcoma PCR;RT-PCR - RT-PCR studies for the presence of a SYT-SSX1 or SYT-SSX2 fusion transcript were positive in every tumor. /// "Identification of the synovial sarcoma-specific chimeric transcript (SYT-SSX1 or SYT-SSX2), in conjunction with immunoperoxidase studies, can be extremely helpful in identifying cases of pleural monophasic synovial sarcoma.. "
SYT_SSX2p11;q11 / 9846971synovial sarcoma;sarcoma - - A subsequent sequence analysis using the polymerase chain reaction products confirmed that the detected messages were derived from either the SYT-SSX1 (22 cases) or SYT-SSX2 (8 cases) fusion gene. /// "Fusion transcripts were detectable in all the 7 biphasic tumors analysed, one of which had an SYT-SSX2 fusion transcript. "
SYT_SSX2- 10737705synovial sarcoma;sarcoma - - Specificity was demonstrated on COS-7 cells transfected with two subtypes of SYT-SSX fusion genes, SYT-SSX1 and SYT-SSX2. /// " To identify and characterize the SYT-SSX fusion proteins in synovial sarcomas, we developed two polyclonal antibodies against the N-terminal part and for the C-terminal part of the SYT-SSX2 protein. "
SYT_SSX2- 10718206synovial sarcoma;sarcoma - - 18), resulting in either the SYT-SSX1 or SYT-SSX2 gene fusion. /// Approximately two thirds of the tumors had an SYT-SSX1 and one third had an SYT-SSX2 fusion transcript. /// "Tumors with SYT-SSX2 had a significantly higher mean and median Ki-67 labeling index than those with SYT-SSX1, but a comparison of Ki-67 according to fusion type, histologic type, and sample source suggested that the main determinants of proliferation rate were the latter two factors. " /// "All biphasic synovial sarcomas had the SYT-SSX1 fusion, whereas all tumors with SYT-SSX2 were of monophasic morphology. "
SYT_SSX2p11.2;q11.2 / 10862210synovial sarcoma;sarcoma - - Type of fusion transcripts (SYT-SSX1 or SYT-SSX2) and Ki-67 were assessed in fresh frozen tissue from 33 patients. /// The 5-year metastasis-free survival for patients with SYT-SSX1 was 42% versus 89% for those with SYT-SSX2.
SYT_SSX2- 10935650synovial sarcoma;sarcoma - - In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX2 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.
SYT_SSX2- 19385976synovial sarcoma;sarcoma - - SYT-SSX1 and SYT-SSX2 fusion transcripts were tested by reverse transcription-polymerase chain reaction in 141 formalin-fixed, paraffin-embedded SS. /// "SYT-SSX1 and SYT-SSX2 were detected in 50 (34.5%) and 91 (64.5%) tumors, respectively. " /// "In conclusion, compared to SYT-SSX1, SYT-SSX2 was more frequent in Chinese patients with SS. "
SYT_SSX2p11.2;q11.2 / 11850075synovial sarcoma;sarcoma ISH - Real-time polymerase chain reaction using primer sets specific for SYT-SSX1 and SYT-SSX2 confirmed the presence of an SYT-SSX1 fusion transcript.
SYT_SSX2- 15105652rhabdoid tumor - - SYT-SSX2 transcripts were detected in all 3 cases.
SYT_SSX2- 10191774synovial sarcoma;sarcoma - - SYT-SSX1 fusion was found in 4 patients and SYT-SSX2 in 5.

ChimerSEQ

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The fusion gene pair SYT--SSX2 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair SYT--SSX2 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair SYT--SSX2 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair SYT--SSX2 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair SYT--SSX2 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair SYT--SSX2 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair SYT--SSX2 information is not available in ConjoinG Database.

1000Genome

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Fusion gene SYT--SSX2 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene SYT--SSX2 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene SYT--SSX2 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene SYT--SSX2 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene SYT--SSX2 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair SYT--SSX2 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene SYT--SSX2 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene SYT--SSX2 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene SYT is a known oncogene according to ONGENE database.


The tail gene SSX2 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene SYT is cancer associated according to Bushman Cancer Gene database.


The tail gene SSX2 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene SYT is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene SSX2 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene SYT--SSX2 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene SYT--SSX2 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair SYT--SSX2 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene SYT--SSX2 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene SYT--SSX2 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair SYT--SSX2 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair SYT--SSX2 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair SYT--SSX2 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene SYT--SSX2 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair SYT--SSX2 information is not available in ChromothripsisDB database.