| STRN_ALK | - |
25527510 | papillary carcinoma;thyloid cancer |
FISH |
- |
Two rearrangements of ALK were striatin (STRN)-ALK fusions, which were identified by 5' RACE analysis.
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| STRN_ALK | - |
24706668 | thyloid cancer |
- |
- |
The STRN-ALK fusion gene promotes thyroid cell transformation and dependency on ALK signaling. /// STRN-ALK Is a Potential Therapeutic Target in Aggressive Thyroid Cancer..
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| STRN_ALK | - |
24475247 | thyroid carcinoma |
PCR;RT-PCR |
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The STRN/ALK transcript consisted of the fusion between exon 3 of STRN and exon 20 of ALK. /// "High resolution array-comparative genomic hybridization data complemented by RT-PCR and sequencing analyses, allowed us to demonstrate the presence of a STRN/ALK fusion. " /// Identification of a recurrent STRN/ALK fusion in thyroid carcinomas..
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| STRN_ALK | - |
24613930 | thyloid cancer |
- |
- |
STRN-ALK leads to constitutive activation of ALK kinase via dimerization mediated by the coiled-coil domain of STRN and to a kinase-dependent, thyroid-stimulating hormone-independent proliferation of thyroid cells. /// "Moreover, expression of STRN-ALK transforms cells in vitro and induces tumor formation in nude mice. " /// The kinase activity of STRN-ALK and the ALK-induced cell growth can be blocked by the ALK inhibitors crizotinib and TAE684. /// "In addition to well-differentiated papillary cancer, STRN-ALK was found with a higher prevalence in poorly differentiated and anaplastic thyroid cancers, and it did not overlap with other known driver mutations in these tumors. " /// Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer.. /// Our data demonstrate that STRN-ALK fusion occurs in a subset of patients with highly aggressive types of thyroid cancer and provide initial evidence suggesting that it may represent a therapeutic target for these patients.
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| STRN_ALK | - |
26848800 | renal cell carcinoma;sickle cell trait |
ISH |
- |
Two Cases of Renal Cell Carcinoma Harboring a Novel STRN-ALK Fusion Gene.. /// "ALK translocation was confirmed by fluorescent in situ hybridization, and further gene analysis revealed a STRN-ALK fusion. " /// "Here, we describe 2 cases of RCC harboring a novel striatin (STRN)-ALK fusion. "
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