STAT5B--RARA

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

STAT5B RARA

COSMIC

The fusion gene pair STAT5B--RARA information is not available in COSMIC database.

ChimerKB

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The fusion gene pair STAT5B--RARA information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
STAT5B_RARA-/1817/ -/16573/ Exonic hg18 - - - Oncogene; Receptor; Transcription_Factor TICdb
STAT5B_RARA-/-/ -/-/ - hg18 acute promyelocytic leukemia - 10441338 Oncogene; Receptor; Transcription_Factor OMIM

ChimerPUB

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The fusion gene pair STAT5B--RARA information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
STAT5B_RARA- 27148563acute promyelocytic leukemia;leukemia PCR;RT-PCR - Additional analysis using a custom next-generation sequencing assay revealed a rearrangement producing a STAT5B-RARA fusion gene, which was confirmed by reverse transcription polymerase chain reaction (RT-PCR) and supplementary cytogenetic studies, allowing the diagnosis of a morphologically atypical form of acute promyelocytic leukemia to be made. /// Myeloid neoplasm demonstrating a STAT5B-RARA rearrangement and genetic alterations associated with all-trans retinoic acid resistance identified by a custom next-generation sequencing assay..
STAT5B_RARAt(15;17)(q22;q21) / t(11;17)(q23;q21) / t(5;17)(q35;q21) / t(11;17)(q13;q21) / 12357344- - - These include the t(11;17)(q23;q21) that produces the PLZF-RAR fusion, t(5;17)(q35;q21) that forms NPM-RAR, t(11;17)(q13;q21) that generates NUMA-RAR, and der(17) that creates STAT5b-RAR.
STAT5B_RARA- 19624718acute promyelocytic leukemia;leukemia - - Acute promyelocytic leukemia harboring a STAT5B-RARA fusion gene and a G596V missense mutation in the STAT5B SH2 domain of the STAT5B-RARA..
STAT5B_RARA- 23271512acute promyelocytic leukemia;leukemia - - All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene..
STAT5B_RARA- 18221386acute promyelocytic leukemia;leukemia;disseminated intravascular coagulation - - We report a rare case of APL with STAT5B-RARA fusion transcript and the normal chromosome 17 on G-banding. /// Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding.. /// Clinical characteristics of APL with STAT5B-RARA are also discussed..
STAT5B_RARAt(15;17) / 22655241acute promyelocytic leukemia;leukemia - - The STAT5b-RARA patient failed to achieve CRm following frontline combination chemotherapy and ultimately proceeded to allogeneic transplant on the basis of a steadily rising fusion transcript level. /// "However, there are few data on tracking disease response in patients with rarer retinoid resistant subtypes of APL, characterized by PLZF-RARA and STAT5b-RARA. " /// "STAT5b-RARA, n?=?1), established the respective breakpoint junction regions and designed reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) assays to detect leukemic transcripts. "
STAT5B_RARAt(15;17) / 26414475acute promyelocytic leukemia;leukemia - - It is important to identify these cryptic and variant translocations because certain variants, including ZBTB16/RARA and STAT5B/RARA, are resistant to treatment with all-trans retinoic acid, arsenic trioxide, and anthracyclines.
STAT5B_RARA- 25629986acute promyelocytic leukemia;leukemia - - Novel STAT5B-RARA fusion transcript in acute promyelocytic leukemia: identification and treatment response..
STAT5B_RARA- 11022230acute promyelocytic leukemia;leukemia - - In acute promyelocytic leukemia (APL) cells with rearrangement of retinoic acid receptor a (RAR alpha) (including: PML-RAR alpha, PLZF-RAR alpha, NPM-RAR alpha, NuMA- RAR alpha or STAT5b-RAR alpha) as a result of chromosomal translocations, the RA signal pathway is disrupted and myeloid differentiation is arrested at the promyelocytic stage.

ChimerSEQ

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The fusion gene pair STAT5B--RARA information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
STAT5B_RARAchr17/40428265/- chr17/38487108/+ 17q21.2 17q21.2 Exonic hg19 5'UTR-5'UTR Intra-chr LUSC TCGA-34-5231-01A Oncogene; Receptor; Transcription_Factor FusionScan

ChiTaRS 2.1

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The fusion gene pair STAT5B--RARA information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair STAT5B--RARA information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
STAT5B-RARA Acute promyelocytic-like leukaemia 5′-Race PCR,FISH,Southern blotting _ PubMed:10441338

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
STAT5B-RARA STAT5B-RARA-Isoform1 STAT5B _ _ 0 RARA _ 1 _ GTAGTGGTAACGAACCTTCAAACTAAGAgGGTACTCTGGGTCTCGTCGTCAACT 10441338 _
STAT5B-RARA STAT5B-RARA-Isoform2 STAT5B _ _ 0 RARA _ 1 _ TGCCACCACACTTGGcGGGCAGGCCGCCCAGGGGCAGG 10441338 _
STAT5B-RARA STAT5B-RARA-Isoform3 STAT5B 40362216 1 0 RARA 38504568 1 0 atcaccattgcttggaagtttgattctcCcattgagacccagagcagcagttc 18221386 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
STAT5B-RARA STAT5B-RARA-Isoform1 - - - -STAT5B 1) STAT_int
2) STAT_alpha
3) STAT_bind
4) SH2
1) STAT_bind
2) STAT_bind , STAT_alpha , SH2
3) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
RARA 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) STAT_int
2) STAT_alpha
3) STAT_bind
4) SH2
5) zf-C4
6) Hormone_recep
1) STAT_bind
2) STAT_bind , STAT_alpha , SH2
3) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
4) zf-C4 , Hormone_recep
5) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
STAT5B-RARA STAT5B-RARA-Isoform2 - - - -STAT5B 1) STAT_int
2) STAT_alpha
3) STAT_bind
4) SH2
1) STAT_bind
2) STAT_bind , STAT_alpha , SH2
3) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
RARA 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) STAT_int
2) STAT_alpha
3) STAT_bind
4) SH2
5) zf-C4
6) Hormone_recep
1) STAT_bind
2) STAT_bind , STAT_alpha , SH2
3) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
4) zf-C4 , Hormone_recep
5) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
STAT5B-RARA STAT5B-RARA-Isoform3 - - 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
STAT5B 1) STAT_int
2) STAT_alpha
3) STAT_bind
4) SH2
1) STAT_bind
2) STAT_bind , STAT_alpha , SH2
3) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
RARA 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) STAT_int
2) STAT_alpha
3) STAT_bind
4) SH2
1) STAT_bind
2) STAT_bind , STAT_alpha , SH2
3) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
STAT5B-RARA hsa-miR-125a-5phsa-miR-218-5phsa-miR-615-3phsa-miR-138-5p hsa-miR-23b-3phsa-miR-1229-3phsa-miR-93-3phsa-miR-324-3p Microarray,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
STAT5B-RARA NM_012448.3 1) STAT1_HUMAN
2) E2F4_HUMAN
3) ESTROGEN RECEPTOR ALPHA_HUMAN
4) ETS1_HUMAN
5) EGR1_HUMAN
6) FOS_HUMAN
7) E2F1_HUMAN
8) CTCF_HUMAN
9) BRG1_HUMAN
10) HNF4A_HUMAN
11) CEBPA_HUMAN
12) SPI1_HUMAN
13) TRIM24_HUMAN
1) RXR/RAR_HUMAN
2) MITF_HUMAN
3) RB1_HUMAN
4) RBL2_HUMAN
5) RUNX1_HUMAN
6) PRDM14_HUMAN
7) GATA2_HUMAN
8) GATA3_HUMAN
9) TFAP2C_HUMAN
10) FOXA1_HUMAN
11) ESR1_HUMAN
12) ESR2_HUMAN
13) FOXP1_HUMAN
14) NR1H3_HUMAN
1) 19122651
2) 21247883
3) 20547749
4) 20019798
5) 20690147
6) 20139302
7) 21310950
8) 21795385
9) 19505939
10) 21646355
11) 20219941
12) 21241896
13) 21164480

TicDB

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The fusion gene pair STAT5B--RARA information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
STAT5B RARA 10441338 GTAGTGGTAACGAACCTTCAAACTAAGAgGGTACTCTGGGTCTCGTCGTCAACT
STAT5B RARA 10441338 TGCCACCACACTTGGcGGGCAGGCCGCCCAGGGGCAGG
STAT5B RARA 18221386 atcaccattgcttggaagtttgattctcCcattgagacccagagcagcagttc

TUMOR FUSION Gene Data Portal

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The fusion gene pair STAT5B--RARA information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair STAT5B--RARA information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair STAT5B--RARA information is not available in ConjoinG Database.

1000Genome

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Fusion gene STAT5B--RARA has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene STAT5B--RARA is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene STAT5B--RARA is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene STAT5B--RARA is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene STAT5B--RARA was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair STAT5B--RARA information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene STAT5B--RARA is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene STAT5B--RARA has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene STAT5B is not a known oncogene according to ONGENE database.


The tail gene RARA is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene STAT5B is cancer associated according to Bushman Cancer Gene database.


The tail gene RARA is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene STAT5B is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene RARA is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene STAT5B--RARA is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene STAT5B--RARA is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair STAT5B--RARA information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene STAT5B--RARA is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene STAT5B--RARA has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair STAT5B--RARA information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair STAT5B--RARA information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair STAT5B--RARA information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene STAT5B--RARA is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair STAT5B--RARA information is not available in ChromothripsisDB database.