SLC34A2--ROS1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

SLC34A2 ROS1

COSMIC

The fusion gene pair SLC34A2--ROS1 information is available in COSMIC database.

Link
SLC34A2--ROS1

ChimerKB

Top
The fusion gene pair SLC34A2--ROS1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
SLC34A2_ROS1-/429/ -/5448/ Exonic hg19 - - - Kinase; Oncogene; Cosmic_recurrent
SLC34A2_ROS1-/2076/ -/5448/ Exonic hg19 - - - Kinase; Oncogene; Cosmic_recurrent
SLC34A2_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 18083107 Kinase; Oncogene; Cosmic_nonrecurrent
SLC34A2_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 22215748 Kinase; Oncogene; Cosmic_nonrecurrent
SLC34A2_ROS1-/-/ -/-/ - hg19 lung cancer - 22327623 Kinase; Oncogene; Cosmic_nonrecurrent
SLC34A2_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 22661537 Kinase; Oncogene; Cosmic_nonrecurrent
SLC34A2_ROS1-/-/ -/-/ - hg19 gastric adenocarcinoma - 23400546 Kinase; Oncogene; Cosmic_nonrecurrent
SLC34A2_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 24346091 Kinase; Oncogene; Cosmic_nonrecurrent
SLC34A2_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 24810493 Kinase; Oncogene; Cosmic_nonrecurrent
SLC34A2_ROS1-/-/ -/-/ - hg19 lung adenocarcinoma - 25157770 Kinase; Oncogene; Cosmic_nonrecurrent

ChimerPUB

Top
The fusion gene pair SLC34A2--ROS1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
SLC34A2_ROS1- 23400546non small cell lung cancer FISH;PCR;RT-PCR - and 2 of those 3 patients harbored a solute carrier family 34 (sodium phosphate), member 2 (SLC34A2)-ROS1 fusion transcripts. /// "In this study, an SLC34A2-ROS1 rearrangement was identified in GC, and the results provide a rationale for investigating the clinical efficacy of ROS1 inhibitors in this unique molecular subset of GC. " /// Both patients who had SLC34A2-ROS1 transcripts had poorly differentiated histology with recurrence and death within 2 years of curative surgery.
SLC34A2_ROS1- 25567305non small cell lung cancer;lung cancer;adenocarcinoma FISH - Among these positive cases, 15 were CD74-ROS1, 13 were SLC34A2-ROS1, 13 were SDC4-ROS1 and 12 were TPM3-ROS1.
SLC34A2_ROS1- 22919003non small cell lung cancer;lung cancer FISH;PCR - The patient and one TMA sample displayed expression of the recently identified SDC4-ROS1 fusion, whereas two TMA samples expressed the CD74-ROS1 fusion and two others expressed the SLC34A2-ROS1 fusion. /// "The HCC78 cell line, which expresses the SLC34A2-ROS1 fusion, was treated with kinase inhibitors that have activity against ROS1. "
SLC34A2_ROS1- 22661537non small cell lung cancer;lung cancer FISH;PCR - ROS1 fusion partners were determined by reverse transcriptase PCR identifying CD74-ROS1, SLC34A2-ROS1, and FIG-ROS1 fusions.
SLC34A2_ROS1- 25384172non small cell lung cancer;lung cancer - - The expressed ROS1-SLC34A2 and CCDC6-RET gene fusions from the NSCLC cell lines HCC78 and LC-2/ad, respectively, were accurately detected by the novel assay.
SLC34A2_ROS1- 27066085non small cell lung cancer;squamous cell carcinoma;lung cancer - - RNA-seq data identified oncogenic fusion genes EML4-ALK and SLC34A2-ROS1 in three of 86 normal-cancer paired samples.
SLC34A2_ROS1- 25691052lung cancer - - Although high response rates and disease control have been observed in lung cancer patients bearing rearranged ROS1 tumors (ROS1+) treated with the kinase inhibitor crizotinib, many of these patients eventually relapse.To identify mechanisms of resistance to ROS1 inhibitors we generated resistant cells from HCC78 lung cancer cells bearing the SLC34A2-ROS1 rearrangement.
SLC34A2_ROS1- 22617245non small cell lung cancer;lung cancer - - The SLC34A2-ROS1 translocated HCC78 cell line had phosphorylated levels of ROS1, AKT, and ERK inhibited by submicromolar doses of crizotinib, and subsequently underwent apoptosis. /// "We selected NSCLC cell lines--A549 (KRAS G12S), NCI-H3255 (EGFR L858R), NCI-H3122 (EML4-ALK E13;A20), and HCC78 (SLC34A2-ROS1)-to evaluate the antiproliferative effects of submicromolar concentrations of the multitargeted TKIs imatinib, sorafenib, erlotinib, and crizotinib. "

ChimerSEQ

Top
The fusion gene pair SLC34A2--ROS1 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
SLC34A2_ROS1chr4/25678323/+ chr6/117650608/- 4p15.2 6q22.1 Exonic hg19 Out-of-Frame Inter-chr LUAD TCGA-62-A46Y-01A Kinase; Oncogene; TopHat-Fusion
SLC34A2_ROS1chr4/25678323/+ chr6/117650608/- 4p15.2 6q22.1 Exonic hg19 Out-of-Frame Inter-chr LUAD TCGA-05-4426-01A Kinase; Oncogene; TopHat-Fusion
SLC34A2_ROS1chr4/25678323/+ chr6/117645577/- 4p15.2 6q22.1 Exonic hg19 Out-of-Frame Inter-chr LUAD TCGA-05-4426-01A Kinase; Oncogene; TopHat-Fusion
SLC34A2_ROS1chr4/25665952/ chr6/117609655/ 4p15.2 6q22.1 Exonic hg19 - Inter-chr non small cell lung cancer EU236946 Kinase; Oncogene; ChiTaRs

ChiTaRS 2.1

Top
The fusion gene pair SLC34A2--ROS1 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human EU236946SLC34A2--ROS1 SLC34A24 25664123 25665952 + 1 379 100 ROS16 117609655 117650611 - 378 2175 100
Human EU236947SLC34A2--ROS1 SLC34A24 25664123 25665952 + 1 379 100 ROS16 117609655 117645580 - 378 1866 100

FARE-CAFE

Top
The fusion gene pair SLC34A2--ROS1 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
SLC34A2-ROS1 lung cancer FISH _ PubMed:18083107

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
SLC34A2-ROS1 SLC34A2-ROS1-Isoform1 SLC34A2 _ _ 1 ROS1 117645548 0 1 gccttccagctggttggagAtgatttttggataccagaaacaagtttcat 18083107 _
SLC34A2-ROS1 SLC34A2-ROS1-Isoform2 SLC34A2 _ _ 1 ROS1 117650579 0 1 gccttccagctggttggagCtggagtcccaaataaaccaggcattcccaa 18083107 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
SLC34A2-ROS1 SLC34A2-ROS1-Isoform1 - - 1) fn3
1) RGM_N , SH2 , CH , HH_signal , IL12p40_C , IL6Ra-bind , Lipocalin , EPO_TPO , Hormone_1 , IL2 , IL7 , PDZ , Rad60-SLD , V-set , EpoR_lig-bind , Hormone_recep , IL4 , Ig_2 , Pkinase , Recep_L_domain , fn3 , Glyco_hydro_28 , I-set , IL6 , Lectin_C , RGM_C , SBP_bac_1
SLC34A2 1) Na_Pi_cotrans
-ROS1 1) fn3
2) Pkinase_Tyr
1) RGM_N , SH2 , CH , HH_signal , IL12p40_C , IL6Ra-bind , Lipocalin , EPO_TPO , Hormone_1 , IL2 , IL7 , PDZ , Rad60-SLD , V-set , EpoR_lig-bind , Hormone_recep , IL4 , Ig_2 , Pkinase , Recep_L_domain , fn3 , Glyco_hydro_28 , I-set , IL6 , Lectin_C , RGM_C , SBP_bac_1
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Na_Pi_cotrans
-
SLC34A2-ROS1 SLC34A2-ROS1-Isoform2 - - 1) fn3
1) RGM_N , SH2 , CH , HH_signal , IL12p40_C , IL6Ra-bind , Lipocalin , EPO_TPO , Hormone_1 , IL2 , IL7 , PDZ , Rad60-SLD , V-set , EpoR_lig-bind , Hormone_recep , IL4 , Ig_2 , Pkinase , Recep_L_domain , fn3 , Glyco_hydro_28 , I-set , IL6 , Lectin_C , RGM_C , SBP_bac_1
SLC34A2 1) Na_Pi_cotrans
-ROS1 1) fn3
2) Pkinase_Tyr
1) RGM_N , SH2 , CH , HH_signal , IL12p40_C , IL6Ra-bind , Lipocalin , EPO_TPO , Hormone_1 , IL2 , IL7 , PDZ , Rad60-SLD , V-set , EpoR_lig-bind , Hormone_recep , IL4 , Ig_2 , Pkinase , Recep_L_domain , fn3 , Glyco_hydro_28 , I-set , IL6 , Lectin_C , RGM_C , SBP_bac_1
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Na_Pi_cotrans
-

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
SLC34A2-ROS1 hsa-miR-26b-5p hsa-miR-335-5p Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
SLC34A2-ROS1 NM_001177998.1 - 1) EGR1_HUMAN
2) FOXA1_HUMAN
3) CTCF_HUMAN
4) AR_HUMAN
-

TicDB

Top
The fusion gene pair SLC34A2--ROS1 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
SLC34A2 ROS1 18083107 gccttccagctggttggagAtgatttttggataccagaaacaagtttcat
SLC34A2 ROS1 18083107 gccttccagctggttggagCtggagtcccaaataaaccaggcattcccaa

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair SLC34A2--ROS1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

Top
The fusion gene pair SLC34A2--ROS1 information is available in FusionCancer Database.
Database_IDHead_gene_symbolHead_breakpoint_locationTail_gene_symbolTail_breakpoint_locationCancer_typeSRA
FUSC003670SLC34A2chr4:25678324ROS1chr6:117645578Lung cancerERR164630
FUSC003670SLC34A2chr4:25678324ROS1chr6:117650609Lung cancerERR164630

ConjoinG

Top
The fusion gene pair SLC34A2--ROS1 information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene SLC34A2--ROS1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene SLC34A2--ROS1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

Top
Fusion gene SLC34A2--ROS1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene SLC34A2--ROS1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene SLC34A2--ROS1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair SLC34A2--ROS1 information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene SLC34A2--ROS1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene SLC34A2--ROS1 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene SLC34A2 is not a known oncogene according to ONGENE database.


The tail gene ROS1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene SLC34A2 is cancer associated according to Bushman Cancer Gene database.


The tail gene ROS1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene SLC34A2 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ROS1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene SLC34A2--ROS1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene SLC34A2--ROS1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair SLC34A2--ROS1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene SLC34A2--ROS1 is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene SLC34A2--ROS1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair SLC34A2--ROS1 information is available in Klijn Dataset.

Cell lineGene 5'Gene 3'Read evidenceKinaseChromosome 5'Position 5'Chromosome 3'Position 3'Fusion type DNAFusion type RNAFusion protein lengthTissueKnown Fusion
HCC78SLC34A2ROS1140Y4256659526117650609TranslocinFrame724LungFull fusion known

Fimereli_Dataset

Top
The fusion gene pair SLC34A2--ROS1 information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair SLC34A2--ROS1 is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
SLC34A2--ROS1Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumorshttps://doi.org/10.1016/j.jmoldx.2018.03.007

Cortex_Dataset

Top
Fusion gene SLC34A2--ROS1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair SLC34A2--ROS1 information is not available in ChromothripsisDB database.