SFPQ--TFE3

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

SFPQ TFE3

COSMIC

The fusion gene pair SFPQ--TFE3 information is available in COSMIC database.

Link
SFPQ--TFE3

ChimerKB

Top
The fusion gene pair SFPQ--TFE3 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
SFPQ_TFE3-/1914/ -/1041/ Exonic hg19 - - - - Cosmic_recurrent
SFPQ_TFE3-/2085/ -/1146/ Exonic hg19 - - - - Cosmic_recurrent
SFPQ_TFE3-/2085/ -/1041/ Exonic hg19 - - - - Cosmic_recurrent
SFPQ_TFE3-/-/ -/-/ - hg19 papillary renal cell carcinoma - 9393982 - Cosmic_nonrecurrent
SFPQ_TFE3-/-/ -/-/ - hg19 perivascular epithelioid cell tumour - 19606011 - Cosmic_nonrecurrent
SFPQ_TFE3-/-/ -/-/ - hg19 renal cancer - 19809274 - Cosmic_nonrecurrent
SFPQ_TFE3-/-/ -/-/ - hg18 adenocarcinoma - - - Mitelman
SFPQ_TFE3-/-/ -/-/ - hg18 papillary renal cell carcinoma - 9393982 - OMIM

ChimerPUB

Top
The fusion gene pair SFPQ--TFE3 information is not available in CHIMERPUB (CHIMERDB 3.0) database.

ChimerSEQ

Top
The fusion gene pair SFPQ--TFE3 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
SFPQ_TFE3chr1/35654604/- chrX/48898095/- 1p34.3 Xp11.23 Exonic hg19 In-frame Inter-chr KIRC TCGA-AK-3456-01A - PRADA
SFPQ_TFE3chr1/35652602/- chrX/48891766/- 1p34.3 Xp11.23 Exonic hg19 In-frame Inter-chr KIRC TCGA-B8-5546-01A - PRADA
SFPQ_TFE3chr1/35654604/- chrX/48898095/- 1p34.3 Xp11.23 Exonic hg19 In-frame Inter-chr KIRC TCGA-BP-4756-01A - PRADA

ChiTaRS 2.1

Top
The fusion gene pair SFPQ--TFE3 information is not available in CHITARS database.

FARE-CAFE

Top
The fusion gene pair SFPQ--TFE3 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
SFPQ-TFE3 Renal-cell carcinoma PCR,RACE,Q-banding,FISH,RT-PCR t(X;1)(p11.2;p34) PubMed: 9393982

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
SFPQ-TFE3 SFPQ-TFE3 SFPQ 35652627 1 0 TFE3 48891743 0 0 gtggttccatgatgggaagtgacatgCtgcctgtgtcagggaatctgctt 9393982 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
SFPQ-TFE3 SFPQ-TFE3 - - - -SFPQ 1) RRM_1
2) NOPS
1) 2OG-FeII_Oxy_2 , Mago-bind , PHD , RRM_6 , La , Mago_nashi , Pkinase , SAP18 , MIF4G_like , NOPS , RRM_1 , SF3b1 , MIF4G_like_2 , NUDIX_2 , RRM_5 , Vinculin
2) RRM_1
TFE3 1) MITF_TFEB_C_3_N
2) HLH
3) DUF3371
1) HLH , Myc-LZ , PAS , LIM
1) RRM_1
2) NOPS
3) MITF_TFEB_C_3_N
4) HLH
5) DUF3371
1) 2OG-FeII_Oxy_2 , Mago-bind , PHD , RRM_6 , La , Mago_nashi , Pkinase , SAP18 , MIF4G_like , NOPS , RRM_1 , SF3b1 , MIF4G_like_2 , NUDIX_2 , RRM_5 , Vinculin
2) 2OG-FeII_Oxy_2 , Mago-bind , PHD , RRM_6 , La , Mago_nashi , Pkinase , SAP18 , MIF4G_like , NOPS , RRM_1 , SF3b1 , MIF4G_like_2 , NUDIX_2 , RRM_5 , Vinculin
3) HLH , Myc-LZ , PAS , LIM

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
SFPQ-TFE3 hsa-miR-335-5phsa-miR-455-3p hsa-miR-141-3phsa-miR-29b-3phsa-miR-1229-3phsa-miR-615-3phsa-miR-92b-3phsa-miR-193b-3phsa-miR-331-3phsa-miR-10a-5p Microarray,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
SFPQ-TFE3 NM_005066.2 1) STAT1_HUMAN
2) RBL2_HUMAN
3) E2F4_HUMAN
4) PRDM14_HUMAN
5) ETS1_HUMAN
6) EGR1_HUMAN
7) FOS_HUMAN
8) BRG1_HUMAN
9) HNF4A_HUMAN
10) TFAP2C_HUMAN
- 1) 19122651
2) 20385362
3) 21247883
4) 20953172
5) 20019798
6) 20690147
7) 20139302
8) 19505939
9) 21646355
10) 21572391

TicDB

Top
The fusion gene pair SFPQ--TFE3 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
SFPQ TFE3 9393982 gtggttccatgatgggaagtgacatgCtgcctgtgtcagggaatctgctt

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair SFPQ--TFE3 information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
KIRC AK-3456-01A SFPQ__TFE3 0.13 1:35654604/-1 X:48898095/-1 tier1 In-frame 15754 NA
KIRC B0-5705-01A SFPQ__TFE3 0.13 1:35652602/-1 X:48891766/-1 tier1 In-frame 15755 NA
KIRC B8-5546-01A SFPQ__TFE3 0.13 1:35652602/-1 X:48891766/-1 tier1 In-frame 15756 NA
KIRC BP-4756-01A SFPQ__TFE3 0.13 1:35654604/-1 X:48898095/-1 tier1 In-frame 15757 non-validated
KIRC BP-4758-01A SFPQ__TFE3 0.13 1:35654604/-1 X:48898095/-1 tier1 In-frame 15758 NA
KIRP G7-7501-01A SFPQ__TFE3 0.13 1:35654604/-1 X:48898095/-1 tier1 In-frame 15759 NA
KIRP SX-A7SO-01A SFPQ__TFE3 0.13 1:35654604/-1 X:48898095/-1 tier1 In-frame 15760 NA

FusionCancer

Top
The fusion gene pair SFPQ--TFE3 information is not available in FusionCancer Database.

ConjoinG

Top
The fusion gene pair SFPQ--TFE3 information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene SFPQ--TFE3 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene SFPQ--TFE3 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

Top
Fusion gene SFPQ--TFE3 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene SFPQ--TFE3 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene SFPQ--TFE3 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair SFPQ--TFE3 information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene SFPQ--TFE3 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene SFPQ--TFE3 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene SFPQ is a known oncogene according to ONGENE database.


The tail gene TFE3 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene SFPQ is cancer associated according to Bushman Cancer Gene database.


The tail gene TFE3 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene SFPQ is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene TFE3 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene SFPQ--TFE3 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene SFPQ--TFE3 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair SFPQ--TFE3 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene SFPQ--TFE3 is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene SFPQ--TFE3 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair SFPQ--TFE3 information is not available in Klijn Dataset.

Fimereli_Dataset

Top
The fusion gene pair SFPQ--TFE3 information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair SFPQ--TFE3 is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
SFPQ--TFE3RNA sequencing of Xp11 translocation-associated cancers reveals novel gene fusions and distinctive clinicopathologic correlationshttps://www.ncbi.nlm.nih.gov/pubmed/29713041
SFPQ--TFE3The pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7

Cortex_Dataset

Top
Fusion gene SFPQ--TFE3 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair SFPQ--TFE3 information is not available in ChromothripsisDB database.