SEC31A--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

SEC31A ALK

COSMIC

The fusion gene pair SEC31A--ALK information is available in COSMIC database.

Link
SEC31A--ALK

ChimerKB

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The fusion gene pair SEC31A--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
SEC31A_ALK-/2904+2329/ -/4080-157/ Exonic hg19 - - - - Cosmic_recurrent
SEC31A_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 16161041 - Cosmic_nonrecurrent
SEC31A_ALK-/2328/ -/1776/ Exonic hg18 - - - - TICdb

ChimerPUB

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The fusion gene pair SEC31A--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
SEC31A_ALK- 25715771non small cell lung cancer;non small cell lung cancer ISH - SEC31A-ALK Fusion Gene in Lung Adenocarcinoma.. /// "In this study, we found a new ALK fusion gene, SEC31A-ALK, in lung carcinoma from a 53-year-old Korean man. " /// "This is the first report of SEC31A-ALK fusion transcript in clinical NSCLC, which could be a novel diagnostic and therapeutic target for patients with NSCLC.. " /// Fluorescence in situ hybridization studies suggested that SEC31A-ALK was generated by an unbalanced genomic rearrangement associated with loss of the 3'-end of SEC31A. /// "SEC31A-ALK encodes a predicted fusion protein of 1,438 amino acids comprising the WD40 domain of SEC31A at the N-terminus and ALK kinase domain at the C-terminus." /// "SEC31A-ALK encodes a predicted fusion protein of 1,438 amino acids comprising the WD40 domain of SEC31A at the N-terminus and ALK kinase domain at the C-terminus. "
SEC31A_ALKt(2;3)(p23;q27) / / 20207848B cell lymphoma;lymphoma ISH - ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions. /// "Further studies of SEC31A-ALK showed that this variant fusion transforms IL3-dependent Ba/F3 cells to growth factor independence, and that the ALK inhibitor TAE-684 reduces cell proliferation and kinase activity of SEC31A-ALK and its downstream effectors ERK1/2, AKT, STAT3 and STAT5.."

ChimerSEQ

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The fusion gene pair SEC31A--ALK information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair SEC31A--ALK information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair SEC31A--ALK information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
SEC31A-ALK Diffuse large B-cell lymphoma DNA sequencing,Southern blot,PCR t(2;4)(p23;q21) PubMed: 20207848

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
SEC31A-ALK SEC31A-ALK-Isoform1 SEC31A 83760987 0 0 ALK 29446528 0 0 TTTAACCTGGCTGAGAAACAGAGtcTTTAATCATTTTATTAGTATTTC 16161041 _
SEC31A-ALK SEC31A-ALK-Isoform2 SEC31A _ _ 0 ALK _ 0 _ gcgtcccaaagaacagTgtaccgccgg 20207848 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
SEC31A-ALK SEC31A-ALK-Isoform1 - - 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
SEC31A 1) WD40
2) Sec16_C
1) Acetyltransf_10 , CPSF_A , DUF1899 , IRK , ARPC4 , EZH2_WD-Binding , PH , Sec16_C , RGS , Cytochrom_C , G-gamma , eIF2A , Sec16 , Nup96 , Phosducin , MMS1_N , DUF1899 , DUF1900 , CAF1C_H4-bd , DEP , Methyltransf_4 , G-alpha , G-gamma , HELP , Lipase_GDSL_2 , Nucleopor_Nup85 , PI3_PI4_kinase , Ribosomal_S17e , P16-Arc , Mad3_BUB1_II , CPSF_A , HORMA , V-set , WD40 , PRMT5 , Ribosomal_S9
2) Sec16_C , Sec16 , WD40
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) WD40
2) Sec16_C
1) Acetyltransf_10 , CPSF_A , DUF1899 , IRK , ARPC4 , EZH2_WD-Binding , PH , Sec16_C , RGS , Cytochrom_C , G-gamma , eIF2A , Sec16 , Nup96 , Phosducin , MMS1_N , DUF1899 , DUF1900 , CAF1C_H4-bd , DEP , Methyltransf_4 , G-alpha , G-gamma , HELP , Lipase_GDSL_2 , Nucleopor_Nup85 , PI3_PI4_kinase , Ribosomal_S17e , P16-Arc , Mad3_BUB1_II , CPSF_A , HORMA , V-set , WD40 , PRMT5 , Ribosomal_S9
2) Sec16_C , Sec16 , WD40
SEC31A-ALK SEC31A-ALK-Isoform2 - - - -SEC31A 1) WD40
2) Sec16_C
1) Acetyltransf_10 , CPSF_A , DUF1899 , IRK , ARPC4 , EZH2_WD-Binding , PH , Sec16_C , RGS , Cytochrom_C , G-gamma , eIF2A , Sec16 , Nup96 , Phosducin , MMS1_N , DUF1899 , DUF1900 , CAF1C_H4-bd , DEP , Methyltransf_4 , G-alpha , G-gamma , HELP , Lipase_GDSL_2 , Nucleopor_Nup85 , PI3_PI4_kinase , Ribosomal_S17e , P16-Arc , Mad3_BUB1_II , CPSF_A , HORMA , V-set , WD40 , PRMT5 , Ribosomal_S9
2) Sec16_C , Sec16 , WD40
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) WD40
2) Sec16_C
3) MAM
4) Gly_rich
5) Pkinase_Tyr
1) Acetyltransf_10 , CPSF_A , DUF1899 , IRK , ARPC4 , EZH2_WD-Binding , PH , Sec16_C , RGS , Cytochrom_C , G-gamma , eIF2A , Sec16 , Nup96 , Phosducin , MMS1_N , DUF1899 , DUF1900 , CAF1C_H4-bd , DEP , Methyltransf_4 , G-alpha , G-gamma , HELP , Lipase_GDSL_2 , Nucleopor_Nup85 , PI3_PI4_kinase , Ribosomal_S17e , P16-Arc , Mad3_BUB1_II , CPSF_A , HORMA , V-set , WD40 , PRMT5 , Ribosomal_S9
2) Sec16_C , Sec16 , WD40
3) ig , Astacin , MATH
4) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
SEC31A-ALK hsa-miR-132-3p hsa-miR-193b-3phsa-miR-98-5phsa-miR-1909-5phsa-miR-331-3phsa-miR-378a-3phsa-miR-26a-5phsa-miR-378c Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
SEC31A-ALK NM_001077206.2 - 1) TRIM28_HUMAN
2) MITF_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) P53_HUMAN
6) RUNX1_HUMAN
7) PRDM14_HUMAN
8) ESTROGEN RECEPTOR ALPHA_HUMAN
9) EGR1_HUMAN
10) FOS_HUMAN
11) GATA3_HUMAN
12) E2F1_HUMAN
13) SOX2_HUMAN
14) CTCF_HUMAN
15) BRG1_HUMAN
16) HNF4A_HUMAN
17) TFAP2C_HUMAN
18) FOXA1_HUMAN
19) ESR1_HUMAN
20) NR1H3_HUMAN
21) SETDB1_HUMAN
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TicDB

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The fusion gene pair SEC31A--ALK information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
SEC31A ALK 16161041 TTTAACCTGGCTGAGAAACAGAGtcTTTAATCATTTTATTAGTATTTC
SEC31A ALK 20207848 gcgtcccaaagaacagTgtaccgccgg

TUMOR FUSION Gene Data Portal

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The fusion gene pair SEC31A--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair SEC31A--ALK information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair SEC31A--ALK information is not available in ConjoinG Database.

1000Genome

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Fusion gene SEC31A--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene SEC31A--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene SEC31A--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene SEC31A--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene SEC31A--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair SEC31A--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene SEC31A--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene SEC31A--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene SEC31A is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene SEC31A is not cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene SEC31A is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene SEC31A--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene SEC31A--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair SEC31A--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene SEC31A--ALK is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene SEC31A--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair SEC31A--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair SEC31A--ALK information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair SEC31A--ALK is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
SEC31A--ALKThe pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7

Cortex_Dataset

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Fusion gene SEC31A--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair SEC31A--ALK information is not available in ChromothripsisDB database.