RUNX1--SH3D19

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

 RUNX1 SH3D19

COSMIC

The fusion gene pair RUNX1--SH3D19 information is not available in COSMIC database.

ChimerKB

 Top
The fusion gene pair RUNX1--SH3D19 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
RUNX1_SH3D19-/0/ -/0/ Exonic hg18 - - - - TICdb

ChimerPUB

 Top
The fusion gene pair RUNX1--SH3D19 information is not available in CHIMERPUB (CHIMERDB 3.0) database.

ChimerSEQ

 Top
The fusion gene pair RUNX1--SH3D19 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
RUNX1_SH3D19chr21/36252948/ chr4/152096766/ 21q22.12 4q31.3 Exonic hg19 - Inter-chr NA EU093087 - ChiTaRs
RUNX1_SH3D19chr21/36252948/ chr4/152096570/ 21q22.12 4q31.3 Exonic hg19 - Inter-chr acute myeloid leukemia EU093086 - ChiTaRs

ChiTaRS 2.1

 Top
The fusion gene pair RUNX1--SH3D19 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human EU093086RUNX1--SH3D19 RUNX121 36231771 36252948 - 1 200 100 SH3D194 152096570 152147238 - 201 874 99.9
Human EU093087RUNX1--SH3D19 RUNX121 36206707 36252948 - 1 392 100 SH3D194 152096766 152147239 - 392 870 100

FARE-CAFE

 		Top
The fusion gene pair RUNX1--SH3D19 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
RUNX1/AML1-SH3D19 Acute myeloid leukemia RT-PCR t(4;21)(q31.3;q22) PubMed:16858696

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
RUNX1/AML1-SH3D19 RUNX1/AML1-SH3D19-Isoform1 RUNX1/AML1 _ _ 0 SH3D19 _ 0 _ CAGAGTCAGATGCAGgaTCGCAACGAACGAAAT 16858696 _
RUNX1/AML1-SH3D19 RUNX1/AML1-SH3D19-Isoform2 RUNX1/AML1 _ _ 0 SH3D19 _ 0 _ CCCCGAGAACCTCGAaaTCGCAACGAACGAAAT 16858696 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
RUNX1/AML1-SH3D19 RUNX1/AML1-SH3D19-Isoform1 - - - -RUNX1/AML1 1) Runt
2) RunxI
1) Runt , CBF_beta
SH3D19 1) SH3_2
2) SH3_1
3) SH3_9
1) Guanylate_kin , SH2 , SH3_1 , SH3_2 , PDZ
2) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
3) SAMP , SH3_9 , ubiquitin , Ank_2 , EspF , FCH , Lys , PH , Pkinase_Tyr , Pkinase_Tyr
1) Runt
2) RunxI
3) SH3_2
4) SH3_1
5) SH3_9
1) Runt , CBF_beta
2) Guanylate_kin , SH2 , SH3_1 , SH3_2 , PDZ
3) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
4) SAMP , SH3_9 , ubiquitin , Ank_2 , EspF , FCH , Lys , PH , Pkinase_Tyr , Pkinase_Tyr
RUNX1/AML1-SH3D19 RUNX1/AML1-SH3D19-Isoform2 - - - -RUNX1/AML1 1) Runt
2) RunxI
1) Runt , CBF_beta
SH3D19 1) SH3_2
2) SH3_1
3) SH3_9
1) Guanylate_kin , SH2 , SH3_1 , SH3_2 , PDZ
2) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
3) SAMP , SH3_9 , ubiquitin , Ank_2 , EspF , FCH , Lys , PH , Pkinase_Tyr , Pkinase_Tyr
1) Runt
2) RunxI
3) SH3_2
4) SH3_1
5) SH3_9
1) Runt , CBF_beta
2) Guanylate_kin , SH2 , SH3_1 , SH3_2 , PDZ
3) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
4) SAMP , SH3_9 , ubiquitin , Ank_2 , EspF , FCH , Lys , PH , Pkinase_Tyr , Pkinase_Tyr

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
RUNX1/AML1-SH3D19 hsa-miR-375, hsa-miR-128-3p, hsa-miR-183-5p, hsa-let-7c-5p hsa-miR-27a-3p, hsa-miR-17-5p, hsa-miR-20a-5p, hsa-miR-106a-5p, hsa-miR-423-5p Microarray,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
RUNX1/AML1-SH3D19 NM_001001890.2 1) MITF_HUMAN
2) HIF1A_HUMAN
3) STAT1_HUMAN
4) RB1_HUMAN
5) RBL2_HUMAN
6) ZNF263_HUMAN
7) E2F4_HUMAN
8) P53_HUMAN
9) RUNX1_HUMAN
10) PRDM14_HUMAN
11) ESTROGEN RECEPTOR ALPHA_HUMAN
12) ETS1_HUMAN
13) EGR1_HUMAN
14) FOS_HUMAN
15) GATA2_HUMAN
16) GATA3_HUMAN
17) E2F1_HUMAN
18) SOX2_HUMAN
19) TAL1_HUMAN
20) CTCF_HUMAN
21) BRG1_HUMAN
22) HNF4A_HUMAN
23) TFAP2C_HUMAN
24) FOXA1_HUMAN
25) CEBPA_HUMAN ,  A
26) STAT6_HUMAN ,  A
27) ESR1_HUMAN ,  A
28) ESR2_HUMAN ,  A
29) AR_HUMAN ,  A
30) MEIS1_HUMAN ,  A
31) FOXP1_HUMAN ,  A
32) NR1H3_HUMAN ,  A
33) SETDB1_HUMAN ,  A
34) SPI1_HUMAN ,  A
35) TAL1_HUMAN ,  A
36) TRIM24_HUMAN ,  A
37) VDR_HUMAN
- 1) 21258399
2) 19828020
3) 19122651
4) 20385362
5) 20385362
6) 19887448
7) 21247883
8) 21394211
9) 20019798
10) 20953172
11) 20547749
12) 20019798
13) 20690147
14) 20139302
15) 21808000
16) 21878914
17) 21310950
18) 21211035
19) 21795385
20) 21795385
21) 19505939
22) 21646355
23) 21572391
24) 21572391
25) 20219941 ,  A
26) 21828071 ,  A
27) 20348243 ,  A
28) 21235772 ,  A
29) 21572438 ,  A
30) 21241896 ,  A
31) 21924763 ,  A
32) 22292898 ,  A
33) 21430779 ,  A
34) 21241896 ,  A
35) 21241896 ,  A
36) 21164480 ,  A
37) 21846776

TicDB

 		Top
The fusion gene pair RUNX1--SH3D19 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
RUNX1 SH3D19 16858696 CAGAGTCAGATGCAGgaTCGCAACGAACGAAAT
RUNX1 SH3D19 16858696 CCCCGAGAACCTCGAaaTCGCAACGAACGAAAT

TUMOR FUSION Gene Data Portal

 		Top
The fusion gene pair RUNX1--SH3D19 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

 		Top
The fusion gene pair RUNX1--SH3D19 information is not available in FusionCancer Database.

ConjoinG

 		Top
The fusion gene pair RUNX1--SH3D19 information is not available in ConjoinG Database.

1000Genome

 		Top
Fusion gene RUNX1--SH3D19 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

 		Top
Fusion gene RUNX1--SH3D19 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

 		Top
Fusion gene RUNX1--SH3D19 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

 		Top
Fusion gene RUNX1--SH3D19 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

 		Top
Fusion gene RUNX1--SH3D19 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

 		Top
The fusion gene pair RUNX1--SH3D19 information is not available in Babiceanu_Dataset.

Banned_Dataset

 		Top
Fusion gene RUNX1--SH3D19 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

 		Top
Fusion gene RUNX1--SH3D19 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

 		Top
The head gene RUNX1 is a known oncogene according to ONGENE database.
The tail gene SH3D19 is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

 		Top
The head gene RUNX1 is cancer associated according to Bushman Cancer Gene database.
The tail gene SH3D19 is not cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

 		Top
The head gene RUNX1 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene SH3D19 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

 		Top
Fusion gene RUNX1--SH3D19 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

 		Top
Fusion gene RUNX1--SH3D19 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

 		Top
The fusion gene pair RUNX1--SH3D19 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

 		Top
Fusion gene RUNX1--SH3D19 is not found in pancreatic tumor dataset, published here.

GTEx

 		Top
Fusion gene RUNX1--SH3D19 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

 		Top
The fusion gene pair RUNX1--SH3D19 information is not available in Klijn Dataset.

Fimereli_Dataset

 		Top
The fusion gene pair RUNX1--SH3D19 information is not found in Fimereli_Dataset.

Literature

 Top
The fusion gene pair RUNX1--SH3D19 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

 		Top
Fusion gene RUNX1--SH3D19 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

 		Top
The fusion gene pair RUNX1--SH3D19 information is not available in ChromothripsisDB database.