RUNX1--MTG8

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

RUNX1 MTG8

COSMIC

The fusion gene pair RUNX1--MTG8 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair RUNX1--MTG8 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair RUNX1--MTG8 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
RUNX1_MTG8t(16;21)(q24;q22) / del(9)(q22q33) / 18656694acute myeloid leukemia;myeloid leukemia;leukemia FISH - The significant homology between MGT16 and MTG8 suggests that the RUNX1-MTG16 fusion gene induced by the t(16;21)(q24;q22) is a variant of the RUNX1-MTG8 that shares similar activity..
RUNX1_MTG8t(8;21) / 18553224acute myeloid leukemia;myeloid leukemia;leukemia - - To examine the prognostic significance of minimal residual disease (MRD) in t(8;21) acute myeloid leukemia (AML), 96 bone marrow samples from 26 Japanese patients in complete remission (CR) were analyzed regarding the RUNX1/MTG8 transcript using real-time reverse transcriptase polymerase chain reaction assay. /// "The median copy number of the RUNX1/MTG8 transcript, measured after each treatment course decreased over time. "
RUNX1_MTG8t(8;21)(q22;q22) / t(8;21) / 15735013acute myeloid leukemia;myeloid leukemia;leukemia - - These results suggest a novel mechanism for gene silencing mediated by RUNX1/MTG8 and support the combination of HDAC and DNMT inhibitors as a novel therapeutic approach for t(8;21) AML.. /// " The translocation t(8;21)(q22;q22) in acute myeloid leukemia (AML) results in the expression of the fusion protein RUNX1/MTG8, which in turn recruits histone deacetylases (HDAC) to silence RUNX1 target genes [e.g., interleukin-3 (IL-3)]. " /// "Thus, we hypothesized that DNMT1 is also part of the transcriptional repressor complex recruited by RUNX1/MTG8. " /// "We previously reported that expression of the RUNX1/MTG8 target gene IL-3 is synergistically restored by the combination of inhibitors of HDACs (i.e., depsipeptide) and DNA methyltransferases (DNMT. " /// The physical association of RUNX1/MTG8 with DNMT1 was shown by coimmunoprecipitation experiments. /// "i.e., decitabine) in RUNX1/MTG8-positive Kasumi-1 cells. " /// "Furthermore, RUNX1/MTG8 and DNMT1 were concurrently released from the IL-3 promoter by exposure to depsipeptide or stabilized on the promoter by decitabine treatment. " /// "By a chromatin immunoprecipitation assay, we identified a RUNX1/MTG8-DNMT1 complex on the IL-3 promoter in Kasumi-1 cells and in primary RUNX1/MTG8-positive AML blasts. " /// "Finally, we proved that RUNX1/MTG8 and DNMT1 were functionally interrelated by showing an enhanced repression of IL-3 after coexpression in 293T cells. " /// Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia..
RUNX1_MTG8t(8;21) / 15988004neurofibroma - - Moreover, the t(8;21) fusion protein RUNX1-MTG8 (R/M), which represses RUNX1-regulated genes, actively repressed the NF1 promoter.
RUNX1_MTG8t(8;21) / inv(16) / 25612891acute myeloid leukemia;myeloid leukemia;leukemia - - Core Binding Factor acute myeloid leukemia (CBF-AML) with t(8;21) RUNX1-MTG8 or inv(16) CBFB-MYH11 fusion proteins often show upregulation of wild type or mutated KIT receptor. /// "Human (U937) or mouse (32D) myeloid clonal lines were used, respectively, to test: 1) the effect of RUNX1-MTG8 and CBFB-MYH11 fusion proteins, or upregulation of miR-17, on KIT-induced proliferation and myeloid differentiation, and 2) the effect of upregulation of KIT-induced proliferation per se on myeloid cell differentiation. " /// "In the first part of this study we found that stable miR-17 upregulation affects, like the CBF-AML fusion proteins (RUNX1-MTG8 or CBFB-MYH11), a core RUNX1-miRNA mechanism leading to KIT-induced proliferation of differentiation-arrested U937 myeloid cells. "

ChimerSEQ

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The fusion gene pair RUNX1--MTG8 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair RUNX1--MTG8 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair RUNX1--MTG8 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair RUNX1--MTG8 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair RUNX1--MTG8 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair RUNX1--MTG8 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair RUNX1--MTG8 information is not available in ConjoinG Database.

1000Genome

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Fusion gene RUNX1--MTG8 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene RUNX1--MTG8 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene RUNX1--MTG8 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene RUNX1--MTG8 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene RUNX1--MTG8 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair RUNX1--MTG8 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene RUNX1--MTG8 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene RUNX1--MTG8 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene RUNX1 is a known oncogene according to ONGENE database.


The tail gene MTG8 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene RUNX1 is cancer associated according to Bushman Cancer Gene database.


The tail gene MTG8 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene RUNX1 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene MTG8 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene RUNX1--MTG8 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene RUNX1--MTG8 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair RUNX1--MTG8 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene RUNX1--MTG8 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene RUNX1--MTG8 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair RUNX1--MTG8 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair RUNX1--MTG8 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair RUNX1--MTG8 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene RUNX1--MTG8 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair RUNX1--MTG8 information is not available in ChromothripsisDB database.