| RUNX1_MTG8 | t(16;21)(q24;q22) / del(9)(q22q33) / |
18656694 | acute myeloid leukemia;myeloid leukemia;leukemia |
FISH |
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The significant homology between MGT16 and MTG8 suggests that the RUNX1-MTG16 fusion gene induced by the t(16;21)(q24;q22) is a variant of the RUNX1-MTG8 that shares similar activity..
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| RUNX1_MTG8 | t(8;21) / |
18553224 | acute myeloid leukemia;myeloid leukemia;leukemia |
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To examine the prognostic significance of minimal residual disease (MRD) in t(8;21) acute myeloid leukemia (AML), 96 bone marrow samples from 26 Japanese patients in complete remission (CR) were analyzed regarding the RUNX1/MTG8 transcript using real-time reverse transcriptase polymerase chain reaction assay. /// "The median copy number of the RUNX1/MTG8 transcript, measured after each treatment course decreased over time. "
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| RUNX1_MTG8 | t(8;21)(q22;q22) / t(8;21) / |
15735013 | acute myeloid leukemia;myeloid leukemia;leukemia |
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These results suggest a novel mechanism for gene silencing mediated by RUNX1/MTG8 and support the combination of HDAC and DNMT inhibitors as a novel therapeutic approach for t(8;21) AML.. /// " The translocation t(8;21)(q22;q22) in acute myeloid leukemia (AML) results in the expression of the fusion protein RUNX1/MTG8, which in turn recruits histone deacetylases (HDAC) to silence RUNX1 target genes [e.g., interleukin-3 (IL-3)]. " /// "Thus, we hypothesized that DNMT1 is also part of the transcriptional repressor complex recruited by RUNX1/MTG8. " /// "We previously reported that expression of the RUNX1/MTG8 target gene IL-3 is synergistically restored by the combination of inhibitors of HDACs (i.e., depsipeptide) and DNA methyltransferases (DNMT. " /// The physical association of RUNX1/MTG8 with DNMT1 was shown by coimmunoprecipitation experiments. /// "i.e., decitabine) in RUNX1/MTG8-positive Kasumi-1 cells. " /// "Furthermore, RUNX1/MTG8 and DNMT1 were concurrently released from the IL-3 promoter by exposure to depsipeptide or stabilized on the promoter by decitabine treatment. " /// "By a chromatin immunoprecipitation assay, we identified a RUNX1/MTG8-DNMT1 complex on the IL-3 promoter in Kasumi-1 cells and in primary RUNX1/MTG8-positive AML blasts. " /// "Finally, we proved that RUNX1/MTG8 and DNMT1 were functionally interrelated by showing an enhanced repression of IL-3 after coexpression in 293T cells. " /// Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia..
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| RUNX1_MTG8 | t(8;21) / |
15988004 | neurofibroma |
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Moreover, the t(8;21) fusion protein RUNX1-MTG8 (R/M), which represses RUNX1-regulated genes, actively repressed the NF1 promoter.
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| RUNX1_MTG8 | t(8;21) / inv(16) / |
25612891 | acute myeloid leukemia;myeloid leukemia;leukemia |
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Core Binding Factor acute myeloid leukemia (CBF-AML) with t(8;21) RUNX1-MTG8 or inv(16) CBFB-MYH11 fusion proteins often show upregulation of wild type or mutated KIT receptor. /// "Human (U937) or mouse (32D) myeloid clonal lines were used, respectively, to test: 1) the effect of RUNX1-MTG8 and CBFB-MYH11 fusion proteins, or upregulation of miR-17, on KIT-induced proliferation and myeloid differentiation, and 2) the effect of upregulation of KIT-induced proliferation per se on myeloid cell differentiation. " /// "In the first part of this study we found that stable miR-17 upregulation affects, like the CBF-AML fusion proteins (RUNX1-MTG8 or CBFB-MYH11), a core RUNX1-miRNA mechanism leading to KIT-induced proliferation of differentiation-arrested U937 myeloid cells. "
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