RUNX1--MECOM

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

RUNX1 MECOM

COSMIC

The fusion gene pair RUNX1--MECOM information is not available in COSMIC database.

ChimerKB

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The fusion gene pair RUNX1--MECOM information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
RUNX1_MECOM-/-/ -/-/ - hg18 acute myeloid leukemia - - Oncogene; Transcription_Factor Mitelman
RUNX1_MECOM-/-/ -/-/ - hg18 chronic myeloid leukemia - - Oncogene; Transcription_Factor Mitelman
RUNX1_MECOM-/-/ -/-/ - hg18 myelodysplastic syndrome - - Oncogene; Transcription_Factor Mitelman
RUNX1_MECOM-/-/ -/-/ - hg18 myeloid leukemia - 7795214 Oncogene; Transcription_Factor OMIM
RUNX1_MECOM-/-/ -/-/ - hg18 chronic myeloid leukemia - 7795214 Oncogene; Transcription_Factor OMIM
RUNX1_MECOM-/-/ -/-/ - hg18 acute myeloid leukemia - 15326310 Oncogene; Transcription_Factor OMIM

ChimerPUB

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The fusion gene pair RUNX1--MECOM information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
RUNX1_MECOMt(1;21)(p36;q22) / t(1;21) / 16015645acute myeloid leukemia;myeloid leukemia;leukemia FISH - In two of them, the PRDM16 reading frame is maintained in the fusion with RUNX1, suggesting that the RUNX1-PRDM16 gene fusion results in the production of a protein that is highly homologous to the RUNX1-MDS1/EVI1 chimeric protein. /// Characterization of the RUNX1-PRDM16 fusion protein and comparison with the RUNX1-MDS1/EVI1 protein will facilitate the understanding of the mechanisms underlying RUNX1-associated leukemia..
RUNX1_MECOM- 23806810acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - Two patients demonstrated two molecular rearrangements simultaneously, with BCR-ABL1 implicated in both, in addition to RUNX1-MECOM in one patient and PML-RARA in another.
RUNX1_MECOMt(3;21) / 22950073acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - Flow cytometric analysis, chromosome analysis, FISH, and reverse transcriptase-PCR (RT-PCR) results indicated AML-MRC resulting from t(3;21) with the RUNX1-MECOM fusion gene. /// Detection of RUNX1-MECOM fusion gene and t(3;21) in a very elderly patient having acute myeloid leukemia with myelodysplasia-related changes..
RUNX1_MECOMt(3;21)(q26;q22) / t(15;17)(q22;q21) / 19027486acute promyelocytic leukemia;myelodysplastic syndrome;leukemia - - Acute promyelocytic leukemia relapsing as secondary acute myelogenous leukemia with translocation t(3;21)(q26;q22) and RUNX1-MDS1-EVI1 fusion transcript.. /// "Here we describe a rare case of APL relapsing as secondary AML with t(3;21)(q26;q22) and clinically characterize this patient using the RUNX1 (previously AML1)-MDS1-EVI1 fusion transcript (with follow-up for 55 months), and review the relevant literature.. "
RUNX1_MECOMt(3;21)(q26;q22) / 22039883leukemia - - We first identify essential domains for leukemogenesis through structure-function studies on both EVI1 and the t(3;21)(q26;q22)-derived RUNX1-MDS1-EVI1 (RME) protein, which revealed that DNA binding to the cognate motif GACAAGATA via the first of two zinc finger domains (ZF1, encompassing fingers 1-7) is essential transforming activity.
RUNX1_MECOM- 25379409acute myeloid leukemia;myeloid leukemia;leukemia - - An unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and RUNX1-MECOM fusion transcripts.. /// " We report the first case of acute myeloid leukemia (AML) with RUNX1-MECOM fusion transcripts, showing marked eosinophilia. "

ChimerSEQ

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The fusion gene pair RUNX1--MECOM information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
RUNX1_MECOMchr21/36231770/- chr3/169099312/- 21q22.12 3q26.2 Exonic hg19 In-Frame Inter-chr LAML TCGA-AB-2915-03A Oncogene; Transcription_Factor FusionScan
RUNX1_MECOMchr21/36206706/- chr3/169099312/- 21q22.12 3q26.2 Exonic hg19 In-Frame Inter-chr LAML TCGA-AB-2915-03A Oncogene; Transcription_Factor FusionScan
RUNX1_MECOMchr21/36261005/ chr3/168802549/ 21q22.12 3q26.2 Exonic hg19 - Inter-chr NA S69002 Oncogene; Transcription_Factor ChiTaRs
RUNX1_MECOMchr21/36206707/- chr3/169099312/- 21q22.12 3q26.2 Exonic hg19 In-frame Inter-chr LAML TCGA-AB-2915-03A Oncogene; Transcription_Factor PRADA
RUNX1_MECOMchr21/36265246/ chr3/169201459/ 21q22.12 3q26.2 Exonic hg19 - Inter-chr acute myeloid leukemia;chronic myeloid leukemia;myelodysplastic syndromes;acute non lymphocytic leukemia L21756 Oncogene; Transcription_Factor ChiTaRs

ChiTaRS 2.1

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The fusion gene pair RUNX1--MECOM information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human L21756RUNX1--MECOM RUNX121 36206707 36265246 - 1 733 100 MECOM3 169201459 169201751 - 733 1025 100
Human S69002RUNX1--MECOM RUNX121 36231771 36261005 - 1 2134 99.8 MECOM3 168802549 169099312 - 2135 5938 100

FARE-CAFE

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The fusion gene pair RUNX1--MECOM information is not available in FARE-CAFE.

TicDB

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The fusion gene pair RUNX1--MECOM information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair RUNX1--MECOM information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
LAML AB-2915-03A RUNX1__MECOM 1.5 21:36206707/-1 3:169099312/-1 tier1 In-frame 15180 NA

FusionCancer

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The fusion gene pair RUNX1--MECOM information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair RUNX1--MECOM information is not available in ConjoinG Database.

1000Genome

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Fusion gene RUNX1--MECOM has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene RUNX1--MECOM is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene RUNX1--MECOM is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene RUNX1--MECOM is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene RUNX1--MECOM was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair RUNX1--MECOM information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene RUNX1--MECOM is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene RUNX1--MECOM has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene RUNX1 is a known oncogene according to ONGENE database.


The tail gene MECOM is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene RUNX1 is cancer associated according to Bushman Cancer Gene database.


The tail gene MECOM is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene RUNX1 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene MECOM is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene RUNX1--MECOM is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene RUNX1--MECOM is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair RUNX1--MECOM information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene RUNX1--MECOM is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene RUNX1--MECOM has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair RUNX1--MECOM information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair RUNX1--MECOM information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair RUNX1--MECOM information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene RUNX1--MECOM is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair RUNX1--MECOM information is not available in ChromothripsisDB database.