Link to Genecards: | RUNX1 | LPXN |
ChimerKB | Top |
ChimerPUB | Top |
Fusion_pair | Translocation | PMID | Disease | Validation | Gene Type | Sentence_highlight |
---|---|---|---|---|---|---|
RUNX1_LPXN | t(11;21)(q12;q22) / | 19760607 | acute myeloid leukemia;myeloid leukemia;leukemia | - | - | This translocation generated four RUNX1/LPXN and one LPXN/RUNX1 chimeric transcripts. /// "Unlike RL and RLs, the LPXN/RUNX1 fusion protein LR was found to localize in the cytoplasm. " /// "Taken together, our data indicated that the RUNX1/LPXN and LPXN/RUNX1 fusion proteins may play important roles in leukemogenesis and that deregulation of cell adhesion pathways may be pathogenetically important in AML. " /// "Two representative RUNX1/LPXN fusion proteins, RL and RLs, were both found to localize in the nucleus and could bring the CBFB protein into the nucleus like the wild-type RUNX1. " |
ChimerSEQ | Top |
ChiTaRS 2.1 | Top |
FARE-CAFE | Top |
Fusion_Protein | Cancer_Type | FP_Experimental_Method | FP_Karyotype | FP_Reference |
---|---|---|---|---|
RUNX1/AML1-LPXN | Acute myeloid leukemia | _ | t(11;21)(q12;q22) | PubMed: 19760607 |
Fusion_Protein | Fusion_Protein_Isoforms | 5'_Protein | F_B_P | FBP_in_Exon/Intron | 5'_Protein_on_Positive/Negative_Strands | 3'_Protein | S_B_P | 3'_Protein_on_Positive/Negative_Strands | SBP_in_Exon/Intron | Fusion_Protein_mRNA_sequence | Fusion_Protein_Reference | Fusion_Protein_GenbankID |
---|---|---|---|---|---|---|---|---|---|---|---|---|
RUNX1/AML1-LPXN | RUNX1/AML1-LPXN-Isoform1 | RUNX1/AML1 | _ | _ | 0 | LPXN | _ | 0 | _ | agtcagatgcagGgactgcttcac | 19760607 | _ |
RUNX1/AML1-LPXN | RUNX1/AML1-LPXN-Isoform2 | RUNX1/AML1 | _ | _ | 0 | LPXN | _ | 0 | _ | agtcagatgcaggGactgcttcac | 19760607 | _ |
RUNX1/AML1-LPXN | RUNX1/AML1-LPXN-Isoform3 | RUNX1/AML1 | _ | _ | 0 | LPXN | _ | 0 | _ | agtcagatgcaggGctttcatgag | 19760607 | _ |
Fusion_Protein | Fusion_Protein_Isoforms | Domains_in_5'Partner | DDIs_for_Domains_in_5'Partner | Domains_in_3'Partner | DDIs_for_Domains_in_3'Partner | 5'_Protein | 5'P_Domains | 5'P_Domains_DDI_partners | 3'_Protein | 3'P_Domains | 3'P_Domains_DDI_partners | Missing_FP_Domains | Missing_FP_Domains_DDI |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RUNX1/AML1-LPXN | RUNX1/AML1-LPXN-Isoform1 | - | - | - | - | RUNX1/AML1 |
1) Runt 2) RunxI |
1) Runt , CBF_beta | LPXN |
1) LIM |
1) Ank_2 , LIM , HLH , GATA , WH1 , V-set |
1) Runt 2) RunxI 3) LIM |
1) Runt , CBF_beta 2) Ank_2 , LIM , HLH , GATA , WH1 , V-set |
RUNX1/AML1-LPXN | RUNX1/AML1-LPXN-Isoform2 | - | - | - | - | RUNX1/AML1 |
1) Runt 2) RunxI |
1) Runt , CBF_beta | LPXN |
1) LIM |
1) Ank_2 , LIM , HLH , GATA , WH1 , V-set |
1) Runt 2) RunxI 3) LIM |
1) Runt , CBF_beta 2) Ank_2 , LIM , HLH , GATA , WH1 , V-set |
RUNX1/AML1-LPXN | RUNX1/AML1-LPXN-Isoform3 | - | - | - | - | RUNX1/AML1 |
1) Runt 2) RunxI |
1) Runt , CBF_beta | LPXN |
1) LIM |
1) Ank_2 , LIM , HLH , GATA , WH1 , V-set |
1) Runt 2) RunxI 3) LIM |
1) Runt , CBF_beta 2) Ank_2 , LIM , HLH , GATA , WH1 , V-set |
Fusion_Protein | miRNAs_Targets_Fusion_protein | Missing_MiRNAs_Targets_Fusion_protein | FP_miRNA_Validation_method |
---|---|---|---|
RUNX1/AML1-LPXN | hsa-miR-9-5p | hsa-miR-27a-3p, hsa-miR-17-5p, hsa-miR-20a-5p, hsa-miR-106a-5p, hsa-miR-423-5p | Microarray |
TicDB | Top |
HeadGene | TailGene | PubmedID | Sequence |
---|---|---|---|
RUNX1 | LPXN | 19760607 | agtcagatgcagGgactgcttcac |
RUNX1 | LPXN | 19760607 | agtcagatgcaggGactgcttcac |
RUNX1 | LPXN | 19760607 | agtcagatgcaggGctttcatgag |
TUMOR FUSION Gene Data Portal | Top |
FusionCancer | Top |
ConjoinG | Top |
1000Genome | Top |
18Cancers | Top |
Bodymap2 | Top |
HPA | Top |
Non_Tumor_Cells | Top |
Babiceanu_Dataset | Top |
Banned_Dataset | Top |
Known_Fusions | Top |
ONGene Database | Top |
Bushman Cancer Gene Database | Top |
Tumor Gene Set By Uniprot | Top |
Oesophagus_Dataset | Top |
Gliomas_Dataset | Top |
Prostate_Dataset | Top |
Pancreases_Dataset | Top |
GTEx | Top |
Klijin_Dataset | Top |
Fimereli_Dataset | Top |
Literature | Top |
Cortex_Dataset | Top |
ChromothripsisDB | Top |