ROS1--CD74

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

ROS1 CD74

COSMIC

The fusion gene pair ROS1--CD74 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair ROS1--CD74 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair ROS1--CD74 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
ROS1_CD74- 22215748non small cell lung cancer;lung cancer;adenocarcinoma FISH - The HCC78 ROS1-rearranged NSCLC cell line and 293 cells transfected with CD74-ROS1 showed evidence of sensitivity to crizotinib.
ROS1_CD74- 22661537non small cell lung cancer;lung cancer FISH;PCR - ROS1 fusion partners were determined by reverse transcriptase PCR identifying CD74-ROS1, SLC34A2-ROS1, and FIG-ROS1 fusions.
ROS1_CD74- 26705279non small cell lung cancer;lung cancer;adenocarcinoma PCR - Moreover, in the 302 NSCLC samples studied, 3.97% (12/302) were found to contain ROS1 fusion genes, with CD74-ROS1 fusion identified in 9 cases.
ROS1_CD74- 23877438non small cell lung cancer - - CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma.. /// "Although the expression of SLC34A2-ROS1, EZR-ROS1, or KIF5B-RET fusion transcripts was not detected in any of the cases, the expression of CD74-ROS1 fusion transcripts was detected in one (0.9%) of the 114 NSCLCs. " /// "To better understand the role of recently identified ROS1 and RET fusion oncokinases in pulmonary carcinogenesis, we examined 114 NSCLCs for SLC34A2-ROS1, EZR-ROS1, CD74-ROS1 and KIF5B-RET fusion transcripts using RT-polymerase chain reaction and subsequent sequencing analyses. " /// The above results suggest that CD74-ROS1 fusion is involved in the carcinogenesis of a subset of NSCLCs and may contribute to the elucidation of the characteristics of ROS1 fusion-positive NSCLC in the future..
ROS1_CD74- 23724914lung cancer - - Resistance to crizotinib developed in a patient with metastatic lung adenocarcinoma harboring a CD74-ROS1 rearrangement who had initially shown a dramatic response to treatment. /// Acquired resistance to crizotinib from a mutation in CD74-ROS1..
ROS1_CD74- 26964870lung cancer - - In this study, to investigate the in vivo oncogenic activities of one of the most frequently detected fusions, CD74-ROS1, as well as another SDC4-ROS1 fusion that has also been reported in several studies, we generated transgenic (TG) mouse strains that express either of the two ROS1-fusion genes specifically in lung alveolar type II cells.
ROS1_CD74- 26673800lung cancer - - Crizotinib resistance of CD74-ROS1(D2033N) was functionally evaluated using cell-based assays and structural modeling. /// "In biochemical and cell-based assays, the CD74-ROS1(D2033N) mutant demonstrated significantly decreased sensitivity to crizotinib. "
ROS1_CD74- 25351743non small cell lung cancer;lung cancer - - As the result of high-throughput drug screening, we found that the cMET/RET/VEGFR inhibitor cabozantinib (XL184) effectively inhibited the survival of CD74-ROS1 wild-type (WT) and resistant mutants harboring Ba/F3 and MGH047 cells. /// Acquired ROS1 inhibitor-resistant mutations in CD74-ROS1 fusion were screened by N-ethyl-N-nitrosourea mutagenesis with Ba/F3 cells.
ROS1_CD74- 25157770- - - Acinar (including cribriform) and solid patterns were the two most common histologic subtypes in the ROS1 fusion tumors (7 of 12, 58.3%) and were predominantly seen in CD74-ROS1 fusion tumors (66.7%).
ROS1_CD74- 25567908adenocarcinoma - - Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET].
ROS1_CD74- 23788756adenocarcinoma ISH - CD74-ROS1 fusions were identified in two patients using reverse transcriptase-polymerase chain reaction.

ChimerSEQ

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The fusion gene pair ROS1--CD74 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
ROS1_CD74chr6/117700221/- chr5/149782188/- 6q22.1 5q32 Exonic hg19 Out-of-Frame Inter-chr LUAD TCGA-86-8278-01A Kinase; Oncogene; FusionScan
ROS1_CD74chr6/117700221/- chr5/149782874/- 6q22.1 5q32 Exonic hg19 Out-of-Frame Inter-chr LUAD TCGA-86-8278-01A Kinase; Oncogene; TopHat-Fusion
ROS1_CD74chr6/117700221/- chr5/149782187/- 6q22.1 5q32 Exonic hg19 Out-of-Frame Inter-chr LUAD TCGA-86-8278-01A Kinase; Oncogene; TopHat-Fusion

ChiTaRS 2.1

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The fusion gene pair ROS1--CD74 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair ROS1--CD74 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair ROS1--CD74 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair ROS1--CD74 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair ROS1--CD74 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair ROS1--CD74 information is not available in ConjoinG Database.

1000Genome

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Fusion gene ROS1--CD74 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene ROS1--CD74 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene ROS1--CD74 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene ROS1--CD74 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene ROS1--CD74 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair ROS1--CD74 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene ROS1--CD74 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene ROS1--CD74 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene ROS1 is a known oncogene according to ONGENE database.
The tail gene CD74 is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene ROS1 is cancer associated according to Bushman Cancer Gene database.


The tail gene CD74 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene ROS1 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene CD74 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene ROS1--CD74 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene ROS1--CD74 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair ROS1--CD74 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene ROS1--CD74 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene ROS1--CD74 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair ROS1--CD74 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair ROS1--CD74 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair ROS1--CD74 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene ROS1--CD74 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair ROS1--CD74 information is not available in ChromothripsisDB database.