RET--KIF5B

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

RET KIF5B

COSMIC

The fusion gene pair RET--KIF5B information is not available in COSMIC database.

ChimerKB

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The fusion gene pair RET--KIF5B information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair RET--KIF5B information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
RET_KIF5B- 23891510non small cell lung cancer;lung cancer;adenocarcinoma FISH - Thus, the aim of this study was to verify the possibility to use RNA purified from cytological specimens to perform KIF5B/RET gene fusion expression analysis. /// "Thus, the aim of this study was to verify the possibility to use RNA purified from cytological specimens to perform KIF5B/RET gene fusion expression analysis." /// "KIF5B/RET fusion gene analysis in a selected series of cytological specimens of EGFR, KRAS and EML4-ALK wild-type adenocarcinomas of the lung.. " /// "In conclusion, our findings confirm that the performance of cytology-based molecular testing for KIF5B/RET rearrangements is at least as effective as histology-based analysis, both with regard to the success rate for nucleic acid isolation and the ability to detect gene alterations. " /// "In conclusion, our findings confirm that the performance of cytology-based molecular testing for KIF5B/RET rearrangements is at least as effective as histology-based analysis, both with regard to the success rate for nucleic acid isolation and the ability to detect gene alterations." /// The tests conducted revealed the presence of 1 positive patient for variant 1 of KIF5B/RET among the 49 analyzed.
RET_KIF5B- 26268359adenocarcinoma FISH;PCR;RT-PCR - KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas.. /// We examined the KIF5B-RET fusion gene in frozen tissues from 154 surgically resected lung tumors using RT-PCR with direct sequencing and the mutation status of EGFR and KRAS genes using PNA clamping. /// The existence of KIF5B-RET fusion gene was identified in 9 patients. /// "However, KIF5B-RET fusion gene coincided with EGFR or KRAS mutation in 6 patients. " /// We tested KIF5B-RET translocation in Formalin Fixed Paraffin Embedded using fluorescence in situ hybridization. /// " The KIF5B-RET rearrangement is detected with the frequency of 1??~??2% in 'triple marker'-negative lung adenocarcinomas, i.e., EGFR, KRAS and EML4-ALK wild type. " /// These six pts were also positive for both RET break-apart probes (23.9%) and KIF5B-RET fusion (44.4%). /// These six pts were also positive for both RET break-apart probes (23.9%) and KIF5B-RET fusion (44.4%).
RET_KIF5B- 24504365large cell carcinoma;squamous cell carcinoma FISH;PCR;RT-PCR - Of the 22 patients, 19 possessed KIF5B-RET fusion genes, whereas 3 possessed CCDC6-RET fusion genes.
RET_KIF5B- 23932363adenocarcinoma FISH;PCR - Both FISH and PCR may be useful methods to detect novel KIF5B-RET rearrangements in pulmonary adenocarcinomas rather than IHC. /// "53 cases of lung adenocarcinomas harbored ""triple (EGFR, KRAS and ALK)-negative"" were tested for KIF5B-RET fusions using whole-transcriptome sequencing, fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), and long-range PCR. " /// All those three patients were also positive in FISH for both KIF5B-RET fusion and RET break-apart probes. /// Dual color break-apart probes and KIF5B-RET fusion probes were used for FISH. /// Diagnostic method for the detection of KIF5B-RET transformation in lung adenocarcinoma. /// Diagnostic method for the detection of KIF5B-RET transformation in lung adenocarcinoma.. /// Primers designed for 3 different variants of KIF5B-RET fusions were used for long-range PCR. /// " KIF5B-RET fusions have recently been reported to occur in pulmonary adenocarcinomas, thereby being proposed as a novel genetic alteration in adenocarcinoma of the lung. "
RET_KIF5B- 25982012non small cell lung cancer;lung cancer;adenocarcinoma FISH - Systemic and CNS activity of the RET inhibitor vandetanib combined with the mTOR inhibitor everolimus in KIF5B-RET re-arranged non-small cell lung cancer with brain metastases..
RET_KIF5B10p11.22 / 22797671papillary adenocarcinoma PCR;RT-PCR - In this study, we have independently investigated the KIF5B/RET fusion gene status in 371?surgically-treated NSCLCs (270 were adenocarcinomas and 101 were squamous cell carcinomas), 60 breast cancers, 11?metastatic lung cancers from colon cancers and thyroid papillary adenocarcinoma cases at the Nagoya City University Hospital. /// We detected 3 of 270 cases of KIF5B/RET fusion genes in adenocarcinomas (1.1%) consisting of female and never smokers with mixed subtype adenocarcinomas. /// "However, the correlation between the KIF5B/RET fusion gene status and the clinicopathological features of surgically-treated lung cancer has not been well characterized. " /// KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung.. /// We reported KIF5B/RET fusion genes as a driver somatic mutation of lung adenocarcinomas. /// The cinicopathological backgrounds of the KIF5B/RET fusion-positive patients were similar with those of the EML4/ALK fusion-positive patients. /// KIF5B/RET fusion was not detected in the cases with squamous cell carcinoma or other types of cancers. /// KIF5B/RET fusion was not detected in the cases with squamous cell carcinoma or other types of cancers.
RET_KIF5B- 25348872adenosquamous carcinoma PCR - KIF5b-RET fusion gene, 1%.
RET_KIF5B- 24722163- - - Experience with erlotinib in lung adenocarcinoma harboring a coexisting KIF5B-RET fusion gene and EGFR mutation: report of a rare case..
RET_KIF5B- 26291023- - - Rapid Response to Sunitinib in a Patient with Lung Adenocarcinoma Harboring KIF5B-RET Fusion Gene..
RET_KIF5B- 24262090non small cell lung cancer;lung cancer - - [The progress of KIF5B-RET fusion gene in non-small cell lung cancer]..
RET_KIF5B- 25625428non small cell lung cancer - - Several related clinical trials for non-small-cell lung cancer (NSCLC) with KIF5B-RET rearrangements using existing RET inhibitors, such as lenvatinib, vandetanib, sunitinib, ponatinib, cabozantinib, and AUY922, have been swiftly initiated by the discovery of the KIF5B-RET fusion gene. /// Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.. /// Anti-RET activity and the status of clinical development of these known RET tyrosine kinase inhibitors (TKIs) for KIF5B-RET fusion-positive NSCLC are discussed. /// " A new chimeric fusion transcript of KIF5B (the kinesin family 5B gene) and the RET (Rearranged during Transcription) oncogene, KIF5B-RET, was found in 1-2% of lung adenocarcinomas (LADCs) in late 2011. "
RET_KIF5B- 25180059- - - Among the 50 EGFR wild type patients who detected fusion genes, 14 carried EML4-ALK fusion (28%), 2 had TPM3-ROS1 fusion (4%), and 3 harbored KIF5B-RET fusion (6%).
RET_KIF5B- 23052255lung cancer;adenocarcinoma FISH;PCR;RT-PCR - The KIF5B-RET patient was one of only five never smokers in this cohort. /// Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions.. /// "The KIF5B-RET fusion defines an additional subset of lung cancer with a potentially targetable driver oncogene enriched in never smokers with ""pan-negative"" lung adenocarcinomas. " /// "RACE isolated a GOPC-ROS1 (FIG-ROS1) fusion in the former and a KIF5B-RET fusion in the latter, both confirmed by RT-PCR. "
RET_KIF5B- 25773866malignant pleural effusion PCR;RT-PCR - The detected RET rearrangements comprised 11 (65%) KIF5B-RET and 6 (35%) CCDC6-RET fusions, including 2 novel fusion variants identified. /// Multiplex reverse transcription-polymerase chain reaction (RT-PCR) was used to detect KIF5B-RET and CCDC6-RET fusions from specimens of malignant pleural effusion (MPE) in patients with metastatic lung adenocarcinoma.
RET_KIF5B10p11.22 / 22194472adenocarcinoma;non small cell lung cancer - - We identified the KIF5B-RET fusion in two more cases out of 20 primary lung adenocarcinomas in the replication study.
RET_KIF5B- 23150706non small cell lung cancer;lung cancer;adenocarc PCR;ISH - Of the 13 patients, nine patients had KIF5B-RET, three patients had CCDC6-RET, and one patient had a novel NCOA4-RET fusion.
RET_KIF5B- 24133367non small cell lung cancer;lung cancer;adenocarcinoma - - Two KIF5B-RET fusions and one CCDC6-RET fusion were identified.
RET_KIF5B- 24481316squamous cell carcinoma;lung cancer;adenocarcinoma - - Of the 76 AdSqLCs, 43 (56.6%) harbored known mutant kinases, including 24 (31.6%) with EGFR mutations, eight (10.5%) with KRAS mutations, two (2.6%) with AKT1 (2.6%) mutations, one (1.3%) with ERBB2 insertion mutation, one (1.3%) with PIK3CA mutation, four (5.3%) with ALK fusions, and three (4%) with KIF5B-RET fusions.
RET_KIF5B- 22327623lung cancer;adenocarcinoma - - In addition, we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas.
RET_KIF5B- 22327624adenocarcinoma - - KIF5B-RET fusions in lung adenocarcinoma.. /// "The KIF5B-RET fusion leads to aberrant activation of RET kinase and is considered to be a new driver mutation of LADC because it segregates from mutations or fusions in EGFR, KRAS, HER2 and ALK, and a RET tyrosine kinase inhibitor, vandetanib, suppresses the fusion-induced anchorage-independent growth activity of NIH3T3 cells.. "
RET_KIF5B- 22327622non small cell lung cancer;colorectal cancer;lung cancer;adenocarcinoma - - Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%. /// " Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. " /// Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET..
RET_KIF5B- 25567908adenocarcinoma - - Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET].

ChimerSEQ

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The fusion gene pair RET--KIF5B information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair RET--KIF5B information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair RET--KIF5B information is not available in FARE-CAFE.

TicDB

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The fusion gene pair RET--KIF5B information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair RET--KIF5B information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair RET--KIF5B information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair RET--KIF5B information is not available in ConjoinG Database.

1000Genome

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Fusion gene RET--KIF5B has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene RET--KIF5B is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene RET--KIF5B is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene RET--KIF5B is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene RET--KIF5B was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair RET--KIF5B information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene RET--KIF5B is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene RET--KIF5B has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene RET is a known oncogene according to ONGENE database.
The tail gene KIF5B is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene RET is cancer associated according to Bushman Cancer Gene database.
The tail gene KIF5B is not cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene RET is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene KIF5B is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene RET--KIF5B is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene RET--KIF5B is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair RET--KIF5B information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene RET--KIF5B is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene RET--KIF5B has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair RET--KIF5B information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair RET--KIF5B information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair RET--KIF5B information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene RET--KIF5B is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair RET--KIF5B information is not available in ChromothripsisDB database.