RET--CCDC6

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

RET CCDC6

COSMIC

The fusion gene pair RET--CCDC6 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair RET--CCDC6 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
RET_CCDC6-/-/ -/-/ - hg18 adenocarcinoma - - Oncogene; Mitelman

ChimerPUB

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The fusion gene pair RET--CCDC6 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
RET_CCDC6- 24504365large cell carcinoma;squamous cell carcinoma FISH;PCR;RT-PCR - Of the 22 patients, 19 possessed KIF5B-RET fusion genes, whereas 3 possessed CCDC6-RET fusion genes.
RET_CCDC6- 25407564- FISH - RET/PTC rearrangement was detected using either RET break-apart FISH followed by multicolor FISH to confirm CCDC6/RET or NCOA4/RET fusions, or by multiplex qPCR to detect 14 RET/PTC subtypes with simultaneous RET mRNA expression. /// "Among 73 PTC patients with sufficient tissue available for FISH and multiplex qPCR, 10 cases were defined as RET/PTC positive by both assays, including eight CCDC6/RET and two NCOA4/RET fusions with relatively high RET mRNA." /// "Among 73 PTC patients with sufficient tissue available for FISH and multiplex qPCR, 10 cases were defined as RET/PTC positive by both assays, including eight CCDC6/RET and two NCOA4/RET fusions with relatively high RET mRNA. " /// "In addition, multiplex qPCR identified another two CCDC6/RET fusion positive cases, but with low RET mRNA expression." /// "In addition, multiplex qPCR identified another two CCDC6/RET fusion positive cases, but with low RET mRNA expression. "
RET_CCDC6- 25384172non small cell lung cancer;lung cancer - - The expressed ROS1-SLC34A2 and CCDC6-RET gene fusions from the NSCLC cell lines HCC78 and LC-2/ad, respectively, were accurately detected by the novel assay.
RET_CCDC6- 23578175- - - Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.. /// "Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing. " /// "CCDC6-RET was constitutively active, and the introduction of a siRNA targeting the RET 3' region decreased cell proliferation by downregulating RET and ERK1/2 phosphorylation." /// "CCDC6-RET was constitutively active, and the introduction of a siRNA targeting the RET 3' region decreased cell proliferation by downregulating RET and ERK1/2 phosphorylation. " /// "The biological relevance of the CCDC6-RET gene products was assessed by cell growth, survival and phosphorylation of ERK1/2 and AKT with or without the suppression of RET expression using RNA interference. " /// Endogenously expressing CCDC6-RET contributed to cell growth.
RET_CCDC6- 22961909thyroid carcinoma - - We did a comprehensive screen for 548 known and putative fusion genes in 27 samples of thyroid tumors and three positive controls-one thyroid cancer cell line (TPC-1) and two PTCs with known CCDC6-RET (alias RET/PTC1) fusion gene, using this microarray.
RET_CCDC6- 21305644thyloid cancer;leukemia;breast cancer - - Two additional fusion genes, BCAS4-BCAS3 in the MCF-7 breast cancer cell line and CCDC6-RET in the TPC-1 thyroid cancer cell line were validated as true positive fusion transcripts.
RET_CCDC6inv(10) / 1542652- - - Therefore, a chromosome 10q inversion provides the structural basis for the D10S170-RET fusion that forms the hybrid transforming sequence RET/PTC..
RET_CCDC6- 25773866malignant pleural effusion PCR;RT-PCR - The detected RET rearrangements comprised 11 (65%) KIF5B-RET and 6 (35%) CCDC6-RET fusions, including 2 novel fusion variants identified. /// Multiplex reverse transcription-polymerase chain reaction (RT-PCR) was used to detect KIF5B-RET and CCDC6-RET fusions from specimens of malignant pleural effusion (MPE) in patients with metastatic lung adenocarcinoma.
RET_CCDC6- 26187428non small cell lung cancer;lung cancer - - We identify two paired pre- and post-EGFR TKI progression EGFR-mutated NSCLC patient tumor samples where both post EGFR TKI samples harbored in-frame CCDC6-RET rearrangements but not in the pre-EGFR TKI tumor samples.
RET_CCDC6- 23150706non small cell lung cancer;lung cancer;adenocarc PCR;ISH - Of the 13 patients, nine patients had KIF5B-RET, three patients had CCDC6-RET, and one patient had a novel NCOA4-RET fusion. /// "Of the 13 patients, nine patients had KIF5B-RET, three patients had CCDC6-RET, and one patient had a novel NCOA4-RET fusion."
RET_CCDC6- 22327623lung cancer;adenocarcinoma - - In addition, we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas.
RET_CCDC6- 25567908adenocarcinoma - - Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET].

ChimerSEQ

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The fusion gene pair RET--CCDC6 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
RET_CCDC6chr10/43610184/+ chr10/61612460/- 10q11.21 10q21.2 Exonic hg19 In-frame Intra-chr THCA TCGA-DJ-A4V5-01A Oncogene; PRADA

ChiTaRS 2.1

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The fusion gene pair RET--CCDC6 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair RET--CCDC6 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair RET--CCDC6 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair RET--CCDC6 information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
THCA DJ-A4V5-01A RET__CCDC6 0.34 10:43610184/1 10:61612460/-1 tier3 In-frame 14568 NA

FusionCancer

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The fusion gene pair RET--CCDC6 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair RET--CCDC6 information is not available in ConjoinG Database.

1000Genome

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Fusion gene RET--CCDC6 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene RET--CCDC6 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene RET--CCDC6 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene RET--CCDC6 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene RET--CCDC6 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair RET--CCDC6 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene RET--CCDC6 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene RET--CCDC6 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene RET is a known oncogene according to ONGENE database.


The tail gene CCDC6 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene RET is cancer associated according to Bushman Cancer Gene database.


The tail gene CCDC6 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene RET is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene CCDC6 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene RET--CCDC6 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene RET--CCDC6 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair RET--CCDC6 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene RET--CCDC6 is found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene RET--CCDC6 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair RET--CCDC6 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair RET--CCDC6 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair RET--CCDC6 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene RET--CCDC6 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair RET--CCDC6 information is not available in ChromothripsisDB database.