RARA--PL

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

RARA PL

COSMIC

The fusion gene pair RARA--PL information is not available in COSMIC database.

ChimerKB

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The fusion gene pair RARA--PL information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair RARA--PL information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
RARA_PLt(15;17) / 10203104acute promyelocytic leukemia;non Hodgkin lymphoma;leukemia;lymphoma - - cytogenetics showed t(15;17), and molecular analysis detected promyelocytic leukemia-retinoic acid receptor alpha rearrangement.
RARA_PLt(3;15) (q26;q13) / t(15;17) (q22;q21) / 24009642disseminated intravascular coagulation - - Acute promyelocytic leukaemia (APML) is a biologically and clinically distinct variant of AML, currently classified as acute myeloid leukaemia with recurrent cytogenetic anomalies t(15;17) (q22;q21), promyelocytic leukaemia-retinoic acid receptor alpha, diagnosis regardless of blast count in the World Health Organization classification system.
RARA_PLt(15;17) / 23049403acute myeloid leukemia - - In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid receptor alpha rearrangement.
RARA_PLt(15;17) / 18504460- - - The PML gene is involved in the t(15;17) translocation of acute promyelocytic leukaemia (APL), which generates the oncogenic fusion protein PML (promyelocytic leukaemia protein)-retinoic acid receptor alpha.
RARA_PLt(15;17) / 18445086- - - The hallmark of acute promyelocytic leukaemia (APL) is the reciprocal translocation t(15;17), which leads to the expression of the promyelocytic leukaemia/retinoic acid receptor alpha (PML/RARalpha) fusion protein and a cell differentiation blockade at the promyelocytic stage.
RARA_PLt(15;17) / 25189308- - - Within the study period, 26 patients were diagnosed with APL based on morphology and the detection of t(15;17)(q24.1;q21.1) and promyelocytic leukaemia-retinoic acid receptor alpha (PML-RARA).
RARA_PLt(15;17) / 20508621acute promyelocytic leukemia;leukemia - - In acute promyelocytic leukemia (APL), the promyelocytic leukemia-retinoic-acid receptor alpha (PML-RARA) fusion protein, which emerges as a consequence of the t(15;17) translocation, acts as a transcriptional repressor that blocks neutrophil differentiation at the promyelocyte (PM) stage.
RARA_PLt(15;17) / 16140954acute promyelocytic leukemia;leukemia;retinoblastoma - - All-trans retinoic acid (ATRA) induces clinical remission in patients with t(15;17) acute promyelocytic leukemia (APL) carrying leukemogenic promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) fusion protein by overcoming PML-RARalpha transcriptional repression and inducing myeloid differentiation.
RARA_PL- 21840703acute promyelocytic leukemia;leukemia PCR - In this study, an enzyme-amplified electrochemical biosensor was developed for detection of the promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR?) fusion gene in acute promyelocytic leukemia (APL).
RARA_PL- 12801531acute promyelocytic leukemia;leukemia PCR;RT-PCR - Reverse transcription-polymerase chain reaction (RT-PCR) analysis of the bone marrow cells at diagnosis showed strong expression of BMP-2, -4, and -7, and their receptors RIA, RIB, and RII, parallel to the expression of promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion gene transcripts.
RARA_PL- 21177095acute promyelocytic leukemia;leukemia - - In this study, a novel DNA electrochemical probe (locked nucleic acid, LNA) was designed and involved in constructing an electrochemical DNA biosensor for detection of promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR?) fusion gene in acute promyelocytic leukemia for the first time.
RARA_PLt(15;17) / 10553020acute promyelocytic leukemia;leukemia PCR;RT-PCR - The development of a rapid and simple reverse-transcription polymerase chain reaction (RT-PCR) assay is described that identifies the promyelocytic leukemia- retinoic acid receptor alpha (PML-RARa) hybrid messenger RNA (mRNA), a characteristic feature of acute promyelocytic leukemia (APL).
RARA_PLt(15;17)(q22;q11-12) / t(15;17) / 9164186acute myeloid leukemia;acute promyelocytic leukemia;myeloid leukemia;leukemia PCR;RT-PCR - To examine, in newly diagnosed patients with acute promyelocytic leukemia (APL), the prognostic significance of secondary cytogenetic changes and the relationship between such changes and the two major promyelocytic leukemia-retinoic acid receptor alpha (PML-RAR alpha) mRNA types.
RARA_PL- 11818666acute promyelocytic leukemia;leukemia - - The presence of the characteristic fusion transcript gene, promyelocytic leukemia-retinoic acid receptor-alpha (PML-RARalpha), provided hematologists with a rationale for the use of all-trans retinoic acid (ATRA) for differentiation therapy for acute promyelocytic leukemia (APL).
RARA_PLt(15;17) / t(15;17) / 8695858acute promyelocytic leukemia;leukemia PCR;RT-PCR - Molecular analysis for the promyelocytic leukemia-retinoic acid receptor alpha (PML-RAR alpha) hybrid gene at diagnosis was performed in 16 patients by means of reverse transcription-polymerase chain reaction (RT-PCR) analysis, and all were RT-PCR+ for the hybrid gene.
RARA_PL- 21248444acute promyelocytic leukemia;leukemia FISH;PCR;RT-PCR - Patients with a presence of Promyelocytic Leukemia-Retinoic Acid Receptor Alpha (PML-RARA) genes rearrangement predict a favorable response to all-trans retinoic acid (ATRA), and a significant improvement in survival. /// "Therefore, establishing the presence of PML-RARA rearrangement is important for optimal patient management. "
RARA_PLt(15;17) / 11559723acute promyelocytic leukemia;leukemia - - Eighty-six percent of the patients who were assessable by reverse transcriptase polymerase chain reaction converted from positive to negative for the promyelocytic leukemia/retinoic acid receptor-alpha transcript by the completion of their consolidation therapy.
RARA_PL- 18290568acute promyelocytic leukemia;leukemia PCR;RT-PCR - Presented patient underwent alloSCT in second complete hematological and cytogenetic remission with presence of promyelocytic leukemia-retinoic acid receptor A (PML-RARA) detected in reverse transcription-polymerase chain reaction (RT-PCR) with sensitivity of 10(-2).
RARA_PL- 18633430acute promyelocytic leukemia;leukemia - - However, darinaparsin does not induce promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR alpha) degradation or rearrange PML nuclear bodies in APL cells, nor is its toxicity increased by glutathione depletion.
RARA_PL- 25815789acute promyelocytic leukemia;leukemia PCR - Rapid diagnosis of acute promyelocytic leukemia (APL) with promyelocytic leukemia-retinoic acid receptor alpha (PML-RARa) contributes to a highly effective therapy with all-trans retinoic acid (ATRA).
RARA_PL- 16925116acute promyelocytic leukemia;myeloid leukemia;leukemia - - Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by the chromosomal translocation t(15:17) that leads to the expression of promyelocytic leukemia/retinoic acid receptor-alpha (PML/ RARalpha) oncofusion protein. /// In vitro inhibition of promyelocytic leukemia/retinoic acid receptor-alpha (PML/RARalpha) expression and leukemogenic activity by DNA/LNA chimeric antisense oligos..
RARA_PL- 25223426- ISH - This report presents a case of acute promyelocytic leukaemia (APL) with the promyelocytic leukaemia-retinoic acid receptor alpha (PML-RARA) gene insertional translocation and a chromosome 21 abnormality in a 29-year-old XYY male patient. /// Acute promyelocytic leukaemia with a PML-RARA insertional translocation and a chromosome 21 abnormality in XYY syndrome: case report..

ChimerSEQ

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The fusion gene pair RARA--PL information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair RARA--PL information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair RARA--PL information is not available in FARE-CAFE.

TicDB

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The fusion gene pair RARA--PL information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair RARA--PL information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair RARA--PL information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair RARA--PL information is not available in ConjoinG Database.

1000Genome

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Fusion gene RARA--PL has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene RARA--PL is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene RARA--PL is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene RARA--PL is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene RARA--PL was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair RARA--PL information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene RARA--PL is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene RARA--PL has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene RARA is a known oncogene according to ONGENE database.
The tail gene PL is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene RARA is cancer associated according to Bushman Cancer Gene database.
The tail gene PL is not cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene RARA is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene PL is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene RARA--PL is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene RARA--PL is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair RARA--PL information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene RARA--PL is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene RARA--PL has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair RARA--PL information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair RARA--PL information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair RARA--PL information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene RARA--PL is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair RARA--PL information is not available in ChromothripsisDB database.