RARA--NPM

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

RARA NPM

COSMIC

The fusion gene pair RARA--NPM information is not available in COSMIC database.

ChimerKB

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The fusion gene pair RARA--NPM information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair RARA--NPM information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
RARA_NPMt(5;17) / t(5;17)(q35;q21) / t(5;17) / 18683144acute promyelocytic leukemia;leukemia FISH - Variant t(5;17) giving rise to the fusion gene of NPM-RAR aleph rarely occurs in APL patients.
RARA_NPMt(15;17) / t(11;17)(q23;q21) / t(5;17) / t(5;17)(q13;q21) / 10942371acute promyelocytic leukemia;leukemia FISH - In the other with an unbalanced der(5)t(5;17)(q13;q21) and a nucleolar NPM localization pattern, an NPM/RAR alpha rearrangement was excluded, and FISH revealed deletion of one RAR alpha allele. /// "Two patients were found to have t(5;17), one with a diffuse nuclear NPM staining pattern and with NPM-RAR alpha and RAR alpha-NPM transcripts detected. "
RARA_NPMt(15;17) / t(15;17) / t(5;17) / t(11;17)(q23;q21) / t(11;17) / 10942370acute promyelocytic leukemia;leukemia - - This group includes (1) cases with cryptic PML/RARA gene rearrangements and t(5;17) that leads to the NPM/RARA fusion gene, which are retinoid-responsive, and (2) cases with t(11;17)(q23;q21) that are associated with the PLZF/RARA fusion gene, which are retinoid-resistant. /// Auer rods were absent in the t(5;17) case expressing NPM/RARA.
RARA_NPMt(11;17)(q23;q21) / t(15;17) / t(11;17) / t(5;17) / 15748426acute myeloid leukemia;chronic myeloid leukemia;acute promyelocytic leukemia;myeloid leukemia;leuke - - Our group first discovered in the world the variant chromosome translocation t(11;17)(q23;q21) of APL, and cloned the PML-RAR alpha, PLZF-RAR alpha and NPM-RAR alpha fusion genes corresponding to the characterized chromosome translocations t(15;17).
RARA_NPMt(5;17) / t(15;17) / t(11;17) / 9204984- - - Our group has identified a variant of APL characterized by t(5;17) and expression of the NPM-RAR fusion gene product.
RARA_NPMt(5;17) / t(5;17)(q32;q12) / t(2;5) / t(15;17) / t(11;17) / 8562957acute promyelocytic leukemia;leukemia;lymphoma - - The NPM sequences contained in the shorter NPM-RAR cDNA are identical to the NPM sequences contained in the NPM-ALK fusion gene expressed in t(2;5) lymphomas. /// "Both NPM-RAR transcripts fuse NPM and RARA sequence in the same reading frame, to generate translation products of 57 kD and 62 kD. " /// "In transcriptional assays using a retinoic acid response element reporter construct, both NPM-RAR fusion proteins act as retinoic acid-dependent transcriptional activators. "
RARA_NPMt(15;17)(q22;q21) / t(11;17)(q23;q21) / t(5;17)(q35;q21) / t(11;17)(q13;q21) / 12357344- - - These include the t(11;17)(q23;q21) that produces the PLZF-RAR fusion, t(5;17)(q35;q21) that forms NPM-RAR, t(11;17)(q13;q21) that generates NUMA-RAR, and der(17) that creates STAT5b-RAR.
RARA_NPM- 22573339acute promyelocytic leukemia;leukemia - - Acute promyelocytic leukemia following aleukemic leukemia cutis harboring NPM/RARA fusion gene..
RARA_NPMt(5;17)(q35;q21) / t(15;17)(q22;q21) / 25033841acute promyelocytic leukemia;leukemia - - The resultant NPM-RAR fusion protein blocks myeloid differentiation and leads to a leukemic phenotype similar to that caused by the t(15;17)(q22;q21) PML-RAR fusion. /// The contribution of the N-terminal 117 amino acids of NPM contained within NPM-RAR has not been well studied. /// This study identifies a novel mechanism through which NPM-RAR affects leukemogenesis.. /// "Therefore, a proteomic analysis was conducted to identify novel NPM-RAR-associated proteins. " /// "Biologic assessment found that NPM-RAR expression impaired TNF-induced signaling through TRADD, blunting TNF-mediated activation of caspase-3 (CASP3) and caspase-8 (CASP8), to ultimately block apoptosis. " /// Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD..
RARA_NPMt(5;17) / t(15;17) / 16504291acute promyelocytic leukemia;leukemia - - In order to test the hypothesis that delocalization of PML from PODs is necessary for APL, we investigated the interaction of the t(5;17) APL fusion protein NPM-RAR with PML. /// The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.. /// These studies suggest that NPM-RAR does not interact with PML.. /// "NPM-RAR does not alter the localization of PML in transfected HeLa cells, and does not associate with PML in vitro. " /// NPM-RAR localizes diffusely throughout the nucleoplasm.
RARA_NPMt(5;17) / 10753851acute promyelocytic leukemia;leukemia - - The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties.. /// "In addition, NPM-RAR decreases basal transcription from some promoters and acts in a dominant-negative fashion when co-transfected with wild-type RARalpha. " /// Two NPM-RAR molecules are expressed as a result of alternative RNA splicing. /// Both NPM-RAR and PML-RAR interact with the co-repressor protein SMRTe in a manner that is less sensitive than RARalpha to dissociation by retinoic acid. /// "The level of transactivation induced by the NPM-RAR fusions differs from the level of transactivation induced by wild-type RARalpha in both a promoter and cell specific fashion, and more closely parallels the pattern of activation of the PML-RAR fusion than wild-type RARalpha. " /// "These data indicate that the NPM-RAR fusion proteins can modulate expression of retinoid-responsive genes in a positive or negative manner, depending on context of the promoter, and lend support to the hypothesis that aberrant transcriptional activation underlies the APL phenotype. " /// The NPM-RAR fusion proteins bind to retinoic acid response element sequences as either homodimers or as heterodimers with RXR.
RARA_NPMt(15;17) / 17988991acute promyelocytic leukemia;leukemia - - These findings suggest that ATRA can be used to treat APL patients with NPM/RAR as well as APL with PML/RAR.. /// We describe a 64-year-old man with NPM-RAR-positive APL who was receiving hemodialysis therapy for chronic uremia. /// Successful all-trans retinoic acid treatment of acute promyelocytic leukemia in a patient with NPM/RAR fusion..
RARA_NPM- 16331271acute promyelocytic leukemia;leukemia - - To analyse whether the variable X moiety could affect the activity of the fusion protein in vivo, we generated and characterized, on a comparative basis, NPM/RAR alpha transgenic mice (TM) in which the fusion gene is expressed under the control of a human Cathepsin G (hCG) minigene. /// hCG-NPM/RAR alpha leukemic cells resembled monoblasts. /// "Similarly to what was observed in human APL patients, we found that NPM/RAR alpha and PML/RAR alpha, but not PLZF/RAR alpha leukemia, was responsive to all-trans retinoic acid (ATRA) or As2O3 treatments. " /// "Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha.. " /// "Importantly, the NPM/RAR alpha oncoprotein was found to localize in the nucleolus, unlike PML/RAR alpha and PLZF/RAR alpha, thus possibly interfering with the normal function of NPM. "
RARA_NPMt(5;17) / t(5;17)(q32;q12) / t(2;5) / t(15;17) / t(11;17) / 8562957acute promyelocytic leukemia;leukemia;lymphoma - - Both NPM-RAR proteins are expressed in the patient's leukemic cells, along with wild-type RARA derived from the uninvolved allele.
RARA_NPMt(5;17)(q35;q21) / t(5;17) / 23927396acute promyelocytic leukemia;leukemia - - We have previously shown that leukemic cells express both NPM-RAR and RAR- NPM reciprocal translocation products. /// Expression of NPM-RAR inhibited vitamin D3/transforming growth factor ? (TGF?)-mediated differentiation of U937 cells by more than 50%.
RARA_NPMt(5;17)(q35;q21) / t(15;17)(q22;q21) / 25033841acute promyelocytic leukemia;leukemia - - TNF receptor type I-associated DEATH domain protein (TRADD) was identified as a relevant binding partner for NPM-RAR.
RARA_NPM- 11022230acute promyelocytic leukemia;leukemia - - In acute promyelocytic leukemia (APL) cells with rearrangement of retinoic acid receptor a (RAR alpha) (including: PML-RAR alpha, PLZF-RAR alpha, NPM-RAR alpha, NuMA- RAR alpha or STAT5b-RAR alpha) as a result of chromosomal translocations, the RA signal pathway is disrupted and myeloid differentiation is arrested at the promyelocytic stage.
RARA_NPMt(5;17) / 25791120leukemia - - We now report that NPM-RAR expression is permissive for TNF activation of NF?B and JNK. /// "We have previously shown that NPM-RAR interaction with TRADD blocks TNF activation of caspase 3, caspase 8, poly(ADP-ribose) polymerase (PARP) cleavage and, ultimately, apoptosis. " /// "We have previously shown that NPM-RAR is a binding partner of the tumor necrosis factor (TNF) receptor type-I-associated DEATH domain protein, TRADD. " /// "We propose that inhibition of TNF activation of apoptosis, while preserving TNF activation of NF?B and JNK pathways that stimulate cell growth and survival, represents a novel mechanism through which NPM-RAR contributes to development of the leukemic phenotype. " /// "NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NF?B and JNK.. "
RARA_NPMt(5;17)(q35;q21) / 24183235- - - U937 subclones expressing the NPM-RAR mutants showed significantly less inhibition of vitamin D3/TGFbeta-induced differentiation, compared with NPM-RAR.

ChimerSEQ

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The fusion gene pair RARA--NPM information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair RARA--NPM information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair RARA--NPM information is not available in FARE-CAFE.

TicDB

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The fusion gene pair RARA--NPM information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair RARA--NPM information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair RARA--NPM information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair RARA--NPM information is not available in ConjoinG Database.

1000Genome

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Fusion gene RARA--NPM has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene RARA--NPM is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene RARA--NPM is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene RARA--NPM is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene RARA--NPM was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair RARA--NPM information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene RARA--NPM is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene RARA--NPM has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene RARA is a known oncogene according to ONGENE database.


The tail gene NPM is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene RARA is cancer associated according to Bushman Cancer Gene database.


The tail gene NPM is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene RARA is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene NPM is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene RARA--NPM is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene RARA--NPM is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair RARA--NPM information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene RARA--NPM is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene RARA--NPM has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair RARA--NPM information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair RARA--NPM information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair RARA--NPM information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene RARA--NPM is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair RARA--NPM information is not available in ChromothripsisDB database.