RANBP2--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

RANBP2 ALK

COSMIC

The fusion gene pair RANBP2--ALK information is available in COSMIC database.

Link
RANBP2--ALK

ChimerKB

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The fusion gene pair RANBP2--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
RANBP2_ALK-/2728/ -/4080/ Exonic hg19 - - - Kinase; Oncogene; Cosmic_recurrent
RANBP2_ALK-/2728+507/ -/4080-360/ Exonic hg19 - - - Kinase; Oncogene; Cosmic_recurrent
RANBP2_ALK-/2728+1587/ -/4080-399/ Exonic hg19 - - - Kinase; Oncogene; Cosmic_recurrent
RANBP2_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 18701132 Kinase; Oncogene; Cosmic_nonrecurrent
RANBP2_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 12661011 Kinase; Oncogene; Cosmic_nonrecurrent
RANBP2_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 17656252 Kinase; Oncogene; Cosmic_nonrecurrent
RANBP2_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 21164297 Kinase; Oncogene; Cosmic_nonrecurrent
RANBP2_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 20979472 Kinase; Oncogene; Cosmic_nonrecurrent
RANBP2_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 21030459 Kinase; Oncogene; Cosmic_nonrecurrent
RANBP2_ALK-/-/ -/-/ - hg19 haematopoietic neoplasm - 20428197 Kinase; Oncogene; Cosmic_nonrecurrent
RANBP2_ALK-/-/ -/-/ - hg19 haematopoietic neoplasm - 24307515 Kinase; Oncogene; Cosmic_nonrecurrent
RANBP2_ALK-/504/ -/1572/ Exonic hg18 - - - Kinase; Oncogene; TICdb
RANBP2_ALK-/1587/ -/1534/ Exonic hg18 - - - Kinase; Oncogene; TICdb

ChimerPUB

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The fusion gene pair RANBP2--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
RANBP2_ALKinv(2)(p23q13) / 24307515myeloid leukemia;myelodysplastic syndrome;leukemia FISH - inv(2)(p23q13)/RAN-binding protein 2 (RANBP2)-ALK fusion gene in myeloid leukemia that developed in an elderly woman.. /// RAN-binding protein 2 (RANBP2)-ALK fusion mRNA was confirmed by reverse transcriptase-mediated polymerase chain reaction and nucleotide sequencing.
RANBP2_ALKinv(2)(p23q12) / del(2) / 1p11.2 / t(2;17)(p23;q23) / 17656252- FISH - FISH showed ALK-RANBP2 fusion in this tumor. /// "The breakpoint was cloned and the fusion was confirmed, making this the third reported case of IMT with ALK-RANBP2 fusion. "
RANBP2_ALKinv(2)(p23q21) / 24613277leukemia FISH;PCR - We detected an ALK rearrangement using fluorescence in situ hybridization, identified the ALK fusion partner by using RNA transcriptome sequencing, and demonstrated the RANBP2-ALK fusion transcript by reverse transcriptase--PCR and Sanger sequencing. /// "Our results, together with a literature review, suggest the RANBP2-ALK fusion combined with monosomy 7 may be related to a unique clonal hematologic disorder of childhood and adolescence, characterized by myelomonocytic leukemia and a poor prognosis.. " /// RANBP2-ALK fusion combined with monosomy 7 in acute myelomonocytic leukemia..
RANBP2_ALKinv(2)(p23q13) / del(1)(p13p22) / 25766836acute myeloid leukemia;myeloid leukemia;leukemia;lung cancer PCR;ISH - An elderly woman with AML with an inv(2)(p23q13)/RANBP2-ALK and monosomy 7 was treated with crizotinib. /// This is the first report on the development of a p.G1269A mutation within the kinase domain (KD) of ALK after crizotinib treatment in RANBP2-ALK acute myeloid leukemia (AML).
RANBP2_ALK- 25028698sarcoma - - A case report of epithelioid inflammatory myofibroblastic sarcoma with RANBP2-ALK fusion gene treated with the ALK inhibitor, crizotinib.. /// Epithelioid inflammatory myofibroblastic sarcoma is a variant of inflammatory myofibroblastic tumor with aggressive clinical course associated with RANBP2-ALK fusion. /// "The feature of the neoplasms, including epithelioid morphology, anaplastic lymphoma kinase staining on the nuclear membrane, and results from the reverse transcriptase-polymerase chain reaction, led to diagnosis of epithelioid inflammatory myofibroblastic sarcoma with RANBP2-ALK fusion. "
RANBP2_ALK- 21030459neuroblastoma - - Here we report the identification of a secondary mutation in ALK, F1174L, as one cause of crizotinib resistance in a patient with an inflammatory myofibroblastic tumor (IMT) harboring a RANBP2-ALK translocation who progressed while on crizotinib therapy. /// "Furthermore, the F1174L mutation inhibits crizotinib-mediated downregulation of ALK signaling and blocks apoptosis in RANBP2-ALK Ba/F3 cells. "
RANBP2_ALK- 12661011dermatofibrosarcoma, - - The N-terminal 867 residues of RANBP2 are fused to the cytoplasmic segment of ALK in the 1,430-amino acid RANBP2-ALK chimeric protein. /// "Myofibroblasts that express RANBP2-ALK exhibit nuclear membrane-associated ALK staining that is unique compared to the subcellular localization observed with other ALK fusions in IMT, presumably attributable to heteroassociation of the fusion with normal RANBP2 at the nuclear pore. "
RANBP2_ALK- 23345154sarcoma ISH - Fluorescence in situ hybridization revealed that the Ran-binding protein 2-ALK fusion gene was present.
RANBP2_ALK- 21164297sarcoma ISH - Fluorescence in situ hybridization was positive for ALK gene rearrangement in 9 cases, and in 3 cases tested, a RANBP2-ALK fusion was detected by reverse transcription polymerase chain reaction.

ChimerSEQ

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The fusion gene pair RANBP2--ALK information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair RANBP2--ALK information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair RANBP2--ALK information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
RANBP2-ALK Inflammatory myofibroblastic tumor _ _ PubMed:12661011

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
RANBP2-ALK RANBP2-ALK-Isoform1 RANBP2 109376591 0 1 ALK 29446719 0 0 CTGTTCCTGTGTTCATAGATTCTTTTTCCTTAATAAAAGTAAACATATATCAAGATGGTCCTTGTTTTTTAAAAaACTTGCAACACAGTCTGCTGGTTCACCCAGCCTTCCCTGGCTCCCTCCCCATTTCCTCTCATGGGCATTTCTCCT 12661011 _
RANBP2-ALK RANBP2-ALK-Isoform2 RANBP2 109375511 0 1 ALK 29446682 0 0 GGAGTTTGGACCTGAATCATACTGGGTTTTTAAGTTCTGCTCTATCACTTACTATAATAGCTGTGTAAGTTAaCCTGGCTCCCTCCCCATTTCCTCTCATGGGCATTTCTCCTAATAAAATCTGCAGACCGTATTGGGTCTAATCCCATC 12661011 _
RANBP2-ALK RANBP2-ALK-Isoform3 RANBP2 _ _ 1 ALK _ 0 _ GGGGCTCCACTAACAgTGTACCGCCGGAAG 12661011 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
RANBP2-ALK RANBP2-ALK-Isoform1 1) TPR_1
1) Apc3 , Sel1 , TPR_8 , TPR_3 , TPR_11 , PPP5 , TPR_2 , TPR_10 , Metallophos , TPR_15 , TPR_1 , FKBP_C , TPR_12
1) MAM
2) Gly_rich
1) ig , Astacin , MATH
RANBP2 1) TPR_1
2) Ran_BP1
3) zf-RanBP
4) IR1-M
5) Pro_isomerase
1) Apc3 , Sel1 , TPR_8 , TPR_3 , TPR_11 , PPP5 , TPR_2 , TPR_10 , Metallophos , TPR_15 , TPR_1 , FKBP_C , TPR_12
2) Ran_BP1 , Ras , CRM1_C
3) ubiquitin , Ras
4) UQ_con , Rad60-SLD
5) Pro_isomerase , PRP4 , Gag_p24 , Metallophos
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) TPR_1
2) Ran_BP1
3) zf-RanBP
4) IR1-M
5) Pro_isomerase
1) Apc3 , Sel1 , TPR_8 , TPR_3 , TPR_11 , PPP5 , TPR_2 , TPR_10 , Metallophos , TPR_15 , TPR_1 , FKBP_C , TPR_12
2) Ran_BP1 , Ras , CRM1_C
3) ubiquitin , Ras
4) UQ_con , Rad60-SLD
5) Pro_isomerase , PRP4 , Gag_p24 , Metallophos
RANBP2-ALK RANBP2-ALK-Isoform2 1) TPR_1
1) Apc3 , Sel1 , TPR_8 , TPR_3 , TPR_11 , PPP5 , TPR_2 , TPR_10 , Metallophos , TPR_15 , TPR_1 , FKBP_C , TPR_12
1) MAM
2) Gly_rich
1) ig , Astacin , MATH
RANBP2 1) TPR_1
2) Ran_BP1
3) zf-RanBP
4) IR1-M
5) Pro_isomerase
1) Apc3 , Sel1 , TPR_8 , TPR_3 , TPR_11 , PPP5 , TPR_2 , TPR_10 , Metallophos , TPR_15 , TPR_1 , FKBP_C , TPR_12
2) Ran_BP1 , Ras , CRM1_C
3) ubiquitin , Ras
4) UQ_con , Rad60-SLD
5) Pro_isomerase , PRP4 , Gag_p24 , Metallophos
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) TPR_1
2) Ran_BP1
3) zf-RanBP
4) IR1-M
5) Pro_isomerase
1) Apc3 , Sel1 , TPR_8 , TPR_3 , TPR_11 , PPP5 , TPR_2 , TPR_10 , Metallophos , TPR_15 , TPR_1 , FKBP_C , TPR_12
2) Ran_BP1 , Ras , CRM1_C
3) ubiquitin , Ras
4) UQ_con , Rad60-SLD
5) Pro_isomerase , PRP4 , Gag_p24 , Metallophos
RANBP2-ALK RANBP2-ALK-Isoform3 - - - -RANBP2 1) TPR_1
2) Ran_BP1
3) zf-RanBP
4) IR1-M
5) Pro_isomerase
1) Apc3 , Sel1 , TPR_8 , TPR_3 , TPR_11 , PPP5 , TPR_2 , TPR_10 , Metallophos , TPR_15 , TPR_1 , FKBP_C , TPR_12
2) Ran_BP1 , Ras , CRM1_C
3) ubiquitin , Ras
4) UQ_con , Rad60-SLD
5) Pro_isomerase , PRP4 , Gag_p24 , Metallophos
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) TPR_1
2) Ran_BP1
3) zf-RanBP
4) IR1-M
5) Pro_isomerase
6) MAM
7) Gly_rich
8) Pkinase_Tyr
1) Apc3 , Sel1 , TPR_8 , TPR_3 , TPR_11 , PPP5 , TPR_2 , TPR_10 , Metallophos , TPR_15 , TPR_1 , FKBP_C , TPR_12
2) Ran_BP1 , Ras , CRM1_C
3) ubiquitin , Ras
4) UQ_con , Rad60-SLD
5) Pro_isomerase , PRP4 , Gag_p24 , Metallophos
6) ig , Astacin , MATH
7) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
RANBP2-ALK hsa-miR-132-3p hsa-miR-708-5phsa-miR-106b-3phsa-miR-421hsa-miR-423-3phsa-miR-186-5phsa-miR-125b-5phsa-let-7g-5phsa-miR-92a-3phsa-let-7e-5phsa-let-7a-5p Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
RANBP2-ALK NM_006267.4 1) RB1_HUMAN
2) STAT1_HUMAN
3) RBL2_HUMAN
4) ZNF263_HUMAN
5) E2F4_HUMAN
6) P53_HUMAN
7) ETS1_HUMAN
8) GATA3_HUMAN
9) BRG1_HUMAN
10) TFAP2C_HUMAN
11) FOXA1_HUMAN
12) ESR2_HUMAN
13) TRIM24_HUMAN
1) TRIM28_HUMAN
2) MITF_HUMAN
3) RUNX1_HUMAN
4) PRDM14_HUMAN
5) ESTROGEN RECEPTOR ALPHA_HUMAN
6) EGR1_HUMAN
7) FOS_HUMAN
8) GATA3_HUMAN
9) E2F1_HUMAN
10) SOX2_HUMAN
11) CTCF_HUMAN
12) HNF4A_HUMAN
13) ESR1_HUMAN
14) NR1H3_HUMAN
15) SETDB1_HUMAN
1) 20385362
2) 19122651
3) 20385362
4) 19887448
5) 21247883
6) 21394211
7) 20019798
8) 21878914
9) 19505939
10) 21572391
11) 21235772
12) 21164480
13) 21164480

TicDB

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The fusion gene pair RANBP2--ALK information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
RANBP2 ALK 12661011 CTGTTCCTGTGTTCATAGATTCTTTTTCCTTAATAAAAGTAAACATATATCAAGATGGTCCTTGTTTTTTAAAAaACTTGCAACACAGTCTGCTGGTTCACCCAGCCTTCCCTGGCTCCCTCCCCATTTCCTCTCATGGGCATTTCTCCT
RANBP2 ALK 12661011 GGAGTTTGGACCTGAATCATACTGGGTTTTTAAGTTCTGCTCTATCACTTACTATAATAGCTGTGTAAGTTAaCCTGGCTCCCTCCCCATTTCCTCTCATGGGCATTTCTCCTAATAAAATCTGCAGACCGTATTGGGTCTAATCCCATC
RANBP2 ALK 12661011 GGGGCTCCACTAACAgTGTACCGCCGGAAG

TUMOR FUSION Gene Data Portal

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The fusion gene pair RANBP2--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair RANBP2--ALK information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair RANBP2--ALK information is not available in ConjoinG Database.

1000Genome

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Fusion gene RANBP2--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene RANBP2--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene RANBP2--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene RANBP2--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene RANBP2--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair RANBP2--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene RANBP2--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene RANBP2--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene RANBP2 is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene RANBP2 is cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene RANBP2 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene RANBP2--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene RANBP2--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair RANBP2--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene RANBP2--ALK is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene RANBP2--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair RANBP2--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair RANBP2--ALK information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair RANBP2--ALK is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
RANBP2--ALKThe pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7

Cortex_Dataset

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Fusion gene RANBP2--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair RANBP2--ALK information is not available in ChromothripsisDB database.