PTC--RET

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

PTC RET

COSMIC

The fusion gene pair PTC--RET information is not available in COSMIC database.

ChimerKB

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The fusion gene pair PTC--RET information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair PTC--RET information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
PTC_RETt(2;3)(q13;p25) / 17123335thyroid adenoma FISH - Other fusion genes found in thyroid lesions are RET/PTC and PAX8/PPAR(gamma).
PTC_RET- 16641909- FISH - In all, 77% of cases showed RET/PTC rearrangements and a distinct intratumoural genetic heterogeneity.
PTC_RET- 16772343papillary carcinoma FISH;PCR;RT-PCR - RET/PTC rearrangements were detected by standard-sensitivity RT-PCR in 14 tumors. /// Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity. /// Our data suggest that broad variability in the reported prevalence of RET/PTC rearrangement is at least in part a result of the use of different detection methods and tumor genetic heterogeneity.. /// RET/PTC rearrangements have been reported in papillary thyroid carcinomas with variable frequency in studies that used different detection methods. /// Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity.. /// Twelve (18%) tumors had nonclonal RET/PTC that were detected only by high-sensitivity RT-PCR. /// Our objective was to determine the role of different detection methods and tumor genetic heterogeneity on RET/PTC detection. /// "High-sensitivity RT-PCR detected RET/PTC in all of these and in 12 additional cases, where the levels of expression corresponded to one to five positive cells. " /// "No other mutations were found in tumors harboring clonal RET/PTC, whereas 60% of tumors with subclonal and 42% of tumors with nonclonal RET/PTC harbored additional mutations. " /// Real-time LightCycler RT-PCR detected RET/PTC in 12 and Southern blot analysis in 11 tumors. /// "Sixty-five papillary carcinomas were analyzed for RET/PTC1 and RET/PTC3 using five detection methods: standard-sensitivity RT-PCR, high-sensitivity RT-PCR, real-time LightCycler RT-PCR, Southern blot analysis, and fluorescence in situ hybridization. "
PTC_RET- 16181547- PCR;RT-PCR - There was no overlap between BRAF(V599E) mutation and RET/PTC rearrangements. /// (1) BRAF(V599E) mutation and RET/PTC rearrangements were unique to PTC. /// (3) There was no overlap between BRAF(V599E) mutation and RET/PTC rearrangements suggest that they are alternative events in PTC.. /// [BRAFV599E mutation and RET/PTC rearrangements in papillary thyroid carcinoma]. /// [BRAFV599E mutation and RET/PTC rearrangements in papillary thyroid carcinoma].. /// "(3) Statistic data did not show any correlation between the BRAF(V599E) mutation, RET/PTC and clinicopathologic features of PTC (P > 0.05). " /// "Among them, 5 cases (7.6%) were RET/PTC1 and 9 cases (13.6%) were RET/PTC3 respectively. " /// (2) Fourteen (21.2%) PTC cases expressed RET/PTC chimeric gene. /// PCR and RT-PCR were employed to detect BRAF(V599E) mutation and RET/PTC chimeric genes in 95 frozen and parraffine-embeded thyroid tissue.

ChimerSEQ

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The fusion gene pair PTC--RET information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair PTC--RET information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair PTC--RET information is not available in FARE-CAFE.

TicDB

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The fusion gene pair PTC--RET information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair PTC--RET information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair PTC--RET information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair PTC--RET information is not available in ConjoinG Database.

1000Genome

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Fusion gene PTC--RET has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene PTC--RET is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene PTC--RET is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene PTC--RET is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene PTC--RET was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair PTC--RET information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene PTC--RET is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene PTC--RET has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene PTC is a known oncogene according to ONGENE database.


The tail gene RET is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene PTC is cancer associated according to Bushman Cancer Gene database.


The tail gene RET is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene PTC is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene RET is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene PTC--RET is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene PTC--RET is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair PTC--RET information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene PTC--RET is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene PTC--RET has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair PTC--RET information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair PTC--RET information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair PTC--RET information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene PTC--RET is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair PTC--RET information is not available in ChromothripsisDB database.