PPAR--PAX8

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

PPAR PAX8

COSMIC

The fusion gene pair PPAR--PAX8 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair PPAR--PAX8 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair PPAR--PAX8 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
PPAR_PAX8- 23738683thyroid carcinoma FISH - There was no correlation between the extent of capsular or vascular invasion and PAX8-PPAR?, or between lymph node or haematogenous metastasis and PAX8-PPAR?. /// "Overall survival (OS), tumour-specific survival (TSS) and relapse-free-survival (RFS) were not influenced by PAX8-PPAR?. "
PPAR_PAX8- 23100233thyroid cancer FISH - FISH analysis using PPAR ?-specific probes for detection of PAX8-PPAR ? translocation in follicular thyroid neoplasms..
PPAR_PAX8t(2;3)(q13;p25) / 12161538thyroid carcinoma PCR;RT-PCR - Recently, a translocation t(2;3)(q13;p25), leading to the formation of a chimeric PAX8-peroxisome proliferator-activated receptor (PPAR)gamma 1 oncogene, was detected in follicular thyroid carcinomas (FTC), but not in follicular thyroid adenomas (FTA), papillary thyroid carcinomas (PTC), or multinodular hyperplasias.
PPAR_PAX8t(2;3)(q13;p25) / 25708358thyroid carcinoma PCR;RT-PCR - The FTC with PAX8-PPAR? rearrangement from a 56-year-old man showed a product consistent with fusion between exon 8 of PAX8 and exon 1 of PPAR?. /// "In this study, we examined PAX8-PPAR? rearrangement in 24 FTC samples from Japanese patients by reverse transcribed-polymerase chain reaction (RT-PCR) using two upstream PAX8 primers located in exons 7 and 8 and a downstream primer in exon 1 of PPAR?. "
PPAR_PAX8- 14500358- - - Recent identification of a PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) fusion gene in human thyroid follicular carcinoma suggests a tumor suppressor role of PPARgamma in thyroid carcinogenesis.
PPAR_PAX8- 21880806thyroid carcinoma PCR - The collected material was adequate for molecular analysis in 967 samples (92%), which yielded 87 mutations including 19 BRAF, 62 RAS, 1 RET/PTC, and five PAX8/PPAR?.
PPAR_PAX8- 12665646thyroid nodule;papillary carcinoma;thyloid cancer;leukemia;sarcoma - - For instance, mutations of the gsp and thyroid-stimulating hormone receptor genes are associated with benign hyperfunctioning thyroid nodules and adenomas while alterations of other specific genes, such as oncogenic tyrosine kinase alterations (RET/PTC, TRK) in papillary carcinoma and the newly discovered PAX8/peroxisome proliferator-activated receptor gamma rearrangement, are distinctive features of cancer.
PPAR_PAX8- 24955024thyroid nodule;thyroid carcinoma;thyloid cancer - - Fine-needle aspiration (FNA) of thyroid nodules can permit to detect many genetic mutations and other molecular alterations, including RAS and BRAF point mutations, PAX8/peroxisome proliferator-activated receptor (PPAR)? and "RET/PTC rearrangements, occurring in thyroid papillary and follicular carcinomas" (more than 70% of cases), which can be used successfully to improve the diagnosis "and the management of patients with thyroid nodules".
PPAR_PAX8- 21526955thyroid nodule;thyroid carcinoma;papillary carcinoma;thyloid cancer - - The most common molecular alterations in thyroid cancer include BRAF and RAS point mutations and RET/PTC and PAX8/PPAR ? rearrangements. /// "The diagnostic role of BRAF mutations has been studied most extensively, and recent studies also demonstrated a significant diagnostic utility of RAS, RET/PTC, and PAX8/PPAR ? mutations, particularly in thyroid fine-needle aspiration samples with indeterminate cytology. "
PPAR_PAX8- 21798995anaplastic thyroid carcinoma - - PAX8/peroxisome proliferator-activated receptor ? (PPAR?) rearrangements, which occur in FTC as an alternative to the RAS mutation, are associated with specific changes in gene expression.
PPAR_PAX8- 26435130thyloid cancer - - B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor ? (PPAR?) rearrangements.

ChimerSEQ

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The fusion gene pair PPAR--PAX8 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair PPAR--PAX8 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair PPAR--PAX8 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair PPAR--PAX8 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair PPAR--PAX8 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair PPAR--PAX8 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair PPAR--PAX8 information is not available in ConjoinG Database.

1000Genome

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Fusion gene PPAR--PAX8 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene PPAR--PAX8 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene PPAR--PAX8 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene PPAR--PAX8 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene PPAR--PAX8 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair PPAR--PAX8 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene PPAR--PAX8 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene PPAR--PAX8 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene PPAR is not a known oncogene according to ONGENE database.


The tail gene PAX8 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene PPAR is not cancer associated according to Bushman Cancer Gene database.


The tail gene PAX8 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene PPAR is not a proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene PAX8 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene PPAR--PAX8 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene PPAR--PAX8 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair PPAR--PAX8 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene PPAR--PAX8 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene PPAR--PAX8 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair PPAR--PAX8 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair PPAR--PAX8 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair PPAR--PAX8 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene PPAR--PAX8 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair PPAR--PAX8 information is not available in ChromothripsisDB database.