| PPAR_PAX8 | - |
23738683 | thyroid carcinoma |
FISH |
- |
There was no correlation between the extent of capsular or vascular invasion and PAX8-PPAR?, or between lymph node or haematogenous metastasis and PAX8-PPAR?. /// "Overall survival (OS), tumour-specific survival (TSS) and relapse-free-survival (RFS) were not influenced by PAX8-PPAR?. "
|
| PPAR_PAX8 | - |
23100233 | thyroid cancer |
FISH |
- |
FISH analysis using PPAR ?-specific probes for detection of PAX8-PPAR ? translocation in follicular thyroid neoplasms..
|
| PPAR_PAX8 | t(2;3)(q13;p25) / |
12161538 | thyroid carcinoma |
PCR;RT-PCR |
- |
Recently, a translocation t(2;3)(q13;p25), leading to the formation of a chimeric PAX8-peroxisome proliferator-activated receptor (PPAR)gamma 1 oncogene, was detected in follicular thyroid carcinomas (FTC), but not in follicular thyroid adenomas (FTA), papillary thyroid carcinomas (PTC), or multinodular hyperplasias.
|
| PPAR_PAX8 | t(2;3)(q13;p25) / |
25708358 | thyroid carcinoma |
PCR;RT-PCR |
- |
The FTC with PAX8-PPAR? rearrangement from a 56-year-old man showed a product consistent with fusion between exon 8 of PAX8 and exon 1 of PPAR?. /// "In this study, we examined PAX8-PPAR? rearrangement in 24 FTC samples from Japanese patients by reverse transcribed-polymerase chain reaction (RT-PCR) using two upstream PAX8 primers located in exons 7 and 8 and a downstream primer in exon 1 of PPAR?. "
|
| PPAR_PAX8 | - |
14500358 | - |
- |
- |
Recent identification of a PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) fusion gene in human thyroid follicular carcinoma suggests a tumor suppressor role of PPARgamma in thyroid carcinogenesis.
|
| PPAR_PAX8 | - |
21880806 | thyroid carcinoma |
PCR |
- |
The collected material was adequate for molecular analysis in 967 samples (92%), which yielded 87 mutations including 19 BRAF, 62 RAS, 1 RET/PTC, and five PAX8/PPAR?.
|
| PPAR_PAX8 | - |
12665646 | thyroid nodule;papillary carcinoma;thyloid cancer;leukemia;sarcoma |
- |
- |
For instance, mutations of the gsp and thyroid-stimulating hormone receptor genes are associated with benign hyperfunctioning thyroid nodules and adenomas while alterations of other specific genes, such as oncogenic tyrosine kinase alterations (RET/PTC, TRK) in papillary carcinoma and the newly discovered PAX8/peroxisome proliferator-activated receptor gamma rearrangement, are distinctive features of cancer.
|
| PPAR_PAX8 | - |
24955024 | thyroid nodule;thyroid carcinoma;thyloid cancer |
- |
- |
Fine-needle aspiration (FNA) of thyroid nodules can permit to detect many genetic mutations and other molecular alterations, including RAS and BRAF point mutations, PAX8/peroxisome proliferator-activated receptor (PPAR)? and "RET/PTC rearrangements, occurring in thyroid papillary and follicular carcinomas" (more than 70% of cases), which can be used successfully to improve the diagnosis "and the management of patients with thyroid nodules".
|
| PPAR_PAX8 | - |
21526955 | thyroid nodule;thyroid carcinoma;papillary carcinoma;thyloid cancer |
- |
- |
The most common molecular alterations in thyroid cancer include BRAF and RAS point mutations and RET/PTC and PAX8/PPAR ? rearrangements. /// "The diagnostic role of BRAF mutations has been studied most extensively, and recent studies also demonstrated a significant diagnostic utility of RAS, RET/PTC, and PAX8/PPAR ? mutations, particularly in thyroid fine-needle aspiration samples with indeterminate cytology. "
|
| PPAR_PAX8 | - |
21798995 | anaplastic thyroid carcinoma |
- |
- |
PAX8/peroxisome proliferator-activated receptor ? (PPAR?) rearrangements, which occur in FTC as an alternative to the RAS mutation, are associated with specific changes in gene expression.
|
| PPAR_PAX8 | - |
26435130 | thyloid cancer |
- |
- |
B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor ? (PPAR?) rearrangements.
|