PDGFRA--KIT

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

PDGFRA KIT

COSMIC

The fusion gene pair PDGFRA--KIT information is not available in COSMIC database.

ChimerKB

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The fusion gene pair PDGFRA--KIT information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair PDGFRA--KIT information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
PDGFRA_KIT- 26606880sarcoma FISH - The screening by FISH of 26 additional cases, including KIT/PDGFRA-mutated GISTs, failed to detect other ETV6 rearrangements beside the index case.
PDGFRA_KIT5p13.3 / 25473890gastrointestinal stromal tumor FISH - AMACR-specific fluorescence in situ hybridization and immunohistochemistry were both informative in tissue microarray sections of 350 independent primary gastrointestinal stromal tumors, including 213 cases with confirmed KIT /PDGFRA genotypes.
PDGFRA_KIT- 17643098gastrointestinal cancer FISH - Mutually exclusive KIT or platelet-derived growth factor receptor-alpha mutations are key events in gastrointestinal stromal tumor pathogenesis, and specific treatment targeting KIT/platelet-derived growth factor receptor-alpha activation is available.
PDGFRA_KIT- 18623623- FISH;PCR - Most GIST patients develop clinical resistance to KIT/PDGFRA tyrosine kinase inhibitors (TKI). /// and KIT/PDGFRA wild-type GISTs. /// "KIT kinase resistance mutations were not found in KIT/PDGFRA wild-type GISTs or in KIT-mutant GISTs showing unusual morphology and/or loss of KIT expression by IHC, indicating that resistance mechanisms are fundamentally different in these tumours. "
PDGFRA_KIT9p21.3 / 19585585gastrointestinal stromal tumor - - Although all 21 mutant GISTs exhibited multiple copy number aberrations, notably losses, eight of the 10 KIT/PDGFRA mutation-negative GISTs exhibited few or no genomic alterations. /// "Using genome-wide DNA arrays, we investigated genomic imbalances in a set of 31 GISTs, including 10 KIT/PDGFRA mutation-negative tumors from nine adults and one pediatric case and 21 mutant tumors. "
PDGFRA_KIT- 25346074synovial sarcoma;sarcoma - - A confident distinction between abdominal synovial sarcoma and GIST requires KIT/PDGFRA mutation analyses and specific molecular testing for synovial sarcoma.. /// "Four cases of primary abdominal synovial sarcoma were reviewed morphologically and with immunohistochemistry, fluorescence in-situ hybridization with an SS18 break-apart probe, and KIT/PDGFRA mutation analysis. "
PDGFRA_KIT- 18537751gastrointestinal stromal tumor - - The introduction of imatinib mesylate (inhibiting KIT/PDGFRA (platelet-derived growth factor receptor-alpha) and their downstream signaling cascade) has revolutionized the therapy of advanced (inoperable and/or metastatic) GISTs.
PDGFRA_KIT- 23774173liposarcoma;gastrointestinal stromal tumor;sarcoma - - A molecular analysis was performed for all suspicions of sarcomas with specific genetic lesions [mutations of KIT/PDGFRA in gastrointestinal stromal tumors (GISTs), reciprocal translocation, or amplification of MDM2 in atypical lipomatous tumors, well-differentiated liposarcoma-dedifferentiated liposarcoma (ALT/WDLPS-DDLPS)].

ChimerSEQ

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The fusion gene pair PDGFRA--KIT information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair PDGFRA--KIT information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair PDGFRA--KIT information is not available in FARE-CAFE.

TicDB

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The fusion gene pair PDGFRA--KIT information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair PDGFRA--KIT information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair PDGFRA--KIT information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair PDGFRA--KIT information is not available in ConjoinG Database.

1000Genome

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Fusion gene PDGFRA--KIT has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene PDGFRA--KIT is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene PDGFRA--KIT is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene PDGFRA--KIT is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene PDGFRA--KIT was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair PDGFRA--KIT information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene PDGFRA--KIT is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene PDGFRA--KIT has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene PDGFRA is a known oncogene according to ONGENE database.


The tail gene KIT is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene PDGFRA is cancer associated according to Bushman Cancer Gene database.


The tail gene KIT is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene PDGFRA is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene KIT is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene PDGFRA--KIT is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene PDGFRA--KIT is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair PDGFRA--KIT information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene PDGFRA--KIT is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene PDGFRA--KIT has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair PDGFRA--KIT information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair PDGFRA--KIT information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair PDGFRA--KIT information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene PDGFRA--KIT is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair PDGFRA--KIT information is not available in ChromothripsisDB database.