PDGFRA--BCR

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

PDGFRA BCR

COSMIC

The fusion gene pair PDGFRA--BCR information is not available in COSMIC database.

ChimerKB

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The fusion gene pair PDGFRA--BCR information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
PDGFRA_BCR-/-/ -/-/ - hg18 chronic myeloid leukemia - 12023981 Kinase; Oncogene; OMIM
PDGFRA_BCR-/-/ -/-/ - hg18 chronic myelogenous leukemia - 12023981 Kinase; Oncogene; OMIM

ChimerPUB

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The fusion gene pair PDGFRA--BCR information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
PDGFRA_BCRt(4;22) / 15034867myeloproliferative disorder;chronic myeloid leukemia;myeloid leukemia;leukemia;B cell lymphoma;lymphoma FISH;PCR - However, although the incidence of MPD involving translocations of PDGFRB has been well established, to our knowledge there are only two previous reports describing a BCR-PDGFRA fusion gene, in 3 patients diagnosed with atypical CML.
PDGFRA_BCRt(4;22) / 26095243acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia - - To date, only eight cases of hematolymphoid neoplasms with the BCR-PDGFRA fusion gene have been reported. /// The BCR-PDGFRA fusion is a very rare event. /// BCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma..
PDGFRA_BCRt(4;22)(q12;q11) / t(9;22)(q34;q11) / t(9;22) / 12023981- FISH;PCR;RT-PCR - An unusual inframe BCR-PDGFRA fusion mRNA was identified in both patients, with either BCR exon 7 or exon 12 fused to short BCR intron-derived sequences, which were in turn fused to part of PDGFRA exon 12.
PDGFRA_BCR- 25941032chronic myeloid leukemia;myeloid leukemia;leukemia PCR - Here we describe a patient with a rare CML-like disease in whom we identified a novel in-frame BCR-PDGFRA rearrangement joining BCR exon 17 to PDGFRA exon 13, resulting in overexpression of PDGFRA. /// "The design of a specific quantitative PCR assay to monitor the molecular response during treatment with imatinib, a multitargeted tyrosine kinase inhibitor (TKI) with activity against ABL, c-Kit, and PDGFRA revealed an outstanding disease control with durably undetectable BCR-PDGFRA transcripts. "
PDGFRA_BCR- 19366796chronic myeloid leukemia;rhabdomyosarcoma;non small cell lung cancer;myeloid leukemia - - Activation of PDGFR signaling has been described in gastrointestinal stromal tumors (PDGFRA mutations) as well as in chronic myeloid leukemia (BCR-PDGFRA translocation), and sunitinib can yield clinical benefit in both settings.

ChimerSEQ

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The fusion gene pair PDGFRA--BCR information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair PDGFRA--BCR information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair PDGFRA--BCR information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
PDGFRA-BCR Myeloproliferative disease PCR,FISH,Western blot,RT-PCR,Southern blot,DNA sequencing,G-Banding,Cyclesequencing,PFGE t(4;22)(q12;q11) PubMed:12023981

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
PDGFRA-BCR PDGFRA-BCR-Isoform1 PDGFRA _ _ 1 BCR _ 1 _ _ _ _
PDGFRA-BCR PDGFRA-BCR-Isoform2 PDGFRA _ _ 1 BCR 23631509 1 0 _ _ _
PDGFRA-BCR PDGFRA-BCR-Isoform3 PDGFRA _ _ 1 BCR 23615344 1 0 _ _ _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
PDGFRA-BCR PDGFRA-BCR-Isoform1 - - - -PDGFRA 1) Ig_2
2) I-set
3) Pkinase_Tyr
1) SCF , hEGF , C1-set , DUF1954 , IL1 , Ig_Tie2_1 , NGF , C2-set_2 , G2F , IL34 , LRR_8 , PDGF , S_100 , ig , CSF-1 , I-set , Ig_2 , Laminin_G_1 , PSI , V-set , Carb_anhydrase , ICAM_N , Ig_3 , MHC_I , Pentaxin , fn3
2) C2-set , FGF , SCF , I-set , LRR_8 , NGF , Carb_anhydrase , Ig_2 , PDGF , Telethonin , CSF-1 , IL34 , SBP_bac_1 , C2-set_2 , Ig_3 , Pkinase , fn3 , V-set
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
BCR 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
4) C2
5) RhoGAP
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
4) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
5) Ras , RhoGAP
1) Ig_2
2) I-set
3) Pkinase_Tyr
4) Bcr-Abl_Oligo
5) RhoGEF
6) PH
7) C2
8) RhoGAP
1) SCF , hEGF , C1-set , DUF1954 , IL1 , Ig_Tie2_1 , NGF , C2-set_2 , G2F , IL34 , LRR_8 , PDGF , S_100 , ig , CSF-1 , I-set , Ig_2 , Laminin_G_1 , PSI , V-set , Carb_anhydrase , ICAM_N , Ig_3 , MHC_I , Pentaxin , fn3
2) C2-set , FGF , SCF , I-set , LRR_8 , NGF , Carb_anhydrase , Ig_2 , PDGF , Telethonin , CSF-1 , IL34 , SBP_bac_1 , C2-set_2 , Ig_3 , Pkinase , fn3 , V-set
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
4) Bcr-Abl_Oligo
5) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
6) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
7) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
8) Ras , RhoGAP
PDGFRA-BCR PDGFRA-BCR-Isoform2 - - 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
PDGFRA 1) Ig_2
2) I-set
3) Pkinase_Tyr
1) SCF , hEGF , C1-set , DUF1954 , IL1 , Ig_Tie2_1 , NGF , C2-set_2 , G2F , IL34 , LRR_8 , PDGF , S_100 , ig , CSF-1 , I-set , Ig_2 , Laminin_G_1 , PSI , V-set , Carb_anhydrase , ICAM_N , Ig_3 , MHC_I , Pentaxin , fn3
2) C2-set , FGF , SCF , I-set , LRR_8 , NGF , Carb_anhydrase , Ig_2 , PDGF , Telethonin , CSF-1 , IL34 , SBP_bac_1 , C2-set_2 , Ig_3 , Pkinase , fn3 , V-set
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
BCR 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
4) C2
5) RhoGAP
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
4) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
5) Ras , RhoGAP
1) Ig_2
2) I-set
3) Pkinase_Tyr
1) SCF , hEGF , C1-set , DUF1954 , IL1 , Ig_Tie2_1 , NGF , C2-set_2 , G2F , IL34 , LRR_8 , PDGF , S_100 , ig , CSF-1 , I-set , Ig_2 , Laminin_G_1 , PSI , V-set , Carb_anhydrase , ICAM_N , Ig_3 , MHC_I , Pentaxin , fn3
2) C2-set , FGF , SCF , I-set , LRR_8 , NGF , Carb_anhydrase , Ig_2 , PDGF , Telethonin , CSF-1 , IL34 , SBP_bac_1 , C2-set_2 , Ig_3 , Pkinase , fn3 , V-set
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
PDGFRA-BCR PDGFRA-BCR-Isoform3 - - 1) Bcr-Abl_Oligo
2) RhoGEF
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
PDGFRA 1) Ig_2
2) I-set
3) Pkinase_Tyr
1) SCF , hEGF , C1-set , DUF1954 , IL1 , Ig_Tie2_1 , NGF , C2-set_2 , G2F , IL34 , LRR_8 , PDGF , S_100 , ig , CSF-1 , I-set , Ig_2 , Laminin_G_1 , PSI , V-set , Carb_anhydrase , ICAM_N , Ig_3 , MHC_I , Pentaxin , fn3
2) C2-set , FGF , SCF , I-set , LRR_8 , NGF , Carb_anhydrase , Ig_2 , PDGF , Telethonin , CSF-1 , IL34 , SBP_bac_1 , C2-set_2 , Ig_3 , Pkinase , fn3 , V-set
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
BCR 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
4) C2
5) RhoGAP
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
4) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
5) Ras , RhoGAP
1) Ig_2
2) I-set
3) Pkinase_Tyr
1) SCF , hEGF , C1-set , DUF1954 , IL1 , Ig_Tie2_1 , NGF , C2-set_2 , G2F , IL34 , LRR_8 , PDGF , S_100 , ig , CSF-1 , I-set , Ig_2 , Laminin_G_1 , PSI , V-set , Carb_anhydrase , ICAM_N , Ig_3 , MHC_I , Pentaxin , fn3
2) C2-set , FGF , SCF , I-set , LRR_8 , NGF , Carb_anhydrase , Ig_2 , PDGF , Telethonin , CSF-1 , IL34 , SBP_bac_1 , C2-set_2 , Ig_3 , Pkinase , fn3 , V-set
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
PDGFRA-BCR hsa-miR-744-5phsa-miR-10a-5phsa-miR-197-3p hsa-let-7b-5phsa-miR-34a-5phsa-miR-140-5phsa-miR-26b-5p NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
PDGFRA-BCR NM_006206.4 1) MITF_HUMAN
2) STAT1_HUMAN
3) RB1_HUMAN
4) RBL2_HUMAN
5) P53_HUMAN
6) PRDM14_HUMAN
7) ETS1_HUMAN
8) EGR1_HUMAN
9) FOS_HUMAN
10) E2F1_HUMAN
11) CTCF_HUMAN
12) BRG1_HUMAN
13) HNF4A_HUMAN
14) TFAP2C_HUMAN
15) FOXA1_HUMAN
16) CEBPA_HUMAN
17) FOXP1_HUMAN
18) NR1H3_HUMAN
19) TRIM24_HUMAN
1) ZNF263_HUMAN
2) E2F4_HUMAN
3) RUNX1_HUMAN
4) ESTROGEN RECEPTOR ALPHA_HUMAN
5) GATA2_HUMAN
6) GATA3_HUMAN
7) SOX2_HUMAN
8) TAL1_HUMAN
9) STAT6_HUMAN
10) ESR1_HUMAN
11) ESR2_HUMAN
12) MEIS1_HUMAN
13) SPI1_HUMAN
1) 21258399
2) 19122651
3) 20385362
4) 20385362
5) 21394211
6) 20953172
7) 20019798
8) 20690147
9) 20139302
10) 21310950
11) 21795385
12) 19505939
13) 21646355
14) 21572391
15) 21572391
16) 20219941
17) 21924763
18) 22292898
19) 21164480

TicDB

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The fusion gene pair PDGFRA--BCR information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair PDGFRA--BCR information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair PDGFRA--BCR information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair PDGFRA--BCR information is not available in ConjoinG Database.

1000Genome

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Fusion gene PDGFRA--BCR has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene PDGFRA--BCR is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene PDGFRA--BCR is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene PDGFRA--BCR is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene PDGFRA--BCR was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair PDGFRA--BCR information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene PDGFRA--BCR is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene PDGFRA--BCR has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene PDGFRA is a known oncogene according to ONGENE database.


The tail gene BCR is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene PDGFRA is cancer associated according to Bushman Cancer Gene database.


The tail gene BCR is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene PDGFRA is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene BCR is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene PDGFRA--BCR is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene PDGFRA--BCR is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair PDGFRA--BCR information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene PDGFRA--BCR is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene PDGFRA--BCR has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair PDGFRA--BCR information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair PDGFRA--BCR information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair PDGFRA--BCR information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene PDGFRA--BCR is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair PDGFRA--BCR information is not available in ChromothripsisDB database.