NUP98--HOXA9

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NUP98 HOXA9

COSMIC

The fusion gene pair NUP98--HOXA9 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair NUP98--HOXA9 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
NUP98_HOXA9-/-/ -/-/ - hg18 acute myeloid leukemia - - Oncogene; Transcription_Factor Mitelman
NUP98_HOXA9-/-/ -/-/ - hg18 acute myelomonocytic leukemia - - Oncogene; Transcription_Factor Mitelman
NUP98_HOXA9-/-/ -/-/ - hg18 chronic myelomonpcytic leukemia - - Oncogene; Transcription_Factor Mitelman
NUP98_HOXA9-/0/ -/488/ Exonic hg18 - - - Oncogene; Transcription_Factor TICdb
NUP98_HOXA9-/0/ -/491/ Exonic hg18 - - - Oncogene; Transcription_Factor TICdb
NUP98_HOXA9-/-/ -/-/ - hg18 acute myeloid leukemia - 11986249 Oncogene; Transcription_Factor OMIM
NUP98_HOXA9-/-/ -/-/ - hg18 myeloid leukemia - 8563754 Oncogene; Transcription_Factor OMIM

ChimerPUB

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The fusion gene pair NUP98--HOXA9 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
NUP98_HOXA9t(1;21)(p32;q22) / t(7;11)(p15;p15) / t(1;21) / 19005624leukemia FISH - Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9.. /// "NUP98-HOXA9 was detected again and karyotypic analysis revealed 46,XY, t(1;21)(p32;q22). " /// " We report a 29-year-old Japanese male with acute myelogenous leukemia (AML)-M4 with a cryptic t(7;11)(p15;p15), in which a chimeric NUP98-HOXA9 fusion was detected by polymerase chain reaction analysis and a chromosomal analysis showed 46,XY. " /// "The patient received intensive chemotherapy and underwent autologous stem cell transplantation, and remission was confirmed by the disappearance of NUP98-HOXA9. "
NUP98_HOXA9t(11;12) / t(7;11)(p15;p15) / 26542893acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR - ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9..
NUP98_HOXA9t(7;11)(p15;p15) / 26418229acute myeloid leukemia;chronic myeloid leukemia;myeloid leukemia;myelodysplastic syndrome;leukemia; FISH;PCR;RT-PCR - Cytogenetic and FISH analysis revealed t(7;11)(p15;p15) and NUP98-HOXA9 fusion gene was demonstrated. /// "Genetic fusion NUP98-HOXA9, caused by t(7;11)(p15;p15), is a recurrent cytogenetic alteration in de novo acute myeloid leukemia (AML) usually found in young Asian patients and its description in therapy-related myeloid neoplasms (t-MN) is rare. " /// "Molecular demonstration of the genetic fusion NUP98-HOXA9 was performed by RT-PCR, and gene expression was analyzed by real-time PCR, including four AML patients with MLL rearrangements for comparative analysis. " /// "NUP98-HOXA9 bearing therapy-related myeloid neoplasm involves myeloid-committed cell and induces HOXA5, EVI1, FLT3, and MEIS1 expression.. " /// Only one Asian case with molecular demonstration of the NUP98-HOXA9 fusion has been reported in therapy-related leukemia. /// "In this work, we include a detailed molecular, clinical, cytological, and cytometric study of the second t-AML bearing NUP98-HOXA9 genetic fusion.. " /// "NUP98-HOXA9 leukemogenic mechanism is derived from the transcription factor activity of the chimeric protein, which enhances the expression of genes related to cellular differentiation arrest and proliferation. "
NUP98_HOXA9t(7;11)(p15;p15) / 11830496myeloid leukemia;myelodysplastic syndrome;leukemia PCR - It has been demonstrated that the chromosomal translocation t(7;11)(p15;p15) in patients with human acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML) invariably involves fusion of the nucleoporin gene, NUP98, on chromosome 11 and the class 1 HOX gene, HOXA9, on chromosome 7, and that the fusion gene NUP98-HOXA9 is an important gene in myeloid leukemogenesis. /// Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15).. /// In both patients chimeric NUP98-HOXA9 transcripts were also observed.
NUP98_HOXA9t(7;11)(p15;p15) / 12112533acute myeloid leukemia;myeloid leukemia;leukemia;hematologic malignancy PCR;RT-PCR - The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). /// "The protein encoded by the NUP98-HOXA13 fusion gene is similar to that encoded by NUP98-HOXA9, and the expression pattern of the HOXA13 gene in leukemic cell lines is similar to that of the HOXA9 gene, suggesting that the NUP98-HOXA13 fusion protein may play a role in leukemogenesis through a mechanism similar to that of the NUP98-HOXA9 fusion protein.. " /// "The NUP98-HOXA13 fusion protein consists of the N-terminal phenylalanine-glycine repeat motif of NUP98 and the C-terminal homeodomain of HOXA13, similar to the NUP98-HOXA9 fusion protein. "
NUP98_HOXA9t(7;11)(p15;p15) / 19338047myeloid leukemia - - The NUP98-HOXA9 fusion gene with t(7;11)(p15;p15) was identified and revealed to be essential for leukemogenesis and myeloproliferative disease.
NUP98_HOXA9t(7;11)(p15;p15) / t(7;11) / t(7;11) / 10583265myelodysplastic syndrome - - Molecular heterogeneity of the NUP98/HOXA9 fusion transcript in myelodysplastic syndromes associated with t(7;11)(p15;p15).. /// Each of them lacked the common 141 bp NUP98 exon which was contained in the NUP98/HOXA9 fusion transcripts detected in patient 2 and the reported AML cases. /// Patient 1 had two types of the novel NUP98/HOXA9 fusion transcripts. /// The invariant chimaeric NUP98/HOXA9 transcripts are a result of the fact that each breakpoint of the NUP98 and the corresponding breakpoint of the HOXA9 gene cluster occur within the same intron.
NUP98_HOXA9t(7;11) / t(7;11) / 15721637acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - The NUP98-HOXA9 fusion transcript was detected by RT-PCR, suggesting its role in the malignant transformation as it has been postulated for other t(7;11)-associated leukemias.
NUP98_HOXA9t(7;11)(p15;p15) / t(7;11) / t(9;22)(q34;q11) / 10848835- - - Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15).. /// We report the first case with CML expressing the NUP98/HOXA9 fusion transcript. /// "Reverse transcriptase polymerase chain reaction identified the NUP98/HOXA9 transcript, suggesting that the NUP98/HOXA9 fusion protein could play a critical role in the progression to blast crisis.. "
NUP98_HOXA9t(7;11)(p15;p15) / 11241795myelodysplastic syndrome;leukemia - - As expected, analysis of the t(7;11)(p15;p15) from one of the patients showed an in-frame NUP98-HOXA9 fusion. /// The fusion points were similar to previously reported NUP98-HOXA9 fusion points from patients with MDS/AML.
NUP98_HOXA9t(7;11) / t(7;11)(p15;p15) / t(7;11) / 10221343acute myeloid leukemia;myeloid leukemia;leukemia - - To ascertain the molecular features and the clinicopathological and prognostic significance of t(7;11)(p15;p15), 208 adult Chinese patients with AML were screened by Southern blot analysis with an HOXA9 cDNA probe and reverse transcription-polymerase chain reaction for NUP98/HOXA9. /// "Two cases were found to have an NUP98/HOXA9 fusion transcript, with a breakpoint at NUP98 different from that previously described. " /// "The remaining case had no rearrangement of NUP98, nor was NUP98/HOXA9 detected. "
NUP98_HOXA9t(7;11) / t(7;11) / 9074407- - - Recently, a consistent chimaeric fusion transcript NUP98-HOXA9 was found in several cases of t(7;11). /// The molecular detection of NUP98-HOXA9 fusion transcript would be a useful method for the diagnosis of t(7;11) and also for monitoring disease status after treatment.. /// NUP98-HOXA9 fusion transcript was detected in both patients who had molecular analysis and the breakpoints on chromosome 11 and 7 respectively were similar to those previously reported.
NUP98_HOXA9- 9858599- - - Here we demonstrate that the NUP98-HOXA9 fusion gene encodes two nuclear oncoproteins with either 19 or 37 NUP98 FG repeats fused to the DNA binding and PBX heterodimerization domains of the transcription factor HOXA9. /// CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity.. /// "Together, our results suggest that NUP98-HOXA9 chimeras are aberrant transcription factors that deregulate HOX-responsive genes through the transcriptional activation properties of nucleoporin-specific FG repeats that recruit CBP/p300. " /// "Both NUP98-HOXA9 chimeras transformed NIH 3T3 fibroblasts, and this transformation required the HOXA9 domains for DNA binding and PBX interaction. "
NUP98_HOXA911p15.5 / t(7;11)(p15;p15) / 17442773acute myeloid leukemia;chronic myeloid leukemia;myeloid leukemia;myelodysplastic syndrome;leukemia - - NUP98-HOXA9 is associated with the t(7;11)(p15;p15) translocation in acute myeloid leukemia (AML), myelodysplastic syndrome, and blastic crisis of chronic myeloid leukemia. /// Expression of NUP98-HOXA9 in murine bone marrow resulted in a myeloproliferative disease progressing to AML by 7-8 months. /// NUP98-HOXA9 expression inhibited erythroid and myeloid differentiation but enhanced serial progenitor replating. /// "NUP98-HOXA9 upregulated a number of homeobox genes of the A and B cluster as well as MEIS1 and Pim-1, and downmodulated globin genes and C/EBPalpha. " /// The HOXA9 component of the NUP98-HOXA9 fusion protein was protected from cullin-4A-mediated ubiquitination and subsequent proteasome-dependent degradation.
NUP98_HOXA9t(7;11)(p13;p14) / t(7;11)(p15;p15) / 10936866down syndrome - - NUP98-HOXA9 chimera mRNA, which is known to be involved in t(7;11)(p15;p15) translocation in acute myeloid leukemia (AML), was not detected by reverse transcriptase-polymerase chain reaction, and NUP98 rearrangement was not detected by Southern blot analysis of the blasts in the MDS phase.
NUP98_HOXA9t(7;11)(p15;p15) / t(7;11) / 24971156chronic myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - Musashi2(Msi2)-Numb pathway de-regulation is a molecular mechanism underlying the transition of chronic phase Ph?+?CML to deadly blast crisis, particularly in cases with a NUP98/HOXA9 fusion from a t(7;11)(p15;p15).
NUP98_HOXA9t(7;11) (p15;p15) / 21810091- - - NUP98-HOXA9 [t(7;11) (p15;p15)] is associated with inferior prognosis in de novo and treatment-related acute myeloid leukaemia (AML) and contributes to blast crisis in chronic myeloid leukaemia (CML). /// "NUP98-HOXA9 perturbed zebrafish embryonic haematopoiesis, with upregulated spi1 expression at the expense of gata1a. " /// "Markers associated with more differentiated myeloid cells, lcp1, lyz, and mpx were also elevated, but to a lesser extent than spi1, suggesting differentiation of early myeloid progenitors may be impaired by NUP98-HOXA9. "
NUP98_HOXA9t(7;11)(p15;p15) / 10565304acute myeloid leukemia;myeloid leukemia;leukemia - - In this report, we describe the unique occurrence of t(7;11)(p15;p15) and NUP98/HOXA9 fusion in a patient with chronic myelomonocytic leukemia, and suggest that the genetic lesion may involve multipotential myeloid stem cells.. /// Chronic myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98/HOXA9 fusion..
NUP98_HOXA9t(9;22)(q34;q22) / t(7;11)(p15;p15) / 12032333acute myeloid leukemia;chronic myeloid leukemia;myeloid leukemia;leukemia - - Progression of CML to acute leukemia (blast crisis) in humans has been associated with acquisition of secondary chromosomal translocations, including the t(7;11)(p15;p15) resulting in the NUP98/HOXA9 fusion protein. /// We demonstrate that BCR/ABL cooperates with NUP98/HOXA9 to cause blast crisis in a murine model. /// "These experiments document cooperative effects between constitutively activated tyrosine kinases, which confer proliferative and survival properties to hematopoietic cells, with mutations that impair differentiation, such as the NUP98/HOXA9, giving rise to the acute myeloid leukemia (AML) phenotype. " /// "The phenotype depends both on expression of BCR/ABL and NUP98/HOXA9, but tumors retain sensitivity to the ABL inhibitor STI571 in vitro and in vivo. " /// A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9..
NUP98_HOXA9t(7;11)(p15;p15) / t(7;11) / 19225539acute myeloid leukemia;myeloid leukemia;leukemia - - Acute myeloid leukemia (AML) with t(7;11)(p15;p15), which results in a NUP98-HOXA9 fusion, is a distinct entity, but this subtype has not been characterized in detail. /// "The NUP98-HOXA9 fusion was strongly associated with KRAS and WT1 mutations (P=0.015 and P=0.0018, respectively). " /// "AML with NUP98-HOXA9 fusion therefore appears to have a distinct clinical and biological profile, and should be regarded as a poor prognostic group.. "
NUP98_HOXA9t(7;11)(p15;p15) / 11841413- - - Although it is well known that a fusion of NUP98-HOXA9 in myeloid malignancies is created by the t(7;11)(p15;p15), this case suggests the possibility that HOXA11 might be another partner gene for NUP98 in t(7;11)(p15;p15) leukaemia..
NUP98_HOXA9t(7;11)(p15;p15) / 16818636acute myeloid leukemia;myeloid leukemia;myelodysplastic syndrome;leukemia - - NUP98-HOXA9, the chimeric protein resulting from the t(7;11)(p15;p15) chromosomal translocation, is a prototype of several NUP98 fusions that occur in myelodysplastic syndromes and acute myeloid leukemia. /// "These findings provide a comprehensive picture of the changes in proliferation, differentiation, and global gene expression that underlie the leukemic transformation of human hematopoietic cells by NUP98-HOXA9.. " /// Colony-forming cell (CFC) assays in semisolid medium combined with morphologic examination and flow cytometric immunophenotyping revealed that NUP98-HOXA9 increased the numbers of erythroid precursors and impaired both myeloid and erythroid differentiation. /// "In continuous liquid culture, cells transduced with NUP98-HOXA9 exhibited a biphasic growth curve with initial growth inhibition followed by enhanced long-term proliferation, suggesting an increase in the numbers of primitive self-renewing cells. " /// NUP98-HOXA9 induces long-term proliferation and blocks differentiation of primary human CD34+ hematopoietic cells.. /// "To understand the molecular mechanisms underlying the effects of NUP98-HOXA9 on hematopoietic cell proliferation and differentiation, oligonucleotide microarray analysis was done at several time points over 16 days, starting at 6 hours posttransduction. "
NUP98_HOXA9t(7;11)(p15;p15) / 12138901acute myeloid leukemia;chronic myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - The NUP98/HOXA9 fusion transcript was detected by reverse transcription-polymerase chain reaction (RT-PCR) at exon A but not exon B of NUP98..
NUP98_HOXA9- 15963848leukemia - - Translocations resulting in development of oncogenic fusion genes are found in AML and the transforming potential of two of these, AML1-ETO and NUP98-HOXA9, will be discussed.
NUP98_HOXA9t(7;11)(p15;p15) / 8563754- - - The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport..
NUP98_HOXA9t(7;11) / 12082612- - - The association between acute myeloid leukaemia (AML) and the aberrant expression of Hoxa9 is evidenced by (1) proviral activation of Hoxa9 and Meis1 in BXH-2 murine AML, (2) formation of the chimeric Nup98-HoxA9 transactivator protein as a consequence of the t(7;11) translocation in human AML, and (3) the strong expression of HoxA9 and Meis1 in human AML. /// "Here we report that Nup98-HoxA9, indeed mimicks Hoxa9 plus Meis1 coexpression - it immortalizes myeloid progenitors, prevents differentiation in response to GM-CSF, IL-3, G-CSF, and permits proliferation in SCF. " /// "Using Hoxa9(-/-) marrow, we demonstrate that expression of Hoxa9 is not required for myeloid immortalization by Nup98-HoxA9. " /// "Because Meis1 binds N-terminal Hoxa9 sequences that are replaced by Nup98, we hypothesized that Nup98-HoxA9 might consolidate the biochemical functions of both Hoxa9 and Meis1 on target gene promoters and might evoke their same lymphokine-responsive profile in immortalized progenitors. " /// "Rapid leukaemogenesis by Nup98-HoxA9 may therefore result from both the intrinsic functions of Nup98-HoxA9, as well as of those of coexpressed HOX and MEIS1 genes.. " /// "Unexpectedly, however, Nup98-Hoxa9 also enforced strong transcription of the cellular Hoxa9, Hoxa7 and Meis1 genes at levels similar to those found in mouse AML's generated by proviral activation of Hoxa9 and Meis1. " /// "Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1.. " /// "In contrast, retroviral expression of Nup98-HoxA9 is sufficient to cause rapid AML in the absence of enforced Meis1 expression. "
NUP98_HOXA9t(7;11)(p15;p15) / t(7;11) / 8563753- - - The translocation produces an invariant chimaeric NUP98/HOXA9 transcript containing the amino terminal half of NUP98 fused in frame to HOXA9.
NUP98_HOXA9t(10;11)(q23;p15) / 18388181acute myeloid leukemia;myeloid leukemia;leukemia - - Comparative gene expression profiling in primary bone marrow cells provided evidence for the presence of common targets in cells expressing NUP98/HOXA9 or NUP98/HHEX. /// "Expression of EGFP-NUP98/HHEX fusions showed a highly similar nuclear localization pattern as for other NUP98/homeodomain fusions, such as NUP98/HOXA9. "
NUP98_HOXA9- 14561764leukemia PCR - Co-transfection experiments using a luciferase reporter linked to the promoter of one of the Nup98-HOXA9 target genes confirmed up-regulation at the transcriptional level by Nup98-HOXA9 but not by either HOXA9 or Nup98. /// "Of the 102 Nup98-HOXA9 target genes identified, 92 were up-regulated, and only 10 were down-regulated, suggesting a transcriptional activation function. " /// These data indicate that Nup98-HOXA9 is an aberrant transcription factor whose activity depends on the HOXA9 DNA binding domain but has a stronger and wider transcriptional effect than HOXA9. /// The oncogene Nup98-HOXA9 induces gene transcription in myeloid cells.. /// "To understand the mechanisms by which Nup98-HOXA9 causes AML, we expressed it in myeloid cells and identified its target genes using high density oligonucleotide microarrays. " /// "The prototype of these fusions, Nup98-HOXA9, is associated with human AML and induces AML in mouse models. "
NUP98_HOXA9- 20339440acute myeloid leukemia;myeloid leukemia;leukemia - - Comparison to another leukemogenic NUP98 fusion, NUP98-HOXA9, reveals a number of genes deregulated by both oncoproteins, including HOX genes, COX-2, MYCN, ANGPT1, REN, HEY1, SOX4 and others.
NUP98_HOXA9t(1;11) / 16651408chronic myeloid leukemia;myeloid leukemia;leukemia - - Moreover, we have provided evidence that the FG domains of NUP98-PMX1 and two other NUP98-containing fusion proteins, i.e., NUP98-HOXA9 and NUP98-HOXC11, all exhibit dual binding ability to both CREB binding protein, a coactivator, and histone deacetylase 1, a corepressor.
NUP98_HOXA9t(1;11)(q23;p15) / t(7;11)(p15;p15) / t(2;11)(q35;p15) / inv(11)(p15;q22) / 10397741- - - Like the NUP98-HOXA9 fusion, NUP98 and PMX1 were fused in frame and the N-terminal GLFG-rich docking region of the NUP98 and the PMX1 homeodomain were conserved in the NUP98-PMX1 fusion, suggesting that PMX1 homeodomain expression is upregulated and that the fusion protein may act as an oncogenic transcription factor.
NUP98_HOXA9- 17601986myeloid leukemia;leukemia - - Primitive normal hematopoietic cells were modified to express the BCR/ABL and Nup98/HoxA9 translocation products, and a distinct LSC population, with the aberrant immunophenotype of lineage(-), Kit(+/-), Flt3(+), Sca(+), CD34(+), and CD150(-), was identified.
NUP98_HOXA9- 11369863leukemia - - Several human leukemias have been associated with a chromosomal translocation involving either the Hox gene (i.e., NUP98/HOXA9) or the gene encoding Pbx1 (E2A/PBX1).
NUP98_HOXA9- 15454493myeloid leukemia;leukemia - - Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.. /// These genes cooperated with NUP98-HOXA9 in transforming NIH 3T3 cells. /// "This suggested that the NUP98-HOXA9 fusion induced a preleukemic phase, and other factors were required for complete leukemogenesis. " /// We generated a transgenic mouse line that specifically expressed the chimeric NUP98-HOXA9 gene in the myeloid lineage. /// NUP98-HOXA9 expression promoted the onset of retrovirus-induced BXH2 myeloid leukemia.
NUP98_HOXA9t(2;11)(q31;p15) / 9766650leukemia ISH - The NUP98-HOXD13 fusion is structurally similar to the NUP98-HOXA9 fusion previously identified in patients with AML, leading to the speculation that NUP98-homeobox gene fusions may be oncogenic.
NUP98_HOXA9t(11;17)(p15;p13) / 27060678acute myeloid leukemia;myeloid leukemia;leukemia;hematologic malignancy - - Gene set enrichment analysis (GSEA) demonstrates that NUP98-PHF23 fusion shares gene expression signature of NUP98-HOXA9 fusion, the prototype of the NUP98-associated fusions, as well as the signature of leukemic stem cells.

ChimerSEQ

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The fusion gene pair NUP98--HOXA9 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
NUP98_HOXA9chr11/3765784/ chr7/27203339/ 11p15.4 7p15.2 Exonic hg19 - Inter-chr acute myeloid leukemia;chronic myeloid leukemia;chromic myelomonocytic leukemia U41814 Oncogene; Transcription_Factor ChiTaRs

ChiTaRS 2.1

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The fusion gene pair NUP98--HOXA9 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human U41814NUP98--HOXA9 NUP9811 3765739 3765784 - 1 46 100 HOXA97 27203339 27204588 - 45 258 99.6

FARE-CAFE

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The fusion gene pair NUP98--HOXA9 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
NUP98-HOXA9 acute myeloid leukemia of the M2 and M4 Southern blot and polymerase chain reaction t(7;11)(p15;p15) PubMed: 8563754,15496970

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
NUP98-HOXA9 NUP98-HOXA9-Isoform1 NUP98 3774587 1 0 HOXA9 _ 0 _ CTGGGACTCTTGGAACTGGGCTTGGTGCAGGATTTGGAACAgTTGATAGAGAAAAAC 10583265 _
NUP98-HOXA9 NUP98-HOXA9-Isoform2 NUP98 3765784 1 0 HOXA9 27204542 0 1 ACTACGACAGCCACTTTGGGCTTTGGAGCCCCCCAGGCCCCAGTAgTTGATAGAGAAAAACAACCCAGCGAAGGCGCCTTCTCTGAAAACA _ U41814

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
NUP98-HOXA9 NUP98-HOXA9-Isoform1 1) Nucleoporin2
2) Nup96
1) Nucleoporin2
2) Nup96 , WD40 , Nup84_Nup100
- -NUP98 1) Nucleoporin2
2) Nup96
1) Nucleoporin2
2) Nup96 , WD40 , Nup84_Nup100
HOXA9 1) Hox9_act
2) Homeobox
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
1) Hox9_act
2) Homeobox
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
NUP98-HOXA9 NUP98-HOXA9-Isoform2 1) Nucleoporin2
2) Nup96
1) Nucleoporin2
2) Nup96 , WD40 , Nup84_Nup100
- -NUP98 1) Nucleoporin2
2) Nup96
1) Nucleoporin2
2) Nup96 , WD40 , Nup84_Nup100
HOXA9 1) Hox9_act
2) Homeobox
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
1) Hox9_act
2) Homeobox
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
NUP98-HOXA9 _ hsa-miR-34a-5phsa-miR-98-5phsa-miR-652-3phsa-miR-18a-3phsa-miR-149-5phsa-miR-30a-3phsa-miR-16-5p _

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
NUP98-HOXA9 NM_005387.5 1) STAT1_HUMAN
2) RB1_HUMAN
3) RBL2_HUMAN
4) E2F4_HUMAN
5) RUNX1_HUMAN
6) ETS1_HUMAN
7) FOS_HUMAN
8) GATA3_HUMAN
9) TAL1_HUMAN
10) BRG1_HUMAN
11) HNF4A_HUMAN
12) TFAP2C_HUMAN
13) CEBPA_HUMAN
14) MEIS1_HUMAN
15) FOXP1_HUMAN
16) SETDB1_HUMAN
17) TRIM24_HUMAN
1) EGR1_HUMAN
2) GATA2_HUMAN
3) CTCF_HUMAN
4) ESR1_HUMAN
5) VDR_HUMAN
1) 19122651
2) 20385362
3) 20385362
4) 21247883
5) 20019798
6) 20019798
7) 20139302
8) 21878914
9) 21795385
10) 19505939
11) 21646355
12) 21572391
13) 20219941
14) 21241896
15) 21924763
16) 21430779
17) 21164480

TicDB

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The fusion gene pair NUP98--HOXA9 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
NUP98 HOXA9 10583265 CTGGGACTCTTGGAACTGGGCTTGGTGCAGGATTTGGAACAgTTGATAGAGAAAAAC
NUP98 HOXA9 U41814 ACTACGACAGCCACTTTGGGCTTTGGAGCCCCCCAGGCCCCAGTAgTTGATAGAGAAAAACAACCCAGCGAAGGCGCCTTCTCTGAAAACA

TUMOR FUSION Gene Data Portal

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The fusion gene pair NUP98--HOXA9 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair NUP98--HOXA9 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair NUP98--HOXA9 information is not available in ConjoinG Database.

1000Genome

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Fusion gene NUP98--HOXA9 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene NUP98--HOXA9 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene NUP98--HOXA9 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene NUP98--HOXA9 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene NUP98--HOXA9 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair NUP98--HOXA9 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene NUP98--HOXA9 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene NUP98--HOXA9 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene NUP98 is a known oncogene according to ONGENE database.


The tail gene HOXA9 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene NUP98 is cancer associated according to Bushman Cancer Gene database.


The tail gene HOXA9 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene NUP98 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene HOXA9 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene NUP98--HOXA9 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene NUP98--HOXA9 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair NUP98--HOXA9 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene NUP98--HOXA9 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene NUP98--HOXA9 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair NUP98--HOXA9 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair NUP98--HOXA9 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair NUP98--HOXA9 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene NUP98--HOXA9 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair NUP98--HOXA9 information is not available in ChromothripsisDB database.