NTRK3--ETV6

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1000Genome18CancersBodymap2HPANon_Tumor_Cells
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NTRK3 ETV6

COSMIC

The fusion gene pair NTRK3--ETV6 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair NTRK3--ETV6 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
NTRK3_ETV6-/1907/ -/1284/ Exonic hg19 - - - Kinase; Cosmic_recurrent
NTRK3_ETV6-/-/ -/-/ - hg19 congenital fibrosarcoma - 11169520 Kinase; Cosmic_nonrecurrent
NTRK3_ETV6-/-/ -/-/ - hg18 fibrosarcoma - 9462753 Kinase; OMIM

ChimerPUB

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The fusion gene pair NTRK3--ETV6 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
NTRK3_ETV6t(12;15) / p13;q25 / t(12;15)(p13;q25) / 9811336sarcoma FISH - The aims of this study were to determine whether congenital mesoblastic nephroma contains the t(12;15)(p13;q25) translocation and ETV6-NTRK3 gene fusion and whether ETV6-NTRK3 fusions, in CMN and CFS, antedate acquisition of nonrandom chromosome polysomies. /// 15)(p13;q25) translocation resulting in ETV6-NTRK3 gene fusion. /// Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma..
NTRK3_ETV6t(12;15)(p13;q25) / 11743047congenital mesoblastic nephroma;fibrosarcoma FISH - Recently, a t(12;15)(p13;q25) resulting in ETV6-NTRK3 gene fusion was detected in patients with IFS and in patients with the cellular type of CMN, suggesting a common pathogenetic pathway.
NTRK3_ETV6t(12;15) / 19011601breast carcinoma;sarcoma FISH - Remarkably, this entity is the only epithelial tumor of the breast with a balanced translocation, t(12;15), that creates an ETV6-NTRK3 gene fusion encoding chimeric tyrosine kinase also encountered in cellular mesoblastic nephroma and infantile fibrosarcoma.
NTRK3_ETV6t(12;15)(p13;q25) / 15101049breast cancer;breast carcinoma;sarcoma FISH - We tested four histologically confirmed cases of SBC for the presence of the ETV6-NTRK3 gene fusion and then applied the FISH assay to tissue microarrays (TMAs) in order to screen 481 cases of formalin-fixed, paraffin-embedded invasive breast carcinomas of various histologic subtypes.
NTRK3_ETV6t(12;15)(p13;q25) / 26291510breast carcinoma FISH - All interpretable cases harbored an ETV6-NTRK3 gene fusion by reverse transcription polymerase chain reaction and/or an ETV6 rearrangement by fluorescence in situ hybridization, with duplication of the oncogenic derivative in 2 cases. /// "Histologic and immunohistochemical analyses, fluorescence in situ hybridization using break-apart probes specific to ETV6 on 12p13, reverse transcription polymerase chain reaction with in-house probes specific to the ETV6-NTRK3 gene fusion, and DNA copy number variation by array comparative genomic hybridization analyses were performed on all cases. " /// Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion.. /// "The 2 cases with ETV6-NTRK3 duplication included a gain of 12p starting from the ETV6 locus to the telomere, associated with a gain of the 15q from the centromere to NTRK3 in 1 case, and in the other a normal profile up to NTRK3 on 15q, and then a loss up to the telomere, suggesting loss of corresponding normal chromosome 15. "
NTRK3_ETV6- 27020209mesoblastic nephroma FISH - Fluorescence in situ hybridisation (FISH) testing for ETV6-NTRK3 gene fusion/rearrangement revealed further differentiation between the subtypes with ETV6-NTRK3 gene fusion detected in 0/5 of the classic MN, 8/8 of the cellular MN and 5/6 of the mixed MN cohorts, respectively.
NTRK3_ETV6- 26606880sarcoma FISH - Intriguingly, the analysis unveiled the presence of an ETV6-NTRK3 gene fusion. /// Transcriptome sequencing identifies ETV6-NTRK3 as a gene fusion involved in GIST.. /// The fusion transcript identified encompasses exon 4 of ETV6 and exon 14 of NTRK3 and therefore differs from the canonical ETV6-NTRK3 chimera of infantile fibrosarcomas.
NTRK3_ETV6t(12;15) / 18462362breast cancer;acinic cell carcinoma FISH - It has been demonstrated that SCs of the breast consistently harbour the t(12;15)ETV6-NTRK3 translocation.
NTRK3_ETV6t(12;15)(p13;q25) / 23807775acinic cell carcinoma FISH - Mammary analog secretory carcinoma of salivary gland is a recently described entity with unique morphologic, clinical, and genetic characteristics, including the characteristic t(12;15)(p13;q25) with ETV6-NTRK3 translocation found in secretory carcinomas of the breast. /// "Mammary analog secretory carcinoma of salivary gland is a recently described entity with unique morphologic, clinical, and genetic characteristics, including the characteristic t(12;15)(p13;q25) with ETV6-NTRK3 translocation found in secretory carcinomas of the breast." /// The ETV6-NTRK3 gene rearrangement was detected in three tumors.
NTRK3_ETV6t(12;15)(p13;q25) / 23225548acinic cell carcinoma;adenocarcinoma FISH - Mammary analogue secretory carcinoma (MASC) of the salivary glands is a newly described tumor entity associated with the t(12;15)(p13;q25) ETV6-NTRK3 translocation.
NTRK3_ETV6- 23955668acinic cell carcinoma FISH;PCR;RT-PCR - Mammary analogue secretory carcinoma (MASC) is a recently described malignancy of the salivary glands characterized by an ETV6-NTRK3 (EN) fusion gene.
NTRK3_ETV6- 12594387chronic myeloid leukemia;myeloid leukemia;leukemia;anaplastic large cell lymphoma;sarcoma;lymphoma FISH - The description of ALK gene rearrangements in IMT and ALCL is the second example, after the observation of ETV6-NTRK3 in congenital fibrosarcoma and in a case of chronic myeloid leukemia, of identical gene fusions occurring in two different cell lines: hematopoietic and mesenchymal.
NTRK3_ETV6- 25703106- FISH;PCR;RT-PCR - Mammary analog secretory carcinoma (MASC) is a newly described rare malignancy of the salivary glands characterized by an ETS variant 6 (ETV6)-neurotrophic tyrosine kinase receptor type 3 (NTRK3) fusion gene (EN fusion gene).
NTRK3_ETV6- 15963235breast carcinoma;breast carcinoma FISH - His tumor showed the ETV6-NTRK3 translocation as demonstrated by fluorescent in situ hybridization (FISH). /// "Recently, the tumor was associated with the ETV6-NTRK3 gene translocation. "
NTRK3_ETV6- 23021923acinic cell carcinoma;adenocarcinoma FISH - Fluorescence in situ hybridization (FISH) for the ETV6-NTRK3 translocation was performed.
NTRK3_ETV6- 25503077adenocarcinoma FISH;PCR;RT-PCR - Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumour that harbours the recurrent ETV6-NTRK3 translocation.
NTRK3_ETV6- 23483204acinic cell carcinoma;adenocarcinoma;salivary gland cancer FISH - A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed.
NTRK3_ETV6- 25976476acinic cell carcinoma FISH - Mammary analogue secretory carcinoma (MASC) has a specific ETV6-NTRK3 translocation and morphologically overlaps with acinic cell carcinoma (AciCC).
NTRK3_ETV6- 26252941salivary gland cancer FISH - It is known that overexpression of signal transducer and activator of transcription 5a (STAT5a) occurs in secretory carcinoma of the breast and MASC, and STAT5a expression may be related to the ETV6-NTRK3 translocation.
NTRK3_ETV6t(12;15)(p13;q25) / 11242790spindle cell sarcoma PCR;RT-PCR - CIFSs have been found to have a novel recurrent reciprocal translocation t(12;15)(p13;q25) resulting in the gene fusion ETV6-NTRK3 (ETS variant gene 6.
NTRK3_ETV6t(12;15)(p13;q25) / 10895816myofibromatosis PCR;RT-PCR - The authors recently identified a novel chromosomal translocation in CFS, t(12;15)(p13;q25), which gives rise to an ETV6-NTRK3 gene fusion. /// "Of the 11 cases diagnosed as CFS, 10 showed the ETV6-NTRK3 gene fusion, whereas none of the 51 other malignant or benign spindle cell tumors demonstrated this fusion gene. " /// "To confirm the use of this assay in the differential diagnosis of CFS, they have screened a larger series of childhood pediatric spindle cell lesions for ETV6-NTRK3 gene fusions, including 11 cases of CFS, 13 malignant spindle cell tumors (including ATFS), and 38 benign spindle cell tumors (including IFB and MFB). " /// "They conclude that RT-PCR analysis is superior to these techniques for the detection of the ETV6-NTRK3 gene fusion in pediatric spindle cell tumors, and it is a reliable and specific modality for the diagnosis of CFS.. " /// Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors.. /// "They conclude that RT-PCR analysis is superior to these techniques for the detection of the ETV6-NTRK3 gene fusion in pediatric spindle cell tumors, and it is a reliable and specific modality for the diagnosis of CFS.." /// They also compared their RT-PCR findings with those of conventional cytogenetics and with immunohistochemical detection of the ETV6-NTRK3 protein using antisera to NTRK3.
NTRK3_ETV6t(12;15) / 19629465pseudoaneurysm PCR;RT-PCR - The cellular tumors shared histopathologic features with infantile fibrosarcoma (IFS), and RT-PCR testing in two children with the cellular form revealed the t(12;15) ETV6-NTRK3 gene fusion common to IFS.
NTRK3_ETV6t(12;15)(p13;q25) / 21843073fibrosarcoma;sarcoma - - All tumors demonstrated CIFS's characteristic t(12;15)(p13;q25) and associated ETV6-NTRK3 gene fusion. /// "One of the three lung cases was previously reported as primary bronchopulmonary fibrosarcoma (PBPF), but molecular analysis of the paraffin embedded tissue revealed the ETV6-NTRK3 gene fusion consistent with CIFS. " /// "We show that CIFS may occur in unusual sites including visceral locations, and we propose that neoplasms displaying the ETV6-NTRK3 gene fusion represent the visceral components of CIFS.. "
NTRK3_ETV6t(12;15)(p13;q25) / t(6;11)(p21;q12) / 12973047rhabdoid tumor - - The cellular variant of congenital mesoblastic nephroma (but not the classic variant) has been shown to bear the same t(12;15)(p13;q25) and ETV6-NTRK3 gene fusion as infantile fibrosarcoma, a tumor with which it shares morphologic and clinical features.
NTRK3_ETV6t(12;15)(p13;q25) / 9823307mesoblastic nephroma - - We show here that t(12;15)(p13;q25)-associated ETV6-NTRK3 gene fusions described in CFS are also present in cellular CMN. /// ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma.. /// "Moreover, we found trisomy 11 only in cellular or mixed CMNs with the ETV6-NTRK3 gene fusion. " /// ETV6-NTRK3 chimeric transcripts were detected in 8 of 9 cellular CMNs and 2 of 2 mixed CMNs.
NTRK3_ETV6t(12;15) / 22129193breast carcinoma;breast carcinoma - - Recent studies have shown the characteristic molecular feature: a balanced translocation t(12;15), resulting in an ETS variant 6-neurotrophic tyrosine kinase receptor type 3 (ETV6-NTRK3) fusion gene encoding a chimeric tyrosine kinase.
NTRK3_ETV6t(12;15)(p13;q25) / 23131561leukemia;breast carcinoma;sarcoma - - The ETV6-NTRK3 (EN) fusion gene which encodes a chimeric tyrosine kinase was first identified by cloning of the t(12;15)(p13;q25) translocation in congenital fibrosarcoma (CFS). /// ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412..
NTRK3_ETV6t(12;15)(p13;q25) / 9462753sarcoma - - A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.. /// "Moreover, ETV6-NTRK3 gene fusions provide a potential diagnostic marker for CFS.. " /// ETV6-NTRK3 fusion transcripts encode the helix-loop-helix (HLH) protein dimerization domain of ETV6 fused to the protein tyrosine kinase (PTK) domain of NTRK3. /// Analysis of mRNA revealed the expression of ETV6-NTRK3 chimaeric transcripts in all three CFS tumours analysed.
NTRK3_ETV6- 11441343nephroma PCR;RT-PCR - MCH-MN-1 cells expressed ETV6-NTRK3 gene fusion transcripts, characteristic of cellular and mixed forms of CMNs.
NTRK3_ETV6- 16538060ewing sarcoma;fibromatoses;neuroectodermal tumor;rhabdomyosarcoma;soft tissue sarcoma PCR;RT-PCR - Four cases tested negative for the ETV6-NTRK3 gene fusion by RT-PCR.
NTRK3_ETV6- 23944930acinic cell carcinoma - - Secretory carcinoma (SC) is a rare histological type of breast cancer, and ETV6-NTRK3 gene fusion is highly specific to it. /// "We confirmed that ETV6-NTRK3 gene rearrangement and amylase positivity are good diagnostic markers for SC and ACCA, respectively. "
NTRK3_ETV6- 24585770salivary gland cancer PCR;RT-PCR - Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is defined by ETV6-NTRK3 gene fusion.
NTRK3_ETV6- 12652616sarcoma PCR;RT-PCR - In each patient, the ETV6-NTRK3 gene fusion was identified by reverse transcriptase-polymerase chain reaction (RT-PCR) in the tumor specimens. /// "In each patient, the ETV6-NTRK3 gene fusion was identified by reverse transcriptase-polymerase chain reaction (RT-PCR) in the tumor specimens." /// Our findings suggest that the ETV6-NTRK3 gene fusion may underlie the distinctive biological properties of these tumors and may also indicate tumor chemosensitivity. /// Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy.. /// " Recently, the ETV6-NTRK3 gene fusion has been identified in both infantile fibrosarcoma and cellular mesoblastic nephroma. "
NTRK3_ETV6- 15750350fibrosarcoma;sarcoma - - Up-regulation of glutathione biosynthesis in NIH3T3 cells transformed with the ETV6-NTRK3 gene fusion.. /// " The ETV6-NTRK3 gene fusion, first identified in the chromosomal translocation in congenital fibrosarcoma, encodes a chimeric protein tyrosine kinase with potent transforming activity. "
NTRK3_ETV6- 10918240fibrosarcoma;sarcoma - - ETV6-NTRK3 gene fusion in metastasizing congenital fibrosarcoma..
NTRK3_ETV6- 15801689fibrosarcoma;sarcoma - - In this case report, we present our experience of an infantile fibrosarcoma of thigh with good clinical course 36 months after tumor resection and the usefulness of detecting the ETV6-NTRK3 gene fusion in differential diagnosis..
NTRK3_ETV6- 15695086breast carcinoma;breast carcinoma - - ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexual.. /// As confirmation of the histopathological diagnosis we detected the novel ETV6-NTRK3 gene fusion in this tumor.. /// "Recently, it has been reported that human secretory breast carcinoma expresses the ETV6-NTRK3 gene fusion that was previously cloned in pediatric mesenchymal cancers. "
NTRK3_ETV6- 21934478- - - Mammary analogue secretory carcinoma of the salivary glands with ETV6-NTRK3 gene fusion..
NTRK3_ETV6t(12;15) (p13;q25) / t(12;15) / 24145651- - - Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, ?-catenin, EGFR, and CCND1 genes.. /// "Recognizing HG-transformed MASC and testing for ETV6 rearrangement may be of potential value in patient treatment, because the presence of the ETV6-NTRK3 translocation may represent a therapeutic target in MASC. "
NTRK3_ETV6t(12;15)(p13;q25) / 21084177sarcoma - - The fusion transcript ETV6-NTRK3 resulting from the specific chromosomal translocation t(12;15)(p13;q25) is now a useful diagnostic tool for infantile fibrosarcoma.
NTRK3_ETV6- 19006426myofibromatosis - - Molecular analysis for the ETV6-NTRK3 gene fusion is an important diagnostic tool in this group of lesions.. /// "With reverse transcriptase polymerase chain reaction, the ETV6-NTRK3 transcript was absent in 3 COIM and was detected in 3 CIFS. "
NTRK3_ETV6t(12;15)(p13;q25) / 14578034fibrosarcoma;sarcoma - - The presence of the t(12;15)(p13;q25) and the fusion transcript ETV6-NTRK3 by RTPCR facilitated the diagnosis..
NTRK3_ETV6t(12;15) (p13;q25) / 20410810pleomorphic adenoma;acinic cell carcinoma;adenocarcinoma;salivary gland cancer - - We have shown a t(12;15) (p13;q25) ETV6-NTRK3 translocation in all but one case of MASC suitable for analysis. /// "This translocation was not found in any conventional salivary AciCC (12 cases), nor in other tumor types including pleomorphic adenoma (1 case) and low-grade cribriform cystadenocarcinoma (1 case), whereas ETV6-NTRK3 gene rearrangements were proven in all 3 tested cases of mammary secretory carcinoma. "
NTRK3_ETV6t(12;15) / 22332016breast cancer;breast carcinoma - - It is the only epithelial tumor of the breast with a balanced translocation, t(12;15), that creates an ETV6-NTRK3 gene translocation.
NTRK3_ETV6t(12;15)(p13;q25) / 25087572salivary gland neoplasm - - Aspiration cytologic findings of mammary analogue secretory carcinoma (MASC), a newly established salivary gland neoplasm defined by a t(12;15)(p13;q25) ETV6-NTRK3 translocation, are not fully characterized to date.
NTRK3_ETV6- 12450792ductal carcinoma - - We report that human secretory breast carcinoma (SBC), a rare subtype of infiltrating ductal carcinoma, expresses the ETV6-NTRK3 gene fusion previously cloned in pediatric mesenchymal cancers. /// Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.. /// "ETV6-NTRK3 expression was confirmed in 12 (92%) of 13 SBC cases, but not in other ductal carcinomas. " /// Retroviral transfer of ETV6-NTRK3 (EN) into murine mammary epithelial cells resulted in transformed cells that readily formed tumors in nude mice.
NTRK3_ETV6- 25989870myofibromatosis;respiratory failure - - Neither ETV6-NTRK3 nor ACTB-GLI fusion gene was identified.
NTRK3_ETV6- 25492889fibrosarcoma;sarcoma - - A reverse transcription polymerase chain reaction assay was performed to detect the gene fusion ETV6-NTRK3 transcript.
NTRK3_ETV6t(12;15) / 21804605- - - ETV6-NTRK3 (EN), a chimeric tyrosine kinase generated by t(12;15) translocations, is a dominantly acting oncoprotein in diverse tumor types.
NTRK3_ETV6- 12210087fibrosarcoma;sarcoma PCR;RT-PCR - Although a variety of non-neuronal tissues have also been shown to express TrkC, the status of TrkC in soft tissue tumours has been poorly investigated, except for a small fraction of tumours including congenital/infantile fibrosarcoma characterized by an ETV6-NTRK3 (also known as Tel-TrkC) fusion gene.
NTRK3_ETV6t(12;15)(p13;q25) / 11751416fibrosarcoma;sarcoma - - Therefore, it remains unknown whether ETV6-NTRK3 transformation involves altered NTRK3 signaling. /// "However, previous studies failed to detect interactions between ETV6-NTRK3 and molecules known to link wild-type NTRK3 to its two major effector pathways, namely the Ras-Raf1-Mek1-Erk1/2 mitogenic pathway or the phosphatidylinositol 3'-kinase pathway leading to activation of the AKT survival factor. " /// "We now report that ETV6-NTRK3 expression in NIH3T3 cells leads to constitutive activation of Mek1 and Akt, as well as to constitutively high expression of cyclin D1. " /// Our results indicate that ETV6-NTRK3 transformation involves a link between known NTRK3 signaling pathways and aberrant cell cycle progression and that Mek1 and Akt activation act synergistically to mediate these effects.. /// The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation..
NTRK3_ETV6t(2;15) / 2p21;15 / 27148571hemimelia - - Molecular characterization of the tumor revealed the absence of the prototypical ETV6-NTRK3 translocation.
NTRK3_ETV6t(12;15)(q13;q25) / 26945684AIDS - - Also, characteristic ETV6-NTRK3 translocation was confirmed in case 1.
NTRK3_ETV6- 22374738congenital mesoblastic nephroma FISH;PCR;RT-PCR - An additional 4/14 were negative by RT-PCR and absence of ETV6-NTRK3 was confirmed by FISH for both ETV6 and NTRK3. /// "Unexpectedly, abundant ETV6-NTRK3 transcript copies were present in only 7/14 IFS, with very low copy number in 3/14. "
NTRK3_ETV6- 26492182hematological malignancy PCR;RT-PCR - In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MASC), and has not been documented in any other salivary tumor type.
NTRK3_ETV6- 25040635cystadenocarcinoma - - Mammary analog secretory carcinoma (MASC) of the salivary gland has been recently described according to morphological, immunohistochemical, and molecular (ETV6-NTRK3 translocation) similarities with the mammary secretory carcinoma.
NTRK3_ETV6- 23060067thyloid cancer;prostate cancer;leukemia;breast cancer;lung cancer;sarcoma;lymphoma - - In this review, we will summarize the histologic features of known recurrent genomic rearrangements in carcinomas, especially focusing on TMPRSS2-ERG fusion in prostate cancer, EML4-ALK in lung cancer, ETV6-NTRK3 in secretory breast cancer, RET/PTC and PAX8/PPAR?1 rearrangements in thyroid cancer.
NTRK3_ETV6- 25439992acinic cell carcinoma;adenocarcinoma - - Diagnostic was confirmed by highlighting the ETV6-NTRK3 gene translocation.
NTRK3_ETV6- 16681692nephoma PCR;RT-PCR - two were non-informative and three expressed ETV6-NTRK3 using both techniques, two showing similar expression, whilst one showed expression two orders of magnitude lower, from a cellular tumour.
NTRK3_ETV6- 23773480acinic cell carcinoma ISH - Mammary analogue secretory carcinoma is a recently described salivary gland neoplasm defined by ETV6-NTRK3 gene fusion. /// Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma..
NTRK3_ETV6- 26367451thyroid nodule;thyroid carcinoma - - These gene fusions included ETV6/NTRK3 (n=3) and TPR/NTRK1 (n=1). /// "Some cases with chromosomal rearrangements, including ETV6/NTRK3, appear to be associated with an aggressive histopathologic phenotype, but had no documented history of radiation exposure. "
NTRK3_ETV6- 23042752pleomorphic adenoma;acinic cell carcinoma;mucoepidermoid carcinoma;salivary gland cancer ISH - Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is defined by ETV6-NTRK3 gene fusion.
NTRK3_ETV6- 14691916ductal carcinoma ISH - On this basis, we evaluated 13 SCAs (12 of them with ETV6-NTRK3 gene fusion) by molecular and immunohistochemical (IHC) methods.
NTRK3_ETV6- 11381370nephroma ISH - RNA extraction was performed on formalin-fixed, paraffin-embedded tissue from 7 mixed epithelial and stromal tumors followed by reverse-transcription polymerase chain reaction to detect the ETV6-NTRK3 gene fusion.
NTRK3_ETV6- 24327398thyloid cancer - - ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid cancer.. /// "Moreover, ETV6-NTRK3 rearrangement can be directly induced in thyroid cells by ionizing radiation in vitro and, thus, may represent a novel mechanism of radiation-induced carcinogenesis.. " /// "The prevalence of ETV6-NTRK3 rearrangement in post-Chernobyl PTCs was associated with increasing (131) I dose, albeit at borderline significance (P?=?.126). " /// The authors report the occurrence of ETV6-NTRK3 rearrangements in thyroid cancer and demonstrate that this rearrangement is significantly more common in tumors associated with exposure to (131) I and has a borderline significant dose response. /// "In vitro exposure of human thyroid cells to 1 gray of (131) I and ?-radiation resulted in the formation of ETV6-NTRK3 rearrangement at a rate of 7.9????10(-6) cells and 3.0????10(-6) cells, respectively. " /// "The group of rearrangement-positive PTCs (ETV6-NTRK3, RET/PTC, PAX8-PPAR?) was associated with significantly higher dose response compared with the group of PTCs with point mutations (BRAF, RAS. "
NTRK3_ETV6- 10658907clear cell sarcoma;sarcoma - - We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks. /// Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors..

ChimerSEQ

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The fusion gene pair NTRK3--ETV6 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
NTRK3_ETV6chr15/88669538/ chr12/12037379/ 15q25.3 12p13.2 Exonic hg19 - Inter-chr NA AF125809 Kinase; ChiTaRs
NTRK3_ETV6chr15/88669502/- chr12/12022358/+ 15q25.3 12p13.2 Exonic hg19 In-frame Inter-chr THCA TCGA-E8-A438-01A Kinase; PRADA

ChiTaRS 2.1

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The fusion gene pair NTRK3--ETV6 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human AF125809NTRK3--ETV6 NTRK315 88576088 88669538 - 1 226 99.6 ETV612 12037379 12037438 + 227 286 100

FARE-CAFE

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The fusion gene pair NTRK3--ETV6 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair NTRK3--ETV6 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair NTRK3--ETV6 information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
THCA E8-A438-01A NTRK3__ETV6 5.5 15:88669502/-1 12:12022358/1 tier1 In-frame 11841 NA

FusionCancer

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The fusion gene pair NTRK3--ETV6 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair NTRK3--ETV6 information is not available in ConjoinG Database.

1000Genome

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Fusion gene NTRK3--ETV6 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene NTRK3--ETV6 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene NTRK3--ETV6 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene NTRK3--ETV6 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene NTRK3--ETV6 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair NTRK3--ETV6 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene NTRK3--ETV6 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene NTRK3--ETV6 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene NTRK3 is a known oncogene according to ONGENE database.


The tail gene ETV6 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene NTRK3 is cancer associated according to Bushman Cancer Gene database.


The tail gene ETV6 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene NTRK3 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ETV6 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene NTRK3--ETV6 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene NTRK3--ETV6 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair NTRK3--ETV6 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene NTRK3--ETV6 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene NTRK3--ETV6 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair NTRK3--ETV6 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair NTRK3--ETV6 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair NTRK3--ETV6 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene NTRK3--ETV6 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair NTRK3--ETV6 information is not available in ChromothripsisDB database.