MYH9--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

MYH9 ALK

COSMIC

The fusion gene pair MYH9--ALK information is not available in COSMIC database.

ChimerKB

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The fusion gene pair MYH9--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
MYH9_ALK-/0/ -/0/ Exonic hg18 - - - Kinase; Oncogene; TICdb

ChimerPUB

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The fusion gene pair MYH9--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MYH9_ALKt(2;22) / p23;q11.2 / 12800156anaplastic large cell lymphoma;lymphoma FISH - If further investigations confirm this latter result, the in vivo tyrosine phosphorylation of MYH9-ALK protein could involve mechanisms different from those described in the other ALK hybrid proteins.. /// "In contrast to the previously reported ALK fusion proteins, MYH9-ALK may lack a functional oligomerization domain. " /// Nucleotide sequence of the MYH9-ALK chimeric cDNA revealed that the ALK breakpoint was different from all those previously reported.

ChimerSEQ

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The fusion gene pair MYH9--ALK information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MYH9--ALK information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MYH9--ALK information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
MYH9-ALK Anaplastic large cell lymphoma 5′ RACE,FISH t(2;22)(p23;q11.2) PubMed:12800156

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
MYH9-ALK MYH9-ALK MYH9 36684333 1 0 ALK 29446315 0 1 CGGGACGAAGCCATCAAACAGCTGCGGAAGCTGCAGGTcCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGC 12800156 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
MYH9-ALK MYH9-ALK 1) Myosin_tail_1
- 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
MYH9 1) Myosin_N
2) Myosin_head
3) IQ
4) Myosin_tail_1
1) Myosin_head , EF-hand_7
2) EFhand_Ca_insen , Myosin_N , Dynamin_N , IQ , EF-hand_1 , Actin
3) IQ , EF-hand_6 , EF-hand_7 , Myosin_head
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
- -

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
MYH9-ALK hsa-miR-132-3p hsa-miR-124-3phsa-miR-9-5phsa-miR-1296-5phsa-miR-877-3phsa-miR-193b-3phsa-miR-484hsa-miR-324-3phsa-miR-331-3phsa-miR-149-5phsa-miR-92a-3p Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
MYH9-ALK NM_002473.4 1) MITF_HUMAN
2) STAT1_HUMAN
3) RB1_HUMAN
4) RBL2_HUMAN
5) E2F4_HUMAN
6) PRDM14_HUMAN
7) ESTROGEN RECEPTOR ALPHA_HUMAN
8) ETS1_HUMAN
9) FOS_HUMAN
10) GATA2_HUMAN
11) GATA3_HUMAN
12) CTCF_HUMAN
13) BRG1_HUMAN
14) HNF4A_HUMAN
15) TFAP2C_HUMAN
16) FOXA1_HUMAN
17) CEBPA_HUMAN
18) STAT6_HUMAN
19) ESR1_HUMAN
20) ESR2_HUMAN
21) NR1H3_HUMAN
22) SETDB1_HUMAN
23) SPI1_HUMAN
24) VDR_HUMAN
1) TRIM28_HUMAN
2) P53_HUMAN
3) RUNX1_HUMAN
4) EGR1_HUMAN
5) E2F1_HUMAN
6) SOX2_HUMAN
1) 21258399
2) 19122651
3) 20385362
4) 20385362
5) 21247883
6) 20953172
7) 20547749
8) 20019798
9) 20139302
10) 21808000
11) 21878914
12) 21795385
13) 19505939
14) 21646355
15) 21572391
16) 21572391
17) 20219941
18) 21828071
19) 21235772
20) 21235772
21) 22292898
22) 21430779
23) 21241896
24) 21846776

TicDB

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The fusion gene pair MYH9--ALK information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
MYH9 ALK 12800156 CGGGACGAAGCCATCAAACAGCTGCGGAAGCTGCAGGTcCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGC

TUMOR FUSION Gene Data Portal

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The fusion gene pair MYH9--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MYH9--ALK information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MYH9--ALK information is not available in ConjoinG Database.

1000Genome

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Fusion gene MYH9--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MYH9--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MYH9--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MYH9--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MYH9--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MYH9--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MYH9--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MYH9--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MYH9 is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MYH9 is cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MYH9 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MYH9--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MYH9--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MYH9--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MYH9--ALK is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MYH9--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MYH9--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MYH9--ALK information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MYH9--ALK information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MYH9--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MYH9--ALK information is not available in ChromothripsisDB database.