MYH11--CBFB

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MYH11 CBFB

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The fusion gene pair MYH11--CBFB information is not available in COSMIC database.

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The fusion gene pair MYH11--CBFB information is not available in CHIMERKB (CHIMERDB 3.0) database.

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The fusion gene pair MYH11--CBFB information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MYH11_CBFBinv(16)(p13q22) / inv(16) / 17052753acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - AML with the CBFB/MYH11 fusion gene but without inv(16) was found in M2, M4, and M5, but not in M4E patients. /// The CBFB/MYH11 fusion gene was detected in 17 patients (7.6%): eight patients had the inv(16) chromosome and in all of them it was M4E. /// "These results indicate that even if eosinophilia is not found, molecular screening for CBFB/MYH11 fusion gene should be performed in all AML patients at the time of diagnosis to help guide disease management.. " /// Detection of the CBFB/MYH11 fusion gene in de novo acute myeloid leukemia (AML): a single-institution study of 224 Japanese AML patients.. /// "In this study, we used RT-PCR and FISH analysis to examine 224 Japanese adult de novo AML patients for the presence of the CBFB/MYH11 fusion transcript at the time of diagnosis. "
MYH11_CBFBinv(16)(p13q22) / 15339697- FISH;PCR - These findings indicate a myeloid to lymphoid lineage switch from an inv(16)(p13q22) positive leukaemia and show that IGH gene rearrangements can occur in the presence of CBFB-MYH11 fusion transcripts..
MYH11_CBFBinv(16) / inv(16) / 10959099acute myeloid leukemia;myeloid leukemia;leukemia FISH - We present a unique case of acute myeloid leukemia M4Eo (AML-M4Eo) with a CBFB/MYH11 fusion transcript and a trisomy 22, but in whom cytogenetic analyses did not disclose an inv(16). /// "The most likely explanation for the formation of the relevant CBFB/MYH11 fusion is an insertion of parts of the MYH11 into the CBFB gene, although it is also possible that it was formed by a double inversion.. " /// CBFB/MYH11 fusion in a patient with AML-M4Eo and cytogenetically normal chromosomes 16..
MYH11_CBFBinv(16) / t(16;16) / t(16;16) / 9204976acute myeloid leukemia;myeloid leukemia;leukemia FISH - The presence of a 16 p deletion in a case of inv(16) associated with CBFB-MYH11 transcript type E indicates that deletions are not limited to CBFB-MYH11 transcript type A rearrangements.
MYH11_CBFBinv(16) / inv(16) / t(16;16) / 7833479acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - The inversion results in two fusion genes: 5'-CBFB/MYH11-3' on 16p and 5'-MYH11/CBFB-3' on 16q. /// Reverse transcription-polymerase chain reaction (RT-PCR) using primers from the 5' region of CBFB and the 3' region of MYH11 (distal to the p-ibc) produced the 5'-CBFB/MYH11-3' chimeric transcript in inv(16)/del patients. /// "These data confirm that the 5'-CBFB/MYH11-3' chimeric transcript, rather than the reciprocal 5'-MYH11/CBFB-3', is the critical product for chromosome 16-related leukemogenesis.. "
MYH11_CBFBinv(16) / t(9;22) / del(7)(q22q32) / inv(16) / t(9;22;19) / t(9;22;19) / 20513535acute myeloid leukemia;myeloid leukemia;leukemia FISH - Acute myeloid leukemia with inv(16) with CBFB-MYH11, 3'CBFB deletion, variant t(9;22) with BCR-ABL1, and del(7)(q22q32) in a pediatric patient: case report and literature review..
MYH11_CBFBt(15;17) / t(8;21) / inv(16) / 19959801acute myeloid leukemia;myeloid leukemia;leukemia FISH - Karyotype and array technology represent genome-wide screens, whereas the other methods target specific prognostic features such as t(15;17) PML-RARA, t(8;21) RUNX1-RUNX1T1, inv(16) CBFB-MYH11, 11q23 MLL rearrangement, FLT3 internal tandem duplication, or NPM1 mutation.
MYH11_CBFBt(8;21)(q22;q22) / inv(16)(p13q22) / 17981216granulocytic sarcoma FISH - Although the myeloblasts did not show the inv(16)(p13q22) (CBFB/MYH11), a gain of multiple copies of the CBFB gene was detected with fluorescence in situ hybridization analysis.
MYH11_CBFBinv(16)(p13q22) / inv(16) / t(12;16)(q24;q22) / t(12;16) / 18617061acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - The presence of inv(16) was confirmed by reverse-transcription polymerase chain reaction (RT-PCR) analysis, which corresponded to the type A CBFB-MYH11 chimeric transcript.
MYH11_CBFBinv(16)(p13q22) / t(9;16)(p23;p13) / t(1;16)(p32;p13) / del(16)(q22) / inv(16) / inv(16) / del(16)(p13p13) / 9598794acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - Reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis showed a CBFB-MYH11 fusion transcript and MYH11 rearrangement, respectively, in all three cases.
MYH11_CBFBdel(20q) / del(20)(q11.2) / 23130347acute myeloid leukemia;myeloid leukemia;leukemia FISH - Using FISH, other rearrangements such as BCR/ABL1, RUNX1/RUNX1T1, PML/RARA, CBFB/MYH11, and MLL were found to be negative.
MYH11_CBFBinv(16) / t(16;16) / inv(16) / 10214358leukemia FISH;PCR;RT-PCR - Molecular analysis of BM cells using RT-PCR identified a CBFB-MYH11 fusion transcript type D.
MYH11_CBFB- 15820957acute myeloid leukemia;acute lymphoblastic leukemia;chronic myeloid leukemia FISH - We compared the incidence of submicroscopic deletions accompanying balanced translocations using interphase fluorescence in situ hybridization (FISH) in 245 patients with chronic myeloid leukemia (CML), 79 patients with acute lymphoblastic leukemia (ALL) and BCR-ABL (n=70) or MLL rearrangements (n=29), and 412 patients with acute myeloid leukemia (AML) with CBFB-MYH11 (n=122), PML-RARalpha (n=108), AML1-ETO (n=112), or MLL rearrangements (n=98).
MYH11_CBFBt(2;11)(q37;q23) / 19445675acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - Cytogenetics, fluorescence in situ hybridization (FISH) and molecular studies (RT-PCR, qRT-PCR and qMSP) were used to characterize 58 acute myeloid leukemia patients (AML) at diagnosis selected to represent the major AML genetic subgroups: CBFB-MYH11 (n = 13), PML-RARA (n = 12).
MYH11_CBFBinv(16)(p13q22) / 21638519acute myeloid leukemia;myeloid leukemia;leukemia FISH - Furthermore, the CBFB-MYH11 distance is significantly reduced compared with CBFB and a control locus in HSCs, although separation between CBFB and the control is ?70% of that between CBFB and MYH11 on metaphase chromosomes.
MYH11_CBFB- 24602728acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR - A novel multiplex RT-nPCR assay was developed to detect 16 AML-related fusion genes (AML1-EVI1, AML1-ETO, AML1-MDS1, AML1-MTG16, MLL-AF9, MLL-AF6, MLL-AF10, MLL-ENL, MLL-MLL, PML-RAR?, PLZFRAR?, NPM1-RAR?, CBFB-MYH11, DEK-CAN, SET-CAN and TLS-ERG) according to 2008 WHO classification of AML.
MYH11_CBFBinv(16) / t(16;16) / 10800163acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - RT-PCR demonstrated amplification of the CBFB/MYH11 product in all cases analyzed.
MYH11_CBFB- 25732229acute myeloid leukemia;myeloid leukemia;leukemia FISH - Of the seven patients with favorable cytogenetics, PML/RARA, CBFB-MYH11 or RUNX1-RUNX1T1 fusion transcripts were detected at various levels in six patients but all patients remained in complete remission.
MYH11_CBFB- 25972330acute myeloid leukemia;myeloid leukemia;leukemia FISH - FISH lent prognostic information in one (0.5%) of 220 cases with normal karyotype/abnormal FISH: CBFB-MYH11 fusion, indicating favorable prognosis.
MYH11_CBFBinv(16) / 12139724- PCR;RT-PCR - Minimal residual disease quantification in patients with acute myeloid leukaemia and inv(16)/CBFB-MYH11 gene fusion.. /// We have designed a real-time CBFB-MYH11 reverse transcription polymerase chain reaction (RT-PCR) assay to quantify minimal residual disease (MRD) in patients with inv(16)-positive acute myeloid leukaemia (AML). /// "For two cases, a patient-specific real-time PCR for CBFB-MYH11 quantification at genomic DNA level was designed. " /// "Similar disease levels were found at the RNA and genomic DNA level during and after treatment, indicating that CBFB-MYH11 gene expression was unaltered during treatment and that the percentage of malignant cells can be accurately quantified at the RNA level. "
MYH11_CBFBinv(16)(p13q22) / t(16;16)(p13;q22) / inv(16) / del(16q22) / inv(16) / 7577615- PCR;RT-PCR - The pericentric inversion of chromosome 16 [inv(16)(p13q22)] and t(16;16)(p13;q22) are chromosomal rearrangements frequently associated with AML FAB type M4Eo resulting in the production of a fusion gene CBFB/MYH11. /// "Though RT-PCR is highly sensitive in detecting CBFB/MYH11 fusion transcripts during remission, monitoring of minimal residual disease in patients with inv(16) remains to be established.. " /// Detection of CBFB/MYH11 transcripts in patients with inversion and other abnormalities of chromosome 16 at presentation and remission.. /// "We studied 17 patients with a chromosome 16 abnormality (eight M4Eo, two M1, one M2, three M4 without abnormal eosinophils, three MDS) for the presence of CBFB/MYH11 transcripts using an RT-PCR technique. "
MYH11_CBFBt(8;21) / inv(16) / t(16;16) / inv(16) / 23878140acute myeloid leukemia;myeloid leukemia;leukemia - - Since the expression of the fusion genes CBFB/MYH11 or RUNX1/RUNX1T1 alone is not sufficient to cause leukemia, we performed exome sequencing of an AML sample with an inv(16) to identify mutations, which may collaborate with the CBFB/MYH11 fusion during leukemogenesis. /// Gene expression analysis of AML patients with CBFB/MYH11 rearrangement and FLT3 N676K mutation showed a trend toward a specific expression profile. /// "In a cohort of 84 de novo AML patients with a CBFB/MYH11 rearrangement and in 36 patients with a RUNX1/RUNX1T1 rearrangement, the FLT3 N676K mutation was identified in 5 and 1 patients, respectively (5 [6%] of 84. "
MYH11_CBFBinv(16) / 8585960- - - Transforming properties of the leukemic inv(16) fusion gene CBFB-MYH11..
MYH11_CBFBinv(16) / t(8;21) / inv(16) / 16504290granulocytic sarcoma;neuroectodermal tumor - - Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome: case report and review of literature.. /// "These observations suggest that when abdominal GS is diagnosed, an analysis of the CBFB/MYH11 fusion gene is necessary to make an appropriate decision regarding treatment options, even if no chromosomal abnormalities are found.. " /// "The chromosomal analysis was normal, but molecular analysis detected the CBFB/MYH11 fusion gene in the blasts. "
MYH11_CBFBinv(16) / inv(16) / 22160378acute myeloid leukemia;myeloid leukemia;leukemia - - It is therefore important to verify that KIT mutations cooperate with CBFB-MYH11, the fusion gene generated by inv(16), for leukemogenesis. /// KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.. /// Our data provide clear evidence for cooperation between mutated KIT and CBFB-MYH11 during leukemogenesis..
MYH11_CBFBinv(16) / 8818654acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells.. /// "One isoform of the transcript of the CBFB-MYH11 fusion gene, containing the MHC204 C-terminus, was the predominant from in all five cases studied.. " /// "A very high molecular weight protein/DNA complex is generated when nuclear extracts from patient cells are used in electrophoretic mobility shift assays, as seen in NIH 3T3 cells transfected with the CBFB-MYH11 cDNA. " /// We have previously shown that a CBFB-MYH11 cDNA construct can produce a chimeric protein and transform NIH 3T3 cells.
MYH11_CBFBt(8;21) / inv(16) / t(15;17) / t(9;22) / t(4;11) / 11896540acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - We investigated 105 consecutive AML cases for the presence of fusion gene transcripts by reverse transcriptase polymerase chain reaction (RT-PCR): AML1-ETO associated with t(8;21), CBFB-MYH11 with inv(16), PML-RARA with t(15;17), BCR-ABL with t(9;22), and MLL-AF4 with t(4;11).
MYH11_CBFB- 16502584acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - Here we describe protocols for the qualitative and quantitative detection of leukemic cells that are characterized by a CBFB-MYH11 gene fusion..
MYH11_CBFBinv(16) / t(16;16) / 17287858acute myeloid leukemia;myeloid leukemia;leukemia - - Rare CBFB-MYH11 fusion transcripts in AML with inv(16)/t(16;16) are associated with therapy-related AML M4eo, atypical cytomorphology, atypical immunophenotype, atypical additional chromosomal rearrangements and low white blood cell count: a study on 162 patients.. /// The spectrum of CBFB-MYH11 fusion transcripts in acute myeloid leukemia (AML) M4eo with inv(16)/t(16;16) is heterogeneous. /// "In total, 128 patients (79.0%) showed the fusion transcript type A, whereas nine different rare CBFB-MYH11 fusion genes were detected in 34 cases (21.0%). " /// Approximately 85% show type A CBFB-MYH11 fusion transcripts. /// "In this study, a molecular characterization of CBFB-MYH11 transcripts in 162 patients with CBFB-MYH11 positive AML at diagnosis was performed. "
MYH11_CBFBinv(16)(p12q22) / inv(16) / 8847901acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - We conclude that CBFB/MYH11 fusion transcript detection, as a surrogate for the favorable prognosis and treatment planning implied by inv(16) in AML M4Eo, should not be exclusively relied upon in AML M1 in the absence of prospective study of this specific (M1) category of AML. /// Clinical aspects of expression of inversion 16 chromosomal fusion transcript CBFB/MYH11 in acute myelogenous leukemia subtype M1 with abnormal bone marrow eosinophilia.. /// "However, the CBFB/MYH11 fusion transcript was not detected in the relapsed specimen. " /// We expand upon our prior abstract of a case of AML subtype M1 with abnormal eosinophils that expressed the inversion 16 fusion transcript CBFB/MYH11.
MYH11_CBFBinv(16) / t(16;16) / p13.1;q22 / 18328953acute myeloid leukemia;myeloid leukemia;leukemia - - At the molecular level, these abnormalities generate a CBFB-MYH11 fusion gene. /// Banding and molecular cytogenetic studies detected a CBFB-MYH11 fusion gene that appeared as abnormal chromosomes 1 and 16 in a baby with acute myeloid leukemia FAB M4-Eo.. /// "We describe clinical, conventional banding, and molecular cytogenetic data for a 12-month-old baby with AML-M4Eo and a chimeric CBFB-MYH11 fusion gene masked by a novel rearrangement between chromosomes 1 and 16. "
MYH11_CBFBinv(16) / inv(16) / 11241787leukemia PCR;RT-PCR - Detection and quantification of CBFB/MYH11 fusion transcripts in patients with inv(16)-positive acute myeloblastic leukemia by real-time RT-PCR.. /// These data indicate that real-time RT-PCR can be used for the sensitive detection and quantification of CBFB/MYH11 transcripts in the follow-up of patients with inv(16)-positive AML.. /// We used a newly established real-time RT-PCR assay for the quantification of the leukemia-specific CBFB/MYH11 transcripts in inv(16)-positive acute myeloblastic leukemia. /// "CBFB/MYH11 could be quantified over a five log range, with a detection limit of 10 molecules of a CBFB/MYH11 plasmid and a 1:10(5) dilution of RNA of the inv(16)-positive ME-1 cell line, respectively. " /// "Three patients relapsed, and their CBFB/MYH11 transcripts rose again to pretreatment levels. " /// All of these patients showed a similar decline of CBFB/MYH11 after intensive therapy. /// "In two patients, this increase in CBFB/MYH11 could be detected by real-time PCR before hematological relapse. " /// Six of these patients are in complete remission with a stable low-level or absent CBFB/MYH11 expression. /// "In nine patients, CBFB/MYH11 was also quantified during/after chemotherapy and autologous or allogeneic stem cell transplantation. " /// The expression of CBFB/MYH11 varied over a two log range without correlation to clinical response or relapse rate.
MYH11_CBFBinv(16)(p13q22) / t(16;16)(p13;q22) / 11920247acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - Both aberrations result in a CBFB-MYH11 fusion gene that can be detected by RT-PCR. /// "To date, a total of 10 different in-frame CBFB-MYH11 fusion transcripts have been identified. " /// "Because all previously established RT-PCR protocols may miss the new CBFB-MYH11 transcript, we propose to use the improved RT-PCR approach described here for the reliable detection of all known CBFB-MYH11 fusion transcripts.. " /// "We describe here a robust two-step RT-PCR assay that reliably detects all known CBFB-MYH11 transcripts types, including the new variant. " /// Identification of a novel CBFB-MYH11 transcript: implications for RT-PCR diagnosis..
MYH11_CBFBinv(16) / 25786458uterine cervical cancer - - A 40-year-old woman developed therapy-related acute myeloid leukemia (t-AML) with inv(16)(p13.1q22) and a rare type D form of core-binding factor ?-subunit gene-myosin heavy chain 11 gene (CBFB-MYH11) fusion transcript approximately 2.5 years after receiving chemoradiotherapy for uterine cervical cancer. /// "t-AML with inv(16)(p13.1q22) and rare non-type A CBFB-MYH11 typically develops after exposure to a topoisomerase II inhibitor, with a short period of latency of one to five years. "
MYH11_CBFBinv(16) / t(16;16) / inv(16)(p13q22) / t(16;16)(p13;q22) / 23160462acute myeloid leukemia;myeloid leukemia;leukemia - - The inv(16)(p13q22)/t(16;16)(p13;q22) in acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. /// "We analyzed CBFB-MYH11 fusion types in 208 inv(16)/t(16;16) patients with de novo disease, and compared clinical and cytogenetic features and the KIT mutation status between type A (n = 182. " /// inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations..
MYH11_CBFBt(16;16) (p13;q22) / inv(16)(p13q22) / t(16;16)(p13;q22) / 24342433acute myeloid leukemia;myeloid leukemia;leukemia - - We report a case of acute myeloid leukemia with a balanced t(16;16)(p13;q22) and additional monosomy 13 showing a new CBFB-MYH11 fusion transcript variant. /// " Acute myeloid leukemia (AML) cases with inv(16)(p13q22) or t(16;16)(p13;q22) are characterized by multiple CBFB-MYH11 fusion transcripts, type A being the most frequent. " /// Acute myeloid leukemia with t(16;16) (p13;q22) showing a new CBFB-MYH11 fusion transcript associated with an atypical leukemic blasts morphology..
MYH11_CBFBinv(16) / 20589720- - - RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1).. /// "Both of these rearrangements result in the formation of fusion proteins, CBFB-MYH11 and AML1-ETO, respectively, that involve members of the CBF family of transcription factors. "
MYH11_CBFBt(8;21)(q22;q22) / inv(16)(p13q22) / t(16;16)(p13;q22) / t(15;17)(q22;q12-21) / 18648004acute myeloid leukemia;acute promyelocytic leukemia;myeloid leukemia;leukemia - - The most frequent chromosome/molecular rearrangements, that is, t(8;21)(q22;q22)/RUNX1-RUNX1T1 and inv(16)(p13q22)/t(16;16)(p13;q22)/CBFB-MYH11 characteristic of core-binding factor (CBF) AML and t(15;17)(q22;q12-21)/PML-RARA characteristic of acute promyelocytic leukemia (APL), confer favorable clinical outcome when patients receive optimal treatment, that is, regimens that include high-dose cytarabine for CBF AML and all-trans-retinoic acid and/or arsenic trioxide for APL.
MYH11_CBFBinv(16)(p13q22) / inv(16) / 7919348acute myeloid leukemia PCR;RT-PCR - These results confirm that CBFB/MYH11 transcripts (with a predominant type A form) are present in most cases of inv(16) AML. /// The clinical relevance of persistent CBFB/MYH11 fusion transcripts in remission remains to be established by studying a large prospective series of patients. /// "To assess the presence of type A CBFB/MYH11 fusion transcripts in five AML-M4Eo patients in remission, we designed a sensitive assay combining nested PCR and allele-specific amplification (NPASA). " /// "We have analyzed 24 patients with AML-M4Eo at diagnosis and 47 patients with AML of other FAB subtypes, by a reverse-transcriptase polymerase chain reaction (RT-PCR) assay for the CBFB/MYH11 fusion mRNAs. "
MYH11_CBFBt(9;22) / inv(16) / t(8;21) / 21275954- - - We identified five cases of Philadelphia positive subclones in AML occurring in coincidence with other genetic lesions: 1:220 patients with inv(16)/CBFB-MYH11 (0??5%), 2:272 AML cases with t(8;21)/RUNX1-RUNX1T1 (0??7%), 1:1029 NPM1-mutated AML (0??1%), and one patient with s-AML following MDS with a 5q-deletion.
MYH11_CBFBt(1;19) / t(4;11) / t(8;21) / t(9;22) / t(12;21) / t(15;17) / inv (16) / 10602411- PCR;RT-PCR - A total of nine well-defined chromosome aberrations with fusion gene transcripts were selected: t(1;19) with E2A-PBX1, t(4;11) with MLL-AF4, t(8;21) with AML1-ETO, t(9;22) with BCR-ABL p190 and BCR-ABL p210, t(12;21) with TEL-AML1, t(15;17) with PML-RARA, inv (16) with CBFB-MYH11, and microdeletion 1p32 with SIL-TAL1.
MYH11_CBFBinv(16)(p13q22) / inv(16) (p13q22) / t(16;16)(p13;q22) / 7795233leukemia PCR;RT-PCR - RT-PCR diagnosis of patients with acute nonlymphocytic leukemia and inv(16)(p13q22) and identification of new alternative splicing in CBFB-MYH11 transcripts.. /// "In all of 27 inv(16)(p13q22) and four t(16;16)(p13;q22) cases tested, a chimeric CBFB-MYH11 transcript coding for an in-frame fusion protein was detected. " /// The CBFB-MYH11 reading frame of the second transcript was maintained in one patient but not in the others. /// We show that the different CBFB-MYH11 transcripts in one patient arise from alternative splicing. /// Translation of the transcript in which the CBFB-MYH11 reading frame is not maintained leads to a slightly truncated CBFB protein.. /// "In a more extensive RT-PCR analysis with different primer pairs, we detected a second new chimeric CBFB-MYH11 transcript in 10 of 11 patients tested. "
MYH11_CBFBt(8;21)(q22;q22) / inv(16)(p13q22) / t(16;16)(p13;q22) / 25635758- - - In acute myeloid leukaemia (AML), the presence of t(8;21)(q22;q22) and inv(16)(p13q22)/t(16;16)(p13;q22) and/or the corresponding molecular rearrangements RUNX1/RUNX1T1 and CBFB/MYH11 [collectively referred to as core binding factor (CBF) AML] predict for a more favourable outcome in patients receiving cytarabine-anthracycline based induction and upon achievement of complete remission, high-dose cytarabine consolidation chemotherapy.
MYH11_CBFB- 20808941acute myeloid leukemia;myeloid leukemia;leukemia - - In contrast, fusion genes such as AML1/ETO or CBFB/MYH11 failed to reproduce the epigenetic signature observed in the patients.
MYH11_CBFBt(8;21)(q22;q22) / inv(16)(p13q22) / t(16;16)(p13;q22) / t(8;21) / inv(16) / inv(16) / 22032582acute myeloid leukemia;myeloid leukemia;leukemia - - The rearrangements t(8;21) and inv(16) involve the RUNX1/RUNX1T1 ( AML1-ETO ) and CBFB/MYH11 genes, respectively.
MYH11_CBFBt(1;19) / t(12;21) / t(8;21) / t(8;14) / t(9;22) / t(10;11) / t(15;17) / inv(16) / 15843827hematologic malignancy - - Using cDNA microarrays, we determined the gene expression profiles of 40 cell lines as well as of primary leukemias harboring 11q23/MLL rearrangements, t(1;19)[TCF3/PBX1], t(12;21)[ETV6/RUNX1], t(8;21)[RUNX1/CBFA2T1], t(8;14)[IGH@/MYC], t(8;14)[TRA@/MYC], t(9;22)[BCR/ABL1], t(10;11)[PICALM/MLLT10], t(15;17)[PML/RARA], or inv(16)[CBFB/MYH11].
MYH11_CBFBinv(16)(p13q22) / del(16)(q22) / del(16) / 8739792leukemia - - To our knowledge, this is the first report of an AML (M1) case with del(16) and CBFB/MYH11 rearrangement.. /// CBFB/MYH11 fusion transcripts in a case of acute myelogenous leukemia (M1) with partial deletion of the long arm of chromosome 16..
MYH11_CBFBinv(16) / 25266220acute myeloid leukemia;myeloid leukemia;leukemia - - Here, we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement that is associated with genes previously described as upregulated in inv(16) AML. /// CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia..
MYH11_CBFBinv(16) / inv(16) / 23236551acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - Although CBFB-MYH11 mRNA was detected in RT-PCR, the conventional cytogenetic analysis failed to reveal inv(16). /// Acute myeloid leukemia with cryptic CBFB-MYH11 type D..
MYH11_CBFBinv(16)(p13q22) / inv(16) / t(16;16) / 9927211acute myeloid leukemia;myeloid leukemia;leukemia - - To gain insight into the mechanisms causing the inv(16) we have analysed 24 genomic CBFB-MYH11 breakpoints.
MYH11_CBFBinv(16) / t(15;17) / 26079545acute myeloid leukemia;myeloid leukemia;leukemia PCR - Acute myeloid leukemia patients with recurrent cytogenetic abnormalities including inv(16);CBFB-MYH11 and t(15;17);PML-RARA may be assessed by monitoring the levels of the corresponding abnormal fusion transcripts by quantitative reverse transcription-PCR (qRT-PCR).
MYH11_CBFB- 16193088- PCR - Quantification of CBFB-MYH11 fusion gene levels in paired peripheral blood and bone marrow samples by real-time PCR..
MYH11_CBFB- 23114122acute myeloid leukemia;myeloid leukemia;leukemia PCR - It is concluded that a novel qPCR method for screening of CBFB-MYH11 fusion gene in AML is established. /// This study was purposed to establish new method for detecting CBFB-MYH11 fusion gene in acute myeloid leukemia (AML) and to evaluate its value in clinical use. /// "This method is fast, comprehensive, sensitive, specific, reliable, and should consider to be a robust tool for identification and management of AML patients with CBFB-MYH11 fusion gene.. " /// [Establishment of a new method for screening of CBFB-MYH11 fusion gene in acute myeloid leukemia and its value in clinical use].. /// "All fusion types of reported CBFB-MYH11 fusion gene were defined by search of references and databank, then the primers and probes were designed on this basis, and 3 positive plasmids and negative cell line as control were established. " /// "The primer/probe sets were tested with 3 positive plasmids and HL-60 cDNA using quantitative real-time PCR (qPCR) assays, which were then combined as a multiplex qPCR for simultaneous detection of CBFB-MYH11 and GUSB. "
MYH11_CBFBt(8;21) / inv(16) / inv(16) / 22875911- PCR;RT-PCR - At remission, after course 1 induction chemotherapy, a > 3 log reduction in RUNX1-RUNX1T1 transcripts in BM in t(8;21) patients and a > 10 CBFB-MYH11 copy number in peripheral blood (PB) in inv(16) patients were the most useful prognostic variables for relapse risk on multivariate analysis.
MYH11_CBFB- 15585652acute myeloid leukemia;myeloid leukemia;leukemia - - The frequent inversion of chromosome 16 creates the CBFB-MYH11 fusion gene that encodes the fusion protein CBFbeta-SMMHC. /// "In this study, we demonstrate that Plag1 and Plagl2 independently cooperate with CBF beta-SMMHC in vivo to efficiently trigger leukemia with short latency in the mouse. " /// "Overall, this study shows that Plag1 and Plagl2 are novel leukemia oncogenes that act by expanding hematopoietic progenitors expressing CbF beta-SMMHC.. " /// A recent genetic screen identified Plag1 and Plagl2 as CBF beta-SMMHC candidate cooperating proteins.
MYH11_CBFBt(8;21) / inv(16) / 20931398acute myeloid leukemia;myeloid leukemia;leukemia - - In a large-scale miRNA expression profiling analysis of 435 human miRNAs in 52 acute myeloid leukemia (AML) samples, we found that miR-126 and its minor counterpart in biogenesis, namely, miR-126*, were specifically aberrantly overexpressed in core binding factor (CBF) AMLs including both t(8;21)/AML1-ETO and inv(16)/CBFB-MYH11 samples.
MYH11_CBFBt(15;17) / t(8;21) / inv (16) / t(16;16) / 22207733acute myeloid leukemia;myeloid leukemia;leukemia - - After excluding patients with t(15;17)/PML-RARA, t(8;21)/RUNX1-RUNX1T1, inv (16)/t(16;16)/CBFB-MYH11, and normal karyotype, 824 patients with AML with cytogenetic abnormalities were analyzed.
MYH11_CBFBt(8;21) / t(15;17) / inv(16) / t(15;17) / t(8;21) / inv(16) / 21198299acute myeloid leukemia - - The most common genetic abnormalities seen in pediatric AML patients are AML1-ETO, PML-RAR? and CBFB-MYH11 genes resulting in t(8;21), t(15;17) and inv(16). /// "The authors analyzed 34 children with AML using the real time-polymerase chain reaction for AML1-ETO, PML-RAR? and CBFB-MYH11 genes. " /// "We investigated in this study, incidence and prognostic significance of the AML1-ETO, PML-RAR? and CBFB-MYH11 genes in children with AML. "
MYH11_CBFB- 20007544leukemia - - It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causative for oncogenic transformation. /// "Previously published reports showed that CBFB-MYH11 dominantly inhibits RUNX1 and CBFB, and such inhibition has been suggested as the mechanism for leukemogenesis. " /// "However, the mechanism by which CBFB-MYH11 initiates leukemogenesis is not clear. " /// The expression of all 3 genes was detected in most human and murine CBFB-MYH11(+) leukemia samples.
MYH11_CBFBinv(16) / 25804769acute myeloid leukemia;myeloid leukemia;leukemia - - Eighty-six adult patients with inv(16) acute myeloid leukemia (AML) in first complete remission (CR1) were serially monitored for CBFB-MYH11 transcript levels during the early courses of chemotherapy. /// "For patients receiving chemotherapy/autologous SCT, the sole independent adverse prognostic factor for the cumulative incidence of relapse (CIR), disease-free survival (DFS) and overall survival (OS) was a CBFB-MYH11 level > 0.2% after course 2 consolidation (p = 0.003, 0.003 and 0.031), which was used to define a poor molecular response (MR). "
MYH11_CBFB- 19466970- - - Acute myeloid leukaemia with associated eosinophilia: justification for FIP1L1-PDGFRA screening in cases lacking the CBFB-MYH11 fusion gene..
MYH11_CBFBinv(16) / 24002588acute myeloid leukemia;myeloid leukemia;leukemia - - CBFB-MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia..
MYH11_CBFBt(9;22) / inv(16) / t(9;22) / inv(16)(p13q22) / 24724063acute myeloid leukemia;myeloid leukemia;leukemia;hematologic malignancy;hematologic malignancy - - This study shows that observations of bone marrow morphology, initial and follow-up cytogenetic studies, and karyotyping of BCR/ABL1 and CBFB/MYH11 provide valuable information for characterizing hematologic malignancies exhibiting t(9;22) and inv(16) coexistence..
MYH11_CBFBt(8;21) / inv(16) / 25612891acute myeloid leukemia;myeloid leukemia;leukemia - - Core Binding Factor acute myeloid leukemia (CBF-AML) with t(8;21) RUNX1-MTG8 or inv(16) CBFB-MYH11 fusion proteins often show upregulation of wild type or mutated KIT receptor. /// "In the first part of this study we found that stable miR-17 upregulation affects, like the CBF-AML fusion proteins (RUNX1-MTG8 or CBFB-MYH11), a core RUNX1-miRNA mechanism leading to KIT-induced proliferation of differentiation-arrested U937 myeloid cells. " /// "Human (U937) or mouse (32D) myeloid clonal lines were used, respectively, to test: 1) the effect of RUNX1-MTG8 and CBFB-MYH11 fusion proteins, or upregulation of miR-17, on KIT-induced proliferation and myeloid differentiation, and 2) the effect of upregulation of KIT-induced proliferation per se on myeloid cell differentiation. "
MYH11_CBFBp13;q22 / inv(16) / 8751466leukemia - - The inversion(16)(p13;q22) gives rise to chimeric transcripts CBFB-MYH11. /// We report the study of CBFB and CBFB-MYH11 protein using two anti-CBFB antisera. /// The gene product of CBFB-MYH11..
MYH11_CBFB- 15044690acute myeloid leukemia;myeloid leukemia;leukemia - - Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. /// We have previously shown that CBFB-MYH11 is necessary but not sufficient for leukemogenesis. /// "Here, we report the identification of genes that specifically cooperate with CBFB-MYH11 in leukemogenesis. "
MYH11_CBFB- 16228048acute myeloid leukemia;acute lymphoblastic leukemia;chronic myeloid leukemia PCR - The Section of Hematology, Department of Pathology and Laboratory Medicine at King Faisal Specialist Hospital and Research Center has shared this experience during the last 10 years with more than 6,546 samples submitted for the analysis of different gene rearrangements, fusion gene transcripts and gene mutations including Ig heavy chain gene rearrangement for B-cell malignancies, T-cell receptor gamma chain gene rearrangement for T-cell malignancies, BCR/ABL-P210 and P190 fusion gene transcripts, for chronic myeloid leukemia and Philadelphia positive acute lymphoblastic leukemia, PML/RARalpha fusion gene for promyelocytic leukemia, AML1/ETO for acute myeloid leukemia AML-M2 with t8;21, CBFB/MYH11 for AML M4E0 with inv 16, BCL-2 for follicular lymphoma, and BCL-1 for mantle cell lymphoma.
MYH11_CBFBinv(16) / inv(16) / 26891877acute myeloid leukemia;myeloid leukemia;leukemia - - Because FLT3-N676K was encountered almost exclusively in inv(16) AML, we investigated the transforming potential of FLT3-N676K, the cooperation between FLT3-N676K and core binding factor ?-smooth muscle myosin heavy chain (CBF?-SMMHC) (encoded by the inv(16) chimeric gene CBFB-MYH11) in inducing acute leukemia, and tested the sensitivity of FLT3-N676K-positive leukemic cells to FLT3 inhibitors.
MYH11_CBFB- 19215788acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - that rare fusion transcripts of CBFB/MYH11 are correlated with an atypical cytomorphology and other aberrant characteristics. /// We report on a 20-year-old man with acute myeloid leukemia (AML) showing a distinct novel CBFB/MYH11 variant fusion transcript. /// Detection of a novel CBFB/MYH11 variant fusion transcript (K-type) showing partial insertion of exon 6 of CBFB gene using two commercially available multiplex RT-PCR kits.. /// "Not only does this case show a partial insertion of exon 6 of the CBFB (ENSG00000067955) gene, but it also involves novel breakpoints within both exon 6 of the CBFB gene and exon 28 (previously exon 7) of the MYH11 (ENSG00000133392) gene, which is regarded as a previously non-reported, new type (K-type) of CBFB/MYH11 fusion transcript. " /// "Initial results of bone marrow, chromosome, and flow cytometric analyses were not in accordance with the diagnosis of acute myelomonocytic leukemia with eosinophilia (AML-M4Eo) or AML with a CBFB/MYH11 rearrangement. " /// "Therefore, multiplex RT-PCR and sequence analysis of these atypical products should be performed to diagnose atypical AML with CBFB/MYH11 rearrangement, to predict prognosis of these patients as well as to elucidate the molecular mechanism.. "
MYH11_CBFBt(8;21) / 11753612acute myeloid leukemia;myeloid leukemia;leukemia - - Breakpoints in general displayed similar complexity of duplications, deletions, and insertions to other common pediatric leukemia translocations (TEL-AML1, MLL-AF4, PML-RARA, CBFB-MYH11) that we and others have analyzed..
MYH11_CBFBinv(16) / t(9;22) / inv(16) / t(8;10)(p23;q25) / t(8;10) / t(10;16)(p13;q22) / inv(16)(p13q22) / t(10;16) / t(9;22)(q34;q11) / 23054652acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - CBFB/MYH11 (A type) and BCR/ABL1 (b3a2) fusion transcripts were both detected by real-time quantitative RT-PCR.
MYH11_CBFB- 16645213acute myeloid leukemia;myeloid leukemia;leukemia - - NPM1 gene mutations are the most frequent genetic lesion in the 60% of adult acute myeloid leukemias (AMLs) with normal karyotype and no evidence of typical fusion genes (BCR/ABL1, PML/RARA, AML1/ETO, CBFB/MYH11, DEK/CAN).
MYH11_CBFBinv(16) / 15370133- PCR;RT-PCR - In three cytogenetically negative cases, RT-PCR detected cryptic CBF rearrangements (one AML1-ETO and two CBFB-MYH11). /// " Our objective was to establish a multiplexed assay using the Biomed 1 primers to detect AML1-ETO transcripts and 10 different CBFB-MYH11 transcripts, using BCR and ABL transcripts as controls. "
MYH11_CBFBt(8;21)(q22;q22) / inv(16)(p13.1;q22) / t(16;16) / p13.1;q22 / 22145956acute myeloid leukemia;myeloid leukemia;leukemia;systemic mastocytosis - - CBFB-MYH11 chromosomal rearrangements, but whether the mutation is indicative of associated SM is unclear.
MYH11_CBFBinv(16)(p13q22) / t(16;16)(p13;q22) / inv(16) / t(16;16) / inv(16)(p13q24) / 8142642leukemia PCR;RT-PCR - In this study we have examined a series of 37 of these cases using reverse transcriptase-polymerase chain reaction (RT-PCR) to detect expression of a hybrid CBFB/MYH11 transcript.
MYH11_CBFBt(15;17) / t(8;21) / inv(16) / del(9q) / inv(16) / 9609531- - - A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RARalpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia.
MYH11_CBFB- 20625124acute myeloid leukemia;myeloid leukemia;leukemia PCR - To evaluate the prognostic impact of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) expressing the CBFB-MYH11 fusion transcript. /// Monitoring of CBFB-MYH11 transcript levels should be incorporated into future clinical trials to guide therapeutic decisions..
MYH11_CBFB- 19463768acute myeloid leukemia;myeloid leukemia;leukemia - - Frequent MRD monitoring was performed in all AML treatment phases using real-time quantitative polymerase chain reaction for fusion transcripts (CBFB/MYH11.
MYH11_CBFBinv(16) / t(4;11) / t(11;19) / 23091311- PCR - Fifteen fusion transcripts were included: BCR-ABL1, PML-RARA, ZBTB16-RARA, RUNX1-RUNX1T1, CBFB-MYH11, DEK-NUP214, TCF3-PBX1, ETV6-RUNX1, MLL-AFF1, MLL-MLLT4, MLL-MLLT3, MLL-MLLT10, MLL-ELL, MLL-MLLT1, and MLL-MLLT6.
MYH11_CBFBinv(16)(p13q22) / inv(16) / inv(16) / del(7)(q32) / del(16)(q22) / 21763633acute myeloid leukemia;myeloid leukemia;leukemia FISH;PCR;RT-PCR - Our patient was a 30-year-old man with newly diagnosed acute myeloid leukemia who was found to have a CBFB-MYH11 fusion by reverse transcriptase-polymerase chain reaction.
MYH11_CBFB- 12842988acute myeloid leukemia;myeloid leukemia;leukemia - - To evaluate the prognostic significance of quantitative PML-RARA, AML1-ETO, and CBFB-MYH11 fusion transcript expression, real-time polymerase chain reaction was used to analyze bone marrow samples of 349 such patients at diagnosis and 522 samples of 142 patients also during therapy (total analyses, n = 859.
MYH11_CBFB- 9844935- - - Identification of a novel CBFB-MYH11 fusion transcript in a patient with AML and inversion of chromosome 16..
MYH11_CBFB- 8630430- - - Novel CBFB-MYH11 fusion transcripts or reverse transcription-polymerase chain reaction artifacts?.
MYH11_CBFBinv(16) / 24452154acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - We report a 40-year-old woman diagnosed as having acute myeloid leukemia with CBFB-MYH11.
MYH11_CBFBt(8;21) / inv(16) / 14645432leukemia PCR;RT-PCR - We quantified MRD at various time points during and after therapy by real-time reverse transcriptase polymerase chain reaction (RT-PCR) for AML1/MTG8 and CBFB/MYH11 in 37 patients with CBF leukemias treated within a multicenter trial.
MYH11_CBFB- 18719738acute myeloid leukemia;myeloid leukemia;leukemia - - Both groups showed similar characteristics regarding white blood cell counts, cytogenetic data or presence of gene rearrangements associated with good prognosis as AML1-ETO, CBFB-MYH11 and PML/RARA.
MYH11_CBFB- 20508610acute myeloid leukemia;myeloid leukemia;leukemia PCR - Prognostic value of minimal residual disease by real-time quantitative PCR in acute myeloid leukemia with CBFB-MYH11 rearrangement: the French experience..
MYH11_CBFB- 18665825acute myeloid leukemia PCR;RT-PCR - Common fusion transcripts in childhood acute lymphoblastic leukemia (ALL) are TEL-AML1, E2A-PBX, MLL-AF4, and BCR-ABL (p190) and in acute nonlymphoblastic leukemia (ANLL) are AML-ETO, PML-RARA, and CBFB-MYH11. /// "Multiplex RT-PCR panel A (ALL) included primers for TEL-AML1, E2A-PBX, MLL-AF4, and BCR-ABL (p190) whereas panel B (ANLL) composed of primers for AML-ETO, PML-RARA, and CBFB-MYH11. "
MYH11_CBFBinv(16) / t(16;16) / inv(16) / p13.1;q22 / 23115274acute myeloid leukemia;myeloid leukemia;leukemia - - CBFB-MYH11.
MYH11_CBFB- 21354057leukemia PCR;RT-PCR - To our knowledge, the presence of PML-RARA and CBFB-MYH11 in healthy individuals has not been previously described. /// "To detect the presence or absence of these genetic alterations in healthy individuals, sensitive nested RT-PCR analyses were performed on a large number of peripheral blood samples for selected markers including MLL partial tandem duplications (PTDs), BCR-ABL p190, BCR-ABL p210, MLL-AF4, AML1-ETO, PML-RARA, and CBFB-MYH11. "
MYH11_CBFB- 24464319acute myeloid leukemia;acute promyelocytic leukemia;myeloid leukemia;leukemia PCR;RT-PCR - Class II mutations: 24 (17.9?%), 19 (14.2?%), and 9 (6.7?%) children had PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 transcripts, respectively.
MYH11_CBFB- 20164853- - - AML with CBFB-MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions..
MYH11_CBFB- 23646898acute myeloid leukemia;myeloid leukemia;leukemia - - Age, leukocyte counts, BAALC, and MN1 gene expressions as well as high copy numbers of RUNX1-RUNXT1 or CBFB-MYH11 after induction chemotherapy are useful tools to predict the outcome and should be considered for risk-adapted therapy.. /// CBFB-MYH11 n?=?76) were prospectively enrolled into two consecutive CETLAM protocols at 19 Spanish institutions. /// "In multivariate analyses, leukocyte count above 20????10(9) /L, BAALC over-expression, and high copy numbers of RUNX1-RUNXT1 or CBFB-MYH11 after induction chemotherapy (CT) led to increased relapse rate. "
MYH11_CBFB- 23053179acute myeloid leukemia;myeloid leukemia;leukemia - - The study patients consisted of 121 patients with CBF AML (82 patients with RUNX1/RUNX1T1 [67.8?%] and 39 patients with CBFB/MYH11 [32.2?%]) recruited from eight institutions in Korea.
MYH11_CBFB- 22915647acute myeloid leukemia;myeloid leukemia;leukemia - - (2) favorable: RUNX1-RUNX1T1 (n = 35), CBFB-MYH11 (n = 31), or NPM1 mutation without FLT3-ITD (n = 186. /// "One thousand patients with cytogenetic data were investigated for the following molecular alterations: PML-RARA, RUNX1-RUNX1T1, CBFB-MYH11, FLT3-ITD, and MLL-PTD, as well as mutations in NPM1, CEPBA, RUNX1, ASXL1, and TP53. "
MYH11_CBFB- 23358744acute myeloid leukemia;acute promyelocytic leukemia;myeloid leukemia;leukemia - - A prerequisite for individualized treatment strategies is a fast pretherapeutic molecular screening including the fusion genes PML-RARA, RUNX1-RUNX1T1 and CBFB-MYH11 as well as mutations in the genes NPM1, FLT3 and CEBPA.
MYH11_CBFB- 9156661acute myeloid leukemia;myeloid leukemia;leukemia - - Using reverse transcriptase-polymerase chain reaction analysis, we tried to detect CBFB/MYH11 chimeric mRNA in blasts from our patients, however, were unable to detect any chimeric mRNA in the blasts: The absence of CBFB/MYH11 transcripts in this case suggests that rare chimeric products might be formed as a result of inv 16 that could not be detected by the primer sets used in this study. /// Analyzing leukemias with inv 16 which do not have a typical CBFB/MYH11 chimeric mRNA might lead to understanding an alternative pathogenesis for acute leukemia with inv 16..

ChimerSEQ

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The fusion gene pair MYH11--CBFB information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MYH11--CBFB information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MYH11--CBFB information is not available in FARE-CAFE.

TicDB

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The fusion gene pair MYH11--CBFB information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair MYH11--CBFB information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MYH11--CBFB information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MYH11--CBFB information is not available in ConjoinG Database.

1000Genome

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Fusion gene MYH11--CBFB has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MYH11--CBFB is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MYH11--CBFB is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MYH11--CBFB is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MYH11--CBFB was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MYH11--CBFB information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MYH11--CBFB is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MYH11--CBFB has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MYH11 is not a known oncogene according to ONGENE database.


The tail gene CBFB is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MYH11 is cancer associated according to Bushman Cancer Gene database.


The tail gene CBFB is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MYH11 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene CBFB is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MYH11--CBFB is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MYH11--CBFB is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MYH11--CBFB information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MYH11--CBFB is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MYH11--CBFB has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MYH11--CBFB information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MYH11--CBFB information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MYH11--CBFB information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MYH11--CBFB is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MYH11--CBFB information is not available in ChromothripsisDB database.