MYH11--CBF

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

MYH11 CBF

COSMIC

The fusion gene pair MYH11--CBF information is not available in COSMIC database.

ChimerKB

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The fusion gene pair MYH11--CBF information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair MYH11--CBF information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MYH11_CBFinv(16)(p13;q22) / inv(16) / inv (16) / 10921098leukemia FISH;PCR;RT-PCR - To study the clinical significance of inv(16) and CBF beta-MYH11 fusion gene in the diagnosis and prognosis for M4Eo. /// [Detection of CBF beta-MYH11 fusion transcript and inv(16)(p13;q22) in acute myelomonocytic leukemia(M4) by RT-PCR and FISH].. /// "CBF beta-MYH11 fusion transcripts and inv (16) were analyzed by reverse-transcriptase polymerase chain reaction(RT-PCR) and fluorescence in situ hybridization(FISH), respectively, in acute myelomonocytic leukemia(M4) with or without eosinophilia. " /// "In fifteen cases tested, one case of M4Eo and one of 9 M4 without eosinophilia were found to have CBF beta-MYH11 fusion transcript. "
MYH11_CBF22p13.1 / inv(16)(p13q22) / t(16;16)(p13q22) / 10958941febrile neutropenia FISH;PCR - This case demonstrates a previously unreported structural abnormality of chromosome 16 in a patient with AML M4, which represents a third mechanism to inv(16)(p13q22) and t(16;16)(p13q22) in producing the CBF beta-MYH11 fusion. /// "A unique structural abnormality of chromosome 16 resulting in a CBF beta-MYH11 fusion transcript in a patient with acute myeloid leukemia, FAB M4.. " /// CBF beta-MYH11 fusions masked by cryptic translocations at the cytogenetic level have been detected by FISH and PCR techniques. /// "Due to the improved prognosis associated with CBF beta-MYH11 fusions compared to the standard risk group for AML, its detection remains important.. "
MYH11_CBF5p15.2 / inv(16) / t(11q23) / 12872151acute myeloid leukemia;myeloid leukemia;leukemia FISH - For FISH the following probes were used: MLL, CBF-beta/MYH11, ETV-6/AML1.
MYH11_CBFt(8;21)(q22;q22) / inv(16)(p13q22) / 11107447acute myeloid leukemia;myeloid leukemia;leukemia - - At the molecular level, t(8;21)(q22;q22) and inv(16)(p13q22) result in the creation of novel fusion genes, AML1/ETO and CBF beta/MYH11, whose structures and functions are being successfully characterized by in vitro studies and transgenic animal models.
MYH11_CBFinv(16)(p13q22) / 12481902leukemia - - Molecular analysis of a new variant of the CBF beta-MYH11 gene fusion..
MYH11_CBFt(9;22)(q34,q11) / p13;q22 / t(1;11)(p32;q23) / / 7723408leukemia PCR;RT-PCR - Following this strategy we were able to synthesize the fusion transcripts m-BCR/ABL, CBF beta/MYH11, and MLL/AFp1 which are the molecular equivalents of t(9;22)(q34,q11), inv16(p13;q22) and t(1;11)(p32;q23), respectively.
MYH11_CBFinv(16)(p13q22) / inv(16) (p13q22) / 9074414- PCR;RT-PCR - We studied 321 patients with AML at diagnosis for the presence of inv(16)(p13q22) and CBF beta/MYH11 fusion transcripts by cytogenetic and RT-PCR techniques respectively. /// The observed frequencies of CBF beta/MYH11 fusion transcripts in our study have been adjusted for the reported incidence of each FAB subtype and we calculate that 10.1% of all new cases of AMLs have molecular evidence of inv(16)(p13q22). /// Frequency of CBF beta/MYH11 fusion transcripts in patients entered into the U.K. /// We conclude that molecular screening for the presence of CBF beta/MYH11 fusion transcripts should be mandatory in all case of AML at diagnosis..
MYH11_CBFinv(16)(p13q22) / t(16;16)(p13;q22) / inv(16) / inv(16) / t(16;16) / 7780153leukemia PCR - Heterogeneity in CBF beta/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia.. /// "In this study, we analyzed 37 cases of inv(16)-containing AML and 4 cases with t(16;16)(p13;q22) for expression of the CBF beta/MYH11 chimeric message by reverse transcription-polymerase chain reaction (PCR) analysis. " /// CBF beta/MYH11 chimeric messages were detected in 33 of 37 cases with the inv(16) and in the 4 t(16;16)-containing cases. /// These data suggest that different CBF beta/MYH11 products may vary subtly in their biologic activities.. /// "To assess whether the portions of CBF-beta contained within the CBF beta/MYH11 chimeric products retain the ability to interact with their heterodimeric DNA-binding partner AML-1, we performed in vitro DNA-binding analysis. "
MYH11_CBF- 15168592acute myeloid leukemia;acute lymphoblastic leukemia;myeloid leukemia; - - All patients with the PML/RAR alpha and MYH11/CBF beta fusion gene continued to be in CR. /// "After the first consolidation therapy (consolidation 1), the expression of Wilms tumor gene (WT1) and/or leukemia-specific fusion genes such as AML1/MTG8, PML/RAR alpha, and MYH11/CBF beta were analyzed. " /// "The AML1/MTG8 fusion gene was expressed in 8 patients, PML/RAR alpha was expressed in 3 patients, and MYH11/CBF beta was expressed in 1 patient. "
MYH11_CBFinv(16)(p13q22) / 18024381acute myeloid leukemia;myeloid leukemia;leukemia - - A case of acute myeloid leukemia with inv(16)(p13q22) reveals a novel MYH11 breakpoint and a new CBF beta-MYH11 transcript variant.. /// "However, studies revealed a CBF beta-MYH11 fusion transcript which did not correspond to any of the 10 known variants. "
MYH11_CBFt(8;21) / t(3;21) / inv(16) / 8035830myeloid leukemia;leukemia - - Since t(8;21), t(3;21), and inv(16), associated with myeloid leukemias, disrupt subunits of PEBP2/CBF, we speculate that the resulting oncoproteins, AML1-ETO, AML1-EAP, AML1-Evi1, and CBF beta-MYH11, inhibit early myeloid differentiation..
MYH11_CBFt(8;21)(q22;22) / inv(16)(p13q22) / t(8;21) / inv(16) / t(16;16) / inv(16) / 11167739- PCR;RT-PCR - Cytogenetically cryptic AML1-ETO and CBF beta-MYH11 gene rearrangements: incidence in 412 cases of acute myeloid leukaemia.. /// We present here a four centre study involving 412 cases of AML screened using both standard cytogenetics and RT-PCR for AML1-ETO and CBF beta-MYH11.
MYH11_CBFinv(16)(p13q22) / 7858261leukemia FISH;PCR;RT-PCR - Detection of the chromosome 16 CBF beta-MYH11 fusion transcript in myelomonocytic leukemias.. /// "We have analyzed CBF beta-MYH11 fusion transcripts by RT-PCR in myelomonocytic leukemias, with or without eosinophilia, to determine whether their presence correlates with morphology. " /// "These data show that CBF beta-MYH11 fusion transcripts occur not only in the vast majority of typical AML M4Eo, but also in approximately 10% of AML M4 without eosinophilic abnormalities, a much higher incidence than the sporadic reports of chromosome 16 abnormalities in AML M4 would suggest. " /// "Taken together with the detection of CBF beta-MYH11 transcripts in the absence of apparent chromosome 16 abnormalities by classical banding techniques, these data show that additional screening by either RT-PCR or FISH should be performed in all AML M4, regardless of morphologic features, to allow accurate evaluation of the prognostic importance of this fusion transcript.. " /// All 11 typical AML M4Eo were CBF beta-MYH11 positive. /// "Three of 29 (10%) AML M4 without abnormal eosinophils were CBF beta-MYH11 positive, 1 of which did not show any apparent chromosome 16 abnormalities by classical metaphase analysis (2 not tested). "
MYH11_CBF- 18445043myelodysplastic syndrome PCR - The presence of BCR/ABL and other relevant fusion gene products (FIP1L1/PDGFRA, AML1/ETO, PML/RAR alpha, CBF beta/MYH11) were excluded by PCR.
MYH11_CBF- 16643429- - - Comparison of methylation data with a series of other molecular alterations in the same patient materials revealed a correlation between hypermethylation of the RARbeta2 promoter and the presence of CBF-MYH11 fusion transcripts (P < 0.01). /// Our data suggest that RARbeta2 promoter methylation is frequent in AML and may co-operate with the expression of CBF-MYH11 fusion transcripts in leukaemogenesis..
MYH11_CBF- 7662994acute myeloid leukemia;myeloid leukemia;leukemia - - Novel CBF beta-MYH11 fusion transcripts and alternative splicing in acute myeloid leukemia with inversion of chromosome 16..
MYH11_CBF- 10846434acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia PCR - Along a 5-year period in a single institution, specific molecular markers were prospectively looked for in consecutive patients with acute leukemia, by means of polymerase chain reaction (PCR): In patients with acute lymphoblastic leukemia (ALL), the BCR/ABL and TEL-AML1 fusion transcripts as well as clonotypic immunoglobulin gene rearrangements were investigated, whereas in patients with acute myelogenous leukemia (AML) the PML-RAR alpha, AML1-ETO and CBF beta-MYH11 fusion proteins were assessed.
MYH11_CBFinv(16) / 10705822acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - Only 8 of 20 CBF beta/MYH11-positive patients had M4Eo morphologic features. /// High concordance of karyotype analysis and RT-PCR for CBF beta/MYH11 in unselected patients with acute myeloid leukemia.

ChimerSEQ

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The fusion gene pair MYH11--CBF information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MYH11--CBF information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MYH11--CBF information is not available in FARE-CAFE.

TicDB

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The fusion gene pair MYH11--CBF information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair MYH11--CBF information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MYH11--CBF information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MYH11--CBF information is not available in ConjoinG Database.

1000Genome

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Fusion gene MYH11--CBF has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MYH11--CBF is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MYH11--CBF is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MYH11--CBF is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MYH11--CBF was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MYH11--CBF information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MYH11--CBF is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MYH11--CBF has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MYH11 is not a known oncogene according to ONGENE database.
The tail gene CBF is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MYH11 is cancer associated according to Bushman Cancer Gene database.
The tail gene CBF is not cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MYH11 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene CBF is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MYH11--CBF is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MYH11--CBF is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MYH11--CBF information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MYH11--CBF is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MYH11--CBF has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MYH11--CBF information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MYH11--CBF information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MYH11--CBF information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MYH11--CBF is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MYH11--CBF information is not available in ChromothripsisDB database.