MUM1--IRF4

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

MUM1 IRF4

COSMIC

The fusion gene pair MUM1--IRF4 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair MUM1--IRF4 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair MUM1--IRF4 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MUM1_IRF4t(14;18) / 21487109follicular lymphoma;B cell lymphoma;lymphoma FISH - Those were predominantly GCB-type DLBCL or follicular lymphoma grade 3, shared strong expression of IRF4/MUM1 and BCL6, and lacked PRDM1/BLIMP1 expression and t(14;18)/BCL2 breaks.
MUM1_IRF4t(14;18) / 21915363B cell lymphoma;lymphoma FISH - Immunohistochemical staining for CD10, BCL6, LMO2, MUM1/IRF4, and BCL2 and fluorescence in situ hybridization for t(14;18) were conducted, with ?93% blinded duplicate agreement. /// "CD10, LMO2, and BCL2 expression was similar to previous reports (32%, 44%, and 44% of DLBCLs, respectively), but BCL6 and MUM1/IRF4 expression was lower than expected (29% and 5%, respectively). "
MUM1_IRF4t(6;14) / p25;q11.2 / 18987657T cell lymphoma;B cell lymphoma;anaplastic large cell lymphoma;lymphoma FISH - Further, due to its involvement in translocations, MUM1/IRF4 protein may play an important biologic role in some PTCLs, and might represent a possible therapeutic target..
MUM1_IRF4- 19786664B cell lymphoma;lymphoma FISH - Paraffin-embedded tumor samples of 119 patients treated with R-CHOP were analyzed by immunohistochemistry for CD10, BCL6, MUM1/IRF4, LMO2, and forkhead box protein P1 (FOXP1) expression and for BCL2, BCL6, and c-MYC breakpoints by fluorescence in situ hybridization (FISH) on tissue microarray. /// "Interestingly, an immunoFISH index, defined by positivity for at least two of three non-GC markers (FOXP1, MUM1/IRF4, BCL6 breakpoint) was significantly associated with a shorter 5-year OS rate (44%. "
MUM1_IRF4- 16943530B cell lymphoma;lymphoma FISH - DLBCL from 66 newly diagnosed poor-risk patients, treated in two sequential prospective Dutch Hemato-Oncology Association (HOVON) trials, were studied retrospectively for expression of CD10, bcl6, MUM1/IRF4, bcl2, Ki67, and CD21+ follicular dendritic cells (FDC) by immunohistochemistry, and for the breakpoints of BCL2, BCL6, and MYC by fluorescent in situ hybridization (FISH).
MUM1_IRF4t(6;14)(p25;q32) / t(6;14) / 10557056multiple myeloma FISH - Detection of MUM1/IRF4-IgH fusion in multiple myeloma..
MUM1_IRF4- 25687653non Hodgkin lymphoma;B cell lymphoma;lymphoma FISH - Paraffin-embedded samples from 112 patients with de novo DLBCL, enrolled in the R-MegaCHOEP trial of the German High Grade Non-Hodgkin Lymphoma Study Group (DSHNHL) were investigated using immunohistochemistry (MYC, FOXP1, LMO2, GCET1, CD5, CD10, BCL2, BCL6, IRF4/MUM1) and fluorescence in situ hybridization (MYC, BCL2, BCL6).
MUM1_IRF4- 22213394B cell lymphoma;lymphoma FISH - Tissue microarrays were constructed from 239 cases of DLBCL, and the expressions of CD10, BCL6, MUM1/IRF4, and BCL2 were evaluated by immunohistochemistry.
MUM1_IRF4- 21997689follicular lymphoma FISH - We performed immunohistochemistry for CD20, CD3, CD10, BCL6, IRF4/MUM1, and BCL2 and interphase fluorescence in situ hybridization for translocations involving BCL2, BCL6, and IRF4.
MUM1_IRF4- 23332472anaplastic large cell lymphoma;lymphomatoid papulosis;lymphoproliferative disorder;mycosis fungoides FISH - The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: a study of 53 cases.. /// In contrast MUM1/IRF4 protein expression was distributed widely without any predictive value..
MUM1_IRF4- 11520558B cell lymphoma;lymphoma FISH - The other partners were 19q13 (BCL3), 6p25 (MUM1/IRF4), 1q36, and chromosome 8 identified in one patient each.
MUM1_IRF4t(6;14) / p25;q32 / 9326949multiple myeloma - - Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.. /// "As a result, the MUM1/IRF4 gene is overexpressed--an event that may contribute to tumorigenesis, a MUM1/IRF4 has oncogenic activity in vitro. "
MUM1_IRF4t(11;14) / t(15;17) / t(2;5) / 11781220T cell lymphoma;leukemia;follicular lymphoma;mantle cell lymphoma;lymphoma - - The protein products of other genes activated by chromosomal rearrangement have a role as markers of either lineage (eg, PAX-5 [B-cell-specific activator protein] for B cells, including B-lymphoblastic neoplasms), or maturation stage (eg, BCL-6 for germinal-center and activated B cells and MUM-1/IRF4 for plasma cells).
MUM1_IRF4t(8;22) / t(8;14) / 20118770leukemia;follicular lymphoma;B cell lymphoma;lymphoma - - Distinguishing features from BL included expression of Bcl2 (P<0.0001), Mum1/IRF4 (P=0.006), Ki-67 <95% (P<0.0001), and absence of EBV-EBER (P=0.006).
MUM1_IRF4t(8;14)(q24;q32) / 26173642lymphoma - - Remarkably, all six primary Burkitt lymphomas with a PCBP1 mutation expressed MUM1/IRF4, which is otherwise detected in around 20-40% of Burkitt lymphomas.
MUM1_IRF4p25;q32 / 12079517B cell chronic lymphocytic leukemia;lymphoma - - MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)..
MUM1_IRF4t(6;14) (p25;q32) / 11455001malignant meningioma;multiple myeloma - - Analysis of MUM1/IRF4 protein expression using tissue microarrays and immunohistochemistry..
MUM1_IRF4t(6;14;18)(p25;q32;q21) / t(14;18)(q32;q21) / t(8;22) / 23995111leukemia - - On the other hand, MUM1/IRF4 functions as a tumor suppressor in c-MYC-induced B-cell leukemia. /// "MUM1/IRF4 has been found to induce c-MYC expression, and in turn, MYC transactivates MUM1/IRF4, creating a positive autoregulatory feedback loop. " /// "The present rare case arouses interest in view of the possible ""dual"" activation of both c-MYC and MUM1/IRF4 through two independent dual-translocations, c-MYC/BCL-2 and IRF4/BCL-2.. " /// "However, the interfollicular larger cells showed plasmacytic differentiation with diminished CD20, Bcl-2, Bcl-6, and positive intracytoplasmic IgM, and co-expression of MUM1/IRF4 and CD138 with increased Ki-67-positive cells (> 90%). " /// "The intrafollicular tumor cells had a germinal center phenotype with the expression of surface IgM, CD10, Bcl-2, Bcl-6, and MUM1/IRF4. "
MUM1_IRF4t(11;14) / 26034867B cell lymphoma;mantle cell lymphoma - - Our data suggest that clinical presentation on the leg and blastoid cytology along with high proliferation and expression of Bcl2, Mum-1/IRF4, and IgM are typical for MCL involving the skin. /// "Moreover, the immunophenotype with expression of BCL2 (100%), MUM-1/IRF4 (83%), and IgM (82%) and lack of CD10 (25%) and BCL6 (0%) closely resembled the features of primary cutaneous diffuse large B-cell lymphoma, leg type. "
MUM1_IRF4- 12379751B cell lymphoma;lymphoma PCR - The CD5+ neoplastic large B-cells expressed bcl-6 and MUM1/IRF4 but not CD138 by immunohistochemistry.
MUM1_IRF4- 23348205primary effusion lymphoma - - Unlike DH-BCL2/MYC lymphomas, however, they are more likely to be CD10(-) but IRF4/MUM-1(+) (P=0.03) and, more like BL, only infrequently express BCL2 (P<0.001), and are cytogenetically less complex (P<0.04)..
MUM1_IRF4t(11;14)(q13;q32) / 26360498B cell lymphoma;mantle cell lymphoma;lymphoma - - However, no differences in the expression of IRF4/MUM1 were observed among these subtypes of mantle cell lymphoma.
MUM1_IRF4- 23599146follicular lymphoma;B cell lymphoma;lymphoma - - Immunohistologic studies showed the expression of CD10 (91%), BCL6 (97%), BCL2 (95%), MUM1/IRF4 (12%), MDM2 (17%), and CD23 (25%).
MUM1_IRF4- 22314189extranodal NK/T-cell lymphoma;T cell lymphoma - - Intestinal ENKTLs were EBV and had significantly more frequent CD30, pSTAT3, and IRF4/MUM1 expression but less frequent CD16 compared with ?? EATL. /// "Of the NK-ENKTLs, 38% were Oct-2 compared with 0% of T-ENKTLs, and 54% were IRF4/MUM1 compared with 20% of T-ENKTLs. "
MUM1_IRF4- 21659362follicular lymphoma;B cell lymphoma;lymphoma - - Both follicular lymphoma grade 3B and diffuse large B-cell lymphoma/follicular lymphoma grade 3B were enriched in samples with a CD10(-)IRF4/MUM1(+) immunophenotype (8/19, 42% and 7/16, 44%), with the vast majority of them lacking BCL2 translocations. /// "We performed a detailed immunohistochemical (CD10, IRF4/MUM1, BCL2, Ig light chains) and genetic (translocations of BCL2, BCL6, MYC, IRF4) characterization of the largest series of purely follicular cases of grade 3B follicular lymphoma available to date, comprising 23 tumor samples. " /// "Our results show that grade 3B follicular lymphomas form a distinct category of follicular lymphomas with infrequent BCL2 and BCL6 translocations, while grades 1, 2 and 3A follicular lymphomas and FL/LCC display homogeneous features with frequent BCL2 translocations and a CD10(+)IRF4/MUM1(-) immunophenotype.. " /// None of the tumor samples tested with increased IRF4/MUM1-expression harbored a translocation of the IRF4 gene locus. /// "In contrast, 42/46 grade 1 or 2 follicular lymphomas, FL/LCC and grade 3A follicular lymphomas were CD10(+) (91%) while 0/46 expressed IRF4/MUM1. "
MUM1_IRF4t(1;6) / t(1;6) / del(11) / 1p35.3 / 6p25.2 / 15510210B cell chronic lymphocytic leukemia ISH - The latter breakpoint was located in the genomic region coding for MUM1/IRF4, one of the key regulators of lymphocyte development and proliferation, suggesting involvement of this gene in the t(1;6).
MUM1_IRF4t(8;14)(q24;q32) / t(12;14)(q24;q32) / t(1;3)(q12;p12) / t(4;17)(q21;p11) / t(8;14) / t(12;14) / t(8;12;14) / 22041376- ISH - Lymphoma cells obtained from the ascitic fluid were CD10(+), CD20(+), CD38(+), HLA-DR(+), BCL6(-), MUM1/IRF4(+), BCL2(+), and immunoglobulin ?/?(+).
MUM1_IRF4t(14;18)(q32;q21) / 18925696follicular lymphoma;B cell lymphoma;lymphoma ISH - In 53 patients with diffuse large B-cell lymphoma and 20 patients with follicular lymphoma grade 3 with >75% follicular growth pattern the following was performed: 1) determination of protein expression of BCL6, CD10, MUM1/IRF4, CD138, and BCL2 by immunohistochemistry.

ChimerSEQ

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The fusion gene pair MUM1--IRF4 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MUM1--IRF4 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MUM1--IRF4 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair MUM1--IRF4 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair MUM1--IRF4 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MUM1--IRF4 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MUM1--IRF4 information is not available in ConjoinG Database.

1000Genome

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Fusion gene MUM1--IRF4 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MUM1--IRF4 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MUM1--IRF4 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MUM1--IRF4 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MUM1--IRF4 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MUM1--IRF4 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MUM1--IRF4 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MUM1--IRF4 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MUM1 is a known oncogene according to ONGENE database.


The tail gene IRF4 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MUM1 is not cancer associated according to Bushman Cancer Gene database.


The tail gene IRF4 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MUM1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene IRF4 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MUM1--IRF4 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MUM1--IRF4 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MUM1--IRF4 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MUM1--IRF4 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MUM1--IRF4 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MUM1--IRF4 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MUM1--IRF4 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MUM1--IRF4 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MUM1--IRF4 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MUM1--IRF4 information is not available in ChromothripsisDB database.