MNX1--ETV6

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

 MNX1 ETV6

COSMIC

The fusion gene pair MNX1--ETV6 information is not available in COSMIC database.

ChimerKB

 Top
The fusion gene pair MNX1--ETV6 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
MNX1_ETV6-/-/ -/-/ - hg18 acute myeloblastic leukemia - - - Mitelman

ChimerPUB

 Top
The fusion gene pair MNX1--ETV6 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MNX1_ETV6t(7;12)(q36;p13) / del(12)(p12p13) / 18940475acute myeloid leukemia;myeloid leukemia;leukemia PCR;RT-PCR - MNX1-ETV6 fusion transcripts (previously HLXB9-ETV6) were rarely detected in AML patients having t(7;12)(q36;p13). /// Reverse transcriptase-polymerase chain reaction (RT-PCR) followed by sequence analysis revealed the presence of an MNX1-ETV6 fusion gene. /// MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia and expression of the MNX1 gene in leukemia and normal B cell lines.. /// This represents a novel case of an AMKL patient with MNX1-ETV6 fusion transcripts who had a good prognosis..

ChimerSEQ

 Top
The fusion gene pair MNX1--ETV6 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

 Top
The fusion gene pair MNX1--ETV6 information is not available in CHITARS database.

FARE-CAFE

 		Top
The fusion gene pair MNX1--ETV6 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
MNX1-ETV6 A)Acute Myelocytic Leukemia,B)Acute Myelocytic Leukemia-M1 A)Southern blot,FISH,DNA sequencing,PCR,RT-PCR,G-Banding,Long-rangePCR,Cyto genetic analysis,B)M-TEL,FISH,Southern blot,Pan handle PCR,Q-banding,RT-PCR,PCR _ _

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
MNX1-ETV6 MNX1-ETV6-Isoform1 MNX1 156802444 1 0 ETV6 _ 1 _ ATCAAGCTGGGCGCCGGCACCTTCCAGCTGgACCAGTGGCTGCGCGCGTCCACCGCGGGC 11454678 _
MNX1-ETV6 MNX1-ETV6-Isoform2 MNX1 _ _ 0 ETV6 _ 1 _ atgcccgacttcaactCAGGAACGAATTTCAT 18940475 _
MNX1-ETV6 MNX1-ETV6-Isoform3 MNX1 _ _ 0 ETV6 _ 1 _ atgcccgacttcaactGCTTGCAGCCAATTT 18940475 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
MNX1-ETV6 MNX1-ETV6-Isoform1 - - - -MNX1 1) Homeobox
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
ETV6 1) SAM_PNT
2) Ets
1) SAM_PNT , Phage_lysozyme
2) SRF-TF , Ank_2 , PAX , Ets
1) Homeobox
2) SAM_PNT
3) Ets
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
2) SAM_PNT , Phage_lysozyme
3) SRF-TF , Ank_2 , PAX , Ets
MNX1-ETV6 MNX1-ETV6-Isoform2 - - - -MNX1 1) Homeobox
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
ETV6 1) SAM_PNT
2) Ets
1) SAM_PNT , Phage_lysozyme
2) SRF-TF , Ank_2 , PAX , Ets
1) Homeobox
2) SAM_PNT
3) Ets
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
2) SAM_PNT , Phage_lysozyme
3) SRF-TF , Ank_2 , PAX , Ets
MNX1-ETV6 MNX1-ETV6-Isoform3 - - - -MNX1 1) Homeobox
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
ETV6 1) SAM_PNT
2) Ets
1) SAM_PNT , Phage_lysozyme
2) SRF-TF , Ank_2 , PAX , Ets
1) Homeobox
2) SAM_PNT
3) Ets
1) Homeobox , Pou , SBP_bac_1 , SRF-TF , CUT , HNF-1_N
2) SAM_PNT , Phage_lysozyme
3) SRF-TF , Ank_2 , PAX , Ets

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
MNX1-ETV6 hsa-miR-129-5p, hsa-miR-296-3p, hsa-miR-99b-5p, hsa-miR-92a-3p hsa-miR-101-3p qPCR,Microarray,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
MNX1-ETV6 NM_001165255.1 - 1) TRIM28_HUMAN
2) MITF_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) P53_HUMAN
6) RUNX1_HUMAN
7) PRDM14_HUMAN
8) ETS1_HUMAN
9) EGR1_HUMAN
10) GATA2_HUMAN
11) GATA3_HUMAN
12) SOX2_HUMAN
13) TAL1_HUMAN
14) CTCF_HUMAN
15) BRG1_HUMAN
16) HNF4A_HUMAN
17) TFAP2C_HUMAN
18) FOXA1_HUMAN
19) CEBPA_HUMAN
20) ESR1_HUMAN
21) SETDB1_HUMAN
22) SPI1_HUMAN
23) TRIM24_HUMAN
-

TicDB

 		Top
The fusion gene pair MNX1--ETV6 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
MNX1 ETV6 11454678 ATCAAGCTGGGCGCCGGCACCTTCCAGCTGgACCAGTGGCTGCGCGCGTCCACCGCGGGC
MNX1 ETV6 18940475 atgcccgacttcaactCAGGAACGAATTTCAT
MNX1 ETV6 18940475 atgcccgacttcaactGCTTGCAGCCAATTT

TUMOR FUSION Gene Data Portal

 		Top
The fusion gene pair MNX1--ETV6 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

 		Top
The fusion gene pair MNX1--ETV6 information is not available in FusionCancer Database.

ConjoinG

 		Top
The fusion gene pair MNX1--ETV6 information is not available in ConjoinG Database.

1000Genome

 		Top
Fusion gene MNX1--ETV6 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

 		Top
Fusion gene MNX1--ETV6 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

 		Top
Fusion gene MNX1--ETV6 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

 		Top
Fusion gene MNX1--ETV6 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

 		Top
Fusion gene MNX1--ETV6 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

 		Top
The fusion gene pair MNX1--ETV6 information is not available in Babiceanu_Dataset.

Banned_Dataset

 		Top
Fusion gene MNX1--ETV6 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

 		Top
Fusion gene MNX1--ETV6 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

 		Top
The head gene MNX1 is not a known oncogene according to ONGENE database.


The tail gene ETV6 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

 		Top
The head gene MNX1 is cancer associated according to Bushman Cancer Gene database.


The tail gene ETV6 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

 		Top
The head gene MNX1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ETV6 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

 		Top
Fusion gene MNX1--ETV6 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

 		Top
Fusion gene MNX1--ETV6 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

 		Top
The fusion gene pair MNX1--ETV6 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

 		Top
Fusion gene MNX1--ETV6 is not found in pancreatic tumor dataset, published here.

GTEx

 		Top
Fusion gene MNX1--ETV6 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

 		Top
The fusion gene pair MNX1--ETV6 information is not available in Klijn Dataset.

Fimereli_Dataset

 		Top
The fusion gene pair MNX1--ETV6 information is not found in Fimereli_Dataset.

Literature

 Top
The fusion gene pair MNX1--ETV6 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

 		Top
Fusion gene MNX1--ETV6 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

 		Top
The fusion gene pair MNX1--ETV6 information is not available in ChromothripsisDB database.