MMSET--FGFR3

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

MMSET FGFR3

COSMIC

The fusion gene pair MMSET--FGFR3 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair MMSET--FGFR3 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair MMSET--FGFR3 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MMSET_FGFR3- 21057542multiple myeloma FISH - Dysregulation of cyclin D2 contributes to the pathogenesis of multiple myeloma, and can occur through translocations that activate MAF/MAFB or MMSET/FGFR3.
MMSET_FGFR3- 17498561leukemia;multiple myeloma FISH - Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes..
MMSET_FGFR3t(4;14) / p16.3;q32 / t(11;14)(q13;q32) / t(6;14)(p21;q32) / t(14;16)(q32;q23) / t(14;20)(q32;q12) / t(4;14) / t(11;14) / t(6;14) / t(14;16) / t(14;20) / 15543617plasma cell leukemia FISH;PCR;RT-PCR - We investigated the expression profiles of the FGFR3/MMSET, CCND1, CCND3, MAF, and MAFB genes, which are involved in t(4;14)(p16.3;q32), t(11;14)(q13;q32), t(6;14)(p21;q32), t(14;16)(q32;q23), and t(14;20)(q32;q12), respectively, in purified plasma cell populations from 39 MMs and six plasma cell leukemias (PCL) by DNA microarray analysis and compared the results with the presence of translocations as assessed by dual-color FISH or RT-PCR.
MMSET_FGFR34p16.3 / 12965277monoclonal gammopathy - - Among the earliest genetic events are translocations of the immunoglobulin heavy-chain gene locus, which leads to dysregulation of oncogenes at translocation partner regions (cyclin D1 at 11q13, FGFR3/MMSET at 4p16.3, c-MAF at 16q23, and cyclin D3 at 6p21), and deletions of 13q14, the site of a putative tumour suppressor gene, which is an adverse prognostic indicator.
MMSET_FGFR3- 16829212multiple myeloma;plasma cell tumor - - The five partner loci include 11q13, 6p21, 4p16, 16q23, and 20q12, with corresponding dysregulation of CYCLIN D1, CYCLIN D3, FGFR3/MMSET, c-MAF, and MAFB, respectively, by strong enhancers in the IgH locus.
MMSET_FGFR3- 15496980- PCR - Using a combination of these methods, we have succeeded in amplifying IGHS translocation breakpoints involving FGFR3/MMSET on 4p16, BCL6 on 3q27, MYC on 8q24, IRTA1 on 1q21 and PAX5 on 9p13 as well as BCL11A on 2p13 and CCND3 on 6p21.
MMSET_FGFR3- 18216867plasma cell leukemia - - in pPCL IgH translocations almost exclusively involve 11q13 (CCND1), supporting a central etiological role, while in sPCL multiple partner oncogenes are involved, including 11q13, 4p16 (FGFR3/MMSET) and 16q23 (MAF), recapitulating MM.
MMSET_FGFR3- 23288641multiple myeloma - - Commonly detected genetic aberrations are translocations involving immunoglobulin heavy chain (IgH) switch regions (chromosome 14q32) and oncogenes such as c-maf [t(14:16)], cyclin D1 [t(11:14)], and FGFR3/MMSET [t(4:14)].
MMSET_FGFR3- 16461302multiple myeloma ISH - Supervised analysis identified 166 genes with significantly different expression among the cell lines harboring MMSET/FGFR3 (4p16), MAF (16q) and CCND1 (11q13) rearrangements.

ChimerSEQ

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The fusion gene pair MMSET--FGFR3 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MMSET--FGFR3 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MMSET--FGFR3 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair MMSET--FGFR3 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair MMSET--FGFR3 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MMSET--FGFR3 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MMSET--FGFR3 information is not available in ConjoinG Database.

1000Genome

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Fusion gene MMSET--FGFR3 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MMSET--FGFR3 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MMSET--FGFR3 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MMSET--FGFR3 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MMSET--FGFR3 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MMSET--FGFR3 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MMSET--FGFR3 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MMSET--FGFR3 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MMSET is a known oncogene according to ONGENE database.


The tail gene FGFR3 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MMSET is cancer associated according to Bushman Cancer Gene database.


The tail gene FGFR3 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MMSET is not a proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene FGFR3 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MMSET--FGFR3 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MMSET--FGFR3 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MMSET--FGFR3 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MMSET--FGFR3 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MMSET--FGFR3 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MMSET--FGFR3 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MMSET--FGFR3 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MMSET--FGFR3 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MMSET--FGFR3 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MMSET--FGFR3 information is not available in ChromothripsisDB database.