MLLT10--MLL

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

MLLT10 MLL

COSMIC

The fusion gene pair MLLT10--MLL information is not available in COSMIC database.

ChimerKB

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The fusion gene pair MLLT10--MLL information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
MLLT10_MLL-/-/ -/-/ - hg18 acute myeloid leukemia - 8896421 - OMIM
MLLT10_MLL-/-/ -/-/ - hg18 acute leukemia - 7888665 - OMIM

ChimerPUB

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The fusion gene pair MLLT10--MLL information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MLLT10_MLLp36;q11 / 19380030leukemia FISH;PCR - Panhandle polymerase chain reaction (PCR) using cDNA demonstrated the formation of an MLL-MLLT10 fusion transcript, although the 10p12 segment, at which the MLLT10 gene is located, was not involved in the breakpoint of the four-way translocation according to G-banding and spectral karyotyping analyses.
MLLT10_MLLt(4;11) / 22846743acute myeloid leukemia;acute lymphoblastic leukemia;myeloid leukemia; FISH - The most frequent rearrangement found in patients with acute myeloid leukemia was the MLL-MLLT3 fusion (42%), followed by MLL-MLLT10 (23%), MLL-MLLT1 (8%), MLL-ELL (8%), MLL-MLLT4 (4%), and MLL-MLLT11 (4%).
MLLT10_MLL- 15262427leukemia FISH - We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. /// MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.. /// Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints.
MLLT10_MLL- 15381373acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia FISH - These both resulted in a large derivative chromosome 10 and transcription of an MLL/MLLT10 fusion product.
MLLT10_MLLdel(10)(p12) / 22261229leukemia - - A rare cryptic and complex rearrangement leading to MLL-MLLT10 gene fusion masked by del(10)(p12) in a child with acute monoblastic leukemia (AML-M5)..
MLLT10_MLLp12;q23q14 / 23278644acute myeloid leukemia;myeloid leukemia;leukemia - - Hyperdiploidy and duplication of der(11)ins(10;11)(p12;q23q14) in acute myeloid leukemia with MLL/MLLT10 fusion gene..
MLLT10_MLL- 11896537acute myeloid leukemia;myeloid leukemia;leukemia - - We observed an as yet unreported chromosomal mechanism with at least four breakpoints, leading to MLL-MLLT10 gene fusion in a 24-year-old male. /// 10;11 rearrangements require at least three breaks in order to generate an in-frame MLL-MLLT10 fusion as a result of the opposite orientations of both genes on the respective chromosome arms. /// "In this study, we describe a detailed molecular cytogenetic analysis of MLL-MLLT10 positive 10;11 rearrangements in two patients. "
MLLT10_MLLt(10;11)(p12;q23) / 20299091acute myeloid leukemia;myeloid leukemia;leukemia - - Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10.. /// " We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);MLL-MLLT10. " /// "To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. "
MLLT10_MLL- 16111539acute myeloid leukemia;myeloid leukemia;leukemia - - MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia.. /// " The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. "
MLLT10_MLLt(10;19;11) / p12.31;q13.31 / 25725124acute myeloid leukemia;myeloid leukemia;leukemia - - Molecular cytogenetics revealed that the MLL gene was disrupted and even partially lost due to a t(10;19;11)(p12.31;q13.31;q23.3), an MLL/MLLT10 fusion appeared, and the der(Y) was an asymmetric inverted duplication with breakpoints in Yp11.2 and Yq11.23.
MLLT10_MLLinv(16) / t(4;11) / t(11;19) / 23091311- PCR - Fifteen fusion transcripts were included: BCR-ABL1, PML-RARA, ZBTB16-RARA, RUNX1-RUNX1T1, CBFB-MYH11, DEK-NUP214, TCF3-PBX1, ETV6-RUNX1, MLL-AFF1, MLL-MLLT4, MLL-MLLT3, MLL-MLLT10, MLL-ELL, MLL-MLLT1, and MLL-MLLT6.
MLLT10_MLL- 25475940acute myeloid leukemia;myeloid leukemia;leukemia - - A new rearrangement giving rise to a very rare MLL-MLLT10 fusion mRNA in an infant acute myeloid leukemia..
MLLT10_MLL- 23666221hemophagocytic lymphohistiocytosis PCR;RT-PCR - We considered tumor-associated HLH to be initiated from leukemic stem cells (LSCs) in the bone marrow niche because reverse transcription-polymerase chain reaction (RT-PCR) analysis of a bone marrow biopsy sample was positive for MLL-MLLT10.

ChimerSEQ

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The fusion gene pair MLLT10--MLL information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MLLT10--MLL information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MLLT10--MLL information is not available in FARE-CAFE.

TicDB

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The fusion gene pair MLLT10--MLL information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair MLLT10--MLL information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MLLT10--MLL information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MLLT10--MLL information is not available in ConjoinG Database.

1000Genome

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Fusion gene MLLT10--MLL has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MLLT10--MLL is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MLLT10--MLL is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MLLT10--MLL is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MLLT10--MLL was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MLLT10--MLL information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MLLT10--MLL is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MLLT10--MLL has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MLLT10 is not a known oncogene according to ONGENE database.


The tail gene MLL is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MLLT10 is cancer associated according to Bushman Cancer Gene database.
The tail gene MLL is not cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MLLT10 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene MLL is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MLLT10--MLL is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MLLT10--MLL is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MLLT10--MLL information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MLLT10--MLL is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MLLT10--MLL has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MLLT10--MLL information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MLLT10--MLL information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MLLT10--MLL information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MLLT10--MLL is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MLLT10--MLL information is not available in ChromothripsisDB database.