MLL--EPS15

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

MLL EPS15

COSMIC

The fusion gene pair MLL--EPS15 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair MLL--EPS15 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
MLL_EPS15-/-/ -/-/ - hg18 lymphoblastic leukemia - - - Mitelman
MLL_EPS15-/-/ -/-/ - hg18 acute monoblastic leukemia - - - Mitelman
MLL_EPS15-/-/ -/-/ - hg18 biphenotypic leukemia - - - Mitelman
MLL_EPS15-/0/ -/0/ Exonic hg18 - - - - TICdb
MLL_EPS15-/-/ -/-/ - hg18 11q23 associated leukemia - 8183552 - OMIM
MLL_EPS15-/-/ -/-/ - hg18 myeloid leukemia - 8134107 - OMIM

ChimerPUB

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The fusion gene pair MLL--EPS15 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MLL_EPS15- 21900057acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia FISH;PCR - In the 19 AML patients with acute myeloblastic leukemia, 31.6% of all characterized MLL fusion genes were MLL/MLLT3, 21.1% MLL/ELL, 10.5% MLL/MLLT6 and 10.5% MLL/EPS15. /// "Splicing fusion genes were found in three patients, leading to a MLL/EPS15 fusion in two and a MLL/ELL fusion in a third patient. "
MLL_EPS15t(1;11)(p32;q23) / 14704037acute lymphoblastic leukemia;acute promyelocytic leukemia;lymphoblastic leukemia;leukemia - - Our case is of interest because of simultaneous relapse of the original leukemia and onset of therapy-related leukemia and relatively rare t(1;11)(p32;q23) translocation with confirmed MLL/AF-1p fusion. /// MLL/AF-1p fusion in therapy-related early pre-B acute lymphoblastic leukemia with t(1;11)(p32;q23) translocation developing in the relapse phase of acute promyelocytic leukemia..
MLL_EPS15- 22581003acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia - - Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute lymphoblastic leukemia..
MLL_EPS15- 19665789acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia - - A novel MLL-AF1p/Eps15 fusion variant in therapy-related acute lymphoblastic leukemia, lacking the EH-domains..
MLL_EPS15t(1;11)(p32;q23) / t(1;11) / 16826222acute myeloid leukemia;myeloid leukemia;leukemia ISH - Taken together, these results suggest that TZ-1 is a new monocytic leukemia cell line with t(1;11) translocation and fusion gene MLL-EPS15. /// Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15.. /// Fluorescence in situ hybridization and reverse transcription-polymerase chain reaction analyses revealed MLL-EPS15 fusion transcript and protein.

ChimerSEQ

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The fusion gene pair MLL--EPS15 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
MLL_EPS15chr11/118355690/ chr1/51930956/ 11q23.3 1p32.3 Exonic hg19 - Inter-chr biphenotypic leukemia;acute myeloid leukemia;acute lymphoblastic leukemia;lymphoblastic lymphoma AY187922 - ChiTaRs

ChiTaRS 2.1

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The fusion gene pair MLL--EPS15 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human AY187922MLL--EPS15 MLL11 118354896 118355690 + 20 267 100 EPS151 51930956 51946988 - 266 584 100

FARE-CAFE

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The fusion gene pair MLL--EPS15 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
MLL-EPS15 Acute myelomonocytic leukemia (FAB type M4) PCR,DNA sequencing,RT-PCR t(1;11)(p32;q23) PubMed:19665789

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
MLL-EPS15 MLL-EPS15-Isoform1 MLL _ _ 1 EPS15 _ 0 _ agtagtgggcatgtagagAacatcataggatcaag 19665789 _
MLL-EPS15 MLL-EPS15-Isoform2 MLL 118353210 0 1 EPS15 51946966 0 1 AAACAAAAACCAAAAGAAAAgTTATCAAGTGGGAATCCTGTA 8134107 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
MLL-EPS15 MLL-EPS15-Isoform1 - - - -MLL 1) zf-CXXC
2) PHD
3) zf-HC5HC2H
4) FYRN
5) FYRC
6) SET
1) DNA_methylase
2) PHD , Bromodomain , JmjC , RRM_1
3) FYRC
4) FYRN
5) MORN , Pre-SET , Rubis-subs-bind
EPS15 1) EF-hand_4
- 1) zf-CXXC
2) PHD
3) zf-HC5HC2H
4) FYRN
5) FYRC
6) SET
7) EF-hand_4
1) DNA_methylase
2) PHD , Bromodomain , JmjC , RRM_1
3) FYRC
4) FYRN
5) MORN , Pre-SET , Rubis-subs-bind
MLL-EPS15 MLL-EPS15-Isoform2 1) zf-CXXC
1) DNA_methylase
- -MLL 1) zf-CXXC
2) PHD
3) zf-HC5HC2H
4) FYRN
5) FYRC
6) SET
1) DNA_methylase
2) PHD , Bromodomain , JmjC , RRM_1
3) FYRC
4) FYRN
5) MORN , Pre-SET , Rubis-subs-bind
EPS15 1) EF-hand_4
- 1) PHD
2) zf-HC5HC2H
3) FYRN
4) FYRC
5) SET
6) EF-hand_4
1) PHD , Bromodomain , JmjC , RRM_1
2) FYRC
3) FYRN
4) MORN , Pre-SET , Rubis-subs-bind

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
MLL-EPS15 _ hsa-miR-128bhsa-miR-335-5phsa-miR-16-5phsa-let-7d-5phsa-miR-320bhsa-miR-1227-3phsa-miR-484hsa-miR-320ahsa-miR-193a-3phsa-miR-17-5p _

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
MLL-EPS15 NM_001197104.1 - - 1) 21258399
2) 20385362
3) 19122651
4) 20385362
5) 21247883
6) 20019798
7) 20690147
8) 20139302
9) 21808000
10) 21310950
11) 21795385
12) 21795385
13) 19505939
14) 21646355
15) 21572391
16) 21572391
17) 20219941
18) 22292898
19) 21430779
20) 21164480

TicDB

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The fusion gene pair MLL--EPS15 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
MLL EPS15 19665789 agtagtgggcatgtagagAacatcataggatcaag
MLL EPS15 8134107 AAACAAAAACCAAAAGAAAAgTTATCAAGTGGGAATCCTGTA
MLL EPS15 8134107 GCCCAGCTCTCTCTGACACAgGAAAAACCACCTCCGGTCAAT

TUMOR FUSION Gene Data Portal

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The fusion gene pair MLL--EPS15 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MLL--EPS15 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MLL--EPS15 information is not available in ConjoinG Database.

1000Genome

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Fusion gene MLL--EPS15 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MLL--EPS15 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MLL--EPS15 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MLL--EPS15 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MLL--EPS15 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MLL--EPS15 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MLL--EPS15 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MLL--EPS15 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MLL is a known oncogene according to ONGENE database.
The tail gene EPS15 is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MLL is not cancer associated according to Bushman Cancer Gene database.


The tail gene EPS15 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MLL is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene EPS15 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MLL--EPS15 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MLL--EPS15 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MLL--EPS15 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MLL--EPS15 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MLL--EPS15 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MLL--EPS15 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MLL--EPS15 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MLL--EPS15 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MLL--EPS15 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MLL--EPS15 information is not available in ChromothripsisDB database.