MECOM--RUNX1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

 MECOM RUNX1

COSMIC

The fusion gene pair MECOM--RUNX1 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair MECOM--RUNX1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
MECOM_RUNX1-/-/ -/-/ - hg18 myeloid leukemia - 7795214 Oncogene; Transcription_Factor OMIM
MECOM_RUNX1-/-/ -/-/ - hg18 chronic myeloid leukemia - 7795214 Oncogene; Transcription_Factor OMIM
MECOM_RUNX1-/-/ -/-/ - hg18 acute myeloid leukemia - 15326310 Oncogene; Transcription_Factor OMIM

ChimerPUB

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The fusion gene pair MECOM--RUNX1 information is not available in CHIMERPUB (CHIMERDB 3.0) database.

ChimerSEQ

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The fusion gene pair MECOM--RUNX1 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MECOM--RUNX1 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MECOM--RUNX1 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
MECOM-RUNX1/AML1 Chronic Myeloid Leukemia PCR,FISH,Western blot,RT-PCR,Southern blot,DNA sequencing,G-Banding,Cyclesequencing,PFGE _ _

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
MECOM-RUNX1/AML1 MECOM-RUNX1/AML1-Isoform1 MECOM _ _ 0 RUNX1/AML1 _ 0 _ _ _ _
MECOM-RUNX1/AML1 MECOM-RUNX1/AML1-Isoform2 MECOM 169139977 0 RUNX1/AML1 36212987 0 0 _ _ _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
MECOM-RUNX1/AML1 MECOM-RUNX1/AML1-Isoform1 - - - -MECOM 1) zf-C2H2
1) zf-C2H2 , zf-H2C2_2 , zf-C2H2_4
RUNX1/AML1 1) Runt
2) RunxI
1) Runt , CBF_beta
1) zf-C2H2
2) Runt
3) RunxI
1) zf-C2H2 , zf-H2C2_2 , zf-C2H2_4
2) Runt , CBF_beta
MECOM-RUNX1/AML1 MECOM-RUNX1/AML1-Isoform2 1) zf-H2C2_2
2) zf-C2H2
1) zf-C2H2 , zf-C2H2_4 , zf-H2C2_2 , zf-C2H2_6
2) zf-C2H2 , zf-H2C2_2 , zf-C2H2_4
1) Runt
1) Runt , CBF_beta
2) Runt , CBF_beta
MECOM 1) zf-C2H2
1) zf-C2H2 , zf-H2C2_2 , zf-C2H2_4
RUNX1/AML1 1) Runt
2) RunxI
1) Runt , CBF_beta
- -

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
MECOM-RUNX1/AML1 hsa-miR-27a-3p, hsa-miR-17-5p, hsa-miR-20a-5p, hsa-miR-106a-5p, hsa-miR-423-5p _ Report assay,Western Blot,qPCR,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
MECOM-RUNX1/AML1 NM_001105077.3 - 1) MITF_HUMAN
2) HIF1A_HUMAN
3) STAT1_HUMAN
4) RB1_HUMAN
5) RBL2_HUMAN
6) ZNF263_HUMAN
7) E2F4_HUMAN
8) P53_HUMAN
9) RUNX1_HUMAN
10) PRDM14_HUMAN
11) ESTROGEN RECEPTOR ALPHA_HUMAN
12) ETS1_HUMAN
13) EGR1_HUMAN
14) FOS_HUMAN
15) GATA2_HUMAN
16) GATA3_HUMAN
17) E2F1_HUMAN
18) SOX2_HUMAN
19) TAL1_HUMAN
20) CTCF_HUMAN
21) BRG1_HUMAN
22) HNF4A_HUMAN
23) TFAP2C_HUMAN
24) FOXA1_HUMAN
25) CEBPA_HUMAN ,  A
26) STAT6_HUMAN ,  A
27) ESR1_HUMAN ,  A
28) ESR2_HUMAN ,  A
29) AR_HUMAN ,  A
30) MEIS1_HUMAN ,  A
31) FOXP1_HUMAN ,  A
32) NR1H3_HUMAN ,  A
33) SETDB1_HUMAN ,  A
34) SPI1_HUMAN ,  A
35) TAL1_HUMAN ,  A
36) TRIM24_HUMAN ,  A
37) VDR_HUMAN
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TicDB

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The fusion gene pair MECOM--RUNX1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair MECOM--RUNX1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MECOM--RUNX1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MECOM--RUNX1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene MECOM--RUNX1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MECOM--RUNX1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MECOM--RUNX1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MECOM--RUNX1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MECOM--RUNX1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MECOM--RUNX1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MECOM--RUNX1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MECOM--RUNX1 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MECOM is a known oncogene according to ONGENE database.


The tail gene RUNX1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MECOM is cancer associated according to Bushman Cancer Gene database.


The tail gene RUNX1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MECOM is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene RUNX1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MECOM--RUNX1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MECOM--RUNX1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MECOM--RUNX1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MECOM--RUNX1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MECOM--RUNX1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MECOM--RUNX1 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MECOM--RUNX1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MECOM--RUNX1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MECOM--RUNX1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MECOM--RUNX1 information is not available in ChromothripsisDB database.