MDM2--CDK4

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

MDM2 CDK4

COSMIC

The fusion gene pair MDM2--CDK4 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair MDM2--CDK4 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair MDM2--CDK4 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MDM2_CDK4- 17895748dedifferentiated liposarcoma FISH;PCR - To evaluate the accuracy of fluorescence in situ hybridization (FISH) analysis in the differential diagnosis of adipose tissue tumors, we investigated MDM2-CDK4 status by FISH, real-time polymerase chain reaction (PCR) [quantitative PCR (Q-PCR)] and immunohistochemistry (IHC) in a series of 200 adipose tumors. /// "In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone.. " /// Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR.. /// "First, we evaluated MDM2-CDK4 amplification and expression in a series of 94 well-defined adipose tissue tumors. "
MDM2_CDK4- 25679065liposarcoma;sarcoma FISH;PCR - Four cases of atypical lipomatous tumor/well-differentiated liposarcoma (4/26, 15%) with a low MDM2 and CDK4 amplification level (MDM2-CDK4/CEP12 ratio ranging between 2 and 2.5) detected by FISH showed no amplification by MLPA, although gain of MDM2 and CDK4 (ratios ranging between 1.6 and 1.9) was seen with MLPA. /// "Detection of MDM2/CDK4 amplification in lipomatous soft tissue tumors from formalin-fixed, paraffin-embedded tissue: comparison of multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH).. " /// "In conclusion, MLPA proves to be an appropriate and straightforward technique for screening MDM2/CDK4 amplification in lipomatous tumors, especially when a correct cut-off value and reference samples are chosen, and could be considered a good alternative to FISH to determine MDM2 and CDK4 amplification in liposarcomas. " /// "In case of high-level amplification (MDM2-CDK4/CEP12 ratio >5), concordance was 100%. "
MDM2_CDK4- 10755400liposarcoma;sarcoma FISH - All lipomas displayed a null MDM2/CDK4 phenotype, whereas all LL-WDL showed MDM2/CDK4 or CDK4 phenotypes. /// The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma.. /// "In conclusion, MDM2/CDK4 product-based immunophenotyping appears to represent a valuable method for the categorization of arguable LDSL.. "
MDM2_CDK4- 24557201liposarcoma;sarcoma FISH - MDM2/CDK4 gene amplification has been shown to be sensitive and specific for the diagnosis of well-differentiated lipoma-like liposarcoma (WD-LLLPS). /// "The incidence of MDM2/CDK4 amplification was reassuringly low (5%) in this cohort of LN, despite their large and/or deep-seated nature. " /// Two (3%) cases showed dual MDM2/CDK4 amplification and 2 (3%) showed MDM2 amplification alone. /// Mdm2/Cdk4 amplification in large and/or deep-seated lipomatous neoplasms without overtly atypical morphological features.. /// "The clinical, radiological and pathological features of all cases with CDK4/MDM2 amplification were reviewed. " /// To assess the incidence of MDM2/CDK4 amplification in large and/or deep seated LN without overtly atypical morphological features and to examine the clinicopathological features of cases showing these alterations.
MDM2_CDK4- 20228779liposarcoma;sarcoma FISH - FISH analysis revealed a deletion of the Rb-1 gene in all six cases, whereas no MDM2/CDK4 amplification was identified in all cases tested.
MDM2_CDK4- 24608573breast cancer - - There was an increased frequency of CDK4/MDM2 amplifications in recurrences, as well as gains and losses of other actionable alterations.
MDM2_CDK4- 20834238benign fibrous histiocytoma - - It is less sensitive than MDM2/CDK4 for dedifferentiated liposarcomas diagnosis, but it appears more specific to distinguish dedifferentiated liposarcomas from other poorly differentiated sarcomas.

ChimerSEQ

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The fusion gene pair MDM2--CDK4 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MDM2--CDK4 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MDM2--CDK4 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair MDM2--CDK4 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair MDM2--CDK4 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MDM2--CDK4 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MDM2--CDK4 information is not available in ConjoinG Database.

1000Genome

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Fusion gene MDM2--CDK4 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MDM2--CDK4 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MDM2--CDK4 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MDM2--CDK4 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MDM2--CDK4 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MDM2--CDK4 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MDM2--CDK4 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MDM2--CDK4 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MDM2 is a known oncogene according to ONGENE database.


The tail gene CDK4 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MDM2 is cancer associated according to Bushman Cancer Gene database.


The tail gene CDK4 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MDM2 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene CDK4 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MDM2--CDK4 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MDM2--CDK4 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MDM2--CDK4 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MDM2--CDK4 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MDM2--CDK4 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MDM2--CDK4 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MDM2--CDK4 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MDM2--CDK4 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MDM2--CDK4 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MDM2--CDK4 information is not available in ChromothripsisDB database.