MALT1--API2

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MALT1 API2

COSMIC

The fusion gene pair MALT1--API2 information is not available in COSMIC database.

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The fusion gene pair MALT1--API2 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair MALT1--API2 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
MALT1_API2t(11;18)(q21;q21) / 20079017MALT lymphoma;B cell lymphoma;lymphoma FISH - To investigate the difference of the prevalence of t(11;18)(q21;q21)/API2-MALT1 fusion gene between gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL). /// API2-MALT1 fusion gene was detected by fluorescent in situ hybridization (FISH) using both dual fusion translocation and break apart probes. /// "The findings suggest that gastrointestinal tract MALT lymphomas with API2-MALT1 fusion gene may not transform into DLBCL, which may represent primary lymphoma or transformed API2-MALT1 negative MALT lymphomas.. " /// "API2-MALT1 fusion gene is a distinctive genetic aberration in MALT lymphomas, and is not present in DLBCL. " /// [Prevalence of API2-MALT1 fusion gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas and diffuse large B cell lymphomas].. /// "Among gastrointestinal MALT lymphomas, API2-MALT1 fusion gene was found in 12 of 57 cases (21.1%, 10 gastric and 2 intestinal lymphomas). "
MALT1_API2t(11;18)(q21;q21) / 19535128acute cholecystitis FISH - Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.. /// "Interphase fluorescence in situ hybridization analysis on paraffin sections, using a fusion probe for API2/MALT1, demonstrated 2 fusion signals in most nuclei, bringing the first documentation of a t(11;18)(q21;q21) in this exceptional primary disease location.. "
MALT1_API2t(11;18)(q21;q21) / t(14;18)(q32;q21) / t(11;18) / t(14;18) / t(11;18) / 17199743MALT Lymphoma FISH - B cell CLL/lymphoma 10 (BCL10) and forkhead box PA (FOXP1) protein expression were studied by immunohistochemistry and translocations identified using fluorescence in situ hybridization (FISH)-specific probes FOXP1, t(11;18)(q21;q21)/API2-MALT1 and t(14;18)(q32;q21)/IgH-MALT1.
MALT1_API2t(11;18)(q21;q21) / t(1;14)(p22;q32) / t(14;18) (q32;q21) / 21055028MALT lymphoma;B cell lymphoma;lymphoma FISH - Fifty seven paraffin-embedded ocular MALT lymphoma specimens from patients in southern China were studied by interphase fluorescence-in-situ hybridization (FISH) for genetic aberrations including t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/IgH-bcl-10, t(14;18) (q32;q21)/IgH-MALT1 and bcl-6/FOXP1 gene translocations. /// "Amongst the 57 cases studied, 9 cases (15.8%) showed chromosome translocations, including 4 cases (7.0%) of t(11;18)(q21;q21)/API2-MALT1, 1 case (1.8%) of t(14;18) (q32;q21)/IgH-MALT1, 1 case (1.8%) of bcl-6 gene-related chromosome translocation and 3 cases (5.3%) of IgH-unknown translocation partner. " /// The MALT lymphoma-associated chromosome translocations t(11;18)(q21;q21)/API2-MALT1 and t(14;18) (q32;q21)/IgH-MALT1 are demonstrated in ocular MALT lymphomas of southern Chinese patients.
MALT1_API2t(14;18) / t(11;14) / t(11;18) / t(14;18) / 20079011small cell lymphoma FISH - A total of 74 fresh tissue samples clinically suspicious of lymphoma were investigated by FISH using three probes including IgH/bcl-2, IgH/CCND1 and API2/MALT1, corresponding the translocation t(14;18), t(11;14) and t(11;18) respectively.
MALT1_API2t(14;18)(q32;q21) / t(14;18) / t(11;18)(q21;q21) / 24236896MALT lymphoma FISH - Fluorescence in-situ hybridization (FISH) assays for the detection of t(14;18)/IGH-MALT1 and t(11;18)(q21;q21)/API2-MALT1, along with immunostaining and histological evaluations, were performed on selected cases.
MALT1_API2- 19035248MALT lymphoma;lymphoma FISH - Under statistic of Fisher exact test, nuclear BCL10 expression and API2-MALT1 fusion gene were two independent factors (P > 0.05). /// "BCL10 was detected by immunohistochemical studies, and API2-MALT1 fusion gene, BCL10, MALT1 and IgH chromosomal abnormalities were detected by fluorescent in situ hybridization (FISH). " /// "FISH results showed that no chromosomal abnormalities related with BCL10 and IgH genes, except 2 cases with API2-MALT1 fusion gene. " /// To detect the BCL10 expression and several types of chromosomal translocations [including t (11;18)/API2-MALT1.
MALT1_API2- 19080537MALT lymphoma;lymphoma FISH - In the FISH results, 9 cases (39.1%, 9/23) showed API2-MALT1 fusion gene, 1 case with possible BCL10-IgH abnormality, but none showed chromosomal abnormalities related with MALT1 and IgH gene simultaneously. /// "BCL10 was detected by immunohistochemistry of EnVision method, and API2-MALT1, BCL10, MALT1, IgH chromosomal abnormalities were detected by fluorescent in situ hybridization (FISH) technique. " /// 18)/API2-MALT1 and BCL10 aberrant nuclear expression in pulmonary mucosa-associated lymphoid tissue lymphomas].. /// "18)/API2-MALT1 was the most common chromosomal abnormality in pulmonary MALT lymphomas, but t (1. " /// 18)/API2-MALT1.
MALT1_API2t(11;18)(q21;q21) / t(11;18) / 15452377MALT lymphoma;B cell lymphoma;lymphoma FISH - Our findings suggest that the presence of the API2-MALT1 fusion transcript resulting from t(11;18)(q21;q21) does not adversely affect the response of gastric MALT lymphoma to chemotherapy with 2CdA. /// t(11;18)(q21;q21) resulting in the API2-MALT1 fusion transcript is an exclusive finding in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).
MALT1_API2t(11;18) (q21;q21) / t(14;18)(q32;q21) / t(14;18) / t(11;18) / 22781798B cell lymphoma;B cell lymphoma;lymphoma FISH - Additionally, interphase fluorescence in-situ hybridization (FISH) was carried out to detect the presence of t(11;18) (q21;q21)/API2-MALT1 and/or t(14;18)(q32;q21)/IGH-MALT1 in 9 cases.
MALT1_API2t(11;18) / 19961773MALT lymphoma FISH - Four different probes were available to detect for API2-MALT1 fusion gene, bcl-10, IgH and MALT1 gene, respectively.
MALT1_API2t(11;18) / t(1;14) / t(14;18) / t(6;7)(q25;q11) / 18927281MALT lymphoma FISH;PCR;RT-PCR - The well-known translocations identified in MALT lymphomas include t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, and t(14;18)/IGH-MALT1. /// "3 cases had t(11;18)/API2-MALT1 and 1 case had novel t(6;7)(q25;q11), respectively. "
MALT1_API2t(11;18) / t(14;18) / 26457033MALT lymphoma;lymphoma FISH - Thirty ocular adnexal MALT lymphomas were investigated for the t(11;18) API2-MALT1, t(14;18) IgH-MALT1 translocations and chromosomes 3 and 18 aneuploidies using fluorescence in situ hybridization. /// "The t(14;18) IgH-MALT1 translocation was demonstrated in only one case (3.3%), and the t(11;18) API2-MALT1 translocation was not found in any of the cases. "
MALT1_API2t(11;18)(q21;q21) / t(11;18) / 23305046lymphoma FISH - pylori status, and assessing t(11;18)/API2-MALT1 would be considered after failure to remission by H. /// The frequency of t(11;18)/API2-MALT1 did not differ between H.
MALT1_API2t(14;18) / t(1;14) / t(11;18) / 18445693MALT lymphoma;B cell lymphoma;lymphoma FISH - t(11;18)/API2-MALT1 was detected in none of the cases, except for one case of DLBCL with MALT lymphoma, which showed positive signals only in MALT lymphoma cells.
MALT1_API2t(11;18)(q21;q21) / 21396678lymphoma FISH - Pulmonary mucosa-associated lymphoid tissue lymphoma is unique in that chronic inflammation is rare and that API2-MALT1 fusion, resulting from t(11;18)(q21;q21), occurs frequently. /// "In this study, we examined 20 cases for API2-MALT1 fusion using the multiplex reverse-transcription polymerase chain reaction and looked for trisomy 3, trisomy 18, and abnormalities of MALT1 and IGH genes using fluorescence in situ hybridization. " /// "Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma.. " /// One case showed API2-MALT1 fusion and trisomy 3. /// MALT1 gene abnormalities were concordant with API2-MALT1 fusion or trisomy 18. /// "On detection of API2-MALT1 fusion and trisomies, we were able to divide our cases into 3 groups, API2-MALT1 positive, trisomy positive, and no detectable gene abnormality, suggesting that tumor development had processed along different genetic pathways. " /// "Of 20 cases studied, we detected gene abnormalities in 16: API2-MALT1 fusion in 9, trisomy 3 in 5, trisomy 18 in 4, MALT1 abnormality in 13, and IGH abnormality in 1. " /// "In addition, both mutated and unmutated tumor cases were found to carry the API2-MALT1 fusion and trisomy 3. "
MALT1_API2- 25876571MALT lymphoma;lymphoma FISH - A fluorescence in situ hybridization analysis revealed no fusion genes of API2-MALT1, although trisomy of chromosome 18 was identified.
MALT1_API2t(11;18)(q21;q21) / 18949449MALT lymphoma;lymphoma FISH - BCL10 nuclear expression and interphase fluorescence in situ hybridization (FISH) for MALT1 and API2/MALT1 were tested.
MALT1_API2- 16952043MALT Lymphoma FISH - The absence of genetic translocation of API2-MALT1 was confirmed with fluorescence in situ hybridization (FISH). /// Helicobacter pylori-negative / API2-MALT1 translocation-negative low-grade MALT lymphoma.. /// "pylori-negative and API2-MALT1 translocation-negative low-grade MALT lymphoma is unknown, and a standard treatment for such lymphoma has yet to be defined. " /// A 71-year-old man with a Helicobacter pylori infection-negative and API2-MALT1 translocation-negative extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type of the stomach has been followed conservatively for over 5 years.
MALT1_API2- 17122510MALT lymphoma;B cell lymphoma;lymphoma FISH - One hundred thirty-three paraffin-embedded North American primary MALT lymphoma specimens from diverse anatomic sites were studied by fluorescence in situ hybridization (FISH) using probes for API2-MALT1, IGH-MALT1, IGH-BCL10, IGH-FOXP1, IGH, +/- centromeres 3, 7, 12, and 18, and a subset (n=74) were analyzed using FISH probes for IGK, IGL, and BCL6. /// "Translocations were mutually exclusive and were detected in 26% of cases (17% API2-MALT1, 5% IGH-MALT1, 3% IGH-unknown translocation partner, and 1% IGH-BCL10). " /// "There was striking site specificity, with API2-MALT1 showing a marked predilection for lung and intestine, and IGH-MALT1 and IGH-BCL10 occurring almost exclusively in lung. " /// Aneuploidy was associated with IGH-MALT1 and IGH-BCL10 but only rarely with API2-MALT1.
MALT1_API2t(11;18) / t(14;18) / t(1;14) / 22243778MALT lymphoma;lymphoma FISH - In this study, we examined 14 cases of thymic MALT lymphomas for API2-MALT1 fusion using multiplex reverse transcription polymerase chain reaction and looked for trisomy 3, trisomy 18 and abnormalities of MALT1 and IGH genes using fluorescence in situ hybridization.
MALT1_API2- 16484127MALT lymphoma;B cell lymphoma;lymphoma FISH - API2-MALT1 translocation was detected in 1 (7%) of 14 DLBCL cases and in 1 (17%) of 6 MALT lymphoma cases.
MALT1_API2- 22742986B cell lymphoma;lymphoma FISH - Select gastric DLBCLs (N?=?6) and MALTs (N?=?13) were further examined for API2-MALT1 and IGH translocations, and P16 and P53 protein expression. /// "Gastric MALTs showed frequent API2-MALT1 (38%) but not IGH translocations (0%), and the DLBCLs showed neither translocation. " /// "In addition, API2-MALT1, P16 and P53 abnormalities occurred frequently in gastric lymphomas from this North American population. "
MALT1_API2- 19576081MALT lymphoma;lymphoma FISH - q21)/API2-MALT1, t (1. /// "q21) API2-MALT1 was found with the highest frequency in MALT lymphoma from lungs (47%, 8/17) and small intestine (29%, 4/14), followed by salivary gland (17%, 1/6), stomach (14%, 12/84) and ocular adnexae (6%, 4/68). " /// "q21) API2-MALT1 13% (29/217), t (1. "
MALT1_API2t(11;18)(q21;q21) / 14681324MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - The API2-MALT1 fusion gene was originally identified from a t(11;18)(q21;q21) translocation, a specific chromosomal abnormality that is found in mucosa-associated lymphoid tissue (MALT) lymphoma. /// API2-MALT1 fusion gene in colorectal lymphoma.. /// API2-MALT1 fusion genes were detected in seven cases (15%) of MALT lymphoma and one case (8%) of diffuse large B-cell lymphoma. /// "Gastric MALT lymphomas positive for the API2-MALT1 fusion gene do not respond to Helicobacter pylori-eradication therapy, but otherwise, the incidence and clinicopathological behavior of colorectal MALT lymphoma with this genetic abnormality are unclear. " /// We examined the API2-MALT1 fusion by multiplex RT-PCR method in 47 cases of MALT lymphoma and 13 cases of diffuse large B-cell lymphoma and evaluated the relevance of API2-MALT1 positivity to the clinical and pathological features.
MALT1_API2t(11;18) / 17852708MALT lymphoma;lymphoma PCR;RT-PCR - To detect the t(11;18) chromosome translocation in different stages of mucosa-associated lymphoid tissue (MALT) lymphoma, we established a RT-PCR method by adopting three new primer pairs and using the RNA extracted from the paraffin tissues to amplify the t(11;18) fusion gene API2-MALT1 in shorter lengths.
MALT1_API2t(11;18)(q21;q21) / t(1;14)(p22;q32) / 11707622MALT Lymphoma - - The t(11;18)(q21;q21), which is far more common, disrupts the api2 gene on chromosome 11q21 and the malt1 (mlt) gene on chromosome 18q21, resulting in the synthesis of a novel fusion gene and protein, API2-MALT1. /// Recent work suggests that API2-MALT1 and BCL-10-MALT1 may activate NF-kB and a common downstream signaling pathway..
MALT1_API2t(11;18)(q21;q21) / 15982633MALT lymphoma;lymphoma - - t(11;18)(q21;q21) is a characteristic as well as the most frequent chromosomal translocation in mucosa-associated lymphoid tissue (MALT) type lymphoma, and this translocation results in a fusion transcript, API2-MALT1. /// "Taken together, our results strongly indicated that API2-MALT1 possesses a novel mechanism of self-activation by up-regulating its own expression in t(11;18)(q21;q21)-carrying MALT lymphomas, highlighting a positive feedback-loop pathway resulting in unremitting NF-kappaB activation.. " /// Luciferase reporter assays with deletion and mutational constructs of the API2 promoter and electrophoretic mobility shift assays established that API2-MALT1 induces transcriptional activation of the API2 gene through two NF-kappaB binding elements. /// "Although API2-MALT1 has been shown to enforce activation of NF-kappaB signaling, the transcriptional target genes of this fusion protein remains to be identified. " /// API2-MALT1 fusion protein induces transcriptional activation of the API2 gene through NF-kappaB binding elements: evidence for a positive feed-back loop pathway resulting in unremitting NF-kappaB activation..
MALT1_API2- 16353132Sjogren's syndrome - - Thymic MALT lymphoma shows certain distinctive features among MALT lymphomas, such as expression of IgA isotype, consistent lack of API2-MALT1 gene fusion, and very strong association with autoimmune disease, especially Sjogren's syndrome.
MALT1_API2- 11943727MALT lymphoma;B cell lymphoma;lymphoma - - These data indicate that thymic MALT lymphoma may represent a distinct subgroup of MALT lymphoma characterized by apparent predilection for Asians, a strong association with autoimmune disease, frequent presence of cysts, consistent plasma cell differentiation, tumor cells expressing IgA phenotype, and consistent lack of API2-MALT1 gene fusion.. /// "Epstein-Barr virus was absent, and API2-MALT1 gene fusion, a recently reported MALT lymphoma-specific gene abnormality, was not detected in any case. "
MALT1_API2t(11;18) (q21;q21) / t(11;18) / 11162514MALT lymphoma;lymphoma - - To gain some insight into the mechanism that generates this translocation, we cloned and sequenced an API2-MALT1 fused transcript as well as genomic DNA of the t(11;18) translocation from a MALT lymphoma.
MALT1_API2t(11;18)(q21;q21) / 11736940MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - The presence of the API2-MALT1 fusion gene was also confirmed by long and accurate (LA)-PCR with genomic DNA, and the result correlated well with that obtained with the RT-PCR assay, thus demonstrating the usefulness of LA-PCR for the detection of the API2-MALT1 fusion gene.. /// " t(11;18)(q21;q21) has been recognized as a characteristic chromosomal translocation in mucosa-associated lymphoid tissue (MALT)-type lymphoma, and recent studies have demonstrated that this translocation results in the chimaeric transcript of API2 (apoptosis inhibitor 2)-MALT1 (mucosa-associated lymphoid tissue lymphoma translocation gene 1). " /// RT-PCR analysis revealed that 17 of the 95 (17.9%) MALT lymphomas but none of the nine nMZBCLs or 16 DLBLs had API2-MALT1 fusion transcripts. /// "The incidence of API2-MALT1 varied among MALT lymphomas arising from different sites and was highest for pulmonary MALT lymphomas (10 out of 16 cases, 62.5%). "
MALT1_API2- 25748153MALT lymphoma;lymphoma - - Genetic analysis showed that a biopsy specimen was positive for API2/MALT1 fusion gene, and IgH rearrangement showed monoclonal banding between colon and stomach. /// "This suggested disseminated monoclonal API2/MALT1-positive MALT lymphoma of the colon, stomach, and small intestine. "
MALT1_API2t(11;18)(q21;q21) / 19279678MALT lymphoma;lymphoma - - Our data indicate the presence of MALT1-API2 transcripts in the majority of t(11;18)(q21;q21)-positive MALT lymphomas. /// Expression of MALT1-API2 transcripts in t(11;18)(q21;q21)-positive MALT lymphomas was however not associated with a reduction of BCL10 protein levels. /// Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma.. /// The translocation t(11;18)(q21;q21) is the most frequent chromosomal aberration associated with MALT lymphoma and results in constitutive NF-kappaB activity via the expression of an API2-MALT1 fusion protein. /// The properties of the reciprocal MALT1-API2 were never investigated as it was reported to be rarely transcribed. /// "As we observed MALT1-API2 to be an efficient target of its own E3 ubiquitin ligase activity, our data suggest that this inherent instability of MALT1-API2 prevents its accumulation and renders a potential effect on MALT lymphoma development via destabilization of BCL10 unlikely.. " /// "Here we show that this RING domain enables MALT1-API2 to function as an E3 ubiquitin ligase for BCL10, inducing its ubiquitination and proteasomal degradation in vitro. " /// "Based on the breakpoints in the MALT1 and API2 gene, the MALT1-API2 protein contains the death domain and one or both immunoglobulin-like domains of MALT1 (approximately 90% of cases)--mediating the possible interaction with BCL10--fused to the RING domain of API2. "
MALT1_API2- 14674990MALT lymphoma;T cell lymphoma;B cell lymphoma;lymphoma;lymphoproliferative disorder PCR;RT-PCR - These findings indicate that the nuclear expression of BCL10 is unlikely to correlate with the API2-MALT1 fusion gene in ocular adnexal MALT lymphoma.. /// "To clarify the correlation between BCL10 protein expression and API2-MALT1 gene rearrangement, the 51 cases of MALT lymphoma and 5 cases of DLBCL were analyzed by immunohistochemical and RT-PCR methods. " /// No evidence of a correlation between BCL10 expression and API2-MALT1 gene rearrangement in ocular adnexal MALT lymphoma.. /// API2-MALT1 transcription was not demonstrated in either the MALT lymphoma cases or the DLBCL cases studied using a multiplex one-tube reverse transcriptase-PCR method.
MALT1_API2t(11;18)(q21;q21) / 15280657- - - MALTs are genetically characterized by the t(11;18)(q21;q21) chromosomal translocation that results in API2/MALT1 fusion products. /// "Furthermore, we demonstrate that API2/MALT1 mediated NF-kappaB activation does not alter p53 protein levels or subcellular localization suggesting a post-translational or indirect mechanism of p53 deregulation.. " /// Actvation of NF-kappaB by the API2/MALT1 fusions inhibits p53 dependant but not FAS induced apoptosis: a directional link between NF-kappaB and p53.. /// "Here, we demonstrate that API2/MALT1 mediated inhibition of apoptosis is p53 specific, as distinct API2/MALT1 fusion proteins fail to protect cells from FAS induced cell death. " /// It was shown that distinct API2/MALT1 chimeric proteins function as oncogenes that bilaterally confer a proliferative advantage to the neoplastic clone by activating the NF-kappaB signaling pathway and also inhibiting p53 mediated cell death.
MALT1_API2- 16630483MALT lymphoma;B cell lymphoma;lymphoma PCR - [Detection of API2-MALT1 fusion gene in extranodal B-cell lymphoma and its significance].. /// The expression of API2-MALT1 mRNA was studied in all cases by reverse transcriptase (RT)-polymerase chain reaction (PCR) and nested PCR. /// API2-MALT1 transcripts were detected in 39 of the 94 lymphoma cases (with 28 cases being MALT lymphoma and 11 cases being extranodal DLBCL). /// "The expression of API2-MALT1 mRNA can be detected in both MALT lymphoma and extranodal DLBCL, but not in Hashimoto's thyroiditis. " /// " To study the expression of API2-MALT1 mRNA in mucosa-associated lymphoid tissue (MALT) lymphoma, extranodal diffuse large B-cell lymphoma (DLBCL) and Hashimoto's thyroiditis, to investigate the expression pattern of API2-MALT1 variants, and to correlate the findings with the clinicopathologic features and prognosis. "
MALT1_API2t(11;18)(q21;q21) / t(11;18) / 26981201MALT lymphoma - - Cytogenetic abnormalities are commonly acquired during the course of disease and the most common is chromosomal translocation t(11;18)(q21;q21), which creates the API2-MALT1 fusion oncoprotein. /// "By effectively mimicking ligand-bound TNF receptor, API2-MALT1 promotes TRAF2-dependent ubiquitination of RIP1, which then acts as a scaffold for nucleating and activating the canonical NF-?B machinery. " /// "Thus, API2-MALT1 harnesses multiple unique pathways to achieve deregulated NF-?B activation. " /// "In this review, we highlight the most recent results characterizing these unique and diverse gain-of-function activities of API2-MALT1 and how they contribute to lymphomagenesis. " /// API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis.. /// "Like NIK, LIMA1 represents a unique substrate for API2-MALT1 protease activity, but unlike NIK, its cleavage sets in motion a major NF-?B-independent pathway for promoting oncogenesis. " /// "Specifically, API2-MALT1 recruits and subverts multiple other signaling factors, including LIM domain and actin-binding protein 1 (LIMA1) and Smac/DIABLO. " /// Emerging data from our group and others have also detailed additional gain-of-function activities of API2-MALT1 that extend beyond NF-?B activation. /// "In this regard, API2-MALT1 recognizes NF-?B inducing kinase (NIK), the essential upstream regulator of non-canonical NF-?B, and cleaves it to generate a stable, constitutively active fragment. "
MALT1_API2t(14;18)(q32;q21) / t(11;18)(q21;q21) / 20430965MALT lymphoma;lymphoma - - The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not..
MALT1_API2t(11;18) / 24363507MALT lymphoma;lymphoma - - pylori-independent cases, activation of the nuclear factor-?B pathway by oncogenic products of specific chromosomal translocations such as t(11;18)/API2-MALT1, or inactivation of tumor necrosis factor alpha-induced protein 3 (A20) are considered to contribute to the lymphomagenesis.
MALT1_API2t(1;14) / 19860212MALT lymphoma;B cell lymphoma;gastric cancer;lymphoma - - t (11;18)/API2-MALT1 and t(1;14)/IGH-BCL10 are specifically associated with the gastric MALT lymphoma entity, and the oncogenic products of these translocations have been shown to target a common molecular pathway, i.e., the nuclear factor-kappaB pathway.
MALT1_API2t(11;18) (q21;q21) / t(3;14) (p14;q32) / 19999120MALT lymphoma;B cell lymphoma;lymphoma - - The chromosomal translocation t(11;18) (q21;q21)/API2-MALT1 has been frequently detected not only in gastric MALT lymphoma cases, but also in gastric diffuse large B-cell lymphoma (DLBCL) cases in two studies.
MALT1_API2t(11;18)(q21;q21) / 23770847- - - The API2-MALT1 fusion oncoprotein is created by the recurrent t(11;18)(q21;q21) chromosomal translocation in mucosa-associated lymphoid tissue (MALT) lymphoma. /// "Furthermore, we found that TNF receptor-associated factor 2 (TRAF2) recruitment is required for API2-MALT1 to induce RIP1 ubiquitination, NF-?B activation and cellular transformation. " /// "API2-MALT1 promotes ubiquitination of RIP1 at lysine (K) 377, which is necessary for full NF-?B activation. " /// The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-?B signaling..
MALT1_API2t(11;18) / t(11;18)(q21;q21) / t(11;18) / 17153776MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - The t(11;18)(q21;q21) API2/MALT1 translocation is a specific chromosomal abnormality in extranodal marginal B-cell lymphomas of the mucosa-associated lymphoid tissue (MALT) type, particularly in those occurring in the stomach and lungs. /// "Detection of the t(11;18) API2/MALT1 translocation associated with gastric MALT lymphoma in routine formalin-fixed, paraffin-embedded small endoscopic biopsy specimens by robust real-time RT-PCR.. "
MALT1_API2t(11;18)(q21;q21) / t(14;18)(q32;q21) / 14652825MALT lymphoma;B cell lymphoma;lymphoma - - These findings indicate that MALT1 translocations are not restricted to indolent-appearing lymphomas, provide further evidence that API2-MALT1 and IGH-MALT1 translocations exhibit biologic differences, have implications regarding the pathogenesis of some extranodal DLBCL, and emphasize that a t(14;18)(q32;q21) cannot be assumed to reflect a BCL2 translocation..
MALT1_API2t(11;18)(q21;q21) / 21465313MALT lymphoma;B cell lymphoma;lymphoma - - Status of t(11;18)(q21;q21) was determined by reverse transcriptase polymerase chain reaction for API2-MALT1 transcript, while expression of NF-?B was detected by immunohistochemistry. /// API2-MALT1 transcript was detected in four (40%) tumors.
MALT1_API2t(11;18)(q21;q21) / 16351637- PCR - We studied the presence of tumour cells in PB in gastric lymphoma patients harbouring or lacking t(11;18)(q21;q21), by real-time immunoglobulin (Ig)H allele-specific oligonucleotide-polymerase chain reaction (ASO-PCR) and API2-MALT1 PCR. /// Monitoring gastric lymphoma in peripheral blood by quantitative IgH allele-specific oligonucleotide real-time PCR and API2-MALT1 PCR..
MALT1_API2- 17274374MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - BCL-10 nuclear expression was correlated with API2-MALT1 fusion gene transcript (r = 0. /// RT-PCR was used to detect the transcripts of API2-MALT1 fusion gene. /// BCL-10 nuclear expression is correlated with API2-MALT1 fusion gene expression in MALT lymphoma.. /// To investigate the relationship of BCL-10 protein and API2-MALT1 fusion gene in MALT lymphoma. /// API2-MALT1 fusion gene was detected in 35 cases (40. /// [Expression of BCL-10 protein and the relationship with API2-MALT1 fusion gene in extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue]..
MALT1_API2- 15696476MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - To investigate the frequency of different variant of API2-MALT1 fusion gene in extranodal marginal zone B-cell lymphoma of mucosa-associated tissue(MALT1) lymphoma and the correlation between API2-MALT1 transcript and apoptosis of MALT lymphoma. /// [The frequency of API2-MALT1 fusion gene variants in MALT lymphoma and its correlation with apoptosis of MALT lymphoma].. /// The API2-MALT1 fusion transcripts were detected in 62 cases of MALT lymphoma by reverse transcription-polymeras chain reaction(RT-PCR) and Nested PCR. /// The frequency of API2-MALT1 transcript was lower in thyroid MALT lymphoma(1/12) but similar in pulmonary and gastrointestinal MALT lymphoma. /// API2-MALT1 transcript was detected in 28 of 62 cases with MALT lymphoma (45.16%). /// API2-MALT1 transcript displayed variable frequency in MALT lymphomas of different sites. /// API2-MALT1 transcript was confirmed to be associated with the levels of apoptosis and API2 of MALT lymphoma.. /// Two kinds of API2-MALT1 variants (A1446-M1123 and A1446-M814) were detected. /// A1446-M1123 was noted to be probably the main type of API2-MALT1 variant in MALT lymphoma of Chinese. /// "In the group of API2-MALT1(+), the apoptosis index was higher and the API2 mRNA and protein were lower when compared against those in the group of API2MALT1(-). "
MALT1_API2- 15256115MALT lymphoma;lymphoma PCR;RT-PCR - To investigate the feasibility of detecting API2-MALT1 fusion gene transcript in paraffin-embedded tissue and its diagnostic value for pulmonary MALT lymphoma. /// [Detection of API2-MALT1 fusion gene transcript and its diagnostic value in pulmonary MALT lymphoma].. /// The presence of API2-MALT1 fusion gene may be correlated with a subset of pulmonary MALT lymphomas that have limited lung involvement.. /// Detection of API2-MALT1 fusion transcript in paraffin-embedded tissues is feasible by nested RT-PCR and is of diagnostic value. /// The API2-MALT1 fusion transcript was found in 3 of 10 pulmonary MALT lymphomas (30%) and in none of the 5 chronic lymphadenitis cases. /// Detection of the API2-MALT1 fusion transcript was performed by RT-PCR followed by second-round PCR using nested primers.
MALT1_API2t(1;14)(p22;q32) / t(14;18)(q32;21) / t(11;18)(q21;q21) / 21261681MALT lymphoma;lymphoma - - To date, it has been shown that at least the oncogenic products of t(1;14)(p22;q32)/BCL10-IGH, t(14;18)(q32;21)/IGH-MALT1 and t(11;18)(q21;q21)/API2-MALT1 activate the nuclear factor (NF)-?B activation pathway.
MALT1_API2t(11;18)(q21;q21) / t(1;14)(p22;q32) / t(14;18)(q32;q21) / 20520640MALT lymphoma;lymphoma - - Mucosa-associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the nuclear factor (NF)-kappaB pathway. /// "Finally, expression of TLR6, in the presence of TLR2, enhanced both API2-MALT1 and BCL10-mediated NF-kappaB activation in vitro. "
MALT1_API2t(11;18)(q21;q21) / 11984515MALT lymphoma;lymphoma - - Diagnostic biopsy specimens were analyzed for t(11;18)(q21;q21) by reverse-transcription polymerase chain reaction of the API2-MALT1 transcript.
MALT1_API2t(11;18)(q21;q21) / 25503310plasma cell myeloma PCR;ISH - The presence of the translocation t(11;18)(q21;q21) or the API2/MALT1 rearrangement could give further information about the clinical course and the prognosis of a gastric MALT lymphoma.
MALT1_API2t(11;18) / 21890816MALT lymphoma;B cell lymphoma;lymphoma - - A logistic regression analysis showed that absence of H pylori, submucosal invasion determined by endoscopic ultrasonography and t(11;18)/API2-MALT1 were independent predictors of resistance to H pylori eradication.
MALT1_API2- 17570523MALT lymphoma;lymphoma - - Successful radiotherapy in a patient with primary rectal mucosa-associated lymphoid tissue lymphoma without the API2-MALT1 fusion gene: a case report and review of the literature.. /// "The patient was negative for API2-MALT1 gene, and radiotherapy was performed and CR was achieved. "
MALT1_API2- 16078567MALT lymphoma;lymphoma PCR - To investigate the expression of API2-MALT1 fusion gene mRNA in Hashimoto's thyroiditis, thyroid MALT lymphoma and DLBCL, as well as the correlation between the expression and the pathogenesis and prognosis of two types of thyroid lymphoma. /// [Detecting the API2-MALT1 fusion gene and its significance in Hashimoto's thyroiditis and thyroid lymphomas].. /// "however, the correlation between API2-MALT1 fusion gene and the progression from Hashimoto's thyroiditis to lymphoma could not be excluded. " /// The effect of API2-MALT1 fusion gene on the prognosis of thyroid lymphomas was assessed by analyzing the clinicopathological features and the follow-up findings. /// The incidence of API2-MALT1 transcript in thyroid lymphomas was low. /// the thyroid lymphoma with API2-MALT1 transcript seemed to develop on a more indolent clinical course.. /// API2-MALT1 transcripts were investigated in all cases by reverse transcript touchdown-PCR and nested PCR.
MALT1_API2- 15071907MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - [The expression of API2-MALT1 fusion gene and its influence on the cellular apoptosis and proliferation in gastrointestinal MALT lymphoma].. /// API2-MALT1 fusion gene mRNA was found in 16 of specimens with gastrointestinal MALT lymphoma. /// " To investigate the expression of API2-MALT1 fusion gene mRNA and its effect on protein of API2, Caspase3 and Ki67 in gastrointestinal MALT lymphoma (Extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue). " /// The mRNA of API2-MALT1 fusion transcript was assayed in 33 archival cases of gastrointestinal MALT lymphoma by RT-PCR and nested PCR. /// "The average area (21177.30 +/- 6171.72) micron 2 and single cell average area (29.81 +/- 7.40) micron 2 of API2 were decreased in the group with the expression of API2-MALT1 mRNA, compared with those in the group without the expression of API2-MALT1 mRNA [(34325.65 +/- 6577.00) micron 2, (37.84 +/- 8.55) micron 2]. " /// The expression of API2-MALT1 mRNA is unrelated to the cellular proliferation.. /// "The expression of API2-MALT1 is related to the down-regulated expression of protein of API2, its effect on apoptosis of MALT lymphoma remains to be detected further. " /// "According to the expression of API2-MALT1 mRNA or not, 33 cases of MALT lymphoma were divided into two groups. "
MALT1_API2- 19094584MALT lymphoma;B cell lymphoma;lymphoma - - Fluorescence in-situ hybridization for API2-MALT1 fusion gene, bcl-10, MALT1 and IgH genes was performed on paraffin sections. /// "Among the 196 cases of MALT lymphoma, 25 cases (12.8%) possessed API2-MALT1 fusion gene. " /// "18)/API2-MALT1, t (1. "
MALT1_API2- 26181449MALT lymphoma;B cell lymphoma;lymphoma - - An API2-MALT1 fusion gene was detected in the gastric lesion.
MALT1_API2- 18307876MALT lymphoma;lymphoma - - Reverse transcription-polymerase chain reaction was used to detect the presence of API2-MALT1 fusion gene transcripts. /// "In the 6 cases of MALT lymphoma with high-grade transformation, nuclear and cytoplasmic expression of bcl-10 was demonstrated in 1 case, while API2-MALT1 fusion gene was present in 2 cases. "
MALT1_API2t(11;18)(q21;q21) / 12651604MALT lymphoma;B cell lymphoma;lymphoma - - t(11;18)(q21;q21) is associated with mucosa-associated lymphoid tissue (MALT)-type lymphoma and results in API2-MALT1 fusion. /// "The API2-MALT1 fusion transcript was detected in 21 of 51 (41%) cases, and was correlated with the absence of any underlying autoimmune disease, and with a normal serum lactate dehydrogenase, a ""typical"" histology without marked plasmacytic differentiation or an increased number of large cells, and aberrant nuclear BCL10 expression. " /// API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.. /// API2-MALT1 fusion is detected most frequently in MALT lymphomas primarily involving the lung. /// A large-scale study with a long follow-up is necessary to establish the prognostic significance of API2-MALT1 fusion.. /// "We therefore screened 51 cases of pulmonary MALT lymphoma for API2-MALT1 fusion, and studied its relationship with clinicopathologic factors including the immunohistochemical expression of BCL10, another MALT lymphoma-associated molecule. " /// "In addition, this alteration may define a homogeneous MALT lymphoma subtype that is clinically more indolent and histologically more ""typical."" Aberrant nuclear BCL10 expression may have a possible role as a tool to screen for this API2-MALT1 fusion. " /// These data suggest that the API2-MALT1 fusion may be a causative gene abnormality unrelated to autoimmune disease.
MALT1_API2t(11;18)(q21;q21) / t(11;18) / 10702396MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - All five cases that were shown to possess t(11;18)(q21;q21) showed the specific amplification of API2-MALT1 chimeric transcripts. /// "Thus, the RT-PCR assay used here should serve as an effective molecular tool for understanding molecular pathogenesis and the clinical significance of API2-MALT1 for MALT lymphomas.. " /// API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products..
MALT1_API2t(11;18)(q21;q21) / 21273489- - - We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-?B-inducing kinase (NIK) at arginine 325. /// Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation..
MALT1_API2t(11;18)(q21;q21) / 14614598MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - pylori) eradication treatment, and many of them contain an API2-MALT1 chimeric transcript mediated by t(11;18)(q21;q21) translocation. /// Gastric MALT lymphoma characterized by unresponsiveness to antibacterial treatment contains all API2-MALT1 chimeric transcript-positive cases and may constitute a distinct group often seen with nodal involvement and an advanced clinical stage. /// All cases were examined for API2-MALT1 chimeric transcript by means of RT-PCR and sequencing analyses using RNA extracted from tissues. /// "pylori infection status, responsiveness to antibacterial treatment, and API2-MALT1 chimeric transcript of gastric MALT lymphoma in a unicenter study experience and discuss the clinicopathologic significance of API2-MALT1 chimeric transcript in gastric MALT lymphoma. " /// "pylori or API2-MALT1 chimeric transcript status revealed a lesser number of the statistically significant factors (two and three, respectively). " /// "pylori infection, API2-MALT1 chimeric transcript, cobblestone mucosa and submucosal tumor in gross appearance, nodal involvement, and clinical stage) were statistically significant. " /// "API2-MALT1 chimeric transcript was detected in 9 patients, all of whom showed no change in response to treatment. "
MALT1_API2t(1;14) / t(11;18) / 11262391MALT lymphoma - - The second, t(11;18), results in the synthesis of a novel fusion protein, API2-MALT1. /// We propose a model whereby both the Bcl10.MALT1 complex and the API2-MALT1 fusion protein activate a common downstream signaling pathway that originates with the oligomerization-dependent activation of the MALT1 caspase-like domain.. /// "Furthermore, the API2-MALT1 fusion protein also strongly activates NF-kappaB and shows dependence upon the same downstream signaling factors. "
MALT1_API2t(11;18) / 14631809MALT lymphoma;lymphoma - - The characteristic translocation t(11;18) and its chimeric transcript API2-MALT1 with antiapoptotic function is emphasised..
MALT1_API2t(11;18)(q21;q21) / 11069033MALT Lymphoma PCR;RT-PCR - The molecular analysis of these variants allowed the design of optimised assays for the diagnosis of the API2-MALT1 gene rearrangement.. /// Heterogeneity of the API2-MALT1 gene rearrangement in MALT-type lymphoma.. /// RT-PCR analysis and DNA sequencing demonstrated the expression of an API2-MALT1 fusion transcript in 18/24 gastral and extragastral MALT-type lymphomas.
MALT1_API2t(14;18)(q32;q21) / t(11;18)(q21;q21) / t(1;14)(p22;q32) / 15682443MALT lymphoma;lymphoma PCR;RT-PCR - t(11;18)(q21;q21) fuses the N-terminus of the API2 gene to the C-terminus of the MALT1 gene and generates a functional API2-MALT1 product.
MALT1_API2t(11;18) (q21;q21) / 14603249MALT lymphoma;lymphoma - - Stability and subcellular localization of API2-MALT1 chimeric protein involved in t(11;18) (q21;q21) MALT lymphoma.. /// "Western blot analysis showed that the products of API2 and MALT1 were unstable, while the API2-MALT1 product was stable. " /// "However, little is known about the characteristics of API2, MALT1, and API2-MALT1 proteins. " /// "Our findings further suggest that the stabilized expression of API2-MALT1 products may continuously stimulate the NF-kappaB activating pathway, thus leading to MALT lymphomagenesis.. " /// "API2 was localized in the nucleus and the cytoplasm, and MALT1 and API2-MALT1 in the cytoplasm only. " /// "These results indicate that the domains responsible for protein instability are located in the end of the C-terminal of API2 and in that of the N-terminal of MALT1, and also that API2-MALT1 became stable because it lacks these domains. " /// "q21) is a chromosomal aberration specific to low-grade mucosa-associated lymphoid tissue (MALT) lymphoma, and generates the chimeric product apoptosis inhibitor 2 (API2)-MALT1, which has been suggested to play an important role in MALT lymphomagenesis. "
MALT1_API2t(11;18)(q21;q21) / 15184680MALT lymphoma;lymphoma - - MALT lymphomas are characterized genetically by the t(11;18)(q21;q21) translocation, which yields chimeric transcripts encoding structurally distinct API2/MALT1 fusion proteins. /// "Using microchip gene expression analysis, we demonstrate that different forms of the API2/MALT1 proteins activate both unique and overlapping gene programs in cells. " /// "Collectively, these data reveal previously unknown functional diversity among API2/MALT1 fusion products and their function in NF-kappaB signaling as it connects to the apoptotic program, a pathway with strong relevance to cancer. " /// "In addition to this genome reprogramming, expression of distinct API2/MALT1 fusion products inhibits DNA damage-induced, p53-mediated apoptosis in an NF-kappaB-dependent manner. " /// "In this study, we provide functional evidence for the contribution of API2/MALT1 fusion proteins to transformation of cells in culture by activating the NF-kappaB pathway through a RelB/p50 dimer. "
MALT1_API2t(11;18)(q21;q21) / t(1;14)(p22;q32) / t(14;18)(q32;q21) / t(11;18) / 16572204MALT lymphoma;lymphoma - - We recently demonstrated that API2-MALT1 can induce transactivation of the API2 gene through NF-kappaB activation, thus highlighting a positive feedback-loop mechanism of self-activation by upregulating its own expression in t(11;18) MALT lymphomas. /// " At least three recurrent chromosomal translocations, t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), involving the API2-MALT1 fusion protein, BCL10 and MALT1, have been implicated in the pathogenesis of mucosa-associated lymphoid tissue (MALT) lymphoma. " /// "These findings therefore led us to hypothesize that the antiapoptotic effect by API2-MALT1 may be mediated by its interaction with apoptotic regulators, on the one hand, and by NF-kappaB-mediated upregulation of apoptotic inhibitor genes on the other. " /// "We also demonstrated that API2-MALT1 possesses an antiapoptotic effect, in part, through its direct interaction with apoptotic regulators. " /// Molecular pathogenesis of MALT lymphoma: two signaling pathways underlying the antiapoptotic effect of API2-MALT1 fusion protein.. /// "Several lines of evidence indicated that both BCL10 and MALT1 are required for nuclear factor kappa B (NF-kappaB) activation by antigen receptor stimulation in lymphocytes, and API2-MALT1 can bypass this BCL10/MALT1 signaling pathway. "
MALT1_API2t(11;18) / t(1;14) / t(14;18) / 15540895MALT lymphoma;lymphoma - - Three distinct chromosomal translocations, t(11;18), t(1;14), and t(14;18), involving the API2-MALT1 fusion protein, BCL10, and MALT1 have been convincingly implicated in the pathogenesis of mucosa-associated lymphoid tissue (MALT) lymphomas. /// "We also have provided direct evidence that API2-MALT1 can exert an antiapoptotic effect, in part through its direct interaction with apoptotic regulators. " /// We therefore hypothesize that the antiapoptotic effect of API2-MALT1 may be mediated by the interaction with apoptotic regulators as well as by the up-regulation of apoptotic inhibitor genes. /// "API2-MALT1 can bypass the BCL10/MALT1 pathway linking to NF-kappaB activation, thereby inducing antigen receptor-independent events of lymphocytes. "
MALT1_API2t(11;18) / t(11;18) / 12950026B cell lymphoma;lymphoma;arthritis - - The t(11;18), which produces the putative anti-apoptotic fusion protein API2-MALT1, has been identified in a large proportion of extracutaneous MALT-type lymphomas and a smaller fraction of tumours harbour mutations that inactivate the pro-apoptotic functions of Fas and Bcl10.
MALT1_API2t(11;18)(q21;q21) / 22832211MALT lymphoma;B cell lymphoma;lymphoma - - Unlike the majority of MALT lymphomas, tumors bearing the t(11;18)(q21;q21) resulting in production of a chimeric protein API2/MALT1 are often resistant to H. /// Introducing some of these components into treatment protocols for patients with API2/MALT1 translocation-positive MALT lymphomas might also prove to be benefitial for other lymphomas with increased number of intratumoral Tregs.. /// Is it possible to overcome antiapoptotic API2/MALT1 events in tumor B-cells by influencing Tregs in MALT lymphoma?.
MALT1_API2t(11;18)(q21;q21) / 10751343lymphoma - - To investigate the incidence of API2-MALT1 fusion transcripts among marginal zone lymphomas and to determine possible marginal zone lymphoma subtype associations, we used reverse transcriptase-polymerase chain reaction to analyze RNAs extracted from frozen tissue samples of 99 marginal zone lymphomas. /// "API2-MALT1 fusion transcripts were detected in 12 of 57 extranodal marginal zone lymphomas (21%), but in none of the nodal or splenic cases. " /// "Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas.. "
MALT1_API2t(11;18)(q21;q21) / 11159207MALT lymphoma;B cell lymphoma;lymphoma PCR;RT-PCR - Using this rapid and simple method, we could detect API2-MALT1 fusion transcripts in 5 of 15 (33%) archival cases of MALT lymphoma for a frequency comparable with those of RT-PCR assays using frozen materials. /// API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens.. /// The lung was the preferential anatomical site of origin of MALT lymphomas harboring API2-MALT1 fusion. /// "Our multiplex RT-PCR assay, which can be used for routinely-processed paraffin samples, should serve as a useful molecular tool for clarifying the clinicopathological significance of API2-MALT1 fusion in MALT lymphoma.. "
MALT1_API2t(11;18)(q21;q21) / 11096264MALT lymphoma;B cell lymphoma;lymphoma PCR - We determined the API2/MALT1 fusion transcript in 2 cases by Northern blot analysis and also showed that MALT1 mRNA is constitutively expressed in a variety of human tissues. /// The API2/MALT1 fusion product may lead to germinal center B cell lymphomas by suppression of apoptosis..
MALT1_API2t(11;18)(q21;q21) / 15370267atopic dermatitis - - Neither t(11;18)(q21;q21) chromosomal translocation nor API2-MALT1 chimeric transcript was found at diagnosis. /// It appears necessary to clarify whether atopy might play a role in the pathogenesis of API2-MALT1(-) BALT lymphoma for HIV(-) young patients who do not exhibit any other antecedent chronic antigenic stimulations.. /// "Human immunodeficiency virus (HIV)-negative, API2-MALT1 fusion-negative bronchus-associated lymphoid tissue (BALT) lymphoma in a young male.. "
MALT1_API2t(11;18)(q21;q21) / 15338367MALT lymphoma;B cell lymphoma;lymphoma - - The positive rate of API2-MALT1 fusion transcripts was significantly greater in patients with multiple lesions with either single or multiple organ involvement than in those with a single gastric lesion (71.4% vs 12.5%. /// Gastric MALT lymphoma with multiple organ involvement is often associated with API2-MALT1 fusion transcripts.
MALT1_API2- 16105761MALT lymphoma;lymphoma PCR;RT-PCR - Detection of API2-MALT1 fusion transcripts in cytologic specimens of patients with pulmonary mucosa-associated lymphoid tissue lymphoma.. /// "In this study, we performed a multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay to detect the API2-MALT1 fusion transcript in archival cytologic specimens used as RNA sources. " /// This finding suggests that such specimens can be used as RNA sources in multiplex RT-PCR assays for the API2-MALT1 fusion transcript. /// API2-MALT1 fusion is specific to MALT lymphoma and is detected in nearly half of the pulmonary cases. /// "The detection of API2-MALT1 fusion as carried out with these specimens would be useful as an ancillary assay for the diagnosis, staging, and follow-up of pulmonary MALT lymphoma.. "
MALT1_API2t(11;18)(q21;q21) / t(11;18) / t(11;18) / 15086412MALT lymphoma;lymphoma - - The translocation fuses the API2 gene to the MALT1 gene and generates a functional API2-MALT1 transcript. /// "Comparative sequence analysis between the API2-MALT1 fusion on der(11) and the MALT1-API2 fusion on der(18) showed extensive alterations including deletions, duplications and non-template-based insertions at the fusion junctions in all cases examined. " /// "An extensive sequence search failed to reveal any known sequence motifs that might be associated with chromosomal recombination or any novel consensus sequences at or near the breakpoints on both der(11) and der(18) except in one case, in which Alu repeats spanned the breakpoint of the MALT1-API2 fusion. "
MALT1_API2- 19060847B cell lymphoma;lymphoma PCR;RT-PCR - API2/MALT1 fusion transcripts were found in two of nine cases (22%). /// "For methylation analyses, 7 independent CpG islands (p15, p16, DAP kinase, hMLH1, MINT1, MINT2, and MINT31) were examined and RT-PCR for detection of API2/MALT1 fusion transcripts were performed in 15 colorectal marginal zone B-cell lymphoma of MALT in a single institution. " /// "In two cases with concurrent gastric and colorectal involvement of marginal zone B-cell lymphoma of MALT, methylation patterns and API2/MALT1 fusion results were different by location. " /// Methylation and API2/MALT1 fusion in colorectal extranodal marginal zone lymphoma.. /// "For this purpose, methylation profiles and API2/MALT1 fusion in marginal zone B-cell lymphoma of MALT in the colorectum were studied and compared with treatment outcomes. "
MALT1_API2- 17052258B cell lymphoma;lymphoma - - No API2-MALT1 fusion transcript was detected in any of the 14 cases examined..
MALT1_API2t(11;18)(q21;q21) / 17492759MALT Lymphoma FISH;PCR;RT-PCR - FISH analysis for MALT1 gene alteration was performed for ocular and nodal MZBCL and RT-PCR for the detection of API2-MALT1 transcripts was performed for pulmonary MZBCL.
MALT1_API2- 18088487MALT lymphoma;lymphoma PCR;RT-PCR - API2-MALT1 rearrangement were found 38.1% in low grade, and 12.5% in transform type. /// "A number of factors including pathological characters, grade, stage, prognosis and treatment of 49 cases of MALT lymphoma were analyzed, and the API2-MALT1 rearrangement was detected by RT-PCR. " /// " The aim of this study was to investigate the clinical feature of mucosa-associated lymphoid tissue lymphoma and clarify the relationship between the pathological, clinical features, the expression of API2-MALT1 and the prognosis. "
MALT1_API2t(11;18)(q21;q21) / 25569716MALT lymphoma;lymphoma - - Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.. /// LIMA1 binding by API2-MALT1 is API2 dependent and proteolytic cleavage is dependent on MALT1 paracaspase activity. /// Here we show that API2-MALT1 induces paracaspase-mediated cleavage of the tumour suppressor protein LIMA1. /// "Importantly, primary MALT lymphomas harbouring the API2-MALT1 fusion uniquely demonstrate LIMA1 cleavage fragments. "
MALT1_API2t(11;18)(q21,q21) / / 17334391MALT lymphoma;lymphoma - - API2-MALT1 promotes cell survival and proliferation via activation of nuclear factor-kappaB (NF-kappaB). /// We find that the API2 moiety mediates oligomerization of API2-MALT1 as well as interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2).
MALT1_API2t(11;18)(q21;q21) / 26185372MALT lymphoma;B cell lymphoma;lymphoma - - pylori-negative gastric MALT lymphomas, and such translocation results in the synthesis of fusion protein API2-MALT1, which causes canonical and noncanonical NF-?B activation.
MALT1_API2- 19631287non Hodgkin Lymphoma - - The remission rate was higher among patients without the API2-MALT1 translocation than in those with this translocation (78% vs 22.2%.
MALT1_API2- 21160595MALT lymphoma - - Neoplasia confined to the submucosa, localized in the antral region of the stomach, and without API2-MALT1 translocation, shows a high probability of remission following H.
MALT1_API2t(11;18)(q21;q21) / 20081812MALT lymphoma;non Hodgkin lymphoma;lymphoma - - It results in the creation of a fusion protein API2-MALT1 that activates the transcription factor NF-kappaB through enhanced IKK gamma polyubiquitination.
MALT1_API2- 17085907gastric cancer - - pylori and t (11;18) (q21;q21) translocation (API2-MALT1 gene).
MALT1_API2- 22880230macroglobulinemia;MALT lymphoma ISH - Chromosome translocation was analyzed by the G-banded karyotype, and API2/MALT1 fusion gene underwent fluorescent in situ hybridization.
MALT1_API2t(11;18)(q21;q21) / t(11;18) / t(11;18) / 16512826MALT lymphoma - - t(11;18)(q21;q21) occurs specifically in mucosa-associated lymphoid tissue (MALT) lymphoma and the translocation generates a functional API2-MALT1 fusion product that activates nuclear factor (NF)kappaB.
MALT1_API2t(11;18)(q21;q21) / 24868477colonic diverticulitis;MALT lymphoma ISH - Fluorescence in situ hybridization studies revealed API2-MALT1 fusion signals consistent with t(11;18)(q21;q21), which confirmed the diagnosis of extranodal marginal zone lymphoma, also known as mucosa associated lymphoid tissue lymphoma.
MALT1_API2t(11;18)(q21;q21) / 15337797MALT lymphoma;lymphoma - - The presence of t(11;18)(q21;q21) was identified by a multiplex reverse transcriptase polymerase chain reaction of the API2-MALT1 chimeric transcript. /// The API2-MALT1 fusion transcript was detected in only one (12.5%) of eight H.
MALT1_API2- 15363040MALT lymphoma;B cell lymphoma;lymphoma - - Therefore, detection of API2-MALT1 fusion transcripts is useful for evaluating the prognosis and clinical behavior of the disease.. /// "Expression of API2-MALT1 fusion transcripts was detected by reverse transcription-polymerase chain reaction analysis using formalin-fixed, paraffin-embedded tissue. " /// Intestinal MALT lymphomas with API2-MALT1 expression have distinctive forms of infiltration compared with those without translocation.
MALT1_API2- 25381826MALT lymphoma ISH - Two months later, pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation in fluorescent in situ hybridization analysis.
MALT1_API2- 19907113B cell lymphoma;lymphoma ISH - There was no API2-MALT1 fusion transcript in any of the eight cases examined.

ChimerSEQ

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The fusion gene pair MALT1--API2 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair MALT1--API2 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair MALT1--API2 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair MALT1--API2 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair MALT1--API2 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair MALT1--API2 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair MALT1--API2 information is not available in ConjoinG Database.

1000Genome

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Fusion gene MALT1--API2 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene MALT1--API2 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene MALT1--API2 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene MALT1--API2 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene MALT1--API2 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair MALT1--API2 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene MALT1--API2 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene MALT1--API2 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene MALT1 is a known oncogene according to ONGENE database.


The tail gene API2 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene MALT1 is cancer associated according to Bushman Cancer Gene database.
The tail gene API2 is not cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene MALT1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene API2 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene MALT1--API2 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene MALT1--API2 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair MALT1--API2 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene MALT1--API2 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene MALT1--API2 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair MALT1--API2 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair MALT1--API2 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair MALT1--API2 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene MALT1--API2 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair MALT1--API2 information is not available in ChromothripsisDB database.