KMT2A--AFF1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

KMT2A AFF1

COSMIC

The fusion gene pair KMT2A--AFF1 information is available in COSMIC database.

Link
KMT2A--AFF1

ChimerKB

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The fusion gene pair KMT2A--AFF1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
KMT2A_AFF1-/4086/ -/1504/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4218/ -/1459/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4086/ -/1459/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4332/ -/1459/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4012/ -/1459/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4012/ -/1591/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4012/ -/1504/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4218/ -/1504/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4086+1554/ -/1591-1238/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4332/ -/1504/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4332+3441/ -/1459-9055/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4086+1073/ -/1459-13201/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4332/ -/1591/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4086/ -/1933/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/4086/ -/1591/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 12433702 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 16924642 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 20051780 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 25861237 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 haematopoietic neoplasm - 7827204 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 10861817 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 11368362 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 10773450 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 24310817 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 9168451 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 8443374 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 haematopoietic neoplasm - 19459927 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 17268512 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 11943339 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 17889710 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 12651265 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 12116073 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 23317202 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 22994759 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 12972812 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 8152249 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 haematopoietic neoplasm - 8152249 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 1423625 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 8358709 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 haematopoietic neoplasm - 8358709 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 19144982 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 19579075 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 haematopoietic neoplasm - 19579075 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 26264145 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 23511488 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 22572394 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 21869488 Oncogene; Cosmic_nonrecurrent
KMT2A_AFF1-/-/ -/-/ - hg19 lymphoid neoplasm - 26266519 Oncogene; Cosmic_nonrecurrent

ChimerPUB

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The fusion gene pair KMT2A--AFF1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
KMT2A_AFF1t(2;8)(p11.2;p22) / t(1;7)(q25;q32) / t(5;6)(q21;q21) / / 26648836acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia FISH;PCR;RT-PCR - Since December 2002, RT-PCR determinations were systematically carried out for BCR-ABL1, KMT2A-AFF1, ETV6-RUNX1, and TCF3-PBX1 rearrangements in children, adding KMT2A-MLLT3 and KMT2A-MLLT1 in infants. /// "Since December 2002, RT-PCR determinations were systematically carried out for BCR-ABL1, KMT2A-AFF1, ETV6-RUNX1, and TCF3-PBX1 rearrangements in children, adding KMT2A-MLLT3 and KMT2A-MLLT1 in infants. " /// "We compared cytogenetic and RT-PCR results for BCR-ABL1, KMT2A-AFF1 and TCF3-PBX1 rearrangements in 497 children evaluated by both methods. "

ChimerSEQ

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The fusion gene pair KMT2A--AFF1 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
KMT2A_AFF1chr11/118359475/ chr4/88005270/ 11q23.3 4q22.1 Exonic hg19 - Inter-chr acute lymphoblastic leukemia;lymphoblastic lymphoma;chronic and acute leukemia;infant precursor B acute lymphoblastic leukemia. JN169752 Oncogene; ChiTaRs

ChiTaRS 2.1

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The fusion gene pair KMT2A--AFF1 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human JN169752KMT2A--AFF1 KMT2A11 118354896 118359475 + 11 405 100 AFF14 88005270 88011213 + 404 528 100

FARE-CAFE

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The fusion gene pair KMT2A--AFF1 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair KMT2A--AFF1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair KMT2A--AFF1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair KMT2A--AFF1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair KMT2A--AFF1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene KMT2A--AFF1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene KMT2A--AFF1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene KMT2A--AFF1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene KMT2A--AFF1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene KMT2A--AFF1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair KMT2A--AFF1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene KMT2A--AFF1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene KMT2A--AFF1 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene KMT2A is a known oncogene according to ONGENE database.


The tail gene AFF1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene KMT2A is cancer associated according to Bushman Cancer Gene database.


The tail gene AFF1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene KMT2A is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene AFF1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene KMT2A--AFF1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene KMT2A--AFF1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair KMT2A--AFF1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene KMT2A--AFF1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene KMT2A--AFF1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair KMT2A--AFF1 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair KMT2A--AFF1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair KMT2A--AFF1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene KMT2A--AFF1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair KMT2A--AFF1 information is not available in ChromothripsisDB database.