KIF5B--RET

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

KIF5B RET

COSMIC

The fusion gene pair KIF5B--RET information is available in COSMIC database.

Link
KIF5B--RET

ChimerKB

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The fusion gene pair KIF5B--RET information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
KIF5B_RET-/2183/ -/2327/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/2372+476/ -/2327-436/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/2372/ -/2327/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/2897/ -/2327/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/3002/ -/2327/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/3219+372/ -/1713-416/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/2183/ -/2177/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/3219/ -/2070/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/3002+152/ -/2327-12/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/2183+2335/ -/2327-1785/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/2183+550/ -/2327-741/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/2183+2204/ -/2327-318/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/2372+334/ -/2327-450/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_RET-/-/ -/-/ - hg19 lung adenocarcinoma - 22194472 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 lung adenocarcinoma - 22327624 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 colorectal cancer, lung adenocarcinoma - 22327622 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 lung cancer - 22327623 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 lung adenocarcinoma - 22797671 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 non small cell lung cancer - 23150706 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 non small cell lung cancer - 23891510 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 non small cell lung cancer - 24133367 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 adenosquamous lung carcinoma - 24481316 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 lung adenocarcinoma - 24722163 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 lung adenocarcinoma - 24700479 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 benign melanocytic nevus - 24445538 Oncogene; Cosmic_nonrecurrent
KIF5B_RET-/-/ -/-/ - hg19 lung adenocarcinoma - 24469108 Oncogene; Cosmic_nonrecurrent

ChimerPUB

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The fusion gene pair KIF5B--RET information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
KIF5B_RET- 23342255non small cell lung cancer;lung cancer;adenocarcinoma FISH;PCR;RT-PCR - We investigated RET mRNA expression by real-time reverse-transcriptase polymerase chain reaction (RT-PCR) assay using LightCycler, and KIF5B/RET gene rearrangements using newly established fluorescence in situ hybridization (FISH) analysis in surgically treated nonsmall cell lung cancer (NSCLC) cases. /// "We investigated RET mRNA expression by real-time reverse-transcriptase polymerase chain reaction (RT-PCR) assay using LightCycler, and KIF5B/RET gene rearrangements using newly established fluorescence in situ hybridization (FISH) analysis in surgically treated nonsmall cell lung cancer (NSCLC) cases. " /// RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer.. /// "Although RET IHC positivity was not perfectly correlated with KIF5B/RET arrangement, we have detected the KIF5B/RET rearrangements using FISH analysis. " /// "Thus, we have successfully introduced FISH for diagnosing KIF5B/RET positive lung adenocarcinoma. " /// "T/N ratio of RET/? actin mRNA levels was significantly higher in KIF5B/RET rearrangement samples (161.763 ?? 123.488) than in wild-type samples (5.9013 ?? 17.148, P = 0.044). "
KIF5B_RET- 23877438non small cell lung cancer - - To better understand the role of recently identified ROS1 and RET fusion oncokinases in pulmonary carcinogenesis, we examined 114 NSCLCs for SLC34A2-ROS1, EZR-ROS1, CD74-ROS1 and KIF5B-RET fusion transcripts using RT-polymerase chain reaction and subsequent sequencing analyses. /// "To better understand the role of recently identified ROS1 and RET fusion oncokinases in pulmonary carcinogenesis, we examined 114 NSCLCs for SLC34A2-ROS1, EZR-ROS1, CD74-ROS1 and KIF5B-RET fusion transcripts using RT-polymerase chain reaction and subsequent sequencing analyses. " /// "Although the expression of SLC34A2-ROS1, EZR-ROS1, or KIF5B-RET fusion transcripts was not detected in any of the cases, the expression of CD74-ROS1 fusion transcripts was detected in one (0.9%) of the 114 NSCLCs. "
KIF5B_RET- 24759083lung cancer - - Here we report the application of CRISPR/Cas technology to successfully generate several types of chromosomal rearrangements implicated as driver events in lung cancer, including the CD74-ROS1 translocation event and the EML4-ALK and KIF5B-RET inversion events. /// "Here we report the application of CRISPR/Cas technology to successfully generate several types of chromosomal rearrangements implicated as driver events in lung cancer, including the CD74-ROS1 translocation event and the EML4-ALK and KIF5B-RET inversion events. "
KIF5B_RET- 25436805adenocarcinoma - - Comprehensive genomic profiling performed by means of a clinical grade cancer gene panel next-generation sequencing assay demonstrated a KIF5B-RET fusion in three; and fluorescence in-situ hybridization documented a RET rearrangement in two. /// Comprehensive genomic profiling performed by means of a clinical grade cancer gene panel next-generation sequencing assay demonstrated a KIF5B-RET fusion in three.
KIF5B_RET- 26076869small cell carcinoma;lung cancer;adenocarcinoma - - However, new molecular targets have been highlighted recently including BRAF mutations, HER2?or PI3K, new translocations such as ROS1?or KIF5B-RET. /// "However, new molecular targets have been highlighted recently including BRAF mutations, HER2?or PI3K, new translocations such as ROS1?or KIF5B-RET. "
KIF5B_RET- 25047660lung cancer PCR;RT-PCR - We aimed to provide a basis for the further development of the therapy for KIF5B-RET positive lung cancer patients. /// RT-PCR was used to screen for KIF5B-RET fusions in Chinese lung cancer patients. /// "To verify the oncogenic activity of KIF5B-RET kinase in lung cancer cells, we manipulated its expression genetically followed by colony formation and tumor formation assays. " /// "Our data suggest that KIF5B-RET promotes the cell growth and tumorigenicity of non-small cell lung cancers through multilevel activation of STAT3 signaling, providing possible strategies for the treatment of KIF5B-RET positive lung cancers.. " /// "The mechanism by which KIF5B-RET kinase induces proliferation was investigated by western blot, coimmunoprecipitation, and administration of RET, MAPK and STAT3 inhibitors. " /// "In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways for cellular transformation. " /// Our study identified a KIF5B-RET fusion in Chinese NSCLC patients and demonstrated that KIF5B-RET transfected cells showed a significantly increased proliferation rate and colony-forming ability. /// KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. /// KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer..
KIF5B_RET- 22928112non small cell lung cancer;non small cell lung cancer;small cell lung c - - It is now clear that heterogeneous cell signaling pathways are disrupted to promote NSCLC, including mutations in critical growth regulatory proteins (K-Ras, EGFR, B-RAF, MEK-1, HER2, MET, EML-4-ALK, KIF5B-RET, and NKX2.1) and inactivation of growth inhibitory pathways (TP53, PTEN, p16, and LKB-1). /// "It is now clear that heterogeneous cell signaling pathways are disrupted to promote NSCLC, including mutations in critical growth regulatory proteins (K-Ras, EGFR, B-RAF, MEK-1, HER2, MET, EML-4-ALK, KIF5B-RET, and NKX2.1) and inactivation of growth inhibitory pathways (TP53, PTEN, p16, and LKB-1). "
KIF5B_RET- 23378251neuroectodermal tumor;squamous cell carcinoma - - The objective of the current study was to determine the prevalence and clinicopathologic characteristics of KIF5B-RET fusions (fusions of the RET and kinesin family member 5B [KIF5B] genes) in Chinese patients with NSCLC. /// "There was no statistically significant difference in age, sex, smoking status, pathologic stage, or histologic type between patients with and without KIF5B-RET fusions." /// All patients who were positive for a KIF5B-RET fusion were never-smokers. /// "KIF5B-RET fusions were quite rare, with a prevalence of approximately 1.5% in Chinese patients with NSCLC, and they were a little more common in patients with adenocarcinoma than in those with squamous carcinoma (1.73% vs 0.84%)." /// The relations between KIF5B-RET fusions and clinicopathologic characteristics were analyzed. /// KIF5B-RET fusions in Chinese patients with non-small cell lung cancer.. /// "In total, 6 patients (1.5%) were identified who harbored KIF5B-RET fusions. " /// "Patients without KIF5B-RET fusions had a better prognosis than those with KIF5B-RET fusions (median survival, 52.6 months vs 21.0 months. " /// The authors screened for KIF5B-RET fusions in 392 patients with NSCLC using multiplex real-time polymerase chain reaction assay and validated all positive samples using direct sequencing. /// "There was no statistically significant difference in age, sex, smoking status, pathologic stage, or histologic type between patients with and without KIF5B-RET fusions. " /// "KIF5B-RET fusions were quite rare, with a prevalence of approximately 1.5% in Chinese patients with NSCLC, and they were a little more common in patients with adenocarcinoma than in those with squamous carcinoma (1.73% vs 0.84%). " /// "In addition, KIF5B-RET fusions also existed in patients with low-grade malignant neuroendocrine tumors.. "
KIF5B_RET- 25349307non small cell lung cancer;lung cancer - - In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M.

ChimerSEQ

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The fusion gene pair KIF5B--RET information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
KIF5B_RETchr10/32345371/ chr10/43612030/ 10p11.22 10q11.21 Exonic hg19 - Intra-chr NA HW088349 Oncogene; ChiTaRs
KIF5B_RETchr10/32345371/ chr10/43612032/ 10p11.22 10q11.21 Exonic hg19 - Intra-chr NA HW088350 Oncogene; ChiTaRs
KIF5B_RETchr10/32345371/ chr10/43607546/ 10p11.22 10q11.21 Exonic hg19 - Intra-chr NA HW088352 Oncogene; ChiTaRs
KIF5B_RETchr10/32345110/ chr10/43612030/ 10p11.22 10q11.21 Exonic hg19 - Intra-chr NA AB795254 Oncogene; ChiTaRs
KIF5B_RETchr10/32345110/ chr10/43612032/ 10p11.22 10q11.21 Exonic hg19 - Intra-chr NA AB795252 Oncogene; ChiTaRs
KIF5B_RETchr10/32345110/ chr10/43609927/ 10p11.22 10q11.21 Exonic hg19 - Intra-chr NA AB795257 Oncogene; ChiTaRs

ChiTaRS 2.1

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The fusion gene pair KIF5B--RET information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human HW088349KIF5B--RET KIF5B10 32317355 32345371 - 1 2196 100 RET10 43612030 43625799 + 2194 5486 100
Human HW088351KIF5B--RET KIF5B10 32306979 32345371 - 1 3015 100 RET10 43612030 43625799 + 3013 6305 100
Human HW088350KIF5B--RET KIF5B10 32311775 32345371 - 1 2385 100 RET10 43612032 43625799 + 2385 5675 100
Human HW088352KIF5B--RET KIF5B10 32306071 32345371 - 1 3231 100 RET10 43607546 43625799 + 3231 7136 100
Human AB795254KIF5B--RET KIF5B10 32307243 32345110 - 1 2649 100 RET10 43612030 43623762 + 2647 3902 100
Human AB795255KIF5B--RET KIF5B10 32306979 32345110 - 1 2754 100 RET10 43612030 43622292 + 2752 3926 99.9
Human AB795252KIF5B--RET KIF5B10 32311775 32345110 - 1 2124 100 RET10 43612032 43623762 + 2124 3377 99.9
Human AB795253KIF5B--RET KIF5B10 32307243 32345110 - 1 2649 100 RET10 43612030 43622292 + 2647 3821 100
Human AB795250KIF5B--RET KIF5B10 32317355 32345110 - 1 1935 100 RET10 43612030 43623762 + 1933 3188 100
Human AB795249KIF5B--RET KIF5B10 32317355 32345110 - 1 1935 100 RET10 43612030 43622292 + 1933 3107 100
Human AB795256KIF5B--RET KIF5B10 32306979 32345110 - 1 2754 100 RET10 43612030 43623762 + 2752 4007 100
Human AB795251KIF5B--RET KIF5B10 32311775 32345110 - 1 2124 100 RET10 43612032 43622292 + 2124 3296 99.8
Human AB795257KIF5B--RET KIF5B10 32306071 32345110 - 1 2970 100 RET10 43609927 43622292 + 2970 4400 99.9

FARE-CAFE

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The fusion gene pair KIF5B--RET information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
KIF5B-RET lung adenocarcinoma PCR 10p11.22–q11.21 PubMed: 22194472

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
KIF5B-RET KIF5B-RET KIF5B 32311795 1 0 RET 43612032 1 0 gtcagcttcgtatctctcaaGaggatccaaagtgggaatt 22194472 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
KIF5B-RET KIF5B-RET - - 1) Pkinase_Tyr
1) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
KIF5B 1) Kinesin
1) Tubulin_C , Tubulin , Kinesin , SBP_bac_1 , EF-hand_8
RET 1) Cadherin
2) Pkinase_Tyr
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Kinesin
2) Cadherin
1) Tubulin_C , Tubulin , Kinesin , SBP_bac_1 , EF-hand_8
2) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
KIF5B-RET hsa-miR-31-5phsa-miR-29a-3phsa-miR-215-5phsa-miR-192-5p hsa-miR-128-3phsa-miR-1hsa-miR-34a-5phsa-miR-103a-3phsa-miR-30a-5phsa-miR-16-5phsa-miR-186-5p Report assay,qPCR,Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
KIF5B-RET NM_004521.2 1) TRIM28_HUMAN
2) STAT1_HUMAN
3) RBL2_HUMAN
4) E2F4_HUMAN
5) ETS1_HUMAN
6) GATA3_HUMAN
7) E2F1_HUMAN
8) CTCF_HUMAN
9) BRG1_HUMAN
10) HNF4A_HUMAN
11) TFAP2C_HUMAN
12) FOXA1_HUMAN
13) SPI1_HUMAN
1) SOX10_HUMAN
2) MITF_HUMAN
3) ZNF263_HUMAN
4) P53_HUMAN
5) ESTROGEN RECEPTOR ALPHA_HUMAN
6) EGR1_HUMAN
7) FOS_HUMAN
8) ESR1_HUMAN
9) ESR2_HUMAN
10) FOXP1_HUMAN
1) 17542650
2) 19122651
3) 20385362
4) 21247883
5) 20019798
6) 21878914
7) 21310950
8) 21795385
9) 19505939
10) 21646355
11) 21572391
12) 21572391
13) 21241896

TicDB

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The fusion gene pair KIF5B--RET information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
KIF5B RET 22194472 gtcagcttcgtatctctcaaGaggatccaaagtgggaatt

TUMOR FUSION Gene Data Portal

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The fusion gene pair KIF5B--RET information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair KIF5B--RET information is available in FusionCancer Database.
Database_IDHead_gene_symbolHead_breakpoint_locationTail_gene_symbolTail_breakpoint_locationCancer_typeSRA
FUSC002348KIF5Bchr10:32345370RETchr10:43612031Lung cancerERR062335
FUSC002348KIF5Bchr10:32317356RETchr10:43612032Lung cancerERR062335
FUSC002348KIF5Bchr10:32345370RETchr10:43612031Lung cancerERR164624

ConjoinG

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The fusion gene pair KIF5B--RET information is not available in ConjoinG Database.

1000Genome

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Fusion gene KIF5B--RET has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene KIF5B--RET is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene KIF5B--RET is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene KIF5B--RET is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene KIF5B--RET was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair KIF5B--RET information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene KIF5B--RET is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene KIF5B--RET has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene KIF5B is not a known oncogene according to ONGENE database.


The tail gene RET is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene KIF5B is not cancer associated according to Bushman Cancer Gene database.


The tail gene RET is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene KIF5B is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene RET is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene KIF5B--RET is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene KIF5B--RET is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair KIF5B--RET information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene KIF5B--RET is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene KIF5B--RET has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair KIF5B--RET information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair KIF5B--RET information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair KIF5B--RET is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
KIF5B--RETDevelopment and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumorshttps://doi.org/10.1016/j.jmoldx.2018.03.007

Cortex_Dataset

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Fusion gene KIF5B--RET is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair KIF5B--RET information is not available in ChromothripsisDB database.