KIF5B--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

KIF5B ALK

COSMIC

The fusion gene pair KIF5B--ALK information is available in COSMIC database.

Link
KIF5B--ALK

ChimerKB

Top
The fusion gene pair KIF5B--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
KIF5B_ALK-/3219/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_ALK-/2183/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_ALK-/2490/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_ALK-/2183+2477/ -/4005/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
KIF5B_ALK-/-/ -/-/ - hg19 lung cancer - 19383809 Oncogene; Cosmic_nonrecurrent
KIF5B_ALK-/-/ -/-/ - hg19 - - 21225871 Oncogene; Cosmic_nonrecurrent
KIF5B_ALK-/-/ -/-/ - hg19 lung cancer - 22327623 Oncogene; Cosmic_nonrecurrent
KIF5B_ALK-/-/ -/-/ - hg19 lung cancer - 23344087 Oncogene; Cosmic_nonrecurrent
KIF5B_ALK-/-/ -/-/ - hg19 non small cell lung cancer - 23951022 Oncogene; Cosmic_nonrecurrent
KIF5B_ALK-/-/ -/-/ - hg19 adenosquamous lung carcinoma - 24481316 Oncogene; Cosmic_nonrecurrent
KIF5B_ALK-/-/ -/-/ - hg19 lung adenocarcinoma - 24992725 Oncogene; Cosmic_nonrecurrent

ChimerPUB

Top
The fusion gene pair KIF5B--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
KIF5B_ALK- 22296236bronchioloalveolar carcinoma FISH - However, FISH studies failed to reveal EML4-ALK and KIF5B-ALK fusion genes in this BAC. /// "However, FISH studies failed to reveal EML4-ALK and KIF5B-ALK fusion genes in this BAC. " /// Echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4-ALK) and kinesin family member 5B (KIF5B)-ALK are newly identified transforming fusion oncogenes causing non-small-cell lung cancers.
KIF5B_ALK- 26142544non small cell lung cancer;lung cancer FISH;PCR - The case missed by ddPCR was identified as KIF5B-ALK gene rearrangement by PCR-based direct sequencing.
KIF5B_ALK- 21757253non small cell lung cancer;lung cancer;adenocarcinoma FISH;PCR;RT-PCR - The echinoderm microtubule-associated protein-like 4(EML4)-ALK or kinesin family member 5B (KIF5B)-ALK translocation was confirmed by the reverse transcription polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH).
KIF5B_ALK- 21656749non small cell lung cancer;lung cancer FISH - Overexpression of KIF5B-ALK in mammalian cells led to the activation of signal transducer and activator of transcription 3 and protein kinase B and to enhanced cell proliferation, migration, and invasion. /// Western blot analysis of clinical tumor tissues revealed the expression of a protein whose size correlated with that of the predicted KIF5B-ALK. /// Western blot analysis of clinical tumor tissues revealed the expression of a protein whose size correlated with that of the predicted KIF5B-ALK. /// The discovery of the novel KIF5B-ALK variant further consolidated the role of aberrant ALK signaling in lung carcinogenesis.. /// A novel KIF5B-ALK variant in nonsmall cell lung cancer..
KIF5B_ALK- 22347464lung cancer FISH - We developed a 5'-rapid amplification of cDNA ends-based system optimized for FFPE tissues and evaluated this system on a lung cancer tissue with ALK rearrangement and without the 2 known ALK fusions EML4-ALK and KIF5B-ALK.
KIF5B_ALK- 19383809lung cancer PCR - Coupling of PCR-based detection to the iAEP method should further facilitate the rapid identification of novel ALK fusion genes such as KIF5B-ALK.. /// Multiplex reverse transcription-PCR analysis of additional archival tumor specimens identified another case of lung adenocarcinoma positive for KIF5B-ALK. /// "KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer.. "

ChimerSEQ

Top
The fusion gene pair KIF5B--ALK information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
KIF5B_ALKchr10/32344911/ chr2/29416073/ 10p11.22 2p23.2 Exonic hg19 - Inter-chr non small cell lung cancer AB462413 Oncogene; ChiTaRs

ChiTaRS 2.1

Top
The fusion gene pair KIF5B--ALK information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human AB462413KIF5B--ALK KIF5B10 32306071 32344911 - 1 2771 100 ALK2 29416073 29446395 - 2771 4479 100

FARE-CAFE

Top
The fusion gene pair KIF5B--ALK information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
KIF5B-ALK Non-small cell lung cancer _ t(2;10)(p23;p11) PubMed:21225871

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
KIF5B-ALK KIF5B-ALK-Isoform1 KIF5B _ _ 0 ALK _ 0 _ ggcaaccactTctcgctgat 21225871 _
KIF5B-ALK KIF5B-ALK-Isoform2 KIF5B _ _ 0 ALK _ 0 _ tgatgtaaagCaccaggagc 21225871 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
KIF5B-ALK KIF5B-ALK-Isoform1 - - - -KIF5B 1) Kinesin
1) Tubulin_C , Tubulin , Kinesin , SBP_bac_1 , EF-hand_8
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Kinesin
2) MAM
3) Gly_rich
4) Pkinase_Tyr
1) Tubulin_C , Tubulin , Kinesin , SBP_bac_1 , EF-hand_8
2) ig , Astacin , MATH
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
KIF5B-ALK KIF5B-ALK-Isoform2 - - - -KIF5B 1) Kinesin
1) Tubulin_C , Tubulin , Kinesin , SBP_bac_1 , EF-hand_8
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Kinesin
2) MAM
3) Gly_rich
4) Pkinase_Tyr
1) Tubulin_C , Tubulin , Kinesin , SBP_bac_1 , EF-hand_8
2) ig , Astacin , MATH
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
KIF5B-ALK hsa-miR-132-3p hsa-miR-128-3phsa-miR-1hsa-miR-215-5phsa-miR-34a-5phsa-miR-192-5phsa-miR-103a-3phsa-miR-30a-5phsa-miR-16-5phsa-miR-186-5p Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
KIF5B-ALK NM_004521.2 1) TRIM28_HUMAN
2) STAT1_HUMAN
3) RBL2_HUMAN
4) E2F4_HUMAN
5) ETS1_HUMAN
6) GATA3_HUMAN
7) E2F1_HUMAN
8) CTCF_HUMAN
9) BRG1_HUMAN
10) HNF4A_HUMAN
11) TFAP2C_HUMAN
12) FOXA1_HUMAN
13) SPI1_HUMAN
1) MITF_HUMAN
2) P53_HUMAN
3) RUNX1_HUMAN
4) PRDM14_HUMAN
5) ESTROGEN RECEPTOR ALPHA_HUMAN
6) EGR1_HUMAN
7) FOS_HUMAN
8) SOX2_HUMAN
9) ESR1_HUMAN
10) NR1H3_HUMAN
11) SETDB1_HUMAN
1) 17542650
2) 19122651
3) 20385362
4) 21247883
5) 20019798
6) 21878914
7) 21310950
8) 21795385
9) 19505939
10) 21646355
11) 21572391
12) 21572391
13) 21241896

TicDB

Top
The fusion gene pair KIF5B--ALK information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
KIF5B ALK 21225871 ggcaaccactTctcgctgat
KIF5B ALK 21225871 tgatgtaaagCaccaggagc

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair KIF5B--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

Top
The fusion gene pair KIF5B--ALK information is not available in FusionCancer Database.

ConjoinG

Top
The fusion gene pair KIF5B--ALK information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene KIF5B--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene KIF5B--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

Top
Fusion gene KIF5B--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene KIF5B--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene KIF5B--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair KIF5B--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene KIF5B--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene KIF5B--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene KIF5B is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene KIF5B is not cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene KIF5B is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene KIF5B--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene KIF5B--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair KIF5B--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene KIF5B--ALK is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene KIF5B--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair KIF5B--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

Top
The fusion gene pair KIF5B--ALK information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair KIF5B--ALK information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

Top
Fusion gene KIF5B--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair KIF5B--ALK information is not available in ChromothripsisDB database.