JAK2--BCR

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

JAK2 BCR

COSMIC

The fusion gene pair JAK2--BCR information is not available in COSMIC database.

ChimerKB

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The fusion gene pair JAK2--BCR information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair JAK2--BCR information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
JAK2_BCRt(9;22) / p24;q11.2 / 16001431chronic myeloid leukemia;myeloid leukemia;leukemia FISH - A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia.. /// The BCR-JAK2 fusion protein contains the coiled-coil dimerization domain of BCR and the protein tyrosine kinase domain (JH1) of JAK2. /// "The patient's disease did not respond to Imatinib, and this unresponsiveness was most likely a result of the BCR-JAK2 fusion protein.. "
JAK2_BCR- 22384256acute myeloid leukemia;acute lymphoblastic leukemia;myeloid leukemia FISH;PCR;RT-PCR - We used fluorescence in situ hybridization and reverse transcription polymerase chain reaction (RT-PCR) assays to describe a BCR-JAK2 fusion gene from a patient with acute lymphoblastic leukemia. /// "Recent reports described a BCR-JAK2 fusion gene in fatal chronic and acute myeloid leukemia, but the functional behavior of the chimeric protein remains uncharacterized. " /// "Therefore, BCR-JAK2 is a novel tyrosine-kinase with transforming activity." /// BCR-JAK2 codes for a protein containing the BCR oligomerization domain fused to the JAK2 tyrosine-kinase domain. /// Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase.. /// "Treatment with the JAK2 inhibitor TG101209 abrogated BCR-JAK2 and STAT5 phosphorylation, decreased Bcl-xL expression and triggered apoptosis of transformed Ba/F3 cells. " /// Primary mouse progenitor cells transduced with BCR-JAK2 also showed increased proliferation and survival. /// "Therefore, BCR-JAK2 is a novel tyrosine-kinase with transforming activity. " /// "Moreover, transformed Ba/F3 cells developed tumors when injected subcutaneously into nude mice, thus proving the tumorigenic capacity of BCR-JAK2 in vivo. " /// In vitro analysis of transfected cells showed that BCR-JAK2 is located in the cytoplasm. /// "Transduction of hematopoietic Ba/F3 cells with retroviral vectors carrying BCR-JAK2 induced IL-3-independent cell growth, constitutive activation of the chimeric protein as well as STAT5 phosphorylation and translocation to the nuclei, where Bcl-xL gene expression was elicited. "
JAK2_BCRt(9;22)(p24;q11) / 18503828acute myeloid leukemia;myeloid leukemia;leukemia - - We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. /// A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia.. /// The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. /// "Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.. "
JAK2_BCRt(8;9)(p22;p24) / t(9;22)(p24;q11) / 25260694- - - Rearrangements of chromosome band 9p24 are known to be associated with JAK2 fusion genes, e.g., t(8;9)(p22;p24) with a PCM1-JAK2 and t(9;22)(p24;q11) with a BCR-JAK2 fusion gene, respectively. /// "With the discovery of inhibitors of the JAK2 tyrosine kinase and based on encouraging in vitro and in vivo data, we treated two male patients with myeloid neoplasms and a PCM1-JAK2 or a BCR-JAK2 fusion gene, respectively, with the JAK1/JAK2 inhibitor ruxolitinib. " /// Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes..
JAK2_BCRt(9;22) / p24;q11.2 / 23904814chronic myeloid leukemia - - We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. /// "Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene.. " /// "This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations: myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid leukemia. "
JAK2_BCRp24;q11 / t(9;22)(p24;q11) / 25789185leukemia - - Here, we report an unclassified case of MPN (MPN-U) showing a t(9;22)(p24;q11), which generates a BCR-JAK2 fusion gene by fusing the BCR at intron 13 to JAK2 at intron 17 on the derivative chromosome 22. /// Transformation of an Unclassified Myeloproliferative Neoplasm with a Rare BCR-JAK2 Fusion Transcript Resulting from the Translocation (9;22)(p24;q11).. /// "To the best of our knowledge, this is the thirteenth case reported worldwide to describe a BCR-JAK2 fusion transcript in MPN-U. "
JAK2_BCRt(9;22) / p24;q11.2 / 25833723myelodysplastic syndrome - - Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature. /// "Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature.. "
JAK2_BCRt(9;22) / p24;q11.2 / 18537978- - - Leukaemia cutis in atypical chronic myeloid leukaemia with a t(9;22) (p24;q11.2) leading to BCR-JAK2 fusion..
JAK2_BCR- 23432689chronic myeloid leukemia;myeloid leukemia;leukemia - - A BCR-JAK2 fusion gene from ins(22;9)(q11;p13p24) in a patient with atypical chronic myeloid leukemia..
JAK2_BCRt(9;18;22) / p11.3;q11.2 / 22018274- - - This is the first report of the simultaneous occurrence of two BCR/JAK2 fusion transcripts in the same sample and of the longer transcript isoform (BCR exon 1 fused to JAK2 exon 15). /// "Notably, both BCR/JAK2 encoded fusion proteins are predicted to juxtapose the coiled-coil dimerization domain of BCR to the catalytically inactive pseudokinase domain (JH2), entirely or partially deprived of the inhibitory region 1 (IR1). "
JAK2_BCRt(8;9)(p22;p24) / t(9;12)(p24;p13) / t(9;22) / p24;q11??2 / 24913195- - - BCR-JAK2 should be documented carefully in order to define their features more clearly and assess whether they can be recognized as entities.
JAK2_BCRp24;q11.2 / t(9;22) / 22549126myeloproliferative disorder;leukemia ISH - A rare translocation, t(9;22)(p24;q11.2), resulting in a novel BCR-JAK2 fusion has been reported in a handful of cases of CML and acute myelogenous leukemia (AML). /// BCR-JAK2 fusion as a result of a translocation (9;22)(p24;q11.2) in a patient with CML-like myeloproliferative disease.. /// We present clinical-pathological and cytogenetic evaluation of a patient with Philadelphia-chromosome negative CML/MPD harboring a t(9;22)(p24;q11.2) resulting in BCR-JAK2 fusion. /// "Fluorescence in situ hybridization and molecular characterization of the translocation confirmed a BCR-JAK2 fusion and helped delineate the breakpoints upstream of exon 1 of minor cluster region of BCR gene and likely intron 18 of the JAK2 gene, resulting in an in-frame transcript This case provides convincing support, along with two previous case-reports, for a role for activation of the Janus kinase 2 in evolution of myeloproliferative disease. "

ChimerSEQ

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The fusion gene pair JAK2--BCR information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair JAK2--BCR information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair JAK2--BCR information is not available in FARE-CAFE.

TicDB

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The fusion gene pair JAK2--BCR information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair JAK2--BCR information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair JAK2--BCR information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair JAK2--BCR information is not available in ConjoinG Database.

1000Genome

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Fusion gene JAK2--BCR has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene JAK2--BCR is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene JAK2--BCR is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene JAK2--BCR is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene JAK2--BCR was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair JAK2--BCR information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene JAK2--BCR is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene JAK2--BCR has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene JAK2 is a known oncogene according to ONGENE database.


The tail gene BCR is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene JAK2 is cancer associated according to Bushman Cancer Gene database.


The tail gene BCR is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene JAK2 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene BCR is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene JAK2--BCR is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene JAK2--BCR is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair JAK2--BCR information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene JAK2--BCR is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene JAK2--BCR has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair JAK2--BCR information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair JAK2--BCR information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair JAK2--BCR information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene JAK2--BCR is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair JAK2--BCR information is not available in ChromothripsisDB database.